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    Obtaining information from a biological sample in a flow cell
    22.
    发明授权
    Obtaining information from a biological sample in a flow cell 有权

    公开(公告)号：US11835510B2

    公开(公告)日：2023-12-05

    申请号：US17470228

    申请日：2021-09-09

    Applicant: ILLUMINA, INC.

    Inventor： Tarun Khurana ,  Ali Agah ,  Aathavan Karunakaran ,  Xi-Jun Chen

    IPC: C12Q1/00 ,  G01N33/483 ,  G01N33/50 ,  G01N33/53 ,  A61K39/12

    CPC classification number: G01N33/4836 ,  G01N33/5047 ,  G01N33/5308 ,  A61K39/12 ,  G01N2500/10

    Abstract: Methods are used for obtaining, cataloguing, and/or storing data derived from a biological source using a flow cell body, electrodes, and an imaging assembly. The data may include DNA and/or RNA obtained from a biological source, such as from the cells of an organism. The methods may be used to obtain, catalog, and/or store data such as DNA or RNA sequence from a pathogen such as a virus and/or a bacteria, human health data over time, and immune system information from an individual. The data obtained using the disclosed methods may be used for a variety of different purposes, including the manufacture of vaccine compositions, and for restoring the immune system of an individual who has undergone an immune system depleting event. The methods may be used for storage of biological cells, which may be used for the screening of compounds, such as small molecules with potential for therapeutic indications.

    Sequencing kits
    25.
    发明授权
    Sequencing kits 有权

    公开(公告)号：US11535890B2

    公开(公告)日：2022-12-27

    申请号：US16750897

    申请日：2020-01-23

    Applicant: ILLUMINA, INC.

    Inventor： Xi-Jun Chen ,  Yir-Shyuan Wu ,  Tarun Kumar Khurana ,  Liangliang Qiang ,  Andrew J. Price ,  Elisabet Rosas

    IPC: C12Q1/6874 ,  C12N15/10

    Abstract: An example of a sequencing kit includes a flow cell, an encapsulation matrix precursor composition, and a radical initiator. The flow cell includes a plurality of chambers and primers attached within each of the plurality of chambers. The encapsulation matrix precursor composition consists of a fluid, a monomer or polymer including a radical generating and chain elongating functional group, a radical source, and a crosslinker. The radical initiator is part of the encapsulation matrix precursor composition or is a separate component.

    Sequencing kits
    26.
    发明授权
    Sequencing kits 有权

    公开(公告)号：US11499192B2

    公开(公告)日：2022-11-15

    申请号：US16750897

    申请日：2020-01-23

    Applicant: ILLUMINA, INC.

    Inventor： Xi-Jun Chen ,  Yir-Shyuan Wu ,  Tarun Kumar Khurana ,  Liangliang Qiang ,  Andrew J. Price ,  Elisabet Rosas

    IPC: C12Q1/6874 ,  C12N15/10

    Abstract: An example of a sequencing kit includes a flow cell, an encapsulation matrix precursor composition, and a radical initiator. The flow cell includes a plurality of chambers and primers attached within each of the plurality of chambers. The encapsulation matrix precursor composition consists of a fluid, a monomer or polymer including a radical generating and chain elongating functional group, a radical source, and a crosslinker. The radical initiator is part of the encapsulation matrix precursor composition or is a separate component.

    Spatial indexing of genetic material and library preparation using hydrogel beads and flow cells
    27.
    发明授权
    Spatial indexing of genetic material and library preparation using hydrogel beads and flow cells 有权

    公开(公告)号：US11352668B2

    公开(公告)日：2022-06-07

    申请号：US16626115

    申请日：2018-07-31

    Applicant: ILLUMINA, INC.

    Inventor： Tarun Kumar Khurana ,  Yir-Shyuan Wu ,  Xi-Jun Chen ,  Filiz Gorpe-Yasar ,  Yan-You Lin ,  Victoria Popic ,  Erich B. Jaeger ,  Mostafa Ronaghi

    IPC: C12Q1/6874 ,  C12Q1/6813

    Abstract: Implementations of a method for seeding sequence libraries on a surface of a sequencing flow cell that allow for spatial segregation of the libraries on the surface are provided. The spatial segregation can be used to index sequence reads from individual sequencing libraries to increase efficiency of subsequent data analysis. In some examples, hydrogel beads containing encapsulated sequencing libraries are captured on a sequencing flow cell and degraded in the presence of a liquid diffusion barrier to allow for the spatial segregation and seeding of the sequencing libraries on the surface of the flow cell. Additionally, examples of systems, methods and compositions are provided relating to flow cell devices configured for nucleic acid library preparation and single cell sequencing. Some examples include flow cell devices having a hydrogel with genetic material disposed therein, and which is retained within the hydrogel during nucleic acid processing.

    Obtaining information from a biological sample in a flow cell
    30.
    发明授权
    Obtaining information from a biological sample in a flow cell 有权

    公开(公告)号：US11137385B2

    公开(公告)日：2021-10-05

    申请号：US17254473

    申请日：2020-05-26

    Applicant: ILLUMINA, INC.

    Inventor： Tarun Khurana ,  Ali Agah ,  Aathavan Karunakaran ,  Xi-Jun Chen

    IPC: C12Q1/00 ,  G01N33/483 ,  G01N33/50 ,  G01N33/53 ,  A61K39/12

    Abstract: Methods are used for obtaining, cataloguing, and/or storing data derived from a biological source using a flow cell body, electrodes, and an imaging assembly. The data may include DNA and/or RNA obtained from a biological source, such as from the cells of an organism. The methods may be used to obtain, catalog, and/or store data such as DNA or RNA sequence from a pathogen such as a virus and/or a bacteria, human health data over time, and immune system information from an individual. The data obtained using the disclosed methods may be used for a variety of different purposes, including the manufacture of vaccine compositions, and for restoring the immune system of an individual who has undergone an immune system depleting event. The methods may be used for storage of biological cells, which may be used for the screening of compounds, such as small molecules with potential for therapeutic indications.

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