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111 条记录 (耗时 0.101 秒)

    AUTOMATED ROOT CAUSE ANALYSIS
    24.
    发明申请
    AUTOMATED ROOT CAUSE ANALYSIS 有权
    自动原因分析

    公开(公告)号：US20140163926A1

    公开(公告)日：2014-06-12

    申请号：US14233744

    申请日：2011-12-09

    申请人： Henrik Pedersen

    发明人： Henrik Pedersen

    IPC分类号： G05B23/02

    CPC分类号： G05B23/02 ,  F01D17/02 ,  F01D21/00 ,  F01D21/003 ,  F02C9/00 ,  G05B23/0278 ,  G06Q10/0631 ,  G07C3/00

    摘要： A method for performing computerized automated root cause analysis for a complex product, such as a turbine, and computer-readable medium encoded with programming instructions for performing such a root cause analysis are provided. The method may include: monitoring the product; detecting a product misbehavior; forming a misbehavior pattern with timeslots of normal operation and timeslots of misbehavior operation; comparing timeslots of the misbehavior pattern to corresponding timeslots of channels of information in at least one database relating to the product; measuring how close the misbehavior pattern numerically fits to the information; and automatically identifying a best numerical fit.

    摘要翻译： 提供了一种用于对复杂产品（例如涡轮机）执行计算机化的自动根本原因分析的方法以及用编程指令编码的用于执行这种根本原因分析的计算机可读介质。 该方法可以包括：监控产品; 检测产品的不当行为; 形成了正常运作时间和不当行为时间的不正当行为模式; 将不正当行为模式的时间间隔与至少一个与产品相关的数据库中的信息通道的相应时隙进行比较; 衡量不正当行为模式在数字上与信息的接近程度; 并自动识别最佳数值拟合。

    Oxaloacetate Hydrolase Deficient Fungal Host Cells
    26.
    发明申请
    Oxaloacetate Hydrolase Deficient Fungal Host Cells 有权
    草酰乙酸水解酶缺乏真菌宿主细胞

    公开(公告)号：US20100173390A1

    公开(公告)日：2010-07-08

    申请号：US12719648

    申请日：2010-03-08

    申请人： Carsten Mailand Hjort ,  Henrik Pedersen

    发明人： Carsten Mailand Hjort ,  Henrik Pedersen

    IPC分类号： C12N1/14

    CPC分类号： C12Q1/6895 ,  C12N9/14

    摘要： The present invention relates to isolated nucleic acid sequences encoding polypeptides having oxaloacetate hydrolase activity. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as recombinant methods for producing the polypeptides.

    摘要翻译： 本发明涉及编码具有草酰乙酸水解酶活性的多肽的分离的核酸序列。 本发明还涉及包含核酸序列的核酸构建体，载体和宿主细胞以及用于产生多肽的重组方法。

    Quasirandom Structure and Function Guided Synthesis Methods
    27.
    发明申请
    Quasirandom Structure and Function Guided Synthesis Methods 有权
    Quasirandom结构与功能引导合成方法

    公开(公告)号：US20080193983A1

    公开(公告)日：2008-08-14

    申请号：US10539288

    申请日：2003-12-19

    申请人： Alex Haahr Gouliaev ,  Anette Holtmann ,  Henrik Pedersen ,  Thomas Franch

    发明人： Alex Haahr Gouliaev ,  Anette Holtmann ,  Henrik Pedersen ,  Thomas Franch

    IPC分类号： C12P19/34 ,  C07H21/04 ,  C07K5/08 ,  G01N33/50

    CPC分类号： C40B30/04 ,  C12N15/1068 ,  C40B20/04 ,  C40B40/06 ,  C40B50/04 ,  C40B50/08 ,  Y10T436/145555

    摘要： The present invention is directed to the synthesis of molecules guided b connector polynucleotides (CPNs capable of hybridizing to complementary connector polynucleotides (CCPNs) harbouring at least one functional entity comprising at least one reactive group. At least one of said CCPNs capable of hybridize to at least two CPNs. Each CPN will “call” for one or more CCPNs capable of hybridization to the CPN. Following the formation of a supramolecular hybridization complex comprising a plurality of CPNs and a plurality of CCPNs, the reaction of functional entity reactive groups result I the formation of a molecule comprising covalently linked functional entities. The formation of the molecule involves the transfer of functional entities from one or more “donor CCPNs” to at least on “acceptor CCPN” with which the transferred functional entities were not associated prior to the transfer.

