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公开(公告)号：US08853209B2
公开(公告)日：2014-10-07
申请号：US13088206
申请日：2011-04-15
Applicant: Xiaohong Song , Hong Ding , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Cheol-Min Park , Zhi-Fu Tao , Xilu Wang , Aaron R. Kunzer
Inventor： Xiaohong Song , Hong Ding , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Cheol-Min Park , Zhi-Fu Tao , Xilu Wang , Aaron R. Kunzer
IPC: C07D209/42 , C07D403/04
CPC classification number: C07D209/42 , C07D403/04
Abstract: Compounds of Formula I wherein A1, B1, C1, D1, E1, F1 and L1 are as defined herein, which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mdl-1 protein, such as leukemia and lymphoma, are disclosed.
Abstract translation: 其中A1，B1，C1，D1，E1，F1和L1如本文所定义的式I化合物，其抑制抗细胞凋亡Mcl-1蛋白的活性，含有该化合物的组合物，以及治疗涉及过表达或未调节的疾病的方法 公开了诸如白血病和淋巴瘤的Md1-1蛋白。
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公开(公告)号：US08757689B2
公开(公告)日：2014-06-24
申请号：US13521503
申请日：2010-02-12
Applicant: Hong Ding
Inventor： Hong Ding
IPC: B66C1/04
CPC classification number: B66C1/04 , H01F7/0257
Abstract: The present invention provides a kind of permanent magnetic lifting device, which has: a housing, at the bottom of which is a clamping surface for clamping objects; fixed magnet(s), set in housing relatively fixed to housing; a turnable magnet, set in housing relatively turnable to fixed magnet. When turnable magnet is in the first position relative to fixed magnet, the magnetic force generated by fixed magnet and turnable magnet to clamping surface is zero magnetic force; when turnable magnet is in the third position relative to fixed magnet, the magnetic force generated by fixed magnet and turnable magnet to clamping surface is the maximum magnetic force. The permanent magnetic lifting device also has a positioning mechanism for second position to position the turnable magnet in the second position relative to fixed magnet, fixed magnet and turnable magnet generate trial clamping magnetic force to clamping surface for clamping objects on trial.
Abstract translation: 本发明提供一种永磁提升装置，其具有：壳体，其底部是夹紧物体的夹紧面; 固定磁体，设置在与壳体相对固定的壳体中; 固定在壳体内的可转动磁体可相对转动到固定磁体。 当可转动磁体相对于固定磁体位于第一位置时，由固定磁体和可转动磁体产生的夹紧磁力对零位磁力; 当可转动磁体相对于固定磁体位于第三位置时，由固定磁铁和可转动磁体产生的夹紧磁力对夹紧表面是最大的磁力。 永磁提升装置还具有用于第二位置的定位机构，用于将可转动磁体相对于固定磁体，固定磁体和可转动磁体定位在第二位置，以将试件夹紧磁力产生到夹紧表面，用于在试验中夹紧物体。
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23.发明授权公开(公告)号：US08188077B2
公开(公告)日：2012-05-29
申请号：US13049569
申请日：2011-03-16
Applicant: Hong Ding , Steven W. Elmore , Laura A. Hexamer , Aaron R. Kunzer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Michael D. Wendt
Inventor： Hong Ding , Steven W. Elmore , Laura A. Hexamer , Aaron R. Kunzer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Michael D. Wendt
IPC: A61K31/5377 , A61K31/5375 , A61K31/435 , A61K31/437 , C07D413/02 , C07D241/02 , C07D295/00 , C07D211/00
CPC classification number: C07D211/58 , C07C311/51 , C07C2601/14 , C07C2603/74 , C07D295/112 , C07D295/195 , C07D417/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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24.发明授权Vinblastine derivatives, their preparation, use and pharmaceutical compositions comprising the said derivatives 失效长春花碱衍生物，它们的制备，用途和包含所述衍生物的药物组合物公开(公告)号：US08168647B2
公开(公告)日：2012-05-01
申请号：US12449180
申请日：2007-12-17
Applicant: Lihong Hu , Xu Shen , Hualiang Jiang , Liguang Lou , Hong Ding , Yong Shao , Hankun Zhang
Inventor： Lihong Hu , Xu Shen , Hualiang Jiang , Liguang Lou , Hong Ding , Yong Shao , Hankun Zhang
IPC: C07D519/04 , A61K31/475 , A61P35/00
CPC classification number: C07D519/04
Abstract: The invention provides vinblastine derivatives represented by the following formula 1 or their physiologically acceptable salts, their preparation, use and pharmaceutical compositions comprising the said derivatives. The said vinblastine derivatives show inhibiting activities against tumor cell lines and can be used as medicaments for treating malignant tumors.
