-
公开(公告)号：US20210146354A1
公开(公告)日：2021-05-20
申请号：US17254462
申请日：2020-05-26
Applicant: ILLUMINA, INC.
Inventor： Merek Siu , Ali Agah , Stanley Hong , Tarun Khurana , Aathavan Karunakaran , Craig Ciesla
IPC: B01L3/00
Abstract: Devices, systems, and methods for non-volatile storage include a well activation device operable to modify one or more wells from a plurality of wells of a flow cell to provide a set of readable wells. Readable wells are configured to allow exposure of a well to substances from nucleotide sequencing fluids, and prevent exposure to other substances and fluids, such as nucleotide synthesizing fluids. The well activation device may also modify wells to provide a set of writeable wells. This set of wells is configured to allow exposure to the nucleotide synthesizing fluids and substances; and prevent exposure to the nucleotide sequencing fluids and substances. There may also be provisions made for risk mitigation for data errors such as generating commands to write specified data to a nucleotide sequence associated with a particular location in a storage device, reading the nucleotide sequence and performing a comparison.
-
公开(公告)号：US12201985B2
公开(公告)日：2025-01-21
申请号：US18103625
申请日：2023-01-31
Applicant: ILLUMINA, INC.
Inventor： Merek Siu , Ali Agah , Stanley Hong , Tarun Khurana , Aathavan Karunakaran , Craig Ciesla , Amirali Kia
Abstract: Devices, systems, and methods for non-volatile storage include a well activation device operable to modify one or more wells from a plurality of wells of a flow cell to provide a set of readable wells. Readable wells are configured to allow exposure of a well to substances from nucleotide sequencing fluids, and prevent exposure to other substances and fluids, such as nucleotide synthesizing fluids. The well activation device may also modify wells to provide a set of writeable wells. This set of wells is configured to allow exposure to the nucleotide synthesizing fluids and substances; and prevent exposure to the nucleotide sequencing fluids and substances. There may also be provisions made for risk mitigation for data errors such as generating commands to write specified data to a nucleotide sequence associated with a particular location in a storage device, reading the nucleotide sequence and performing a comparison.
-
公开(公告)号：US20230321651A1
公开(公告)日：2023-10-12
申请号：US18202461
申请日：2023-05-26
Applicant: ILLUMINA, INC.
Inventor： Ali Agah , Aathavan Karunakaran , Tarun Khurana , Stanley Hong , Merek Siu , Arvin Emadi , Craig Ciesla
CPC classification number: B01L3/502715 , B01L3/502707 , B01L3/502738 , G11C13/02 , B01J19/0046 , C12Q1/6874
Abstract: An apparatus includes a flow cell body, a plurality of electrodes, an integrated circuit, and an imaging assembly. The flow cell body defines one or more flow channels and a plurality of wells. Each flow channel is configured to receive a flow of fluid. Each well is fluidically coupled with the corresponding flow channel. Each well is configured to contain at least one polynucleotide. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are operable to effect writing of polynucleotides in the corresponding wells. The integrated circuit is operable to drive selective deposition or activation of selected nucleotides to attach to polynucleotides in the wells to thereby generate polynucleotides representing machine-written data in the wells. The imaging assembly is operable to capture images indicative of one or more nucleotides in a polynucleotide.
-
公开(公告)号：US20230296516A1
公开(公告)日：2023-09-21
申请号：US18111298
申请日：2023-02-17
Applicant: Illumina, Inc. , Illumina Software, Inc.
Inventor： Anindita Dutta , Michael Gallaspy , Jeffrey Gau , Stanley Hong , Aathavan Karunakaran , Simon Prince , Merek Siu , Yina Wang , Rishi Verma
CPC classification number: G01N21/6456 , G06N3/08
Abstract: Artificial intelligence driven signal enhancement of sequencing images enables enhanced sequencing by synthesis that determines a sequence of bases in genetic material with any one or more of: improved performance, improved accuracy, and/or reduced cost. A training set of images taken at unreduced and reduced power levels used to excite fluorescence during sequencing by synthesis is used to train a neural network to enable the neural network to recover enhanced images, as if taken at the unreduced power level, from unenhanced images taken at the reduced power level.
-
公开(公告)号：US20230228984A1
公开(公告)日：2023-07-20
申请号：US18097947
申请日：2023-01-17
Applicant: ILLUMINA, INC.
Inventor： Dakota Watson , Merek Siu , Dustin Blair , Danilo Condello , John Earney , Paul Sangiorgio
CPC classification number: G02B21/245 , G02B21/26 , G02B21/0036 , G02B21/0032 , H04N23/56 , G02B21/0076 , G02B21/362
Abstract: Some implementations of the disclosure relate to an imaging system, including: a sample holder to support a sample container having multiple sample locations; an optical stage having; an assembly comprising one or more actuators physically coupled to the sample holder to tilt the sample holder relative to the optical stage during imaging of the multiple sample locations to focus the optical stage onto a current sample location; a first light source to project a first pair of spots on the sample container; and a controller to control, based on a sample tilt determined from a first separation measurement of the first pair of spots from one or more images taken by an image sensor at one or more of the sample locations, the one or more actuators to tilt the sample holder along a first direction of the imaging or a second direction substantially perpendicular to the first direction.
-
Patent Agency Ranking
公开(公告)号：US11691146B2
公开(公告)日：2023-07-04
申请号：US17898663
申请日：2022-08-30
Applicant: ILLUMINA, INC.
