公开(公告)号：US07094409B2

公开(公告)日：2006-08-22

申请号：US10289454

申请日：2002-11-07

Applicant: Martin Bachmann ,  Gary Jennings ,  Ivo Sonderegger

Inventor： Martin Bachmann ,  Gary Jennings ,  Ivo Sonderegger

IPC: A61K39/385 ,  C12N7/00 ,  C07K17/00

CPC classification number: A61K39/0007 ,  A61K38/00 ,  A61K38/162 ,  A61K39/0005 ,  A61K39/0008 ,  A61K39/001 ,  A61K39/35 ,  A61K39/385 ,  A61K39/39 ,  A61K47/646 ,  A61K47/6901 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/6075 ,  A61K2039/627 ,  C07K14/005 ,  C07K14/523 ,  C07K14/5409 ,  C07K14/5437 ,  C07K16/00 ,  C07K16/082 ,  C07K16/22 ,  C07K16/2863 ,  C07K16/2875 ,  C07K16/40 ,  C07K16/4291 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2730/10122 ,  C12N2730/10123 ,  C12N2730/10142 ,  C12N2795/18122 ,  C12N2810/852

Abstract: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an array comprising a protein or peptide of IL-5, IL-13 or eotaxin. More specifically, the invention provides a composition comprising a virus-like particle and at least one protein, or peptide of IL-5, IL-13 and/or eotaxin bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of allergic diseases with an eosinophilic component and as a pharmaccine to prevent or cure allergic diseases with an eosinophilic component and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

公开(公告)号：US20110123541A1

公开(公告)日：2011-05-26

申请号：US12745537

申请日：2008-09-11

Applicant: Martin Bachmann ,  Monika Bauer ,  Roger Beerli ,  Patrik Maurer

Inventor： Martin Bachmann ,  Monika Bauer ,  Roger Beerli ,  Patrik Maurer

IPC: A61K39/395 ,  C07K16/44 ,  A61P25/34

CPC classification number: C07K16/00 ,  A61K2039/505 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/92

Abstract: The invention relates to recombinantly produced human monoclonalantibodies which are specifically binding nicotine and to nucleic acids encoding the same. The invention further relates to the use of such antibodies in the treatment of nicotine addiction.

Abstract translation: 本发明涉及重组产生的特异性结合尼古丁的人单克隆抗体和编码该烟碱的核酸。 本发明还涉及这种抗体在治疗尼古丁成瘾中的用途。

公开(公告)号：US20090175896A1

公开(公告)日：2009-07-09

申请号：US11886577

申请日：2006-03-17

Applicant: Martin Bachmann ,  Monika Bauer ,  Klaus Dietmeier ,  Nicole Schmitz ,  Stephan Utzinger

Inventor： Martin Bachmann ,  Monika Bauer ,  Klaus Dietmeier ,  Nicole Schmitz ,  Stephan Utzinger

IPC: A61K39/385 ,  A61K35/76 ,  C12N7/00

CPC classification number: A61K47/48776 ,  A61K39/35 ,  A61K47/6901 ,  A61K2039/5258 ,  A61K2039/55505 ,  C07K14/005 ,  C07K2319/00

Abstract: The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides compositions comprising a virus-like particle (VLP) or a virus particle and at least one antigen, particularly at least one feline antigen, and more particularly at least one feline antigen that is a human allergen. In certain embodiments, the antigen is a Fel d1 antigen or a fragment thereof, covalently linked to the VLP. The invention also provides methods for producing the compositions. The compositions of the invention induce efficient immune responses, in particular antibody responses, in mammals, particularly humans. The compositions and methods of the invention are useful in the production of vaccines, in particular for the treatment and/or prevention of allergies to cat dander and other cat antigens and allergens.

