公开(公告)号：US10040842B2

公开(公告)日：2018-08-07

申请号：US14921589

申请日：2015-10-23

Applicant: Janssen Biotech, Inc.

Inventor： Steven Jacobs ,  Karyn O'Neil

IPC: C40B40/08 ,  C07K14/78 ,  C40B50/06

CPC classification number: C07K14/78 ,  C40B40/08 ,  C40B50/06

Abstract: A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.

公开(公告)号：US20180143203A1

公开(公告)日：2018-05-24

申请号：US15845657

申请日：2017-12-18

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Steven Jacobs

IPC: G01N33/68

Abstract: Protein scaffolds and scaffold libraries based on a fibronectin type III (FN3) repeat with an alternative binding surface design, isolated nucleic acids encoding the protein scaffolds, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.

公开(公告)号：US09897612B2

公开(公告)日：2018-02-20

申请号：US14822335

申请日：2015-08-10

Applicant: Janssen Biotech, Inc.

Inventor： Michael Diem ,  Steven Jacobs

IPC: C40B30/04 ,  G01N33/68 ,  C12N15/10 ,  C40B40/08 ,  C40B50/06

CPC classification number: G01N33/6845 ,  C12N15/1044 ,  C40B30/04 ,  C40B40/08 ,  C40B50/06 ,  G01N2333/78

Abstract: Protein scaffolds and scaffold libraries based on a fibronectin type III (FN3) repeat with an alternative binding surface design, isolated nucleic acids encoding the protein scaffolds, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.

公开(公告)号：US09725497B2

公开(公告)日：2017-08-08

申请号：US14086250

申请日：2013-11-21

Applicant: Janssen Biotech, Inc.

Inventor： Mark Anderson ,  Ricardo Attar ,  Michael Diem ,  Linus Hyun ,  Steven Jacobs ,  Alastair King ,  Donna Klein ,  Sheri Moores ,  Karyn O'Neil ,  Kristen Picha

IPC: C07K19/00 ,  C07K14/78 ,  A61K45/06 ,  C07K16/28 ,  C07K14/705 ,  C07K14/71 ,  C07K14/47 ,  A61K38/00 ,  A61K39/00

CPC classification number: C07K14/78 ,  A61K38/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/705 ,  C07K14/71 ,  C07K16/28 ,  C07K16/2863 ,  C07K2317/31 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2318/20 ,  C07K2319/70

Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.

公开(公告)号：US09695228B2

公开(公告)日：2017-07-04

申请号：US14085340

申请日：2013-11-20

Applicant: Janssen Biotech, Inc.

Inventor： Anderson Mark ,  Ricardo Attar ,  Michael Diem ,  Linus Hyun ,  Steven Jacobs ,  Alastair King ,  Donna Klein ,  Sheri Moores ,  Karyn O'Neil ,  Kristen Picha

IPC: C07K16/46 ,  A61K39/395 ,  C07K14/78 ,  A61K45/06 ,  C07K16/28 ,  C07K14/705 ,  C07K14/71 ,  C07K14/47 ,  A61K38/00 ,  A61K39/00

CPC classification number: C07K14/78 ,  A61K38/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/705 ,  C07K14/71 ,  C07K16/28 ,  C07K16/2863 ,  C07K2317/31 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2318/20 ,  C07K2319/70

Abstract: Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.

公开(公告)号：US20160347840A1

公开(公告)日：2016-12-01

申请号：US15148371

申请日：2016-05-06

Applicant: Janssen Biotech, Inc.

Inventor： Glenn Anderson ,  Rosa Cardoso ,  Michael Diem ,  Francois Gaudet ,  Shalom Goldberg ,  Benjamin Harman ,  Linus Hyun ,  Steven Jacobs ,  Donna Klein ,  Yingzhe Li ,  Jinquan Luo ,  Ronan McDaid ,  Jill Mooney ,  Jennifer Nemeth-Seay ,  Karyn O'Neil ,  Steven Pomerantz ,  Galla Chandra Rao ,  Tracy Spinka-Doms ,  Alexey Teplyakov ,  Leopoldo Luistro ,  Sheng-Jiun Wu

IPC: C07K16/28 ,  C07K14/78 ,  A61K45/06 ,  C07K16/30 ,  A61K39/395

CPC classification number: C07K16/2809 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6869 ,  A61K49/0045 ,  A61K49/0058 ,  A61K2039/505 ,  C07K14/78 ,  C07K16/3069 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/524 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/70 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2318/20 ,  C07K2319/30 ,  C12Y304/17021

Abstract: Provided herein are isolated CD3×PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof wherein a FN3 domain specifically binds human prostate specific membrane antigen (PSMA) and a second antigen-binding site immunospecifically binds CD3. Also described are fusion proteins and related polynucleotides capable of encoding the provided fusion proteins and, cells expressing the provided fusion proteins. In addition, methods of using the provided isolated CD3×PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof are described.

