公开(公告)号：US08891184B2

公开(公告)日：2014-11-18

申请号：US10442381

申请日：2003-05-21

Applicant: Ilya Feygin

Inventor： Ilya Feygin

IPC: G02B7/02 ,  G02B27/14 ,  G02B13/14 ,  G01J5/08

CPC classification number: G02B13/14 ,  G01J5/08

Abstract: The illustrative embodiment of the present invention is an apparatus and method that is capable of non-contact cooling of a hot body by optically-enhanced radiation. An apparatus in accordance with the illustrative embodiment includes a cold body and an optical system. The optical system couples the cold body to a hot body for the transmission of infrared radiation. Once optically coupled, heat will flow, at an enhanced rate, from the hot body to the cold body, as dictated by thermodynamics, thereby cooling the hot body. In some embodiment, the temperature of the cold body is held substantially constant.

Abstract translation: 本发明的说明性实施例是能够通过光学增强的辐射非接触地冷却热体的装置和方法。 根据说明性实施例的装置包括冷体和光学系统。 光学系统将冷体连接到热体以传递红外辐射。 一旦光学耦合，如热力学所指示的那样，热将以增强的速率从热体流向冷体，由此冷却热体。 在一些实施例中，冷体的温度保持基本恒定。

公开(公告)号：US07364905B2

公开(公告)日：2008-04-29

申请号：US10139766

申请日：2002-05-06

Applicant: Ilya Feygin ,  Rafail Kushak

Inventor： Ilya Feygin ,  Rafail Kushak

IPC: G01N33/00

CPC classification number: B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00423 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00756 ,  C40B60/12 ,  Y10T436/10

Abstract: An article and method for high throughput and a high content investigation of compound interactions with live tissue or its substitutes under controlled conditions during compound absorption and related processes. In some variations of the illustrative embodiment, the article is a multi-chamber enclosure having at least two chambers separated by a membrane. Membranes can be prepared from live epithelial tissue or from an artificial material with or without attached cells from cell-line cultures. Each chamber is advantageously connected to a fluidic-control system by tubes that pass through a feed fitting. In addition to coupling the chambers with the fluidic-control system, the feed fitting, which is spring-biased, provides a sealing force to seal the enclosure. In some variations, one or more multi-chamber enclosures are installed in a mother chamber, which provides controlled environmental conditions. Operation of the article includes automatic introduction of compounds, buffers, and gases into the chambers, establishing reaction conditions inside the chambers, and individually sampling from the chambers.

Abstract translation: 一种用于在化合物吸收和相关过程中在受控条件下与活组织或其替代物的复合相互作用的高通量和高含量的研究的文章和方法。 在说明性实施例的一些变型中，制品是具有由隔膜隔开的至少两个室的多室外壳。 膜可以从活上皮组织或具有或不具有来自细胞系培养物的附着细胞的人造材料制备。 每个室有利地通过穿过进料配件的管连接到流体控制系统。 除了将腔室与流体控制系统联接之外，被弹簧偏置的进给配件提供密封力以密封外壳。 在一些变型中，一个或多个多腔室安装在母室中，其提供受控的环境条件。 物品的操作包括将化合物，缓冲剂和气体自动引入室中，在室内建立反应条件，并从室中单独取样。

公开(公告)号：US07309470B2

公开(公告)日：2007-12-18

申请号：US10976135

申请日：2004-10-28

Applicant: Ilya Feygin

Inventor： Ilya Feygin

IPC: B01L11/00 ,  G01N1/10 ,  F16K11/00

CPC classification number: G01N35/1097 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00308 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00423 ,  B01L3/567 ,  C40B60/14 ,  Y10T137/4259 ,  Y10T137/7293 ,  Y10T436/2575

