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60 条记录 (耗时 0.022 秒)

    Method of enzymatically measuring hydrogen peroxide and reagent therefor
    27.
    发明授权
    Method of enzymatically measuring hydrogen peroxide and reagent therefor 失效
    酶法测定过氧化氢及其试剂的方法

    公开(公告)号：US5474908A

    公开(公告)日：1995-12-12

    申请号：US797011

    申请日：1991-11-25

    申请人： Masayasu Kurono ,  Shizuo Uno ,  Osamu Takehiro ,  Kiichi Sawai

    发明人： Masayasu Kurono ,  Shizuo Uno ,  Osamu Takehiro ,  Kiichi Sawai

    IPC分类号： C12Q1/28 ,  C12Q1/30 ,  C12Q1/00 ,  C12Q1/26

    CPC分类号： C12Q1/28 ,  C12Q1/30 ,  C12Q2326/32

    摘要： A method of enzymatically measuring hydrogen peroxide by developing a color with use of 3-methyl-2-benzothiazolinoehydrazone as a coupler and in combination with an oxidative color developing reagent with peroxidase, and a reagent therefor is described. Catalase is added to the 3-methyl-2-benzothiazolinonehydrazone reagent as a stabilizer and the reaction is carried out in the presence of ethylenediaminetetraacetic acid or an analogue thereof. The color developing reaction may be carried out in neutral or weak alkali conditions. A reagent is described which comprises a buffer, 3-methyl-2-benzothiazolinohydrazone, and catalase.

    摘要翻译： 描述了使用3-甲基-2-苯并噻唑腙腙作为偶联剂并与具有过氧化物酶的氧化显色剂组合的显色测定过氧化氢的方法及其试剂。 将过氧化氢酶作为稳定剂加入到3-甲基-2-苯并噻唑啉酮腙试剂中，反应在乙二胺四乙酸或其类似物的存在下进行。 显色反应可以在中性或弱碱性条件下进行。 描述了包含缓冲剂，3-甲基-2-苯并噻唑腙和过氧化氢酶的试剂。

    Nootropic agents, compositions of, and method of use thereof
    28.
    发明授权
    Nootropic agents, compositions of, and method of use thereof 失效
    诱导剂，组合物及其使用方法

    公开(公告)号：US5434165A

    公开(公告)日：1995-07-18

    申请号：US976499

    申请日：1992-11-13

    申请人： Masayasu Kurono ,  Yutaka Baba ,  Tomoo Suzuki ,  Tsunemasa Suzuki ,  Kiyotaka Hirooka ,  Kiichi Sawai

    发明人： Masayasu Kurono ,  Yutaka Baba ,  Tomoo Suzuki ,  Tsunemasa Suzuki ,  Kiyotaka Hirooka ,  Kiichi Sawai

    IPC分类号： C07C211/59 ,  C07D213/72 ,  C07D215/38 ,  C07D219/08 ,  C07D487/04 ,  C07D471/04 ,  A61K31/41 ,  A61K31/47 ,  C07D403/14

    CPC分类号： C07D487/04 ,  C07C211/59 ,  C07D213/72 ,  C07D215/38 ,  C07D219/08

    摘要： An aromatic amino-substituted compound represented by formula: ##STR1## wherein A represents CH, N, or N.fwdarw.O; R.sub.1 represents a nitro group or an amino group; R.sub.2 represents a hydrogen atom, a lower alkyl group, or an acyl group; and R.sub.3 represents a group: ##STR2## wherein m represents 0 or 1; n represents an integer of from 0 to 3; R.sub.4 and R.sub.5 each represents a hydrogen atom or a lower alkyl group; R.sub.6 and R.sub.7 each represents a hydrogen atom or a straight chain or branched lower alkyl group; R.sub.4 and R.sub.6 may be joined together to form an alkylene chain forming a heterocyclic ring; R.sub.5 and R.sub.7 may be joined together to form an alkylene chain forming a heterocyclic ring and R.sub.6 and R.sub.7 may be joined together to form an alkylene chain forming a heterocyclic ring,or a pharmaceutically acceptable salt thereof, a process for producing the same, and a method for preventing or treating brain disfunction such as senile dementia or Alzheimer's disease by administering a nootropic agent containing the same as an active ingredient are disclosed.

