公开(公告)号：US20130164251A1

公开(公告)日：2013-06-27

申请号：US13575752

申请日：2010-06-30

申请人： Xiaofang Wen ,  Yiliang Wu ,  Yefei Wang ,  Zhiyu Yang ,  Min Fan ,  Yujiao Wang ,  Xiaochun Fang ,  You Lu

发明人： Xiaofang Wen ,  Yiliang Wu ,  Yefei Wang ,  Zhiyu Yang ,  Min Fan ,  Yujiao Wang ,  Xiaochun Fang ,  You Lu

IPC分类号： C07K14/535 ,  C07K14/765

CPC分类号： C07K14/535 ,  A61K38/00 ,  C07K2319/31

摘要： The present invention relates to a mutant G-CSF fusion protein. The mutant G-CSF fusion protein is a fusion protein having the activity of stimulating the proliferation of neutrophilic granulocytes, and having a basic structure of G-CSF/carrier protein or carrier protein/G-CSF; wherein the G-CSF moiety comprises multipoint substitutions thus resulting in changes in biological activity and binding affinity. Compared with existing products, the mutant G-CSF fusion protein in the present invention has longer half-life and higher biological activity. Administration of the pharmaceutical preparation containing this mutant G-CSF fusion protein could be used in the treating neutropenia.

摘要翻译： 本发明涉及突变型G-CSF融合蛋白。 突变型G-CSF融合蛋白是具有刺激嗜中性粒细胞增殖活性的融合蛋白，具有G-CSF /载体蛋白或载体蛋白/ G-CSF的基本结构; 其中G-CSF部分包含多点置换，从而导致生物活性和结合亲和力的变化。 与现有产品相比，本发明的突变型G-CSF融合蛋白具有较长的半衰期和较高的生物活性。 含有该突变型G-CSF融合蛋白的药物制剂的给药可用于治疗中性粒细胞减少症。

公开(公告)号：US08369469B1

公开(公告)日：2013-02-05

申请号：US13085350

申请日：2011-04-12

申请人： Atul Salhotra ,  Kedar Shirali ,  Zhiyu Yang ,  Hui-Ling Lou

发明人： Atul Salhotra ,  Kedar Shirali ,  Zhiyu Yang ,  Hui-Ling Lou

IPC分类号： H04L25/08

CPC分类号： H04B7/0857 ,  H04B7/084 ,  H04L2025/03414 ,  H04L2025/03426

摘要： A method including: receiving, through a wireless channel, a plurality of modulated signals at a plurality of antennas, wherein each antenna receives a corresponding modulated signal; generating a plurality of autocorrelated signals by autocorrelating the plurality of modulated signals; determining whether a signal strength associated with each modulated signal is (i) below a threshold or (ii) above the threshold; for each modulated signal having a signal strength below the threshold, disabling the antenna that received the modulated signal having the signal strength below the threshold; combining the modulated signals having a signal strength above the threshold; generating weighted autocorrelated signals based on (i) the plurality of autocorrelated signals and (ii) the combined modulated signals; generating a combined weighted signal by summing the weighted autocorrelation signals; demodulating the combined weighted signal; and determining a state of the wireless channel based on the demodulation of the combined weighted signal.

摘要翻译： 一种方法，包括：通过无线信道在多个天线处接收多个调制信号，其中每个天线接收对应的调制信号; 通过对所述多个调制信号进行自相关来生成多个自相关信号; 确定与每个调制信号相关联的信号强度是否是（i）低于阈值或（ii）高于阈值; 对于具有低于阈值的信号强度的每个调制信号，禁用接收到信号强度低于阈值的调制信号的天线; 组合具有高于阈值的信号强度的调制信号; 基于（i）所述多个自相关信号和（ii）所述组合调制信号产生加权自相关信号; 通过对加权的自相关信号求和来产生组合的加权信号; 解调组合加权信号; 以及基于所述组合加权信号的解调来确定所述无线信道的状态。