Abstract: A U-valve apparatus including a bidirectional check valve for controlling the flow of liquid from a vessel while preventing inadvertent discharge from the vessel. The check valve allows passage of a fluid such a gas into the vessel, for purposes of agitating the liquid or for other purposes, and also permits the evacuation of the liquid from the vessel. The U-valve apparatus is advantageously included in a universal fluid exchange device including upper and lower reaction vessel supports which include pressure sealed injection and evacuation ports for each supported reaction vessel. Reaction vessels matingly engage through the injection and evacuation ports with fittings which are connected through flexible tubing to respective supplying and receiving vessels. Each of one or more reaction vessels may suitably be connected by a U-valve apparatus including a check valve to a corresponding receiving vessel. The reaction vessels or fittings are moved into position, as required, so that reactants may be directly supplied from supplying vessels in the order and amount desired without operation of valves that can become contaminated, and so that the reaction vessels may dispel their contents into the appropriate receiving vessels. The system may be highly advantageous in applications such as combinatorial chemistry where myriad combinations of chemicals, solvents and reagents are employed.

Abstract translation: 一种U型阀装置，包括用于控制来自容器的液体流动的双向止回阀，同时防止从容器中泄漏。 止回阀允许流体例如气体进入容器，用于搅拌液体或用于其它目的，并且还允许从容器排出液体。 U型阀装置有利地包括在通用流体交换装置中，包括上和下反应容器支撑件，其包括用于每个支撑的反应容器的压力密封注射和排出口。 反应容器配合地通过注射和抽空端口配合，配件通过柔性管连接到相应的供应和接收容器。 一个或多个反应容器中的每一个可以适当地通过包括止回阀的U形阀装置连接到相应的接收容器。 反应容器或配件根据需要移动到适当的位置，使得反应物可以从供应容器直接供应，其顺序和数量不需要可能被污染的阀的操作，并且使得反应容器可将其内容物分散到 适当的接收船只。 该系统在诸如使用化学品，溶剂和试剂的无数组合的组合化学品的应用中可能是非常有利的。

公开(公告)号：US07179420B2

公开(公告)日：2007-02-20

申请号：US10280537

申请日：2002-10-25

Applicant: Thomas James Hatcher ,  Ilya Feygin ,  Aleksandr Grinberg ,  Joseph J. Brzezinski

Inventor： Thomas James Hatcher ,  Ilya Feygin ,  Aleksandr Grinberg ,  Joseph J. Brzezinski

IPC: G01N33/00 ,  G01N35/08

CPC classification number: B01L3/0268 ,  B01L2200/0647 ,  B01L2400/0487 ,  B01L2400/084 ,  G01N15/1404 ,  G01N2015/0065 ,  G01N2015/0092 ,  G01N2015/025 ,  G01N2015/1413 ,  G01N2015/149 ,  G01N2015/1493 ,  Y10T436/117497 ,  Y10T436/2575

Abstract: A particle sorter/dispenser wherein particles that are suspended in a liquid are flowed through a conduit and selectively dispensed through a dispensing orifice. The conduit includes a sensing zone wherein the liquid-suspended particles are interrogated by a sensor. Data from the sensor is received by processing electronics that analyzes the data from the sensor and makes a decision whether or not to dispense a particle. The particle sorter/dispenser further includes a switch that, responsive to a signal from the processing electronics, controls whether or not a given particle is dispensed through the dispensing orifice. The switch has one or two valves that introduce relatively high-pressure liquid into the conduit. The flow streamlines of the high-pressure liquid controls the flow of the relatively low-pressure liquid-suspended particles in the conduit. Particles that are not dispensed are flowed past the dispensing orifice to a recycle reservoir that depends from the downstream end of the conduit.

