公开(公告)号：US20110232794A1

公开(公告)日：2011-09-29

申请号：US13131893

申请日：2009-12-22

申请人： Masaya Nakatani ,  Makoto Takahashi ,  Hiroshi Ushio ,  Takeki Yamamoto

发明人： Masaya Nakatani ,  Makoto Takahashi ,  Hiroshi Ushio ,  Takeki Yamamoto

IPC分类号： F16L55/00 ,  B05D3/00 ,  B32B38/10

CPC分类号： B01F13/0059 ,  B01F5/061 ,  B01F13/0091 ,  B01F2005/0632 ,  B01F2005/0636 ,  B01L3/502746 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2300/16 ,  B01L2400/086 ,  B01L2400/088 ,  B81B3/0078 ,  B81B2201/058 ,  B81B2203/0338 ,  B81C1/00206 ,  G01N1/38 ,  G01N27/44756 ,  Y10T137/0329 ,  Y10T137/2224 ,  Y10T137/2229

摘要： A flow channel structure includes a substrate having a flow channel formed therein, and plural fibrous bristles extending from the inner wall of the flow channel. The flow channel is configured to allow a solution to flow through the flow channel. The inner wall of the flow channel is made of silicon. The flow channel is configured to allow a solution to flow through the flow channel. This flow channel structure can homogenize the solution inside the flow channel.

摘要翻译： 流路结构包括其中形成有流动通道的基板和从流动通道的内壁延伸的多个纤维刷毛。 流动通道被配置为允许溶液流过流动通道。 流动通道的内壁由硅制成。 流动通道被配置为允许溶液流过流动通道。 该流道结构可以使流道内的溶液均匀化。

公开(公告)号：US20100203621A1

公开(公告)日：2010-08-12

申请号：US12670206

申请日：2008-07-14

申请人： Makoto Takahashi ,  Masaya Nakatani ,  Hiroshi Ushio

发明人： Makoto Takahashi ,  Masaya Nakatani ,  Hiroshi Ushio

IPC分类号： C12M1/34

CPC分类号： G01N33/48728

摘要： A biosensor has the following elements: a diaphragm having a through-hole; a frame supporting the diaphragm and having a cavity; and pillars formed on the side of inner wall surface of the frame and on the surface of the diaphragm. This structure can suppress the occurrence of bubbles in the vicinity of the through-hole, and easily remove the remaining bubbles. Thus the measuring reliability of the biosensor can be improved.

摘要翻译： 生物传感器具有以下元件：具有通孔的隔膜; 支撑隔膜并具有空腔的框架; 以及形成在框架的内壁表面侧和隔膜表面上的柱。 该结构能够抑制通孔附近的气泡的产生，容易除去残留的气泡。 因此，可以提高生物传感器的测量可靠性。

公开(公告)号：US08354271B2

公开(公告)日：2013-01-15

申请号：US12668538

申请日：2008-07-08

申请人： Makoto Takahashi ,  Masaya Nakatani ,  Hiroshi Ushio

发明人： Makoto Takahashi ,  Masaya Nakatani ,  Hiroshi Ushio

IPC分类号： G01N27/327

CPC分类号： G01N33/48728 ,  C12M23/12 ,  C12M23/20 ,  C12M29/20

摘要： A sensor includes a diaphragm having a through-hole (1), and includes a frame supporting a diaphragm and having a cavity. Kerfs are formed in a frame so as to extend from an end surface of the frame, and the wall surfaces of the kerfs are made hydrophilic. This structure can suppress the occurrence of bubbles in the vicinity of the through-hole, and efficiently remove the remaining bubbles. As a result, the bubbles adhering to the vicinity of the through-hole can be removed, and the measuring reliability of the sensor can be improved.

摘要翻译： 传感器包括具有通孔（1）的隔膜，并且包括支撑隔膜并具有空腔的框架。 齿框形成在框架中以从框架的端面延伸，并且切口的壁表面被制成亲水性。 该结构可以抑制通孔附近的气泡的产生，有效地除去残留的气泡。 结果，可以去除附着在通孔附近的气泡，并且可以提高传感器的测量可靠性。

公开(公告)号：US20110111984A1

公开(公告)日：2011-05-12

申请号：US13002691

申请日：2009-06-26

申请人： Masaya Nakatani ,  Makoto Takahashi ,  Hiroshi Ushio ,  Daniel Yazbeck

发明人： Masaya Nakatani ,  Makoto Takahashi ,  Hiroshi Ushio ,  Daniel Yazbeck

IPC分类号： C40B40/06 ,  C12Q1/68

CPC分类号： C12Q1/6876 ,  B01J19/0046 ,  B01J2219/00432 ,  B01J2219/00509 ,  B01J2219/00529 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00722 ,  C12Q1/6825 ,  C12Q1/6837 ,  C12Q1/6874 ,  C12Q2565/507

摘要： A sequencer that measures a nucleic acid sequence in a nucleic acid strand includes: a base material having a surface made of silicon; and a fibrous protrusion that is made of silicon dioxide and is directly joined to the surface of the base material made of silicon, wherein a plurality of the nucleic acid strands are fixed onto the fibrous protrusion.