Abstract translation: 本发明涉及医药，公共卫生，免疫学，分子生物学和病毒学领域。 本发明提供包含病毒样颗粒（VLP）或病毒颗粒和至少一种抗原，特别是至少一种猫科动物抗原，更特别是至少一种作为人类变应原的猫科动物抗原的组合物。 在某些实施方案中，抗原是与VLP共价连接的Fel d1抗原或其片段。 本发明还提供了用于制备组合物的方法。 本发明的组合物在哺乳动物，特别是人类中诱导有效的免疫应答，特别是抗体应答。 本发明的组合物和方法可用于疫苗的制备，特别是用于治疗和/或预防猫皮屑和其它猫抗原和变应原的过敏。

公开(公告)号：US07494656B2

公开(公告)日：2009-02-24

申请号：US11601687

申请日：2006-11-20

Applicant: Martin Bachmann ,  Alain Tissot ,  Paul Pumpens ,  Indulis Cielens ,  Regina Renhofa

Inventor： Martin Bachmann ,  Alain Tissot ,  Paul Pumpens ,  Indulis Cielens ,  Regina Renhofa

IPC: A61K39/145 ,  A61K39/385 ,  C12N7/00 ,  C12N15/09

CPC classification number: C12N7/00 ,  A61K39/00 ,  A61K39/0005 ,  A61K39/35 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/6075 ,  C07K14/005 ,  C07K14/5409 ,  C07K16/24 ,  C07K16/40 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/50 ,  C12N2795/18122 ,  C12N2795/18123 ,  Y02A50/412

Abstract: The present invention provides a composition comprising an AP205 virus like particle (VLP) and an antigen. The invention also provides a process for producing an antigen or antigenic determinant bound to AP205 VLP. AP205 VLP bound to an antigen is useful in the production of compositions for inducing immune responses that are useful for the prevention or treatment of diseases, disorders or conditions including infectious diseases, allergies, cancer, drug addiction, poisoning and to efficiently induce self-specific immune responses, in particular antibody responses.

Abstract translation: 本发明提供包含AP205病毒样颗粒（VLP）和抗原的组合物。 本发明还提供了一种制备与AP205 VLP结合的抗原或抗原决定簇的方法。 与抗原结合的AP205 VLP可用于产生用于诱导免疫应答的组合物，其可用于预防或治疗疾病，病症或病症，包括感染性疾病，过敏，癌症，药物成瘾，中毒，并有效诱导自身特异性 免疫应答，特别是抗体应答。

公开(公告)号：US20070248617A1

公开(公告)日：2007-10-25

申请号：US11628244

申请日：2005-06-02

Applicant: Martin Bachmann ,  Patrik Maurer ,  Gunther Spohn

Inventor： Martin Bachmann ,  Patrik Maurer ,  Gunther Spohn

IPC: A61K39/12 ,  A61P1/02 ,  A61P1/16 ,  A61P17/06 ,  A61P19/02 ,  A61P19/08 ,  A61P19/10 ,  A61P3/10 ,  A61P31/00 ,  A61P35/04 ,  A61P37/00 ,  A61P43/00 ,  A61P7/00 ,  A61P9/10

CPC classification number: A61K39/0005 ,  A61K39/0008 ,  A61K39/385 ,  A61K47/6901 ,  A61K2039/5258 ,  A61K2039/6031 ,  A61K2039/6075 ,  A61K2039/627 ,  A61K2039/64 ,  C07K14/005 ,  C07K14/70575 ,  C12N7/00 ,  C12N2795/18122 ,  C12N2795/18123

Abstract: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a modified virus-like particle (VLP) comprising—a VLP and a particular peptide derived from a polypeptide from the TNF-superfamily linked thereto for use in the production of vaccines for the treatment of autoimmune diseases and bone-related diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

Abstract translation: 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供了修饰的病毒样颗粒（VLP），其包含VLP和源自与其连接的TNF-超家族的多肽的特定肽，用于生产用于治疗自身免疫疾病和骨相关疾病的疫苗，以及 以有效地诱导免疫应答，特别是抗体应答。 此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。