公开(公告)号：US08339174B2

公开(公告)日：2012-12-25

申请号：US12712930

申请日：2010-02-25

申请人： Zhiyu Yang ,  Dilip S ,  Tushar Dhayagude

发明人： Zhiyu Yang ,  Dilip S ,  Tushar Dhayagude

IPC分类号： H03K3/00

CPC分类号： H05B33/0809 ,  H03K3/012 ,  H03K7/08 ,  H05B33/0842

摘要： Systems, circuits and methods for phase-shifting pulse width modulated signal generation are disclosed. In some embodiments, a phase-shifting pulse width modulation circuit is configured to output pulses based on an input pulse width modulated signal. The pulses are staggered relative to one another, and can be received by a light-emitting diode driver for driving a light-emitting diode string at one or more time periods. The phase-shifting pulse width modulation circuit can include a counter-based programmable delay subcircuit consisting of two counter-based programmable delay blocks.

摘要翻译： 公开了用于相移脉宽调制信号产生的系统，电路和方法。 在一些实施例中，移相脉宽调制电路被配置为基于输入脉宽调制信号输出脉冲。 脉冲相对于彼此交错，并且可以由用于在一个或多个时间段驱动发光二极管串的发光二极管驱动器接收。 相移脉宽调制电路可以包括由两个基于计数器的可编程延迟块组成的基于计数器的可编程延迟子电路。

公开(公告)号：US08785597B2

公开(公告)日：2014-07-22

申请号：US13575752

申请日：2010-06-30

申请人： Xiaofang Wen ,  Yiliang Wu ,  Yefei Wang ,  Zhiyu Yang ,  Min Fan ,  Yujiao Wang ,  Xiaochun Fang ,  You Lu

发明人： Xiaofang Wen ,  Yiliang Wu ,  Yefei Wang ,  Zhiyu Yang ,  Min Fan ,  Yujiao Wang ,  Xiaochun Fang ,  You Lu

IPC分类号： C07K1/00 ,  C12P21/04 ,  C12N15/00 ,  C12N5/00 ,  A61K38/18

CPC分类号： C07K14/535 ,  A61K38/00 ,  C07K2319/31

摘要： The present invention relates to a mutant G-CSF fusion protein. The mutant G-CSF fusion protein is a fusion protein having the activity of stimulating the proliferation of neutrophilic granulocytes, and having a basic structure of G-CSF/carrier protein or carrier protein/G-CSF; wherein the G-CSF moiety comprises multipoint substitutions thus resulting in changes in biological activity and binding affinity. Compared with existing products, the mutant G-CSF fusion protein in the present invention has longer half-life and higher biological activity. Administration of the pharmaceutical preparation containing this mutant G-CSF fusion protein could be used in the treating neutropenia.

摘要翻译： 本发明涉及突变型G-CSF融合蛋白。 突变型G-CSF融合蛋白是具有刺激嗜中性粒细胞增殖活性的融合蛋白，具有G-CSF /载体蛋白或载体蛋白/ G-CSF的基本结构; 其中G-CSF部分包含多点置换，从而导致生物活性和结合亲和力的变化。 与现有产品相比，本发明的突变型G-CSF融合蛋白具有较长的半衰期和较高的生物活性。 含有该突变型G-CSF融合蛋白的药物制剂的给药可用于治疗中性粒细胞减少症。

