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    Method of preparing organomagnesium compounds
    21.
    发明授权
    Method of preparing organomagnesium compounds 有权
    制备有机镁化合物的方法

    公开(公告)号：US07384580B2

    公开(公告)日：2008-06-10

    申请号：US11097707

    申请日：2005-04-01

    申请人： Paul Knochel ,  Arkady Krasovskiy

    发明人： Paul Knochel ,  Arkady Krasovskiy

    IPC分类号： C07F3/04

    CPC分类号： C07B49/00 ,  C07F3/02

    摘要： The present invention is directed to a reagent for use in the preparation of organomagnesium compounds as well as to a method of preparing such organomagnesium compounds. The present invention furthermore provides a method of preparing functionalized or unfunctionalized organic compounds as well as the use of the reagents of the present invention in the preparation of organometallic compounds and their reaction with electrophiles. Finally, the present invention is directed to the use of lithium salts—LiY in the preparation of organometallic compounds and their reactions with electrophiles and to an organometallic compound which is obtainable by the disclosed method.

    摘要翻译： 本发明涉及用于制备有机镁化合物的试剂以及制备这种有机镁化合物的方法。 本发明还提供了制备官能化或未官能化的有机化合物的方法以及本发明的试剂在制备有机金属化合物中的用途及其与亲电体的反应。 最后，本发明涉及锂盐-LYY在制备有机金属化合物中的用途及其与亲电体的反应以及通过所公开的方法可获得的有机金属化合物。

    Method of preparing organomagnesium compounds
    22.
    发明申请
    Method of preparing organomagnesium compounds 有权
    制备有机镁化合物的方法

    公开(公告)号：US20070194468A1

    公开(公告)日：2007-08-23

    申请号：US11787974

    申请日：2007-04-18

    申请人： Paul Knochel ,  Arkady Krasovskiy

    发明人： Paul Knochel ,  Arkady Krasovskiy

    IPC分类号： C07F3/02

    CPC分类号： C07B49/00 ,  C07F3/02

    摘要： The present invention is directed to a reagent for use in the preparation of organomagnesium compounds as well as to a method of preparing such organomagnesium compounds. The present invention furthermore provides a method of preparing functionalized or unfunctionalized organic compounds as well as the use of the reagents of the present invention in the preparation of organometallic compounds and their reaction with electrophiles. Finally, the present invention is directed to the use of lithium salts—LiY in the preparation of organometallic compounds and their reactions with electrophiles and to an organometallic compound which is obtainable by the disclosed method.

    摘要翻译： 本发明涉及用于制备有机镁化合物的试剂以及制备这种有机镁化合物的方法。 本发明还提供了制备官能化或未官能化的有机化合物的方法以及本发明的试剂在制备有机金属化合物中的用途及其与亲电体的反应。 最后，本发明涉及锂盐-LYY在制备有机金属化合物中的用途及其与亲电体的反应以及通过所公开的方法可获得的有机金属化合物。

    ORGANOZINC COMPLEXES AND PROCESSES FOR MAKING AND USING THE SAME
    28.
    发明申请
    ORGANOZINC COMPLEXES AND PROCESSES FOR MAKING AND USING THE SAME 审中-公开
    ORGANOZINC复合物及其制备和使用方法

    公开(公告)号：US20140031545A1

    公开(公告)日：2014-01-30

    申请号：US13996953

    申请日：2011-12-21

    申请人： Paul Knochel ,  Sebastian Bernhardt ,  Georg Manolikakes

    发明人： Paul Knochel ,  Sebastian Bernhardt ,  Georg Manolikakes

    IPC分类号： C07F3/06 ,  C07C253/30 ,  C07F7/18 ,  C07D213/85 ,  C07C67/343 ,  C07F7/08 ,  C07C231/12 ,  C07D239/52 ,  C07D213/84 ,  C07D215/12

    CPC分类号： C07F3/06 ,  C07B37/04 ,  C07C67/343 ,  C07C231/12 ,  C07C253/30 ,  C07D213/84 ,  C07D213/85 ,  C07D215/12 ,  C07D239/52 ,  C07F7/083 ,  C07F7/1892

    摘要： Processes for making an organozinc reagents are disclosed comprising reacting (A) organomagnesium or organozinc complexes with (B) at least one coordination compound comprising one or more carboxylate groups and/or alcoholate groups and/or tertiary amine groups, optionally in combination with zinc ions and/or lithium ions and/or halide ions, wherein the halide ions are selected from chloride, bromide and iodide, the organozinc complex comprises an aryl group, a heteroaryl group or a benzyl group when the coordinating compound is a chelating polyamine, and the reaction is conducted in the presence of zinc complexed with at least one coordinating compound when reactant (A) comprises at least one organomagnesium complex. The resulting organozinc reagents may optionally be isolated from solvents to obtain a solid reagent. The reagents may be used for making organic compounds via Negishi cross-coupling reactions or via aldehyde and/or ketone oxidative addition reactions. The organozinc reagents are stable and, due to their high selectivity, permit maintenance of sensitive functional groups such as aldehydes during cross-coupling.