公开(公告)号：US20060251623A1

公开(公告)日：2006-11-09

申请号：US10563944

申请日：2004-07-12

Applicant: Martin Bachmann ,  Katrin Schwarz

Inventor： Martin Bachmann ,  Katrin Schwarz

IPC: A61K48/00 ,  A61K39/00

CPC classification number: A61K39/02 ,  A61K39/00 ,  A61K39/002 ,  A61K39/12 ,  A61K39/292 ,  A61K39/35 ,  A61K39/39 ,  A61K2039/5258 ,  A61K2039/55511 ,  A61K2039/55516 ,  A61K2039/55561 ,  A61K2039/55572 ,  A61K2039/57 ,  C07K14/005 ,  C07K2319/00 ,  C12N7/00 ,  C12N2710/20022 ,  C12N2730/10122 ,  C12N2730/10123 ,  C12N2730/10134 ,  C12N2760/10034 ,  Y02A50/467

Abstract: The present invention is related to the fields of vaccinology, immunology and medicine. The invention provides compositions and methods for enhancing immunological responses against antigens coupled or fused to virus-like particles (VLPs) packaged with immunostimulatory nucleic acids, preferably oligonucleotides containing at least one non-methylated CpG sequence and a toll-like receptor (TLR) ligand. The invention can be used to induce strong antibody and T cell responses particularly useful for the treatment of allergies, tumors and chronic viral diseases as well as other chronic diseases.

Abstract translation: 本发明涉及疫苗学，免疫学和医学领域。 本发明提供用于增强针对与免疫刺激性核酸包装的病毒样颗粒（VLP）偶联或融合的抗原的免疫应答的组合物和方法，优选含有至少一种非甲基化CpG序列和toll样受体（TLR）配体的寡核苷酸 。 本发明可用于诱导特异于治疗过敏，肿瘤和慢性病毒疾病以及其它慢性疾病的强抗体和T细胞应答。

公开(公告)号：US20060222652A1

公开(公告)日：2006-10-05

申请号：US11270774

申请日：2005-11-10

Applicant: Peter Sebbel ,  Nicolas Dunant ,  Martin Bachmann ,  Alain Tissot ,  Franziska Lechner ,  Wolfgang Renner ,  Frank Hennecke ,  Lars Nieba

Inventor： Peter Sebbel ,  Nicolas Dunant ,  Martin Bachmann ,  Alain Tissot ,  Franziska Lechner ,  Wolfgang Renner ,  Frank Hennecke ,  Lars Nieba

IPC: A61K39/40 ,  A61K39/295 ,  A61K39/29 ,  A61K39/108

CPC classification number: A61K39/385 ,  A61K38/00 ,  A61K2039/57 ,  A61K2039/6068 ,  A61K2039/625 ,  C07K14/245 ,  C07K2319/00 ,  Y10S530/807

Abstract: The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the production of vaccines for the prevention of infectious diseases, the treatment of allergies and the treatment of cancers. Various embodiments of the invention provide for a core particle that is coated with any desired antigen in a highly ordered and repetitive fashion as the result of specific interactions.

公开(公告)号：US20060182793A1

公开(公告)日：2006-08-17

申请号：US10565264

申请日：2004-07-22

Applicant: Martin Bachmann ,  Vania Manolova ,  Tazio Storni

Inventor： Martin Bachmann ,  Vania Manolova ,  Tazio Storni

IPC: A61K48/00 ,  A61K9/127

CPC classification number: A61K39/39 ,  A61K9/127 ,  A61K2039/55555 ,  A61K2039/55561 ,  Y02A50/412

Abstract: Liposomes are known to enhance the activity of K- (B-) type CpGs which trigger the production of IL-12. In the present invention, the surprising finding was made that liposomes also enhance the activity of D- (A-) type CpGs, leading to the production of IFNα in vivo. These findings are relevant for the humans situation, since IFNα rather than IL-12 is the key cytokine for the induction of Th1 responses and anti-viral protection in humans.

