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公开(公告)号：US20180312548A1
公开(公告)日：2018-11-01
申请号：US16034237
申请日：2018-07-12
发明人： Vincent Craig BOND , Michael Powell , Ming Bo Huang , Syed Ali
IPC分类号： C07K14/005 , C12P21/02 , A61K38/16 , A61K39/39 , A61K45/06 , G01N33/543 , C07K14/16 , G01N33/566 , A61K9/127 , A61K38/00 , A61K39/00 , C12N15/00
CPC分类号： C07K14/005 , A61K9/127 , A61K38/00 , A61K38/162 , A61K39/39 , A61K45/06 , A61K2039/55555 , C07K14/163 , C07K2319/00 , C07K2319/055 , C07K2319/50 , C07K2319/60 , C12N15/00 , C12N2740/16322 , C12P21/02 , G01N33/543 , G01N33/566
摘要： The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
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公开(公告)号：US10053496B2
公开(公告)日：2018-08-21
申请号：US15660572
申请日：2017-07-26
发明人： Vincent Craig Bond , Michael Powell , Ming Bo Huang , Syed Ali
IPC分类号： C07K14/05 , C07K14/005 , C07K14/16 , G01N33/543 , A61K9/127 , A61K38/16 , A61K39/39 , A61K45/06 , G01N33/566 , C12P21/02 , C12N15/00 , A61K39/00 , A61K38/00
CPC分类号： C07K14/005 , A61K9/127 , A61K38/00 , A61K38/162 , A61K39/39 , A61K45/06 , A61K2039/55555 , C07K14/163 , C07K2319/00 , C07K2319/055 , C07K2319/50 , C07K2319/60 , C12N15/00 , C12N2740/16322 , C12P21/02 , G01N33/543 , G01N33/566
摘要： The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
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公开(公告)号：US12083158B2
公开(公告)日：2024-09-10
申请号：US16226242
申请日：2018-12-19
IPC分类号： A61K38/00 , A61K38/08 , A61K38/16 , A61K45/06 , A61K47/60 , A61K47/64 , C07K7/06 , C07K14/005 , C12N7/00
CPC分类号： A61K38/162 , A61K38/08 , A61K45/06 , A61K47/60 , A61K47/6455 , C07K7/06 , C07K14/005 , C12N7/00 , C07K2319/10 , C12N2740/16032 , C12N2740/16322 , Y02A50/30
摘要： Compositions and methods for reducing the growth of and/or preventing the formation of a microbial biofilm are disclosed. The composition comprises an antimicrobial SMR peptide comprising an HIV-1 SMRwt peptide and a cell penetrating peptide (CPP) domain. In some embodiments, the composition further comprises one or more other antimicrobial peptides (AMPs), antibiotics, matrix-inhibiting compounds, matrix-disaggregating compounds, quorum sensing inhibitors, or a combination thereof. In other embodiments, the compositions are used for impregnating or coating an article and/or material surface with the composition to render it less prone to microbial infections.
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公开(公告)号：US11098087B2
公开(公告)日：2021-08-24
申请号：US16458218
申请日：2019-07-01
发明人： Vincent C. Bond , Michael Powell , Ming Bo Huang , Syed Ali
IPC分类号： C07K14/16 , C12P21/02 , G01N33/543 , A61K9/127 , A61K38/16 , A61K39/39 , A61K45/06 , C07K14/005 , G01N33/566 , C12N15/00 , A61K39/00 , A61K38/00
摘要： The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
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公开(公告)号：US20190135873A1
公开(公告)日：2019-05-09
申请号：US16226283
申请日：2018-12-19
CPC分类号： C07K14/005 , A61K38/162 , A61K45/06 , A61K47/60 , A61K47/64 , A61K47/641 , A61K47/645 , C07K2319/035 , C07K2319/70 , C12N7/00 , C12N2740/16022 , C12N2740/16322
摘要： A method for treating a cancer comprises administering to a subject in need of such treatment an effective amount of a pharmaceutical composition comprising an anti-cancer agent having at least one secretion modifying region (SMR) peptide from HIV-1 Nef fused to at least one cell-penetrating peptide (CPP) or at least one Clusterin (Clu)-binding peptide (Clu-BP).
