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公开(公告)号：US20190264017A1
公开(公告)日：2019-08-29
申请号：US16305372
申请日：2017-06-07
Inventor： Kristian ANDERSSON , Geir FONNUM , Korbinian HEIL
IPC: C08L25/14 , C08F212/08 , B01J19/00
Abstract: This invention relates to polymer particles for solid phase oligonucleotide synthesis. The oligonucleotide may be linked to the particle via a linker having an amide-oligoethyleneglycol-amine structure. The particles may be considered to act as a solid support during the oligonucleotide synthesis. Also disclosed are processes for preparing such polymer particles, compositions and systems comprising such particles, and uses thereof.
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公开(公告)号：US20180215852A1
公开(公告)日：2018-08-02
申请号：US15745620
申请日：2016-07-19
Applicant: LIFE TECHNOLOGIES AS
Inventor： Geir FONNUM , Nils LUNDBERG , Muhammed GOKMEN , Synne LARSEN , Wilhelm Glomm , Heidi Johnsen , Ruth SCHMID , Lars Kilaas
IPC: C08F265/10 , C08F120/54 , C08F265/06
CPC classification number: C08F265/10 , C08F120/54 , C08F265/06 , C08F220/56
Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non-crosslinked oligomers of poly N,N-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.
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公开(公告)号：US20180163255A1
公开(公告)日：2018-06-14
申请号：US15891535
申请日：2018-02-08
Applicant: LIFE TECHNOLOGIES AS
Inventor： Darren ELLIS , Geir FONNUM , Nini KJUS
IPC: C12Q1/6806 , C12N15/10
CPC classification number: C12Q1/6806 , C12N15/1006 , C12N15/1013
Abstract: A method for processing a nucleic acid, in which the nucleic acid is exposed to an aqueous medium which includes a polyol in sufficient proportion for at least a portion of the nucleic acid to enter or remain in an extra-solution phase. Thus, a polyol may be used to bind a nucleic acid which is in solution to a solid support or to wash a nucleic acid on a solid support whilst maintaining it on the support. The polyol may for example be a C2-C10 alkanediol.
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公开(公告)号：US20170204398A1
公开(公告)日：2017-07-20
申请号：US15431678
申请日：2017-02-13
Applicant: LIFE TECHNOLOGIES AS
Inventor： Darren ELLIS , Geir FONNUM , Nini KJUS
CPC classification number: C12Q1/6806 , C12N15/1006 , C12N15/1013
Abstract: A method for processing a nucleic acid, in which the nucleic acid is exposed to an aqueous medium which includes a polyol in sufficient proportion for at least a portion of the nucleic acid to enter or remain in an extra-solution phase. Thus, a polyol may be used to bind a nucleic acid which is in solution to a solid support or to wash a nucleic acid on a solid support whilst maintaining it on the support. The polyol may for example be a C2-C10 alkanediol.
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Patent Agency Ranking
公开(公告)号：US20160075800A1
公开(公告)日：2016-03-17
申请号：US14867394
申请日：2015-09-28
Applicant: Arvid BERGE , Viola Ugelstad , LIFE TECHNOLOGIES AS
Inventor： Arne JØRGEDAL , Elin Marie AKSNES , Geir FONNUM , Astrid MOLTEBERG , Rolf NORDAL , Henning PETTERSEN , Tollef TÅARNEBY , Solveig STAALE , Ellen WENG , Finn HANSEN , Silje NORDBØ , Oddvar AUNE , Arvid BERGE , John BJØRGUM , Turid ELLINGSEN , John UGELSTAD
CPC classification number: C08J9/16 , C08F2/22 , C08F257/02 , C08F265/04 , C08F265/10 , C08F291/00 , C08J9/22 , C08J9/224 , C08J2203/14 , C08J2325/06 , C08J2347/00
Abstract: A process for the preparation of monodisperse polymer particles which are formed by contacting monomers with aqueous dispersions comprising monodisperse swellable seed polymers/oligomers, and initiating polymerization in the presence of a steric stabilizer. The resulting swollen seed particles are characterized by the particle mode diameter.
