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68 条记录 (耗时 0.065 秒)

    Metalloproteinase ADAM 22
    21.
    发明申请
    Metalloproteinase ADAM 22 审中-公开
    金属蛋白酶ADAM 22

    公开(公告)号：US20050221376A1

    公开(公告)日：2005-10-06

    申请号：US11142737

    申请日：2005-06-02

    申请人： Paul Young ,  Steven Ruben

    发明人： Paul Young ,  Steven Ruben

    IPC分类号： A61K38/00 ,  C07H21/04 ,  C12N9/64 ,  C12N15/09 ,  C12Q1/68 ,  C12Q1/6883

    CPC分类号： C12N9/6489 ,  A61K38/00 ,  C12Q1/6883

    摘要： The present invention relates to a novel metalloproteinase protein called ADAM 22. In particular, isolated nucleic acid molecules are provided encoding the human ADAM 22 proteins. ADAM 22 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of ADAM 22 activity. Also provided are diagnostic methods for detecting cancer and therapeutic methods for cancer and other disorders characterized by an over or under production of this metalloproteinase.

    摘要翻译： 本发明涉及称为ADAM22的新型金属蛋白酶蛋白质。特别地，提供编码人ADAM22蛋白质的分离的核酸分子。 还提供了ADAM22多肽，载体，宿主细胞以及用于制备它们的重组方法。 本发明还涉及用于鉴定ADAM22活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测癌症的诊断方法和癌症的治疗方法以及其特征在于该金属蛋白酶的过量或不足产生的其它病症。

    Stable acidic milk based beverage
    22.
    发明申请
    Stable acidic milk based beverage 审中-公开
    稳定的基于酸性牛奶的饮料

    公开(公告)号：US20050153030A1

    公开(公告)日：2005-07-14

    申请号：US10663154

    申请日：2004-08-19

    申请人： Paul Young ,  Peter Bluestein

    发明人： Paul Young ,  Peter Bluestein

    IPC分类号： A23C9/154 ,  A23L2/38 ,  A23C3/00

    CPC分类号： A23C9/1542 ,  A23L2/38 ,  A23V2002/00 ,  A23V2250/5424 ,  A23V2250/5026 ,  A23V2250/5072 ,  A23V2250/032 ,  A23V2250/2482 ,  A23V2250/70

    摘要： Acidic milk based beverage products which do not precipitate over time and are physically stable, and a process for preparing these products, are disclosed. These products contain from about 0.5% to 5.0% milk proteins and 0.1 to 2.0% of a food stabilizer and a food acid sufficient to lower the pH below 4.5. The first step of the process involves mixing milk proteins with a food grade weak base to raise the pH above 7.0. Food grade stabilizers are added to the elevated pH mixture of milk proteins and base under low shear conditions. Other ingredients are then added to provide the desired sweetness, flavor, color and microbiological stability. This mixture is homogenized before acidification. A chilled food grade acid is then added at a temperature below 30° C. under low to moderate shear conditions.

    摘要翻译： 公开了不随时间沉淀并且物理稳定的酸性乳基饮料产品及其制备方法。 这些产品含有约0.5％至5.0％的乳蛋白和0.1至2.0％的食物稳定剂和足以降低pH低于4.5的食用酸。 该方法的第一步包括将牛奶蛋白质与食品级弱碱混合以使pH高于7.0。 在低剪切条件下将食品级稳定剂加入到乳蛋白和碱的升高的pH混合物中。 然后加入其它成分以提供所需的甜味，风味，颜色和微生物稳定性。 在酸化之前将该混合物均化。 然后在低至中等剪切条件下，在低于30℃的温度下加入冷冻的食品级酸。