公开(公告)号：US08581828B2

公开(公告)日：2013-11-12

申请号：US12772067

申请日：2010-04-30

申请人： Zhiyu Yang ,  Kien Vi ,  Dilip S ,  Tushar Dhayagude

发明人： Zhiyu Yang ,  Kien Vi ,  Dilip S ,  Tushar Dhayagude

IPC分类号： G09G3/36

CPC分类号： G09G3/342 ,  G09G3/3406 ,  G09G2320/064 ,  H05B33/0818 ,  H05B33/0827 ,  H05B33/0851 ,  Y02B20/346

摘要： System(s) and method(s) are provided for power management in an electronic display via compensation of a power source of a light-emitting-diode (LED) backlighting system. A compensation feedback loop includes a load-aware controller that receives the load condition from a dimming controller and supplies a control signal to the power source. An efficiency regulator functionally connected the backlight circuitry closes the compensation feedback loop and provides an input signal to the load-aware controller. The dimming controller implements phase-shifted pulse-modulation dimming, which based on duty cycle can establish a dimming equilibrium with two load conditions. The load aware controller includes a set of compensation blocks arranged in parallel, with a single compensation block connected to the input signal and that provides the control signal. A selector component in the load aware controller determines a compensation block to be connected to the compensation feedback loop based on the received load condition.

摘要翻译： 通过补偿发光二极管（LED）背光系统的电源，为电子显示器中的电源管理提供系统和方法。 补偿反馈回路包括负载感知控制器，其从调光控制器接收负载状况，并向控制电源提供控制信号。 功能上连接到背光电路的效率调节器关闭补偿反馈回路并向负载感知控制器提供输入信号。 调光控制器实现相移脉冲宽度调制调光，其基于占空比可以在两个负载条件下建立调光平衡。 负载感知控制器包括并联布置的一组补偿块，单个补偿块连接到输入信号并提供控制信号。 负载感知控制器中的选择器部件基于接收的负载条件确定要连接到补偿反馈回路的补偿块。

公开(公告)号：US20110267375A1

公开(公告)日：2011-11-03

申请号：US12772067

申请日：2010-04-30

申请人： Zhiyu Yang ,  Kien Vi ,  Dilip S. ,  Tushar Dhayagude

发明人： Zhiyu Yang ,  Kien Vi ,  Dilip S. ,  Tushar Dhayagude

IPC分类号： G09G5/10 ,  H05B37/02

CPC分类号： G09G3/342 ,  G09G3/3406 ,  G09G2320/064 ,  H05B33/0818 ,  H05B33/0827 ,  H05B33/0851 ,  Y02B20/346

摘要： System(s) and method(s) are provided for power management in an electronic display via compensation of a power source of a light-emitting-diode (LED) backlighting system. A compensation feedback loop includes a load-aware controller that receives the load condition from a dimming controller and supplies a control signal to the power source. An efficiency regulator functionally connected the backlight circuitry closes the compensation feedback loop and provides an input signal to the load-aware controller. The dimming controller implements phase-shifted pulse-modulation dimming, which based on duty cycle can establish a dimming equilibrium with two load conditions. The load aware controller includes a set of compensation blocks arranged in parallel, with a single compensation block connected to the input signal and that provides the control signal. A selector component in the load aware controller determines a compensation block to be connected to the compensation feedback loop based on the received load condition.

摘要翻译： 通过补偿发光二极管（LED）背光系统的电源，为电子显示器中的电力管理提供系统和方法。 补偿反馈回路包括负载感知控制器，其从调光控制器接收负载状况，并向控制电源提供控制信号。 功能上连接到背光电路的效率调节器关闭补偿反馈回路并向负载感知控制器提供输入信号。 调光控制器实现相移脉冲调制调光，其基于占空比可以在两个负载条件下建立调光平衡。 负载感知控制器包括并联布置的一组补偿块，单个补偿块连接到输入信号并提供控制信号。 负载感知控制器中的选择器部件基于接收的负载条件确定要连接到补偿反馈回路的补偿块。

公开(公告)号：US20060275138A1

公开(公告)日：2006-12-07

申请号：US11144100

申请日：2005-06-03

申请人： Ping Sheng ,  Ning Wang ,  Jianying Miao ,  Zhiyu Yang ,  Shihe Yang ,  Xinyi Zhang

发明人： Ping Sheng ,  Ning Wang ,  Jianying Miao ,  Zhiyu Yang ,  Shihe Yang ,  Xinyi Zhang

IPC分类号： F04B37/02

CPC分类号： F04B19/006 ,  F04B17/00

摘要： A technique has been developed to fabricate micro- or nanopumps based on porous alumina thin films. The main body of the nanopump consists of a porous alumina thin film (containing nano-sized channels of about 40-300 nm in diameter) with conductive surfaces (e.g. Au coating layers) on both sides of the film. Through the fabrication of nanochannels in (the alumina films) and the subsequent annealing and surface activation processes, high-efficiency micro- or nanopumps can be made. The nanofluidic flow through the nanochannels of the alumina thin films is driven by an electric field with no moving parts. The flow rate (up to 50 millilitres/(min·cm2)) of water through the alumina thin film can be continuously tuned through the intensity of the electric field, i.e., the DC electric potential applied across the nanochannels.