Abstract translation: 悬浮在液体中的颗粒流过导管并通过分配孔选择性分配的颗粒分选机/分配器。 导管包括感测区域，其中液体悬浮颗粒被传感器询问。 来自传感器的数据由处理电子设备接收，分析来自传感器的数据，并决定是否分配颗粒。 颗粒分选器/分配器还包括开关，其响应于来自处理电子器件的信号来控制是否通过分配孔分配给定的颗粒。 开关具有一个或两个将相对高压液体引入导管的阀。 高压液体的流动流线控制管道中相对低压的液体悬浮颗粒的流动。 未分配的颗粒流过分配孔至从导管的下游端延伸的循环储存器。

公开(公告)号：US07082847B2

公开(公告)日：2006-08-01

申请号：US10769447

申请日：2004-01-30

Applicant: Ilya Feygin

Inventor： Ilya Feygin

IPC: G01N1/20

CPC classification number: A61J1/1412 ,  A61J1/12 ,  A61J1/1406 ,  A61J1/1475

Abstract: An apparatus for sealing a wide variety of vessels and for providing access to the interior of such vessels while sealed. In some embodiments, a sealing apparatus includes a base plate, a cover plate, and a seal that is disposed therebetween. In use on a vessel, when the seal is disposed in a rest position, it covers a vessel-access hole that penetrates the base plate and communicates with the underlying vessel. To temporarily displace the seal, a tube, such as a syringe needle, etc., is inserted through a guide hole in the cover plate. The tube contacts the seal, which forces the seal to move at least partially out of its sealing position. With continued downward movement, the tube enters the underlying vessel so that it can withdraw or add fluid to it. When the tube is withdrawn, the seal returns to its sealing position.

Abstract translation: 一种用于密封各种容器并用于在密封时提供通向这些容器的内部的装置。 在一些实施例中，密封装置包括底板，盖板和设置在它们之间的密封件。 在船舶上使用时，当密封件处于静止位置时，它覆盖穿过底板并与下面的船只连通的容器进入孔。 为了临时移动密封件，通过盖板中的引导孔插入诸如注射器针等的管。 管接触密封件，这迫使密封件至少部分地移出其密封位置。 随着向下运动，管进入下面的容器，以便它可以抽出或添加流体。 当管被抽出时，密封件返回到其密封位置。

公开(公告)号：US20050059164A1

公开(公告)日：2005-03-17

申请号：US10976135

申请日：2004-10-28

Applicant: Ilya Feygin

Inventor： Ilya Feygin

IPC: B01L99/00 ,  B01J19/00 ,  B01L3/00 ,  C40B60/14 ,  G01N1/00 ,  B01L11/00

CPC classification number: G01N35/1097 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00308 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00423 ,  B01L3/567 ,  C40B60/14 ,  Y10T137/4259 ,  Y10T137/7293 ,  Y10T436/2575

Abstract: A U-valve apparatus including a bidirectional check valve for controlling the flow of liquid from a vessel while preventing inadvertent discharge from the vessel. The check valve allows passage of a fluid such a gas into the vessel, for purposes of agitating the liquid or for other purposes, and also permits the evacuation of the liquid from the vessel. The U-valve apparatus is advantageously included in a universal fluid exchange device including upper and lower reaction vessel supports which include pressure sealed injection and evacuation ports for each supported reaction vessel. Reaction vessels matingly engage through the injection and evacuation ports with fittings which are connected through flexible tubing to respective supplying and receiving vessels. Each of one or more reaction vessels may suitably be connected by a U-valve apparatus including a check valve to a corresponding receiving vessel. The reaction vessels or fittings are moved into position, as required, so that reactants may be directly supplied from supplying vessels in the order and amount desired without operation of valves that can become contaminated, and so that the reaction vessels may dispel their contents into the appropriate receiving vessels. The system may be highly advantageous in applications such as combinatorial chemistry where myriad combinations of chemicals, solvents and reagents are employed.