    摘要翻译： 本发明涉及分子引导的b连接体多核苷酸（能够与包含至少一个包含至少一个反应性基团的至少一个功能实体的互补连接子多核苷酸（CCPN）杂交）的分子的合成，所述至少一种能够与 至少两个CPN，每个CPN将“呼叫”一个或多个能够与CPN杂交的CCPN，形成包含多个CPN和多个CCPN的超分子杂交复合物后，功能性实体反应性基团的反应导致I 分子的形成包括共价连接的功能实体。分子的形成涉及将功能性实体从一个或多个“供体CCPN”转移至至少在“受体CCPN”之间，转移的功能实体在其之前不相关联 转让。

    Protein
    29.
    发明申请
    Protein 有权
    蛋白

    公开(公告)号：US20080038404A1

    公开(公告)日：2008-02-14

    申请号：US11519734

    申请日：2006-09-12

    申请人： Janne Brunstedt ,  Jorn Mikkelsen ,  Henrik Pedersen ,  Jorn Soe

    发明人： Janne Brunstedt ,  Jorn Mikkelsen ,  Henrik Pedersen ,  Jorn Soe

    IPC分类号： A21D8/04 ,  A23C9/12 ,  A23D7/00 ,  A23D9/00 ,  A23G3/34 ,  A23L1/105 ,  A23L1/212 ,  A23L1/22 ,  A23L1/24 ,  A23L1/322 ,  A23L1/39 ,  C07H21/04 ,  C12N9/02

    CPC分类号： A21D8/042 ,  A23C19/0328 ,  A23D7/02 ,  A23K20/189 ,  A23K50/75 ,  A23L7/107 ,  A23L7/109 ,  A23L7/111 ,  A23L27/60 ,  A23L29/06 ,  C11B3/003 ,  C12N9/18 ,  C12P7/62 ,  C12P19/44 ,  C12Y301/01

    摘要： A fungal wild-type lipolytic enzyme having a higher ratio of activity on polar lipids compared with triglycerides, wherein the enzyme preferably has a phospholipid:triglyceride activity ratio of at least 4. Preferably, the lipolytic enzyme according to the present invention has a glycolipid:triglyceride hydrolyzing activity ratio of at least 1.5. In one embodiment, the fungal lipolytic enzyme according to the present invention comprises an amino acid sequence as shown in SEQ ID NO: 1 or SEQ ID No. 2 or SEQ ID No. 4 or SEQ ID No. 6 or an amino acid sequence which has at least 90% identity thereto. The present invention further encompasses a nucleic acid encoding a fungal lipolytic enzyme, which nucleic acid is selected from the group consisting of: (a) a nucleic acid comprising a nucleotide shown in SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7; (b) a nucleic acid which is related to the nucleotide sequence of SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7 by the degeneration of the genetic code; and (c) nucleic acid comprising a nucleotide sequence which has at least 90% identity with the nucleotide sequence shown in SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7.

    摘要翻译： 与甘油三酯相比，极性脂质活性比例更高的真菌野生型脂肪分解酶，其中所述酶优选具有至少为4的磷脂：甘油三酯活性比。优选地，根据本发明的脂肪分解酶具有糖脂： 甘油三酯水解活性比至少为1.5。 在一个实施方案中，根据本发明的真菌脂肪分解酶包含如SEQ ID NO：1或SEQ ID No.2或SEQ ID No.4或SEQ ID No.6所示的氨基酸序列或氨基酸序列， 与其具有至少90％的同一性。 本发明还包括编码真菌脂肪分解酶的核酸，该核酸选自：（a）包含SEQ ID No.3，SEQ ID No.5或SEQ ID No.5所示核苷酸的核酸 第7号 （b）通过遗传密码的退化与SEQ ID No.3，SEQ ID No.5或SEQ ID No.7的核苷酸序列有关的核酸; 和（c）核酸，其包含与SEQ ID No.3，SEQ ID No.5或SEQ ID No.7所示的核苷酸序列具有至少90％同一性的核苷酸序列。

    Gene shuffling by template switching
    30.
    发明申请
    Gene shuffling by template switching 审中-公开
    基因改组通过模板切换

    公开(公告)号：US20060099589A1

    公开(公告)日：2006-05-11

    申请号：US10522171

    申请日：2003-07-11

    申请人： Henrik Pedersen ,  Thomas Thisted ,  Hans Moller

    发明人： Henrik Pedersen ,  Thomas Thisted ,  Hans Moller

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12P19/34 ,  C12N15/1027 ,  C12N15/1096 ,  C12Q1/6811

    摘要： The present invention provides a new approach to creating novel polynucleotide sequences by point mutation and recombination in vitro of a set of parental sequences. The new polynucleotide sequences can be useful in themselves or they can be used for the templated synthesis of polymers, e.g. polypeptides composed of α-amino acids as occurring naturally in protein synthesis or polymers comprised of β-amino acids or other building blocks as described (Templated molecules).

    摘要翻译： 本发明提供了通过点突变和体外重组一组亲本序列来产生新的多核苷酸序列的新方法。 新的多核苷酸序列本身可以有用，或者它们可以用于聚合物的模板化合成，例如， 由蛋白质合成中天然存在的α-氨基酸组成的多肽或由β-氨基酸或所述的其他结构单元（模板分子）组成的聚合物。