Abstract translation: 本发明提供由下式1表示的长春花碱衍生物或其生理上可接受的盐，其制备，用途和包含所述衍生物的药物组合物。 所述长春花碱衍生物显示对肿瘤细胞系的抑制活性，可用作治疗恶性肿瘤的药物。
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公开(公告)号：US08084607B2
公开(公告)日：2011-12-27
申请号：US12390945
申请日：2009-02-23
Applicant: Milan Bruncko , Hong Ding , Steven Elmore , Aaron R. Kunzer , Christopher L. Lynch , William J. McClellan , Cheol-min Park , Andrew M. Petros , Xiaohong Song , Noah P. Tu , Xilu Wang , Michael D. Wendt
Inventor： Milan Bruncko , Hong Ding , Steven Elmore , Aaron R. Kunzer , Christopher L. Lynch , William J. McClellan , Cheol-min Park , Andrew M. Petros , Xiaohong Song , Noah P. Tu , Xilu Wang , Michael D. Wendt
IPC: C07D241/04 , C07D295/00
CPC classification number: C07D277/74 , C04B35/632 , C07C323/25 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D211/46 , C07D211/60 , C07D211/74 , C07D213/70 , C07D213/75 , C07D233/06 , C07D233/84 , C07D239/06 , C07D263/58 , C07D277/36 , C07D295/13 , C07D295/192 , C07D307/64 , C07D335/02 , C07D401/12 , C07D403/04 , C07D409/12 , C07D487/04 , C07D487/08
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
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Patent Agency Ranking
公开(公告)号：US07981888B2
公开(公告)日：2011-07-19
申请号：US12104319
申请日：2008-04-16
Applicant: Xiaohong Song , Hong Ding , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Cheol-Min Park , Zhi-Fu Tao , Xilu Wang , Aaron R. Kunzer
Inventor： Xiaohong Song , Hong Ding , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Cheol-Min Park , Zhi-Fu Tao , Xilu Wang , Aaron R. Kunzer
IPC: A61K31/535
CPC classification number: C07D209/42 , C07D403/04
Abstract: Compounds of Formula I wherein A1, B1, C1, D1, E1, F1 and L1 are as defined herein, which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein, such as leukemia and lymphoma, are disclosed.
Abstract translation: 其中A1，B1，C1，D1，E1，F1和L1如本文所定义的式I化合物，其抑制抗细胞凋亡Mcl-1蛋白的活性，含有该化合物的组合物，以及治疗涉及过表达或未调节的疾病的方法 公开了Mcl-1蛋白，如白血病和淋巴瘤。
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公开(公告)号：US20100240715A1
公开(公告)日：2010-09-23
申请号：US12800702
申请日：2010-05-19
Applicant: Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt
Inventor： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt
IPC: A61K31/4192 , C07C311/15 , A61K31/18 , C07C311/19 , C07D235/06 , A61K31/4184 , C07D249/18 , A61P35/00
CPC classification number: C07D295/155 , C07D207/24 , C07D211/20 , C07D211/26 , C07D211/48 , C07D211/70 , C07D211/72 , C07D213/38 , C07D213/70 , C07D213/74 , C07D213/81 , C07D215/12 , C07D257/04 , C07D277/36 , C07D295/185 , C07D295/30 , C07D307/22 , C07D309/20 , C07D333/20 , C07D333/34 , C07D401/12 , C07D403/12 , C07D487/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
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公开(公告)号：US07754886B2
公开(公告)日：2010-07-13
申请号：US12364987
申请日：2009-02-03
Applicant: David J. Augeri , Steven A. Baumeister , Milan Bruncko , Daniel A. Dickman , Hong Ding , Jurgen Dinges , Stephen W. Fesik , Philip J Hajduk , Aaron R Kunzer , William J. Mcclellan , David D. Nettesheim , Thorsten K. Oost , Andrew M. Petros , Saul Howard Rosenberg , Wang Shen , Sheela A. Thomas , Xilu Wang , Michael D. Wendt
Inventor： David J. Augeri , Steven A. Baumeister , Milan Bruncko , Daniel A. Dickman , Hong Ding , Jurgen Dinges , Stephen W. Fesik , Philip J Hajduk , Aaron R Kunzer , William J. Mcclellan , David D. Nettesheim , Thorsten K. Oost , Andrew M. Petros , Saul Howard Rosenberg , Wang Shen , Sheela A. Thomas , Xilu Wang , Michael D. Wendt
IPC: C07C211/00 , A61K31/445
CPC classification number: C07D207/27 , A61K31/18 , A61K31/4015 , A61K31/44 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , C07C311/51 , C07C323/30 , C07C323/37 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D203/26 , C07D207/06 , C07D209/08 , C07D209/52 , C07D209/54 , C07D211/22 , C07D211/74 , C07D213/54 , C07D213/61 , C07D213/64 , C07D213/70 , C07D213/78 , C07D215/12 , C07D221/20 , C07D231/12 , C07D235/08 , C07D235/26 , C07D239/26 , C07D249/04 , C07D263/32 , C07D263/56 , C07D263/58 , C07D277/56 , C07D277/64 , C07D295/205 , C07D295/26 , C07D317/60 , C07D333/28 , C07D333/56 , C07D333/70 , C07D417/12 , C07D451/02
Abstract: N-Benzoyl arylsulfonamides having the formula are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.