摘要翻译： 测量核酸链中的核酸序列的测序仪包括：具有由硅制成的表面的基材; 以及由二氧化硅制成并且直接接合到由硅制成的基材的表面的纤维状突起，其中多个核酸丝束固定在纤维突起上。

公开(公告)号：US08375745B2

公开(公告)日：2013-02-19

申请号：US12808499

申请日：2008-11-28

申请人： Hiroshi Ushio ,  Masaya Nakatani ,  Makoto Takahashi

发明人： Hiroshi Ushio ,  Masaya Nakatani ,  Makoto Takahashi

IPC分类号： C03B23/043 ,  C03B23/09

CPC分类号： G01N33/48728

摘要： A process including holding sensor chip; holding glass tube surrounding the outer periphery of the side surface of sensor chip; applying a wind pressure to the side surface of glass tube from the outside of glass tube and melting glass tube to be glass-welded to the side surface of sensor chip. Thereby, the outer periphery of sensor chip can be surrounded by a highly hydrophilic glass tube. Thus, a cell electrophysiological sensor with high measurement accuracy can be produced.

摘要翻译： 一种包括保持传感器芯片的过程; 围绕传感器芯片侧面外周的玻璃管; 从玻璃管的外侧将玻璃管的侧面施加风压并将玻璃熔融的玻璃管玻璃焊接到传感器芯片的侧面。 因此，传感器芯片的外周可以被高度亲水性的玻璃管包围。 因此，可以制造具有高测量精度的细胞电生理传感器。

公开(公告)号：US20110120864A1

公开(公告)日：2011-05-26

申请号：US12677977

申请日：2009-07-22

申请人： Makoto Takahashi ,  Masaya Nakatani ,  Hiroshi Ushio ,  Takeki Yamamoto

发明人： Makoto Takahashi ,  Masaya Nakatani ,  Hiroshi Ushio ,  Takeki Yamamoto

IPC分类号： G01N33/487 ,  B32B37/00

CPC分类号： H01L21/02356 ,  G01N33/48728

摘要： A cellular electrophysiology sensor is adapted to measure an electrical change of a test cell. A chip for the sensor includes a diaphragm, and a thermally-oxidized film mainly containing silicon dioxide on the diaphragm. The diaphragm includes a silicon layer and a silicon dioxide layer on an upper surface of the silicon layer. A through-hole passing through the silicon layer and the silicon dioxide layer is formed. The through-hole has an opening which opens at the silicon dioxide layer and is adapted to capture the test cell. The thermally-oxidized film is provided on an inner wall surface of the through-hole, and unified with the silicon dioxide layer at the opening of the through-hole. This cellular electrophysiology sensor chip can stably capture the test cell and provides a gigaseal stably even if test cells have different properties,

摘要翻译： 细胞电生理学传感器适于测量测试电池的电气变化。 用于传感器的芯片包括隔膜以及在隔膜上主要含有二氧化硅的热氧化膜。 隔膜在硅层的上表面上包括硅层和二氧化硅层。 形成穿过硅层和二氧化硅层的通孔。 通孔具有在二氧化硅层处开口并且适于捕获测试电池的开口。 热氧化膜设置在通孔的内壁表面上，并且在通孔的开口处与二氧化硅层一体化。 这种细胞电生理学传感器芯片可以稳定地捕获测试细胞，并且即使测试细胞具有不同的性质也能稳定地提供gigaseal，

公开(公告)号：US08840850B2

公开(公告)日：2014-09-23

申请号：US13131893

申请日：2009-12-22

申请人： Masaya Nakatani ,  Makoto Takahashi ,  Hiroshi Ushio ,  Takeki Yamamoto

发明人： Masaya Nakatani ,  Makoto Takahashi ,  Hiroshi Ushio ,  Takeki Yamamoto

IPC分类号： F16L55/00 ,  B05D3/00 ,  B32B38/10 ,  B01F13/00 ,  B81C1/00 ,  B01L3/00 ,  G01N27/447 ,  B81B3/00 ,  G01N1/38 ,  B01F5/06

CPC分类号： B01F13/0059 ,  B01F5/061 ,  B01F13/0091 ,  B01F2005/0632 ,  B01F2005/0636 ,  B01L3/502746 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2300/16 ,  B01L2400/086 ,  B01L2400/088 ,  B81B3/0078 ,  B81B2201/058 ,  B81B2203/0338 ,  B81C1/00206 ,  G01N1/38 ,  G01N27/44756 ,  Y10T137/0329 ,  Y10T137/2224 ,  Y10T137/2229

摘要： A flow channel structure includes a substrate having a flow channel formed therein, and plural fibrous bristles extending from the inner wall of the flow channel. The flow channel is configured to allow a solution to flow through the flow channel. The inner wall of the flow channel is made of silicon. The flow channel is configured to allow a solution to flow through the flow channel. This flow channel structure can homogenize the solution inside the flow channel.

