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68 条记录 (耗时 0.035 秒)

    Agent for recruitment of bone-marrow-derived pluripotent stem cell into peripheral circulation
    21.
    发明授权
    Agent for recruitment of bone-marrow-derived pluripotent stem cell into peripheral circulation 有权
    将骨髓衍生的多能干细胞募集到外周循环中的药剂

    公开(公告)号：US08673580B2

    公开(公告)日：2014-03-18

    申请号：US12990047

    申请日：2009-04-30

    申请人： Katsuto Tamai ,  Takehiko Yamazaki ,  Takenao Chino ,  Yasufumi Kaneda

    发明人： Katsuto Tamai ,  Takehiko Yamazaki ,  Takenao Chino ,  Yasufumi Kaneda

    IPC分类号： G01N33/567

    CPC分类号： A61K35/36 ,  A61K38/1709 ,  G01N33/5029

    摘要： The present invention for the first time demonstrated that: (1) bone marrow-derived pluripotent tissue stem cells can be induced in peripheral blood by intravenously administering tissue extract prepared from isolated skin pieces; (2) the substance in the isolated skin pieces, which is responsible for mobilizing bone marrow-derived pluripotent tissue stem cells to peripheral blood, is HMGB1; and (3) HMGB1 with the activity of mobilizing bone marrow-derived pluripotent stem cells to peripheral blood can be easily purified from cultured cells.

    摘要翻译： 本发明首次证明：（1）通过静脉内施用从分离的皮肤片制备的组织提取物可以在外周血中诱导骨髓衍生的多能组织干细胞; （2）负责将骨髓衍生的多能组织干细胞移植至外周血的分离皮肤块中的物质为HMGB1; 和（3）可以从培养的细胞中容易地纯化具有将骨髓衍生的多能干细胞移动到外周血的活性的HMGB1。

    Balance filter comprising two acoustic wave filters connected to a single ground terminal
    23.
    发明授权
    Balance filter comprising two acoustic wave filters connected to a single ground terminal 失效
    平衡滤波器包括连接到单个接地端子的两个声波滤波器

    公开(公告)号：US08063722B2

    公开(公告)日：2011-11-22

    申请号：US12392622

    申请日：2009-02-25

    申请人： Akira Moriya ,  Yasufumi Kaneda ,  Osamu Kawachi

    发明人： Akira Moriya ,  Yasufumi Kaneda ,  Osamu Kawachi

    IPC分类号： H03H9/64

    CPC分类号： H03H9/0076 ,  H03H9/02913 ,  H03H9/1092

    摘要： A balance filter includes two acoustic wave filters connected between a single unbalanced terminal and two balanced terminals, and a ground terminal connected to the two acoustic wave filters via a first interconnection portion and a second interconnection portion. The first interconnection portion is connected to the two acoustic wave filters, and the second interconnection portion is connected to the first interconnection portion in a region that is located between the two acoustic wave filters and extends in a direction orthogonal to a direction in which the two acoustic wave filters are aligned.

    摘要翻译： 平衡滤波器包括连接在单个不平衡端子和两个平衡端子之间的两个声波滤波器，以及经由第一互连部分和第二互连部分连接到两个声波滤波器的接地端子。 第一互连部分连接到两个声波滤波器，并且第二互连部分在位于两个声波滤波器之间的区域中连接到第一互连部分，并且在与两个声波滤波器的方向正交的方向上延伸 声波滤波器对齐。

    Pharmaceuticals That Promote Functional Regeneration of Damaged Tissues
    26.
    发明申请
    Pharmaceuticals That Promote Functional Regeneration of Damaged Tissues 审中-公开
    促进损伤组织功能再生的药物

    公开(公告)号：US20090202500A1

    公开(公告)日：2009-08-13

    申请号：US12161982

    申请日：2007-10-30

    申请人： Katsuto Tamai ,  Takehiko Yamazaki ,  Yasufumi Kaneda

    发明人： Katsuto Tamai ,  Takehiko Yamazaki ,  Yasufumi Kaneda

    IPC分类号： A61K35/12 ,  C12N5/00 ,  C07H1/00 ,  C12P19/44 ,  C12Q1/02

    CPC分类号： A61K31/711 ,  A61K38/00 ,  C07K14/52 ,  G01N33/5073 ,  G01N33/6863 ,  G01N2500/10

    摘要： The present inventors revealed the following for the first time in the world: 1) a large amount of bone marrow-derived cells are mobilized to grafted skin; 2) the mobilized bone marrow-derived cells are differentiated into any of dermal fibroblasts, adipocytes, muscle cells, vascular endothelial cells, and epidermal keratinocytes in the grafted skin, and the mobilized bone marrow derived cells include bone marrow-derived mesenchymal stem cells; 3) the factors which mobilize bone marrow-derived mesenchymal stem cells from peripheral blood to the grafted skin are HMGB1, HMGB2, and HMGB3 released from the necrosed tissue of recipient skin; 4) purified HMGB1, HMGB2, and HMGB3 promote the migration of mesenchymal stem cells isolated and cultured from bone marrow; 5) activators containing HMGB1 which allows the migration of bone marrow mesenchymal stem cells can be conveniently purified from several organ extracts including skin, brain, and heart; 6) activators which allow the migration of bone marrow mesenchymal stem cells can be conveniently extracted from cultured cells; and 7) a heparin-column purified fraction of skin extract mobilizes a large amount of bone marrow-derived cells in case of brain injury.