Abstract translation: 具有下式的N-苯甲酰基芳基磺酰胺是BCL-X1抑制剂，可用于促进凋亡。 还公开了BCL-X1抑制组合物和促进哺乳动物细胞凋亡的方法。
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公开(公告)号：US20070015787A1
公开(公告)日：2007-01-18
申请号：US11491851
申请日：2006-07-24
Applicant: Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt , Alexander Shoemaker , Michael Mitten
Inventor： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt , Alexander Shoemaker , Michael Mitten
IPC: A61K31/4745 , A61K31/4412 , A61K31/277 , A61K31/198 , A61K31/18
CPC classification number: C07D233/06 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/20 , C07D207/24 , C07D207/50 , C07D211/14 , C07D211/20 , C07D211/26 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D211/72 , C07D213/36 , C07D213/38 , C07D213/42 , C07D213/70 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/12 , C07D231/12 , C07D231/56 , C07D233/61 , C07D233/64 , C07D235/08 , C07D239/06 , C07D239/38 , C07D241/04 , C07D249/18 , C07D257/04 , C07D261/20 , C07D263/12 , C07D263/22 , C07D263/58 , C07D265/30 , C07D267/10 , C07D273/01 , C07D277/36 , C07D277/74 , C07D295/155 , C07D295/185 , C07D295/30 , C07D307/14 , C07D307/22 , C07D307/81 , C07D309/14 , C07D309/20 , C07D317/66 , C07D333/20 , C07D333/34 , C07D335/02 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/10 , C07D413/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/04 , C07D491/08 , C07D498/08
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
Abstract translation: 公开了抑制抗凋亡蛋白家族成员的活性的化合物，含有该化合物的组合物和该化合物用于制备用于治疗疾病的药物的用途，其中发生表达一种或多种抗凋亡蛋白家族成员。
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公开(公告)号：US20050159427A1
公开(公告)日：2005-07-21
申请号：US10988338
申请日：2004-11-12
Applicant: Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt
Inventor： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt
IPC: A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/635 , C07C311/51 , C07C323/25 , C07D205/04 , C07D207/16 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/74 , C07D213/70 , C07D213/75 , C07D233/06 , C07D233/84 , C07D239/06 , C07D263/58 , C07D277/36 , C07D277/74 , C07D295/13 , C07D295/155 , C07D295/192 , C07D307/64 , C07D335/02 , C07D401/12 , C07D403/04 , C07D403/12 , C07D409/12 , C07D413/02 , C07D413/12 , C07D417/02 , C07D487/04 , C07D487/08 , C07D43/02
CPC classification number: C07D277/74 , C04B35/632 , C07C323/25 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D211/46 , C07D211/60 , C07D211/74 , C07D213/70 , C07D213/75 , C07D233/06 , C07D233/84 , C07D239/06 , C07D263/58 , C07D277/36 , C07D295/13 , C07D295/192 , C07D307/64 , C07D335/02 , C07D401/12 , C07D403/04 , C07D409/12 , C07D487/04 , C07D487/08
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and methods of treatment of diseases during which occurs expression of one or more than one of an anti-apoptotic protein family member using the compounds.
Abstract translation: 公开了抑制抗凋亡蛋白家族成员的活性的化合物，含有化合物的组合物和治疗疾病的方法，其中发生使用该化合物的一种或多种抗凋亡蛋白家族成员的表达。
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