    摘要翻译： 公开了制备有机锌试剂的方法，其包括使（A）有机镁或有机锌络合物与（B）至少一种包含一个或多个羧酸酯基团和/或醇化物基团和/或叔胺基团的配位化合物，任选与锌离子 和/或锂离子和/或卤离子，其中卤离子选自氯化物，溴化物和碘化物，当配位化合物是螯合多胺时，有机锌络合物包括芳基，杂芳基或苄基， 当反应物（A）包含至少一个有机镁络合物时，在与至少一种配位化合物络合的锌的存在下进行反应。 所得到的有机锌试剂可以任选地从溶剂中分离以获得固体试剂。 试剂可用于通过Negishi交叉偶联反应或通过醛和/或酮氧化加成反应制备有机化合物。 有机锌试剂是稳定的，并且由于其高选择性，允许在交联期间维持敏感官能团如醛。

    Preparation and use of magnesium amides
    30.
    发明授权
    Preparation and use of magnesium amides 有权
    制备和使用镁酰胺

    公开(公告)号：US08134005B2

    公开(公告)日：2012-03-13

    申请号：US12087351

    申请日：2007-01-18

    申请人： Paul Knochel ,  Arkady Krasovskiy ,  Valeria Krasovskaya ,  Christoph Josef Rohbogner ,  Giuliano Cesar Clososki

    发明人： Paul Knochel ,  Arkady Krasovskiy ,  Valeria Krasovskaya ,  Christoph Josef Rohbogner ,  Giuliano Cesar Clososki

    IPC分类号： C07D295/027 ,  C07D207/00 ,  C07F7/02 ,  C07C211/01

    CPC分类号： C07B49/00 ,  C07F3/003 ,  C07F3/02

    摘要： The present application relates to mixed Mg/Li amides of the general formula R1R2N—Mg(NR3R4)mX,.m zLiY (II) wherein R1, R2, R3, and R4 are, independently, selected from H, substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or silyl derivatives thereof; and R1 and R2 together, or R3 and R4 together can be part of a cyclic or polymeric structure; and wherein at least one of R1 and R2 and at least one of R3 and R is other than H; X and Y are, independently, selected from the group consisting of F; Cl; Br; I; CN; SCN; NCO; HaIOn, wherein n=3 or 4 and Hal is selected from Cl, Br and I; NO3; BF4; PF6; H; a carboxylate of the general formula RXCO2; an alcoholate of the general formula ORX; a thiolate of the general formula SRX; RXP(O)O2; or SCORX; or SCSRX; OnSRx, wherein n=2 or 3; or NOn, wherein n=2 or 3; and a derivative thereof; wherein Rx is a substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or derivatives thereof, or H; m is O or 1; and z>O; as well as a process for the preparation of the mixed Mg/Li amides and the use of these amides, e.g. as bases.

    摘要翻译： 本申请涉及通式为R 1 R 2 N-Mg（NR 3 R 4）m X，m z L i Y（II）的混合Mg / Li酰胺，其中R 1，R 2，R 3和R 4独立地选自H，取代或未取代的芳基或 含有一个或多个杂原子的杂芳基，其直链，支链或环状的取代或未取代的烷基，烯基，炔基或甲硅烷基衍生物; R 1和R 2一起，或者R 3和R 4一起可以是环状或聚合物结构的一部分; 并且其中R 1和R 2以及R 3和R R中的至少一个不是H; X和Y独立地选自F; Cl; Br; 一世; CN; SCN; NCO; 其中n = 3或4，Hal选自Cl，Br和I; NO3; BF4; PF6; H; 通式为RXCO2的羧酸酯; 通式ORX的醇化物; 通式SRX的硫醇盐; RXP（O）O2; 或SCORX; 或SCSRX; OnSRx，其中n = 2或3; 或NO n，其中n = 2或3; 及其衍生物; 其中Rx是取代或未取代的芳基或含有一个或多个杂原子的直链，支链或环状取代或未取代的烷基，烯基，炔基或衍生物，或H; m为O或1; 和z> O; 以及制备混合的Mg / Li酰胺的方法和这些酰胺的使用，例如。 作为基础。