摘要:
The present application relates to a novel tetrahydroquinoline derivative, to a process for its preparation, to its use on its own or in combination for treating and/or preventing diseases and to its use for preparing medicaments, in particular as an inhibitor of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinaemias, dyslipidaemias, hypertriglyceridaemias, hyperlipidaemias, hypercholesterolaemias and arteriosclerosis.
摘要:
The present invention relates to the use of strains of Parapoxvirus ovis as immunotherapeutic agents for immunodeficiencies of an infectious or non-infectious nature, and to the use of strains of Parapoxvirus ovis for treating tumor diseases and viral infections, and diseases which accompany them, and the use of strains of Parapoxvirus ovis for producing medicaments for use in humans and animals.
摘要:
An intake system (13) for an internal combustion engine (12) which includes a housing (15a) with a filter insert (16) and a membrane (22) for separating nitrogen and enriching the combustion air with oxygen. The membrane is integrated into the filter housing so as to save construction space and provide a lower cost system. The membrane (22) can alternatively be arranged on the clean air side of the air filter insert (16) to prevent the membrane from being soiled and to improve the functional reliability of the oxygen enrichment. Alternatively, instead of arranging the membrane (22) on the clean side of the filter insert (16), the membrane can be protected from being soiled by using a cover (23).
摘要:
The present invention relates to the use, in humans, of inactivated parapoxviruses for the prophylaxis and treatment of diseases which are accompanied by an increased deposition of collagen, with it being possible for both internal organs, such as the liver, and the skin and its appended structures, to be affected. The invention relates, in particular, to liver fibrosis and/or liver cirrhosis consequent upon virus hepatitis, or to ethanol-induced liver diseases and to cystic fibrosis.
摘要:
A rotor (1) designed to be installed in the housing (16) of a free jet centrifuge, the rotor being provided with at least one inlet (3) and at least one outlet (4), which outlet is configured as a nozzle which is oriented at least substantially tangentially to the axis of rotation (13) of the rotor. The rotor is provided with receptacles for bearings for rotatably mounting the rotor, and the rotor having at least one guide element (7) which extends from an inner wall (38) to an outer wall (39) of a rotor interior space (8). At least the rotor shell (11) is made of synthetic resin material. Owing to its form, the synthetic resin centrifuge rotor can be made up of a reduced number of parts. The rotor may be composed of two elements, a base (10) and a shell (11), connected together either by a snap connection or by welding, such as vibration welding. An oil centrifuge fitted with such a rotor is particularly suitable for cleaning lubricating oil used in an internal combustion engine.
摘要:
A secondary air system for an internal combustion engine (32), including at least one line (14) through which air is blown into the exhaust pipe of the engine, a pump (26) and a drive (27) for the pump (26). In addition an air-feed line (13) is provided through which the secondary air is supplied to the pump (26). The power necessary to drive the pump is provided by the engine (32).
摘要:
An air filter system with an air filter element having an inflow and an outflow face and comprising alternating flat and pleated layers, which are configured to form channels. The channels are alternately sealed in inflow and outflow direction, such that the medium to be filtered must pass through one of the layers as it flows from the inflow face through the filter to the outflow face. An adsorber element made of an activated carbon coated honeycomb structure is disposed adjacent the air filter element.
摘要:
The present invention relates to the use of Parapoxviruses in combination with other agents for the treatment of viral diseases, and in particular HIV infections and AIDS. The invention also relates to methods for producing medicaments based on combinations of Parapoxviruses and other antiviral agents, and to such medicaments. In particular, the invention relates to the use of Parapoxviruses in combination with agents of the kind used for antiretroviral therapy and highly active antiretroviral therapy (HAART).
摘要:
A valve assembly for use in an air management assembly having an engine, an exhaust side, and an intake side, where the valve assembly provides a housing, a plurality of openings in the housing, a valve in the housing, and an actuator operably connected to the valve. The housing is in fluid communication with the exhaust side and the intake side. The plurality of openings in the housing form at least one inlet and at least one outlet in the housing. The valve moves with respect to the plurality of openings.
摘要:
Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.