Abstract translation: 一种U型阀装置，包括用于控制来自容器的液体流动的双向止回阀，同时防止从容器中泄漏。 止回阀允许流体例如气体进入容器，用于搅拌液体或用于其它目的，并且还允许从容器排出液体。 U型阀装置有利地包括在通用流体交换装置中，包括上和下反应容器支撑件，其包括用于每个支撑的反应容器的压力密封注射和排出口。 反应容器配合地通过注射和抽空端口配合，配件通过柔性管连接到相应的供应和接收容器。 一个或多个反应容器中的每一个可以适当地通过包括止回阀的U形阀装置连接到相应的接收容器。 反应容器或配件根据需要移动到适当的位置，使得反应物可以从供应容器直接供应，其顺序和数量不需要可能被污染的阀的操作，并且使得反应容器可将其内容物分散到 适当的接收船只。 该系统在诸如使用化学品，溶剂和试剂的无数组合的组合化学品的应用中可能是非常有利的。

公开(公告)号：US06563117B2

公开(公告)日：2003-05-13

申请号：US09872211

申请日：2001-06-02

Applicant: Ilya Feygin

Inventor： Ilya Feygin

IPC: G01N2135

CPC classification number: G01N21/35 ,  B01L3/5085 ,  B01L2300/0645 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/168 ,  G01N21/03 ,  G01N21/3563

Abstract: An article including a multi-well plate that has an infrared radiation (“IR”) reflective coating disposed over the surface of the wells. In some embodiments, the wells have a parabolic or near parabolic shape. In additional embodiments, the wells, which have a parabolic or near parabolic shape, are truncated at or near a focal plane of the well. In some further embodiments, the wells have a hemispheric shape or a truncated hemispheric shape. IR imaging systems that incorporate the multi-well plates described herein exhibit improved sensitivity and signal-to-noise ratio.

公开(公告)号：US06254835B1

公开(公告)日：2001-07-03

申请号：US09283126

申请日：1999-03-31

Applicant: Ilya Feygin

Inventor： Ilya Feygin

IPC: B01L1100

CPC classification number: G01N35/1097 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00308 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00423 ,  B01L3/567 ,  C40B60/14 ,  Y10T137/4259 ,  Y10T137/7293 ,  Y10T436/2575

Abstract: A U-valve apparatus including a bidirectional check valve for controlling the flow of liquid from a vessel while preventing inadvertent discharge from the vessel. The check valve allows passage of a fluid such a gas into the vessel, for purposes of agitating the liquid or for other purposes, and also permits the evacuation of the liquid from the vessel. The U-valve apparatus is advantageously included in a universal fluid exchange device including upper and lower reaction vessel supports which include pressure sealed injection and evacuation ports for each supported reaction vessel. Reaction vessels matingly engage through the injection and evacuation ports with fittings which are connected through flexible tubing to respective supplying and receiving vessels. Each of one or more reaction vessels may suitably be connected by a U-valve apparatus including a check valve to a corresponding receiving vessel. The reaction vessels or fittings are moved into position, as required, so that reactants may be directly supplied from supplying vessels in the order and amount desired without operation of valves that can become contaminated, and so that the reaction vessels may dispel their contents into the appropriate receiving vessels. The system may be highly advantageous in applications such as combinatorial chemistry where myriad combinations of chemicals, solvents and reagents are employed.

Abstract translation: 一种U型阀装置，包括用于控制来自容器的液体流动的双向止回阀，同时防止从容器中泄漏。 止回阀允许流体例如气体进入容器，用于搅拌液体或用于其它目的，并且还允许从容器排出液体。 U型阀装置有利地包括在通用流体交换装置中，包括上和下反应容器支撑件，其包括用于每个支撑的反应容器的压力密封注射和排出口。 反应容器配合地通过注射和抽空端口配合，配件通过柔性管连接到相应的供应和接收容器。 一个或多个反应容器中的每一个可以适当地通过包括止回阀的U形阀装置连接到相应的接收容器。 反应容器或配件根据需要移动到适当的位置，使得反应物可以从供应容器直接供应，其顺序和数量不需要可能被污染的阀的操作，并且使得反应容器可将其内容物分散到 适当的接收船只。 该系统在诸如使用化学品，溶剂和试剂的无数组合的组合化学品的应用中可能是非常有利的。

