公开(公告)号：US20230310576A1

公开(公告)日：2023-10-05

申请号：US18055193

申请日：2022-11-14

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Eric Yi-Chun Huang ,  Kerim Babaoglu ,  Jessica Anne Flynn ,  Lan Zhang ,  David Nickle

IPC: A61K39/145

CPC classification number: A61K39/145 ,  A61K2039/5252

Abstract: The disclosure relates to broad spectrum influenza virus ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.

公开(公告)号：US11278611B2

公开(公告)日：2022-03-22

申请号：US16850519

申请日：2020-04-16

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks

IPC: A61K39/12 ,  A61K39/015 ,  A61P11/00 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61K39/39 ,  A61K39/42 ,  A61K48/00 ,  A61K39/00

Abstract: The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.

公开(公告)号：US20200289639A1

公开(公告)日：2020-09-17

申请号：US16853973

申请日：2020-04-21

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks ,  Sayda Mahgoub Elbashir

IPC: A61K39/12 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61K39/015 ,  A61P11/00 ,  A61K39/39 ,  A61K39/42 ,  A61K48/00

Abstract: The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.

公开(公告)号：US10675342B2

公开(公告)日：2020-06-09

申请号：US16136503

申请日：2018-09-20

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks ,  Sayda Mahgoub Elbashir

IPC: A61K39/12 ,  A61K39/015 ,  A61K39/39 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61P11/00 ,  A61K39/42 ,  A61K48/00 ,  A61K39/00

Abstract: The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.

公开(公告)号：US20190008947A1

公开(公告)日：2019-01-10

申请号：US16136503

申请日：2018-09-20

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks ,  Sayda Mahgoub Elbashir

IPC: A61K39/12 ,  A61K9/127 ,  A61K9/51 ,  A61K39/015 ,  A61K39/39 ,  A61K39/42 ,  A61K9/00 ,  A61K39/00

Abstract: The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.

公开(公告)号：US20180291335A1

公开(公告)日：2018-10-11

申请号：US15815020

申请日：2017-11-16

Applicant: ModernaTX, Inc.

Inventor： Stephane Bancel ,  Antonin de Fougerolles ,  Susan Whoriskey ,  Tirtha Chakraborty ,  Eric Yi-Chun Huang

IPC: C12N5/071 ,  C12N15/67 ,  C12N9/02 ,  C12P21/00 ,  C07K14/535

Abstract: The present invention relates to compositions, methods and kits using cell phenotype altering polynucleotides, cell phenotype altering primary transcripts and cell phenotype altering mmRNA molecules.

公开(公告)号：US09878056B2

公开(公告)日：2018-01-30

申请号：US14390103

申请日：2013-03-09

Applicant: ModernaTX, Inc.

Inventor： Stephane Bancel ,  Eric Yi-Chun Huang

IPC: C07K14/47 ,  A61K48/00 ,  A61K31/7115 ,  A61K9/127 ,  C12N9/64 ,  C07K14/515 ,  C07K16/00 ,  C07K14/535 ,  A61K38/17 ,  A61K38/45 ,  C07K14/005 ,  C07K14/435 ,  C07K14/485 ,  C07K14/505 ,  C07K14/62 ,  C07K14/705 ,  C12N9/10 ,  C12N9/16 ,  C12N9/24 ,  C12N9/42 ,  C12N9/88 ,  C12N9/00 ,  C12N15/11 ,  C12N15/52 ,  C12N15/85 ,  C12N15/87 ,  C12P13/04 ,  C12P21/00 ,  A61K9/51 ,  A61K38/18 ,  A61K38/19 ,  A61K38/21 ,  A61K38/48 ,  C07K14/525 ,  C07K14/56 ,  A61K9/14 ,  A61K47/54 ,  A61K38/00

CPC classification number: A61K48/0066 ,  A61K9/1271 ,  A61K9/145 ,  A61K9/5123 ,  A61K9/5146 ,  A61K9/5153 ,  A61K31/7115 ,  A61K38/00 ,  A61K38/17 ,  A61K38/177 ,  A61K38/1816 ,  A61K38/1891 ,  A61K38/191 ,  A61K38/193 ,  A61K38/212 ,  A61K38/45 ,  A61K38/4846 ,  A61K47/543 ,  A61K48/0033 ,  A61K48/005 ,  A61K48/0075 ,  C07K14/005 ,  C07K14/435 ,  C07K14/47 ,  C07K14/4705 ,  C07K14/4713 ,  C07K14/485 ,  C07K14/505 ,  C07K14/515 ,  C07K14/525 ,  C07K14/535 ,  C07K14/56 ,  C07K14/62 ,  C07K14/705 ,  C07K16/00 ,  C12N9/1051 ,  C12N9/16 ,  C12N9/2402 ,  C12N9/2445 ,  C12N9/644 ,  C12N9/6451 ,  C12N9/88 ,  C12N9/93 ,  C12N15/11 ,  C12N15/52 ,  C12N15/85 ,  C12N15/87 ,  C12P13/04 ,  C12P21/00 ,  C12P21/005 ,  C12Y304/21022 ,  C12Y603/02019

Abstract: The invention relates to cosmetic mRNAs encoding elastin, and methods of using such mRNAs.

公开(公告)号：US11603399B2

公开(公告)日：2023-03-14

申请号：US15591820

申请日：2017-05-10

Applicant: ModernaTX, Inc.

Inventor： Stephen G. Hoge ,  Eric Yi-Chun Huang ,  Tirtha Chakraborty ,  Sayda M. Elbashir

IPC: C07K14/76 ,  C12N15/67 ,  C07K14/50 ,  C07K14/535 ,  C07K14/59 ,  C07K14/605 ,  C07K14/61 ,  C07K14/765 ,  C07K16/00 ,  A61K48/00

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of long-lived polynucleotides, primary transcripts and mmRNA molecules.

公开(公告)号：US20230020362A1

公开(公告)日：2023-01-19

申请号：US17737532

申请日：2022-05-05

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Eric Yi-Chun Huang ,  Kapil Bahl ,  Tal Zaks ,  Sunny Himansu ,  Sayda Mahgoub Elbashir

IPC: A61K39/12 ,  A61K9/14 ,  A61K9/51 ,  A61K47/10 ,  A61K47/18 ,  A61K47/22 ,  A61K47/28 ,  A61K48/00 ,  A61P31/12 ,  A61P31/14 ,  C07K14/005 ,  C07K14/18 ,  C07K16/10 ,  C07K16/28 ,  C12N7/00 ,  A61K9/00

Abstract: Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.

公开(公告)号：US20220257746A1

公开(公告)日：2022-08-18

申请号：US17590479

申请日：2022-02-01

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks

IPC: A61K39/12 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61K39/015 ,  A61P11/00 ,  A61K39/39 ,  A61K39/42 ,  A61K48/00

Abstract: The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.