公开(公告)号：US20210171498A1

公开(公告)日：2021-06-10

申请号：US17062676

申请日：2020-10-05

Applicant: Gilead Sciences, Inc.

Inventor： Gediminas Brizgys ,  Eda Canales ,  Chienhung Chou ,  Michael Graupe ,  Jiayao Li ,  Roland D. Saito ,  Scott D. Schroeder ,  Winston C. Tse ,  Qiaoyin Wu ,  Jennifer R. Zhang

IPC: C07D401/14 ,  A61P31/18 ,  C07D405/14 ,  C07D413/14

Abstract: The invention provides compounds having Formula (I): or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.

公开(公告)号：US20200317689A1

公开(公告)日：2020-10-08

申请号：US16825142

申请日：2020-03-20

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Ana Z. Gonzalez Buenrostro ,  Hongyan Guo ,  Xiaochun Han ,  Lan Jiang ,  Jiayao Li ,  Michael L. Mitchell ,  Hyung-Jung Pyun ,  Scott D. Schroeder ,  Gregg M. Schwarzwalder ,  Nathan D. Shapiro ,  Devleena M. Shivakumar ,  Qiaoyin Wu ,  Hong Yang ,  Jennifer R. Zhang

IPC: C07D498/18 ,  C07D471/18

Abstract: Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2, L, W1, W2, X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：US09944619B2

公开(公告)日：2018-04-17

申请号：US15357290

申请日：2017-02-03

Applicant: Gilead Sciences, Inc.

Inventor： Steven S. Bondy ,  Carina E. Cannizzaro ,  Chien-Hung Chou ,  Randall L. Halcomb ,  Yunfeng Eric Hu ,  John O. Link ,  Qi Liu ,  Scott D. Schroeder ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: A01N43/00 ,  A61K31/00 ,  C07D401/12 ,  C07D213/40 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D471/04 ,  C07D471/06 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4985 ,  A61K31/50 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D409/14 ,  C07D413/14 ,  C07D491/052

CPC classification number: C07D401/12 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4985 ,  A61K31/50 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D213/40 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D409/14 ,  C07D413/14 ,  C07D471/04 ,  C07D471/06 ,  C07D487/04 ,  C07D491/04 ,  C07D491/052 ,  C07D495/04

Abstract: The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.

公开(公告)号：US09789089B2

公开(公告)日：2017-10-17

申请号：US14943931

申请日：2015-11-17

Applicant: Gilead Sciences, Inc.

Inventor： Steven S. Bondy ,  Carina E. Cannizzaro ,  Chien-Hung Chou ,  John O. Link ,  Qi Liu ,  Scott D. Schroeder ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: A61K31/4178 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/437 ,  A61K45/06 ,  A61K31/422

CPC classification number: A61K31/4178 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/437 ,  A61K45/06 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: Compounds of formula I: or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.

公开(公告)号：US09220710B2

公开(公告)日：2015-12-29

申请号：US14151746

申请日：2014-01-09

Applicant: Gilead Sciences, Inc.

Inventor： Steven S. Bondy ,  Carina E. Cannizzaro ,  Chien-Hung Chou ,  John O. Link ,  Qi Liu ,  Scott D. Schroeder ,  Winston C. Tse ,  Jennifer R. Zhang

IPC: C07D403/12 ,  C07D417/12 ,  C07D413/12 ,  A61K31/437 ,  C07D471/04 ,  A61K31/4178 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/427 ,  A61K45/06

CPC classification number: A61K31/4178 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/437 ,  A61K45/06 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

Abstract: Compounds of formula I: or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.

Abstract translation: 公开了式I化合物或其盐。 还公开了包含式I化合物的药物组合物，制备式I化合物的方法，可用于制备式I化合物的中间体和用于治疗包括HIV病毒引起的感染的逆转录病毒科病毒感染的治疗方法。

公开(公告)号：US20240217990A1

公开(公告)日：2024-07-04

申请号：US18264670

申请日：2022-02-08

Applicant: Gilead Sciences, Inc.