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公开(公告)号：US20190134151A1
公开(公告)日：2019-05-09
申请号：US16226242
申请日：2018-12-19
摘要： Compositions and methods for reducing the growth of and/or preventing the formation of a microbial biofilm are disclosed. The composition comprises an antimicrobial SMR peptide comprising an HIV-1 SMRwt peptide and a cell penetrating peptide (CPP) domain. In some embodiments, the composition further comprises one or more other antimicrobial peptides (AMPs), antibiotics, matrix-inhibiting compounds, matrix-disaggregating compounds, quorum sensing inhibitors, or a combination thereof. In other embodiments, the compositions are used for impregnating or coating an article and/or material surface with the composition to render it less prone to microbial infections.
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公开(公告)号：US10040831B2
公开(公告)日：2018-08-07
申请号：US15383454
申请日：2016-12-19
IPC分类号： A61K38/16 , A61K47/64 , C07K14/00 , C07K19/00 , C07K14/005 , A61K47/48 , A61K45/06 , C12N7/00
CPC分类号： C07K14/005 , A61K38/162 , A61K45/06 , A61K47/60 , A61K47/64 , A61K47/641 , C07K2319/035 , C07K2319/70 , C12N7/00 , C12N2740/16022 , C12N2740/16322
摘要： A multipartite peptide that inhibits release of exosomes in a cell, comprising an N-terminal end and a C-terminal end and comprising at least one secretion modifying region (SMR) peptide from HIV-1 Nef and at least one Clusterin (Clu)-binding peptide (Clu-BP). Pharmaceutical compositions comprising these peptides alone or in synergistic combinations with other active agents in methods for treating cancers and/or infectious diseases are further provided herein.
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公开(公告)号：US20180170969A1
公开(公告)日：2018-06-21
申请号：US15383454
申请日：2016-12-19
IPC分类号： C07K14/005 , A61K38/16 , A61K45/06 , C12N7/00
CPC分类号： C07K14/005 , A61K38/162 , A61K45/06 , A61K47/48215 , A61K47/60 , A61K47/64 , C07K2319/035 , C07K2319/70 , C12N7/00 , C12N2740/16022
摘要： A multipartite peptide that inhibits release of exosomes in a cell, comprising an N-terminal end and a C-terminal end and comprising at least one secretion modifying region (SMR) peptide from HIV-1 Nef and at least one Clusterin (Clu)-binding peptide (Clu-BP). Pharmaceutical compositions comprising these peptides alone or in synergistic combinations with other active agents in methods for treating cancers and/or infectious diseases are further provided herein.
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公开(公告)号：US09556224B2
公开(公告)日：2017-01-31
申请号：US14156119
申请日：2014-01-15
CPC分类号： A61K38/162 , A61K38/08 , A61K45/06 , A61K47/60 , C07K7/06 , C12N7/00 , C12N2740/16032 , Y02A50/401 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
摘要翻译： 本申请公开了一种使用抗微生物组合物治疗微生物感染的方法，其包含含有至少一种VGFPV基序的抗微生物肽。
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30.发明授权Compositions and methods for treating AIDS or cancer by inhibiting the secretion of microparticles 有权通过抑制微粒分泌来治疗AIDS或癌症的组合物和方法公开(公告)号：US08871708B2
公开(公告)日：2014-10-28
申请号：US14015438
申请日：2013-08-30
发明人： Vincent Craig Bond , Michael Powell , Ming Bo Huang , Syed Ali , Andrea D. Raymond , Martin Neville Shelton , Francois Jean Villinger
IPC分类号： A61P31/12 , A61P31/18 , A61P35/00 , A61K39/00 , A61K39/21 , C12N5/22 , C07K7/06 , C07K7/08 , C07K14/005 , A61K38/00
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/005 , C12N2740/16033 , C12N2740/16322
摘要： Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
摘要翻译： 公开了抑制细胞释放微粒的新型肽。 肽在N-末端含有至少一个VGFPV基序，长度为10-100个氨基酸。 还公开了编码肽的多核苷酸，携带多核苷酸的表达载体，以及使用新肽治疗AIDS和肿瘤的方法。
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