Abstract translation: 已知脂质体可增强触发IL-12产生的K-（B-）型CpG的活性。 在本发明中，令人惊奇的发现是，脂质体还增强D-（A-）型CpG的活性，导致体内IFNα的产生。 这些发现与人类情况相关，因为IFNalpha而不是IL-12是人类Th1应答诱导和抗病毒保护的关键细胞因子。

公开(公告)号：US20050281845A1

公开(公告)日：2005-12-22

申请号：US11125402

申请日：2005-05-10

Applicant: Martin Bachmann ,  Patrik Maurer

Inventor： Martin Bachmann ,  Patrik Maurer

IPC: A61K39/385 ,  A61K47/48 ,  C07K14/005 ,  C07K14/02 ,  C07K14/08 ,  C07K14/195 ,  C12Q1/68 ,  A01N37/12 ,  A01N37/44 ,  A61K31/195 ,  A61K39/12

CPC classification number: C07K17/02 ,  A61K39/0013 ,  A61K39/385 ,  A61K47/6901 ,  A61K2039/5258 ,  A61K2039/55505 ,  A61K2039/6075 ,  C07K14/005 ,  C12N2730/10122 ,  C12N2795/18123

Abstract: The present invention provides compositions comprising a conjugate of a hapten with a carrier in an ordered and repetitive array, and methods of making such compositions. The conjugates and compositions of the invention may comprise a variety of haptens, including hormones, toxins and drugs, especially drugs of addiction such as nicotine. Compositions and conjugates of the invention are useful for inducing immune responses against haptens, which can use useful in a variety of therapeutic, prophylactic and diagnostic regimens. In certain embodiments, immune responses generated using the conjugates, compositions and methods of the present invention are useful to prevent or treat addiction to drugs of abuse and the resultant diseases associated with drug addiction.

Abstract translation: 本发明提供了包含有序和重复排列的半抗原与载体的缀合物的组合物，以及制备这种组合物的方法。 本发明的缀合物和组合物可以包含各种半抗原，包括激素，毒素和药物，特别是成瘾药物如尼古丁。 本发明的组合物和缀合物可用于诱导针对半抗原的免疫应答，其可用于各种治疗，预防和诊断方案中。 在某些实施方案中，使用本发明的缀合物，组合物和方法产生的免疫应答可用于预防或治疗滥用药物的成瘾以及与药物成瘾相关的所得疾病。

公开(公告)号：US07785873B2

公开(公告)日：2010-08-31

申请号：US11589321

申请日：2006-10-30

Applicant: Martin Bachmann ,  Patrik Maurer ,  Gunther Spohn

Inventor： Martin Bachmann ,  Patrik Maurer ,  Gunther Spohn

IPC: C12N15/63 ,  A61K48/00

CPC classification number: A61K39/0007 ,  A61K38/00 ,  A61K39/0005 ,  A61K39/0008 ,  A61K39/001 ,  A61K39/35 ,  A61K39/385 ,  A61K39/39 ,  A61K47/6901 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/6075 ,  A61K2039/627 ,  C07K14/005 ,  C07K14/523 ,  C07K14/5409 ,  C07K14/5437 ,  C07K14/70575 ,  C07K16/00 ,  C07K16/082 ,  C07K16/22 ,  C07K16/2863 ,  C07K16/2875 ,  C07K16/40 ,  C07K16/4291 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2730/10122 ,  C12N2730/10123 ,  C12N2795/18122

Abstract: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular a RANKL protein, RANKL fragment or RANKL peptide-VLP-array. More specifically, the invention provides a composition comprising a virus-like particle and at least one RANKL protein, RANKL fragment or RANKL peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of bone diseases and as a pharmaccine to prevent or cure bone diseases and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.

Abstract translation: 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供包含有序和重复抗原或抗原决定簇，特别是RANKL蛋白，RANKL片段或RANKL肽-VLP阵列的组合物。 更具体地，本发明提供包含病毒样颗粒和与其结合的至少一种RANKL蛋白，RANKL片段或RANKL肽的组合物。 本发明还提供了分别制备共轭物和有序和重复阵列的方法。 本发明的组合物可用于生产用于治疗骨疾病的疫苗和用于预防或治愈骨疾病并有效诱导免疫应答，特别是抗体应答的药物。 此外，本发明的组合物特别有用于在指定的上下文中有效诱导自身特异性免疫应答。