    Chromatography column
    23.
    发明授权
    Chromatography column 失效
    色谱柱

    公开(公告)号：US5462659A

    公开(公告)日：1995-10-31

    申请号：US77427

    申请日：1993-06-15

    申请人： Vinit Saxena ,  Paul Young

    发明人： Vinit Saxena ,  Paul Young

    IPC分类号： B01D15/08 ,  G01N30/52 ,  G01N30/60

    CPC分类号： B01D15/18 ,  B01D15/22 ,  B01D15/206 ,  B01D15/34 ,  G01N2030/522 ,  G01N30/6004

    摘要： An improved axial flow chromatography column for separations dependent upon bed depth, such as size exclusion and where changes of column volume necessitate bed height adjustments. The improvements include a snap-action lever or a collet arrangement which permits quick and easy movement of the bed adjuster; a flush seal assembly at the outlet frit and a V-shaped seal in the bed adjuster which obviates dead volume gap of conventional O-ring seals; lens-shaped frits convex on the inlet and outlet sides provide for uniform flow through the column, and the access ports eliminate the contamination problem by providing easy access for cleaning and aspiration of liquid; and a combined inlet tube and adjuster tube assembly eliminates the need for threaded components which make sanitation difficult.

    摘要翻译： 用于根据床深度进行分离的改进的轴流色谱柱，例如尺寸排除和柱体积的变化需要床高度调节。 这些改进包括快速操作杆或夹头装置，其允许床调节器的快速和容易的移动; 在出口玻璃料处的冲洗密封组件和床调节器中的V形密封件，其消除常规O形圈密封件的死体积间隙; 在入口侧和出口侧凸出的透镜状玻璃料提供均匀流过色谱柱的流通孔，通过提供易于清洗和吸取液体的方便消除污染问题; 并且组合的入口管和调节管组件消除了使得卫生困难的螺纹部件的需要。

    Delivery device for a powder aerosol
    28.
    发明申请
    Delivery device for a powder aerosol 审中-公开
    送粉装置用于粉剂

    公开(公告)号：US20070151560A1

    公开(公告)日：2007-07-05

    申请号：US10559372

    申请日：2004-06-14

    申请人： Robert Price ,  John Stanifort ,  Derek Woodcock ,  Paul Young

    发明人： Robert Price ,  John Stanifort ,  Derek Woodcock ,  Paul Young

    IPC分类号： A61M15/00 ,  A61M15/08

    CPC分类号： A61M15/0028 ,  A61M15/0005 ,  A61M15/0043 ,  A61M2202/064 ,  A61M2205/8225 ,  A61M2209/06

    摘要： The invention provides a delivery device (10) for a medicament comprising: a housing (50), a receptacle (54) holding a medicament (80) in the form of a powder; and a source of propellant (53), characterized in that the housing (50) provides an inlet (63) and an outlet (56) for the receptacle (54) wherein the inlet (63) is in fluid communication with the source of propellant (53) and is directed against the medicament (80) and the outlet (56) is spaced from the medicament (80) to allow aerosolisation of the medicament (80); the device (10) provides improved delivery efficiency, particularly a delivered fine particle fraction of greater than 20% by weight.

    摘要翻译： 本发明提供了一种用于药物的输送装置（10），包括：壳体（50），容纳有粉末形式的药物（80）的容器（54） 和推进剂源（53），其特征在于，所述壳体（50）为所述容器（54）提供入口（63）和出口（56），其中所述入口（63）与所述推进剂源流体连通 （53）并且引导所述药物（80），并且所述出口（56）与所述药物（80）间隔开，以允许所述药物（80）雾化; 装置（10）提供改善的输送效率，特别是递送的大于20重量％的细颗粒分数。

    Carpet and method of making same
    30.
    发明申请
    Carpet and method of making same 有权
    地毯及其制作方法

    公开(公告)号：US20060280901A1

    公开(公告)日：2006-12-14

    申请号：US11453285

    申请日：2006-06-13

    申请人： James Bailey ,  Paul Young

    发明人： James Bailey ,  Paul Young

    IPC分类号： D04H11/00 ,  D06B3/20

    CPC分类号： A47G27/0275 ,  D04H11/00 ,  Y10T428/16 ,  Y10T428/192 ,  Y10T428/23929 ,  Y10T428/23936 ,  Y10T428/2481

    摘要： A carpet that can be installed onto a flooring surface without the requirement for registration between adjacent broadloom carpet pieces. The carpet comprises a design member that comprises a plurality of pattern members that are colorized and that define a void area, which has a substantially uniform color and pile height.

    摘要翻译： 可以安装在地板表面上的地毯，而不需要在相邻的宽幅地毯片之间进行配准。 地毯包括设计构件，其包括多个着色的图案构件，并且限定空隙区域，其具有基本上均匀的颜色和绒头高度。