    摘要翻译： 本发明人首次在世界上发现了以下几个原因：1）大量骨髓来源的细胞被移动到移植皮肤; 2）动员的骨髓来源的细胞分化为移植皮肤中的真皮成纤维细胞，脂肪细胞，肌肉细胞，血管内皮细胞和表皮角化细胞中的任何一种，动员的骨髓衍生细胞包括骨髓间充质干细胞; 3）将骨髓间充质干细胞从外周血移植到移植皮肤的因素是从受体皮肤坏死组织释放的HMGB1，HMGB2和HMGB3; 4）纯化的HMGB1，HMGB2和HMGB3促进从骨髓​​分离培养的间充质干细胞的迁移; 5）可以从几种器官提取物（包括皮肤，脑和心脏）中方便地纯化含有允许骨髓间充质干细胞迁移的HMGB1的激活剂; 6）允许骨髓间充质干细胞迁移的激活剂可以方便地从培养的细胞中提取; 和7）皮肤提取物的肝素柱纯化部分在脑损伤的情况下起动大量骨髓来源的细胞。

    Filter having multiple surface acoustic wave filters connected in parallel
    27.
    发明申请
    Filter having multiple surface acoustic wave filters connected in parallel 有权
    具有并联连接的多个声表面波滤波器的滤波器

    公开(公告)号：US20080024246A1

    公开(公告)日：2008-01-31

    申请号：US11878747

    申请日：2007-07-26

    申请人： Yasufumi Kaneda ,  Osamu Kawachi ,  Seiichi Mitobe ,  Kouta Ookubo

    发明人： Yasufumi Kaneda ,  Osamu Kawachi ,  Seiichi Mitobe ,  Kouta Ookubo

    IPC分类号： H03H9/00

    CPC分类号： H03H9/6476 ,  H03H9/14582

    摘要： A filter includes a first filter that is connected between an input node and an output node and is a surface acoustic wave filter, and a second filter that is provided between the input node and the output node and is connected in parallel with the first filter. The first filter has a total number N1 of pairs of electrode fingers of interdigital transducers and the second filter having a total number N2 of pairs of electrode fingers of interdigital transducers, in which N1 is greater than N2.

    摘要翻译： 滤波器包括连接在输入节点和输出节点之间并且是表面声波滤波器的第一滤波器，以及设置在输入节点和输出节点之间并与第一滤波器并联连接的第二滤波器。 第一滤波器具有交叉指型换能器的电极指数对N1的总数，并且第二滤波器具有跨数字换能器的电极指对的总数N2，其中N1大于N2。

    Balanced output filter having specified package input and output ground metal patterns
    28.
    发明授权
    Balanced output filter having specified package input and output ground metal patterns 有权
    平衡输出滤波器具有指定的封装输入和输出接地金属图案

    公开(公告)号：US07233219B2

    公开(公告)日：2007-06-19

    申请号：US11114128

    申请日：2005-04-26

    申请人： Shogo Inoue ,  Motoyuki Tajima ,  Takayuki Yamaji ,  Yasufumi Kaneda ,  Osamu Kawachi ,  Masanori Ueda

    发明人： Shogo Inoue ,  Motoyuki Tajima ,  Takayuki Yamaji ,  Yasufumi Kaneda ,  Osamu Kawachi ,  Masanori Ueda

    IPC分类号： H03H9/64

    CPC分类号： H03H9/059 ,  H03H9/0071 ,  H03H9/0095

    摘要： A balanced filter includes a package having an input ground metal pattern and an output ground metal pattern, and a filter chip having an inphase filter and an antiphase filter, which filters are mounted on the package, at least one of the inphase and antiphase filters having an input ground terminal connected to the input ground metal pattern and an output ground terminal connected to the output ground metal pattern, the input and output ground terminals of said at least one of the inphase and antiphase filters being separate from each other on the filter chip.

    摘要翻译： 平衡滤波器包括具有输入接地金属图案和输出接地金属图案的封装以及具有同相滤波器和反相滤波器的滤波器芯片，该滤波器安装在封装上，至少一个同相滤波器和反相滤波器具有 连接到输入接地金属图案的输入接地端子和连接到输出接地金属图案的输出接地端子，所述至少一个同相和反相滤波器的输入和输出接地端子在滤波器芯片上彼此分离 。

    Drug for auditory dysfunction
    29.
    发明申请
    Drug for auditory dysfunction 有权
    药物用于听觉功能障碍

    公开(公告)号：US20060233755A1

    公开(公告)日：2006-10-19

    申请号：US10527195

    申请日：2003-10-02

    申请人： Yasufumi Kaneda ,  Kazuo Oshima ,  Ryuichi Morishita ,  Takeshi Kubo

    发明人： Yasufumi Kaneda ,  Kazuo Oshima ,  Ryuichi Morishita ,  Takeshi Kubo

    IPC分类号： A61K48/00

    CPC分类号： C07K14/4753 ,  A61K38/1833 ,  A61K48/00 ,  A61K48/005 ,  C12N2799/021

    摘要： The present invention provides a pharmaceutical preparation for hearing impairment, which is suitable for gene therapy of hearing impairment, that is, a pharmaceutical preparation for hearing impairment which comprises a virus envelope vector encapsulating a hepatocyte growth factor (HGF) gene or its plasmid as an active ingredient. Particularly, it is suitable as a pharmaceutical preparation for gene therapy for the purpose of prevention and treatment of deafness.

    摘要翻译： 本发明提供一种适用于听力障碍的基因疗法的听力损伤药物制剂，即用于听觉障碍的药物制剂，其包含包封肝细胞生长因子（HGF）基因的病毒包膜载体或其质粒作为 有效成分。 特别地，作为用于预防和治疗耳聋的基因治疗的药物制剂是合适的。