摘要翻译： 已经开发了一种基于多孔氧化铝薄膜制造微米或纳米囊的技术。 纳米孔的主体由多孔氧化铝薄膜（包含直径约40-300nm的纳米尺寸的通道）和薄膜两侧的导电表面（例如Au涂层）组成。 通过（氧化铝膜）中的纳米通道的制造和随后的退火和表面活化过程，可以制成高效率的微米或者纳米粉。 通过氧化铝薄膜的纳米通道的纳米流体流动由没有移动部件的电场驱动。 通过氧化铝薄膜的水的流速（高达50毫升/（分钟/秒））可以通过电场的强度，即跨越施加的直流电势， 纳米通道。

公开(公告)号：US20130193859A1

公开(公告)日：2013-08-01

申请号：US13724649

申请日：2012-12-21

申请人： Zhiyu Yang ,  Dilip Sangam ,  Tushar Dhayagude

发明人： Zhiyu Yang ,  Dilip Sangam ,  Tushar Dhayagude

IPC分类号： H05B33/08 ,  H03K3/012

CPC分类号： H05B33/0809 ,  H03K3/012 ,  H03K7/08 ,  H05B33/0842

摘要： Systems, circuits and methods for phase-shifting pulse width modulated signal generation are disclosed. In some embodiments, a phase-shifting pulse width modulation circuit is configured to output pulses based on an input pulse width modulated signal. The pulses are staggered relative to one another, and can be received by a light-emitting diode driver for driving a light-emitting diode string at one or more time periods. The phase-shifting pulse width modulation circuit can include a counter-based programmable delay subcircuit consisting of two counter-based programmable delay blocks.

摘要翻译： 公开了用于相移脉宽调制信号产生的系统，电路和方法。 在一些实施例中，移相脉宽调制电路被配置为基于输入脉宽调制信号输出脉冲。 脉冲相对于彼此交错，并且可以由用于在一个或多个时间段驱动发光二极管串的发光二极管驱动器接收。 相移脉宽调制电路可以包括由两个基于计数器的可编程延迟块组成的基于计数器的可编程延迟子电路。

公开(公告)号：US07924930B1

公开(公告)日：2011-04-12

申请号：US11642442

申请日：2006-12-20

申请人： Atul Salhotra ,  Kedar Shirali ,  Zhiyu Yang ,  Hui-Ling Lou

发明人： Atul Salhotra ,  Kedar Shirali ,  Zhiyu Yang ,  Hui-Ling Lou

IPC分类号： H04K1/10 ,  H04L27/28 ,  H04B7/02 ,  H04L1/02

CPC分类号： H04B7/0857 ,  H04B7/084 ,  H04L2025/03414 ,  H04L2025/03426

摘要： A synchronization module for an orthogonal frequency-division multiplexing (OFDM) receiver system including a signal combination module that generates N combination signals that correspond to N received signals by performing at least one of weighted combining and selection and equal-gain-combining (EGC) on the N signals. A weighted signal generator module generates N weighted signals based on the N combination signals. N is an integer greater than one.

摘要翻译： 一种用于正交频分复用（OFDM）接收机系统的同步模块，包括信号组合模块，其通过执行加权组合和选择以及等增益组合（EGC）中的至少一个来产生对应于N个接收信号的N个组合信号， 对N信号。 加权信号发生器模块基于N个组合信号产生N个加权信号。 N是大于1的整数。