    摘要翻译： 由下式表示的芳族氨基取代的化合物：其中A表示CH，N或N-> O; R1表示硝基或氨基; R2表示氢原子，低级烷基或酰基; 并且R 3表示基团：其中m表示0或1; n表示0〜3的整数， R4和R5各自表示氢原子或低级烷基; R6和R7各自表示氢原子或直链或支链的低级烷基; R4和R6可以连接在一起形成形成杂环的亚烷基链; R5和R7可以连接在一起以形成形成杂环的亚烷基链，并且R 6和R 7可以连接在一起形成形成杂环的亚烷基链，或其药学上可接受的盐，其制备方法和 公开了通过施用含有其作为活性成分的诱导剂来预防或治疗脑功能障碍的方法，例如老年性痴呆或阿尔茨海默氏病。

    Motlin-like polypeptide and use thereof
    30.
    发明授权
    Motlin-like polypeptide and use thereof 失效
    Motlin样多肽及其用途

    公开(公告)号：US5432261A

    公开(公告)日：1995-07-11

    申请号：US943992

    申请日：1992-09-11

    申请人： Masayasu Kurono ,  Takahiko Mitani ,  Haruo Takahashi ,  Kenichi Tanaka ,  Katsuya Fujimura ,  Yuji Hayashi ,  Yohei Kobayashi ,  Kiichi Sawai

    发明人： Masayasu Kurono ,  Takahiko Mitani ,  Haruo Takahashi ,  Kenichi Tanaka ,  Katsuya Fujimura ,  Yuji Hayashi ,  Yohei Kobayashi ,  Kiichi Sawai

    IPC分类号： A61K38/00 ,  C07K14/63 ,  C12N15/16 ,  C07K14/00

    CPC分类号： C07K14/63 ,  A61K38/00 ,  C07K2319/02

    摘要： A pharmaceutical composition for stimulating peristaltic contraction in the intestinal canal which contains a pharmaceutically acceptable carrier or excipient and an effective amount of a polypeptide, or a salt thereof, having a pharmacological activity similar to motilin. The polypeptide has the formula B.sub.1 -Z.sub.1 -A.sub.1 -Z.sub.2 -B.sub.2 -Thr-B.sub.3 -A.sub.2 -Glu-Z.sub.3 -C-Arg-X'-Gln-Glu-Lys-Glu-Arg-D-Lys-Gly-E-Y, with Z.sub.1,Z.sub.2 and Z.sub.3 each being an amino acid residue having a hydrophobic side-chain, A.sub.1 and A.sub.2 each being an amino acid residue such as Pro, Gly, Asn and Ser, B.sub.1, B.sub.2 and B.sub.3 are each an amino acid residue having a side-chain with an aromatic ring, C is Gln, Glu or Asp, D is Asn, Glu or Asp, X' is an amino acid residue other than Met, E is Gln, Lys or Arg, and Y is homoserine, homoserine-lactone or a peptide chain having amino acid residues not exceeding 10 and containing homoserine or homoserine-lactone at the C-terminal where the first amino acid of said peptide chain is other than Lys, Arg or Pro.

    摘要翻译： 一种用于刺激肠道蠕动收缩的药物组合物，其含有药学上可接受的载体或赋形剂和有效量的具有与胃动素相似的药理活性的多肽或其盐。 该多肽具有式B1-Z1-A1-Z2-B2-Thr-B3-A2-Glu-Z3-C-Arg-X'-Gln-Glu-Lys-Glu-Arg-D-Lys-Gly-EY， Z 1，Z 2和Z 3各自为具有疏水侧链的氨基酸残基，A1和A2各自为氨基酸残基，例如Pro，Gly，Asn和Ser，B1，B2和B3各自为具有 具有芳环的侧链，C是Gln，Glu或Asp，D是Asn，Glu或Asp，X'是Met以外的氨基酸残基，E是Gln，Lys或Arg，Y是高丝氨酸，高丝氨酸 β-内酯或氨基酸残基不超过10的肽链，并且在所述肽链的第一个氨基酸不是Lys，Arg或Pro的C末端含有高丝氨酸或高丝氨酸 - 内酯。