摘要翻译： 流路结构包括其中形成有流动通道的基板和从流动通道的内壁延伸的多个纤维刷毛。 流动通道被配置为允许溶液流过流动通道。 流动通道的内壁由硅制成。 流动通道被配置为允许溶液流过流动通道。 该流道结构可以使流道内的溶液均匀化。

公开(公告)号：US20110126590A1

公开(公告)日：2011-06-02

申请号：US12808499

申请日：2008-11-28

申请人： Hiroshi Ushio ,  Masaya Nakatani ,  Makoto Takahashi

发明人： Hiroshi Ushio ,  Masaya Nakatani ,  Makoto Takahashi

IPC分类号： C03B23/207 ,  C03B23/20 ,  C03B5/235

CPC分类号： G01N33/48728

摘要： A process including holding sensor chip; holding glass tube surrounding the outer periphery of the side surface of sensor chip; applying a wind pressure to the side surface of glass tube from the outside of glass tube and melting glass tube to be glass-welded to the side surface of sensor chip. Thereby, the outer periphery of sensor chip can be surrounded by a highly hydrophilic glass tube. Thus, a cell electrophysiological sensor with high measurement accuracy can be produced.

摘要翻译： 一种包括保持传感器芯片的过程; 围绕传感器芯片侧面外周的玻璃管; 从玻璃管的外侧将玻璃管的侧面施加风压并将玻璃熔融的玻璃管玻璃焊接到传感器芯片的侧面。 因此，传感器芯片的外周可被高度亲水性的玻璃管包围。 因此，可以制造具有高测量精度的细胞电生理传感器。

公开(公告)号：US20100170790A1

公开(公告)日：2010-07-08

申请号：US12668538

申请日：2008-07-08

申请人： Makoto Takahashi ,  Masaya Nakatani ,  Hiroshi Ushio

发明人： Makoto Takahashi ,  Masaya Nakatani ,  Hiroshi Ushio

IPC分类号： G01N33/487 ,  G01N27/26

CPC分类号： G01N33/48728 ,  C12M23/12 ,  C12M23/20 ,  C12M29/20

摘要： A sensor includes a diaphragm having a through-hole (1), and includes a frame supporting a diaphragm and having a cavity. Kerfs are formed in a frame so as to extend from an end surface of the frame, and the wall surfaces of the kerfs are made hydrophilic. This structure can suppress the occurrence of bubbles in the vicinity of the through-hole, and efficiently remove the remaining bubbles. As a result, the bubbles adhering to the vicinity of the through-hole can be removed, and the measuring reliability of the sensor can be improved.

摘要翻译： 传感器包括具有通孔（1）的隔膜，并且包括支撑隔膜并具有空腔的框架。 齿框形成在框架中以从框架的端面延伸，并且切口的壁表面被制成亲水性。 该结构可以抑制通孔附近的气泡的产生，有效地除去残留的气泡。 结果，可以去除附着在通孔附近的气泡，并且可以提高传感器的测量可靠性。

公开(公告)号：US20130008786A1

公开(公告)日：2013-01-10

申请号：US13636976

申请日：2012-01-11

申请人： Kiyoshi Hashimotodani ,  Yusuke Nakano ,  Masaya Nakatani ,  Takeki Yamamoto ,  Yoshiki Yamada ,  Takuya Oka ,  Hiroshi Ushio

发明人： Kiyoshi Hashimotodani ,  Yusuke Nakano ,  Masaya Nakatani ,  Takeki Yamamoto ,  Yoshiki Yamada ,  Takuya Oka ,  Hiroshi Ushio

IPC分类号： G01N27/28 ,  B65B63/08 ,  G01N33/50

CPC分类号： G01N33/48728 ,  Y10T428/31663

摘要： A sensor chip is a sensor device for measuring a property of a substance by adsorbing the substance on a surface of the sensor chip. The sensor chip includes a diaphragm having a first surface, a second surface, and at least one through hole penetrating from the first surface to the second surface. At least a part of the first surface, the second surface, and an inner wall surface of the through hole is covered with a noncrystalline solid layer including SiOX as a main component, in which substance X is an element having higher electronegativity than that of silicon.

摘要翻译： 传感器芯片是用于通过将物质吸附在传感器芯片的表面上来测量物质的性质的传感器装置。 传感器芯片包括具有第一表面，第二表面和从第一表面穿透到第二表面的至少一个通孔的隔膜。 第一表面，第二表面和通孔的内壁表面的至少一部分被包括SiO x作为主要成分的非结晶固体层覆盖，其中物质X是比硅的电负性高的元素 。