Abstract translation: 本文提供了分离的CD3×PSMA-双特异性抗原结合分子或其双特异性抗原结合片段，其中FN3结构域特异性结合人前列腺特异性膜抗原（PSMA）和第二抗原结合位点免疫特异性结合CD3。 还描述了能够编码所提供的融合蛋白的融合蛋白和相关多核苷酸，以及表达所提供的融合蛋白的细胞。 此外，描述了使用所提供的分离的CD3×PSMA-双特异性抗原结合分子或其双特异性抗原结合片段的方法。

公开(公告)号：US20160326232A1

公开(公告)日：2016-11-10

申请号：US15148312

申请日：2016-05-06

Applicant: Janssen Biotech, Inc.

Inventor： Cardosa Rosa ,  Michael Diem ,  Shalom Goldberg ,  Linus Hyun ,  Steven Jacobs ,  Donna Klein ,  Karyn O'Neil ,  Tracy Spinka-Doms

IPC: C07K14/78 ,  G01N33/573 ,  A61K51/08

CPC classification number: C07K14/78 ,  A61K38/00 ,  A61K51/08 ,  G01N33/57434 ,  G01N2333/705

Abstract: PSMA binding FN3 domains, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.

Abstract translation: PSMA结合FN3结构域，它们的缀合物，编码分子的分离的核苷酸，载体，宿主细胞及其制备方法可用于治疗分子的产生以及疾病和病症的治疗和诊断。

公开(公告)号：US20140206599A1

公开(公告)日：2014-07-24

申请号：US14225821

申请日：2014-03-26

Applicant: Janssen Biotech, Inc.

Inventor： Michael Baumann ,  Gaby Tresch ,  Steven Jacobs ,  Karyn O'Neil

IPC: C07K14/705

CPC classification number: C07K14/705 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/70 ,  Y02A50/409 ,  Y02A50/423

Abstract: IL4/IL13-binding proteins comprise binding domains, which inhibit IL4/IL13 binding to IL4Ralpha and common gamma chain complexes (Type 1) and inhibit IL4 binding to IL4Ralpha and IL13Ralpha1 complexes (Type 2), and IL13 binding to IL13Ralpha1 and/or IL13Ralpha2, are useful in the treatment of cancer, inflammatory, and other pathological conditions, such as allergic or fibrotic conditions, especially pulmonary conditions.

Abstract translation: IL4 / IL13结合蛋白包含结合结构域，其抑制IL4 / IL13与IL4Rα和常见的γ链复合物（1型）结合并抑制IL4与IL4Rα和IL13Rα1复合物（2型）的结合，IL13与IL13Rα1和/或IL13Rα2的结合 ，可用于治疗癌症，炎症和其他病理状况，如过敏或纤维化病症，特别是肺部疾病。

公开(公告)号：US11932680B2

公开(公告)日：2024-03-19

申请号：US17689869

申请日：2022-03-08

Applicant: JANSSEN BIOTECH, INC.

Inventor： Rebecca Hawkins ,  Steven Jacobs ,  Manuel Sepulveda

IPC: C07H21/04 ,  A61K49/00 ,  A61K51/08 ,  C07K14/78 ,  C12N5/02 ,  C12N15/74 ,  C12N15/87 ,  C12P21/06 ,  G01N33/53 ,  G01N33/566 ,  G01N33/569 ,  G01N33/574 ,  G01N33/68

CPC classification number: C07K14/78 ,  A61K49/0002 ,  A61K51/088 ,  G01N33/53 ,  G01N33/566 ,  G01N33/569 ,  G01N33/56966 ,  G01N33/574 ,  G01N33/57492 ,  G01N33/68 ,  G01N33/6887 ,  G01N2333/70517 ,  G01N2333/78

Abstract: Fibronectin type III domains (FN3) that specifically bind to CD8A, related polynucleotides capable of encoding CD8A-specific FN3 domains, cells expressing the FN3 domains, as well as associated vectors, and detectably labeled FN3 domains are useful in therapeutic and diagnostic applications.

公开(公告)号：US11479880B2

公开(公告)日：2022-10-25

申请号：US16860613

申请日：2020-04-28

Applicant: Janssen Biotech, Inc.

Inventor： Steven Jacobs ,  Karyn O'Neil

IPC: C40B40/10 ,  C07K14/78 ,  C40B50/06 ,  C40B40/08

Abstract: A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.