利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

112 条记录 (耗时 0.046 秒)

    PH-dependent NMDA receptor antagonists
    21.
    发明申请
    PH-dependent NMDA receptor antagonists 审中-公开
    PH依赖性NMDA受体拮抗剂

    公开(公告)号：US20090023791A1

    公开(公告)日：2009-01-22

    申请号：US12151633

    申请日：2008-05-08

    申请人： Stephen F. Traynelis ,  Dennis C. Liotta ,  James P. Snyder ,  Yesim Altas ,  David D. Mott ,  James J. Doherty, JR. ,  Raymond J. Dingledine

    发明人： Stephen F. Traynelis ,  Dennis C. Liotta ,  James P. Snyder ,  Yesim Altas ,  David D. Mott ,  James J. Doherty, JR. ,  Raymond J. Dingledine

    IPC分类号： A61K31/421 ,  C07C311/01 ,  A61K31/18 ,  A61K31/13 ,  A61P25/00 ,  C07C211/01 ,  C07C311/15 ,  C07D263/30

    CPC分类号： C07C217/34 ,  C07C311/08 ,  C07C311/21 ,  C07D263/24

    摘要： NMDA receptor blockers, including pH-sensitive NMDA receptor blockers, are provided as neurprotective drugs that are useful in stroke, traumatic brain injury, epilepsy, and other neurologic events that involve acidification of brain or spinal cord tissue. Compositions and methods of this invention are used for treating neurodegeneration resulting from NMDA receptor activation. The compounds described herein have enhanced activity in brain tissue having lower than normal pH due to pathological conditions such as hypoxia resulting from stroke, traumatic brain injury, global ischemia that may occur during cardiac surgery, hypoxia that may occur following cessation of breathing, pre-eclampsia, spinal cord trauma, epilepsy, chrounic pain, vascular dementia and glioma rumors. Compounds described herein are also useful in preventing neurodegeneration in patients with Parkinson's Alzheimer's, Huntington's chorea, ALS, and other neurodegenerative conditions known to the art to be responsive to treatment using NMDA receptor blockers. Prefebably the compounds provided herein are allosteric NMDA inhibitors.

    摘要翻译： NMDA受体阻滞剂，包括pH敏感的NMDA受体阻断剂，作为神经保护药物提供，其可用于中风，创伤性脑损伤，癫痫以及涉及脑或脊髓组织酸化的其他神经系统事件。 本发明的组合物和方法用于治疗由NMDA受体活化引起的神经变性。 本文所述的化合物由于病理状况如卒中引起的缺氧，创伤性脑损伤，心脏手术期间可能发生的全身缺血，呼吸停止后可能发生的缺氧等病理状况，具有低于正常pH值的脑组织中的活性增强， 子痫，脊髓创伤，癫痫，腮腺炎，血管性痴呆和神经胶质瘤。 本文所述的化合物也可用于预防帕金森氏老年痴呆症，亨廷顿氏舞蹈病，ALS患者和本领域已知的对NMDA受体阻断剂治疗有反应的其它神经变性病症患者的神经变性。 本文提供的化合物可能是变构NMDA抑制剂。

    pH-dependent NMDA receptor antagonists
    22.
    发明授权
    pH-dependent NMDA receptor antagonists 有权
    pH依赖性NMDA受体拮抗剂

    公开(公告)号：US07375136B2

    公开(公告)日：2008-05-20

    申请号：US10469824

    申请日：2002-03-08

    申请人： Stephen F. Traynelis ,  Dennis C. Liotta ,  James P. Snyder ,  Yesim Altas ,  David D. Mott ,  James J. Doherty, Jr. ,  Raymond J. Dingledine

    发明人： Stephen F. Traynelis ,  Dennis C. Liotta ,  James P. Snyder ,  Yesim Altas ,  David D. Mott ,  James J. Doherty, Jr. ,  Raymond J. Dingledine

    IPC分类号： A61K31/18 ,  C07C311/18

    CPC分类号： C07C217/34 ,  C07C311/08 ,  C07C311/21 ,  C07D263/24

    摘要： NMDA receptor blockers, including pH-sensitive NMDA receptor blockers, are provided as neuroprotective drugs that are useful in stroke, traumatic brain injury, epilepsy, and other neurologic events that involve acidification of brain or spinal cord tissue. Compositions and methods of this invention are used for treating neurodegeneration resulting from NMDA receptor activation. The compounds described herein have enhanced activity in brain tissue having lower-than normal pH due to pathological conditions such as hypoxia resulting from stroke, traumatic brain injury, global ischemia that may occur during cardiac surgery, hypoxia that may occur following cessation of breathing, pre-eclampsia, spinal cord trauma, epilepsy, chronic pain, vascular dementia and glioma tumors. Compounds described herein are also useful in preventing neurodegeneration in patients with Parkinson's Alzheimer's, Huntington's chorea, ALS, and other neurodegenerative conditions known to the art to be responsive to treatment using NMDA receptor blockers. Preferably the compounds provided herein are allosteric NMDA inhibitors.

    摘要翻译： 提供NMDA受体阻滞剂，包括pH敏感的NMDA受体阻断剂，作为神经保护药物，其可用于中风，创伤性脑损伤，癫痫和涉及脑或脊髓组织酸化的其它神经系统事件。 本发明的组合物和方法用于治疗由NMDA受体活化引起的神经变性。 本文所述的化合物由于病理状况如中风，外伤性脑损伤，心脏手术期间可能发生的全身缺血，呼吸停止后可能发生的缺氧等病理状况，具有低于正常pH值的脑组织中的活性增强， 癫痫，脊髓创伤，癫痫，慢性疼痛，血管性痴呆和神经胶质瘤。 本文所述的化合物还可用于预防帕金森氏老年痴呆症，亨廷顿舞蹈症，ALS患者和本领域已知的对NMDA受体阻断剂治疗有反应的其它神经变性病症患者的神经变性。 优选地，本文提供的化合物是变构NMDA抑制剂。