公开(公告)号：US5957167A

公开(公告)日：1999-09-28

申请号：US993106

申请日：1997-12-18

Applicant: Ilya Feygin

Inventor： Ilya Feygin

IPC: B01L3/02 ,  C40B60/14 ,  G01N1/00 ,  G01N35/00 ,  G01N35/10 ,  G01F11/00

CPC classification number: B01L3/0244 ,  B01L3/0248 ,  G01N35/1016 ,  B01J2219/00315 ,  B01J2219/00369 ,  B01L2400/021 ,  C40B60/14 ,  G01N2035/00237 ,  G01N2035/1037 ,  G01N35/1095

Abstract: A method for handling and dispensing small volumes of liquid, and apparatus for carrying out the method, are disclosed. A small volume of liquid, which is retained within a fluid-dispensing member, is dispensed therefrom by accelerating, and then abruptly decelerating, the member. The abrupt deceleration causes the retained liquid to discharge. The discharged liquid may be directed toward a receiver. A micro volume liquid dispenser for practicing the method includes a plurality of fluid-dispensing members configured for aspiring and retaining a small liquid volume via capillary action. The dispenser further includes an actuator for moving/accelerating the fluid-dispensing members and for stopping/abruptly decelerating the fluid-dispensing members.

Abstract translation: 公开了一种处理和分配小体积液体的方法以及用于实施该方法的装置。 保留在流体分配构件内的小体积的液体通过加速，然后突然减速而从其中分配。 突然减速使得保留的液体排出。 排出的液体可以被引向接收器。 用于实施该方法的微量液体分配器包括多个流体分配部件，其构造成用于通过毛细管作用来吸持和保持小的液体体积。 分配器还包括用于移动/加速流体分配构件并用于使流体分配构件停止/突然减速的致动器。

公开(公告)号：US4614866A

公开(公告)日：1986-09-30

申请号：US741102

申请日：1985-06-04

Applicant: Saul Liss ,  Bernard S. Liss ,  Sam Krakower ,  Ilya Feygin

Inventor： Saul Liss ,  Bernard S. Liss ,  Sam Krakower ,  Ilya Feygin

IPC: A61N5/06 ,  A61N5/067 ,  G01J1/42 ,  H01S5/00 ,  H01J40/14

CPC classification number: A61N5/0616 ,  G01J1/4257 ,  H01S5/0014 ,  A61N2005/065 ,  A61N2005/0665 ,  A61N2005/067 ,  G01J2001/4238

Abstract: Improved circuitry for detecting pulsed infrared light which is particularly suitable for use with laser therapeutic devices. Laser therapeutic devices generally utilize pulsed laser energy of infrared wavelengths. Because such light is invisible the operator of the therapeutic device cannot determine if it is actually working. The invention provides pulsed infrared light detection circuitry which is very compact so that it may be made part of the therapeutic device. The circuitry includes an infrared sensitive transducer coupled to the input of an inverting operational amplifier, a peak detector coupled to the output of the inverting amplifier, and a non-inverting amplifier coupled to the output of the peak detector for driving a display to indicate the detection of pulsed infrared energy.

Abstract translation: 用于检测特别适用于激光治疗装置的脉冲红外光的改进的电路。 激光治疗装置通常利用红外波长的脉冲激光能量。 因为这样的光不可见，治疗装置的操作者不能确定它是否实际工作。 本发明提供了非常紧凑的脉冲红外光检测电路，使得其可以被制成治疗装置的一部分。 电路包括耦合到反相运算放大器的输入的红外敏感传感器，耦合到反相放大器的输出的峰值检测器以及耦合到峰值检测器的输出的非反相放大器，用于驱动显示器以指示 检测脉冲红外能量。