Inventor： Ali Agah , Aathavan Karunakaran , Tarun Khurana , Stanley Hong , Merek Siu , Arvin Emadi , Craig Ciesla
IPC: B01L3/00 , G11C13/02 , B01J19/00 , C12Q1/6874 , C12N15/09
CPC classification number: B01L3/502715 , B01J19/0046 , B01L3/502707 , B01L3/502738 , G11C13/02 , B01J2219/00711 , B01J2219/00713 , B01J2219/00722 , B01L2200/026 , B01L2300/0645 , B01L2300/0816 , B01L2300/0867 , B01L2400/0487 , B01L2400/0622 , B01L2400/0655 , B01L2400/08 , C12N15/09 , C12Q1/6874
Abstract: An apparatus includes a flow cell body, a plurality of electrodes, an integrated circuit, and an imaging assembly. The flow cell body defines one or more flow channels and a plurality of wells. Each flow channel is configured to receive a flow of fluid. Each well is fluidically coupled with the corresponding flow channel. Each well is configured to contain at least one polynucleotide. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are operable to effect writing of polynucleotides in the corresponding wells. The integrated circuit is operable to drive selective deposition or activation of selected nucleotides to attach to polynucleotides in the wells to thereby generate polynucleotides representing machine-written data in the wells. The imaging assembly is operable to capture images indicative of one or more nucleotides in a polynucleotide.
-
公开(公告)号：US20230149933A1
公开(公告)日：2023-05-18
申请号：US18154510
申请日：2023-01-13
Applicant: Illumina, Inc.
Inventor： M. Shane Bowen , Michael Graige , Stanley S. Hong , John A. Moon , Merek Siu
CPC classification number: B01L3/5085 , B01J19/0046 , B01J2219/00317 , B01J2219/00509 , B01J2219/00621 , B01J2219/00662 , B01J2219/00668 , B01J2219/00722 , B01L2300/0636 , B01L2300/0819 , B01L2300/0848 , B01L2300/0851 , C12Q1/6837
Abstract: An array including a solid support having a plurality of contours along its exterior surface. A first subset of contours is positioned along the exterior surface of the solid support to form a first pattern of features and a second subset of contours is positioned along the exterior surface to form a second pattern of features. The contours of the first subset are juxtaposed with the second subset along the exterior surface, whereby the first and second patterns form an interleaved pattern. The features of the first pattern occur at a first elevation z1 and the features of the second pattern occur at a second elevation z2. The features of the first pattern are configured to attach analytes at a different elevation relative to analytes attached to the features of the second pattern.
-
公开(公告)号：US20220410154A1
公开(公告)日：2022-12-29
申请号：US17898663
申请日：2022-08-30
Applicant: ILLUMINA, INC.
Inventor： Ali Agah , Aathavan Karunakaran , Tarun Khurana , Stanley Hong , Merek Siu , Arvin Emadi , Craig Ciesla
Abstract: An apparatus includes a flow cell body, a plurality of electrodes, an integrated circuit, and an imaging assembly. The flow cell body defines one or more flow channels and a plurality of wells. Each flow channel is configured to receive a flow of fluid. Each well is fluidically coupled with the corresponding flow channel. Each well is configured to contain at least one polynucleotide. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are operable to effect writing of polynucleotides in the corresponding wells. The integrated circuit is operable to drive selective deposition or activation of selected nucleotides to attach to polynucleotides in the wells to thereby generate polynucleotides representing machine-written data in the wells. The imaging assembly is operable to capture images indicative of one or more nucleotides in a polynucleotide.
-
公开(公告)号：US20220317100A1
公开(公告)日：2022-10-06
申请号：US17846538
申请日：2022-06-22
Applicant: ILLUMINA, INC.
Inventor： Tarun Khurana , Ali Agah , Aathavan Karunakaran , Stanley Hong , Merek Siu , Arvin Emadi , Craig Ciesla
IPC: G01N30/74 , C12Q1/6874
Abstract: An apparatus includes a flow cell body, a plurality of electrodes, an imaging assembly, and one or more barrier features. The flow cell body defines one or more flow channels and a plurality of wells defined as recesses in the floor of each flow channel. Each well is fluidically coupled with the corresponding flow channel. The flow cell body further defines interstitial surfaces between adjacent wells. Each well defines a corresponding depth. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are to effect writing of polynucleotides in the wells. The imaging assembly is to capture images of polynucleotides written in the wells. The one or more barrier features are positioned in the wells, between the wells, or above the wells. The one or more barrier features contain reactions in each well, reduce diffusion between the wells, or reduce optical cross-talk between the wells.
-
公开(公告)号：US20220150394A1
公开(公告)日：2022-05-12
申请号：US17513042
申请日：2021-10-28
Applicant: ILLUMINA, INC. , ILLUMINA CAMBRIDGE LIMITED
Inventor： Geraint Evans , Stanley Hong , Merek Siu , Shaoping Lu , John Moon
Abstract: A method is used to generate an analysis image of a moving sample based on one or more exposures. An illumination source illuminates a field of view of a camera for one or more pulses while the sample moves through the field of view. The distance moved by the sample during each of these one or more pulses may be less than the size of one pixel in an image captured by the camera.
-
-
-
-
-
-
-
-
-
Search Results
30
records
(took 0.018 seconds)