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公开(公告)号：US20140231697A1
公开(公告)日：2014-08-21
申请号：US14228158
申请日：2014-03-27
Applicant: LIFE TECHNOLOGIES AS
Inventor： Ellen WENG , Geir FONNUM , Grete MODAHL , Astrid MOLTEBERG , Erling FINNE , Torkel STENE
CPC classification number: C09K11/06 , B82Y25/00 , B82Y40/00 , C08F220/18 , C09K11/025 , G01N33/5434 , H01F1/0018 , H01F1/01 , H01F1/26 , H01F41/00 , Y10T428/2991 , Y10T428/2998
Abstract: A coated magnetic particle comprising an optionally porous magnetic polymer particle of a matrix polymer, said polymer particle having on a surface and/or in the pores thereof superparamagnetic crystals, said coated particle having a coat formed of a coating polymer, wherein said coated magnetic particle is essentially non-autofluorescent.
Abstract translation: 一种涂覆的磁性颗粒，其包含基质聚合物的任选多孔磁性聚合物颗粒，所述聚合物颗粒在表面上和/或其孔中具有超顺磁性晶体，所述涂覆颗粒具有由涂覆聚合物形成的涂层，其中所述涂覆的磁性颗粒 本质上是非自发荧光。
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公开(公告)号：US20210139626A1
公开(公告)日：2021-05-13
申请号：US17066326
申请日：2020-10-08
Applicant: Life Technologies AS , SINTEF
Inventor： Geir FONNUM , Nils Pontus LUNDBERG , Muhammed Talha GOKMEN , Synne LARSEN , Wilhelm Glomm , Heidi Johnsen , Ruth SCHMID , Lars Kilaas
IPC: C08F265/10 , C08F120/54 , C08F265/06
Abstract: This invention relates to monodisperse cross-linked hydrogel polymer particles comprising a polymer formed from (a) a hydrophilic vinylic monomer; and (b) a crosslinker comprising at least two vinyl groups. The invention also relates to monodisperse seed particles with a Z-average diameter of from 100 nm to 1500 nm that comprise a plurality of non-crosslinked oligomers of poly N,N-dimethylacrylamide. Also provided are methods of forming the monodisperse cross-linked hydrogel polymer particles and monodisperse seed particles.
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公开(公告)号：US20140256836A1
公开(公告)日：2014-09-11
申请号：US14152793
申请日：2014-01-10
Applicant: LIFE TECHNOLOGIES AS
Inventor： Arne JØRGEDAL , Elin Marie AKSNES , Geir FONNUM , Astrid MOLTEBERG , Rolf NORDAL , Henning PETTERSEN , Tollef TÂRNEBY , Solveig STAALE , Ellen WENG , Finn HANSEN , Silje NORDBØ , Oddvar AUNE , Arvid BERGE , John BJØRGUM , Turid ELLINGSEN , John UGELSTAD
CPC classification number: C08J9/16 , C08F2/22 , C08F257/02 , C08F265/04 , C08F265/10 , C08F291/00 , C08J9/22 , C08J9/224 , C08J2203/14 , C08J2325/06 , C08J2347/00
Abstract: A process for the preparation of monodisperse polymer particles which are formed by contacting monomers with aqueous dispersions comprising monodisperse swellable seed polymers/oligomers, and initiating polymerization in the presence of a steric stabilizer. The resulting swollen seed particles are characterized by the particle mode diameter.
Abstract translation: 通过使单体与包含单分散可溶胀种子聚合物/低聚物的水性分散体接触而形成的单分散聚合物颗粒的制备方法，以及在空间稳定剂存在下引发聚合。 所得的溶胀种子颗粒的特征在于颗粒模式直径。
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公开(公告)号：US20190233558A1
公开(公告)日：2019-08-01
申请号：US16259963
申请日：2019-01-28
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Geir FONNUM , Grete Irene MODAHL , Nini KJUS , Astrid Evenroed MOLTEBERG , Diem Thuy Thi TRAN , Jo AASERUD , Muhammed GOKMEN , Steven M. MENCHEN , Carl FULLER , Luisa ANDRUZZI , Wolfgang HINZ
IPC: C08F130/08 , C07F7/18 , C08F230/08 , C08F8/32 , C08F8/34 , C08J9/20 , G01N27/414 , C12Q1/6874 , C12P19/34 , C08F222/38 , C12Q1/686 , C08F220/58 , C08F2/26 , C08F2/20 , C08F6/24 , C08F8/12
CPC classification number: C08F130/08 , C07F7/1804 , C07F7/188 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F220/58 , C08F222/385 , C08F230/08 , C08F2800/20 , C08J9/20 , C08J2343/04 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/4145 , Y10T428/2982 , C08F257/02 , C08F2222/1013 , C08F212/36 , C08F220/60 , C12Q2563/149 , C12Q2563/159 , C12Q2565/543
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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