Inventor： Stephen E. Ammann ,  Eda Y. Canales ,  Weng K. Chang ,  Julian A. Codelli ,  Lan Jiang ,  Henok H. Kinfe ,  Scott E. Lazerwith ,  Michael L. Mitchell ,  Scott D. Schroeder ,  Daniel G. Shore

IPC: C07D519/00 ,  A61K31/437 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545

CPC classification number: C07D519/00 ,  A61K31/437 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of an autoimmune disease and/or inflammatory condition, including systemic lupus erythematosus and cutaneous lupus erythematosus.

公开(公告)号：US20240199589A1

公开(公告)日：2024-06-20

申请号：US18496137

申请日：2023-10-27

Applicant: Gilead Sciences, Inc.

Inventor： Megan K. Armstrong ,  James S. Cassidy ,  Elbert Chin ,  Chienhung Chou ,  Jeromy J. Cottell ,  Chao-I Hung ,  Kavoos Kolahdouzan ,  David W. Lin ,  Michael L. Mitchell ,  Ezra Roberts ,  Scott D. Schroeder ,  Nathan D. Shapiro ,  James G. Taylor ,  Rhiannon Thomas-Tran ,  Nathan E. Wright ,  Zheng-Yu Yang

IPC: C07D405/14 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/675 ,  C07D401/08 ,  C07D401/10 ,  C07D401/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D493/08 ,  C07D493/10 ,  C07F9/6558

CPC classification number: C07D405/14 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/675 ,  C07D401/08 ,  C07D401/10 ,  C07D401/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D493/08 ,  C07D493/10 ,  C07F9/65586

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition in a human.

公开(公告)号：US20240067629A1

公开(公告)日：2024-02-29

申请号：US18223169

申请日：2023-07-18

Applicant: Gilead Sciences, Inc.

Inventor： Gediminas Brizgys ,  Eda Canales ,  Chienhung Chou ,  Michael Graupe ,  Jiayao Li ,  Roland D. Saito ,  Scott D. Schroeder ,  Winston C. Tse ,  Qiaoyin Wu ,  Jennifer R. Zhang

IPC: C07D401/14 ,  A61P31/18 ,  C07D405/14 ,  C07D413/14

CPC classification number: C07D401/14 ,  A61P31/18 ,  C07D405/14 ,  C07D413/14

Abstract: The invention provides compounds having Formula (I):




or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.

公开(公告)号：US20240043427A1

公开(公告)日：2024-02-08

申请号：US17997594

申请日：2021-04-29

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L. Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Hon C. Hui ,  Richard L. Mackman ,  Michael R. Mish ,  Scott D. Schroeder ,  Nathan D. Shapiro ,  Dustin S. Siegel ,  Doris T. Tang ,  Hai Yang

IPC: C07D487/04 ,  C07D519/00 ,  A61K45/06 ,  C07K16/28

CPC classification number: C07D487/04 ,  C07D519/00 ,  C07K16/2827 ,  C07K16/2818 ,  A61K45/06

Abstract: The present disclosure provides pyrimidine dione compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors. The compounds can be used alone or in combination with other anti-cancer agents.

公开(公告)号：US20230365594A1

公开(公告)日：2023-11-16

申请号：US18180438

申请日：2023-03-08

Applicant: Gilead Sciences, Inc.

Inventor： Stephen E. Ammann ,  Eda Y. Canales ,  Weng K. Chang ,  Henok H. Kinfe ,  Scott E. Lazerwith ,  Michael L. Mitchell ,  Yasamin Moazami ,  Scott D. Schroeder ,  Daniel G. Shore ,  Christopher J. Swank

IPC: C07D519/00 ,  C07D495/04

CPC classification number: C07D519/00 ,  C07D495/04

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of an autoimmune disease and/or inflammatory condition, including systemic lupus erythematosus and cutaneous lupus erythematosus.