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21.发明授权Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of prostate cancer 有权核苷酸和氨基酸序列，以及其用于诊断前列腺癌的测定和方法公开(公告)号：US07368548B2
公开(公告)日：2008-05-06
申请号：US11043806
申请日：2005-01-27
申请人： Dvir Dahary , Sarah Pollock , Zurit Levine , Rotem Sorek , Michal Ayalon-Soffer , Pinchas Akiva , Amir Toporik , Osnat Sella-Tavor , Shirley Sameah-Greenwald
发明人： Dvir Dahary , Sarah Pollock , Zurit Levine , Rotem Sorek , Michal Ayalon-Soffer , Pinchas Akiva , Amir Toporik , Osnat Sella-Tavor , Shirley Sameah-Greenwald
CPC分类号： C07K14/705 , C07K14/47 , C07K14/82 , C07K16/3069 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/57434
摘要： Novel markers for prostate cancer that are both sensitive and accurate. Furthermore, these markers are able to distinguish between prostate cancer and benign prostate hyperplasia (“BPH”). These markers are overexpressed in prostate cancer specifically, as opposed to normal prostate tissue and/or BPH. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of prostate cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between prostate cancer and non-cancerous states.
摘要翻译： 前列腺癌的新型标记既灵敏又准确。 此外，这些标记能够区分前列腺癌和良性前列腺增生（“BPH”）。 与正常的前列腺组织和/或BPH相反，这些标记物在前列腺癌中过度表达。 这些标记物在患者样品中单独或组合的测量提供了诊断者可以与前列腺癌的可能诊断相关的信息。 本发明的标记物单独或组合显示前列腺癌与非癌状态之间的高度差异检测。
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22.发明申请Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of prostate cancer 有权新型核苷酸和氨基酸序列，以及其用于诊断前列腺癌的测定和方法公开(公告)号：US20060051774A1
公开(公告)日：2006-03-09
申请号：US11043806
申请日：2005-01-27
申请人： Dvir Dahary , Sarah Pollock , Zurit Levine , Rotem Sorek , Michal Ayalon-Soffer , Pinchas Akiva , Amir Toporik , Osnat Sella-Tavor , Shirley Sameah-Greenwald
发明人： Dvir Dahary , Sarah Pollock , Zurit Levine , Rotem Sorek , Michal Ayalon-Soffer , Pinchas Akiva , Amir Toporik , Osnat Sella-Tavor , Shirley Sameah-Greenwald
CPC分类号： C07K14/705 , C07K14/47 , C07K14/82 , C07K16/3069 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/57434
摘要： Novel markers for prostate cancer that are both sensitive and accurate. Furthermore, these markers are able to distinguish between prostate cancer and benign prostate hyperplasia (“BPH”). These markers are overexpressed in prostate cancer specifically, as opposed to normal prostate tissue and/or BPH. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of prostate cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between prostate cancer and non-cancerous states.
摘要翻译： 前列腺癌的新型标记既灵敏又准确。 此外，这些标记能够区分前列腺癌和良性前列腺增生（“BPH”）。 与正常的前列腺组织和/或BPH相反，这些标记物在前列腺癌中过度表达。 这些标记物在患者样品中单独或组合的测量提供了诊断者可以与前列腺癌的可能诊断相关的信息。 本发明的标记物单独或组合显示前列腺癌与非癌状态之间的高度差异检测。
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公开(公告)号：US20100075891A1
公开(公告)日：2010-03-25
申请号：US11043770
申请日：2005-01-27
申请人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
发明人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
CPC分类号： C07K14/47 , Y10S435/81
摘要： Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention. Also provided are methods and kits for diagnosing, determining predisposition and/or prognosis of various disorders using as diagnostic markers the novel polypeptides and polynucleotides of the present invention.
摘要翻译： 提供了新的多肽和编码它们的多核苷酸。 还提供了可用于使用本发明的多肽和多核苷酸治疗各种疾病如癌症，免疫相关，血液相关和皮肤相关疾病的方法和药物组合物。 还提供了用于诊断，确定各种疾病的倾向和/或预后的方法和试剂盒，其使用本发明的新型多肽和多核苷酸作为诊断标记。
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24.发明申请VARIANTS OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) RECEPTOR AND USE THEREOF 审中-公开血管内皮生长因子（VEGF）受体及其用途的变异公开(公告)号：US20110212051A1
公开(公告)日：2011-09-01
申请号：US13037196
申请日：2011-02-28
申请人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
发明人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
IPC分类号： A61K38/19 , G01N33/53 , C07K16/28 , C07K14/535 , C07K7/06 , C07K14/715 , C07K14/47 , C07K14/735 , C07K14/475 , A61K38/17 , C07K16/24 , C07K16/22 , C12N9/66 , C07K16/40 , G01N33/573 , A61K38/48 , A61K38/18 , A61K38/08 , A61P31/00 , A61P19/08 , A61P9/00 , A61P27/02 , A61P13/12 , A61P35/00 , A61P3/04 , A61P3/10 , A61P19/10 , A61P9/10 , A61P9/04 , A61P11/00 , A61P7/02 , A61P7/04 , A61P29/00 , A61P37/06 , A61P1/18 , A61P27/14 , A61P31/10 , A61P31/20 , A61P31/22 , A61P31/18 , A61P31/14 , A61P35/04 , A61P1/16 , A61P3/00 , A61P37/02 , A61P13/00 , A61P25/00 , A61P25/28 , A61P25/16
CPC分类号： C07K14/47 , Y10S435/81
摘要： Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention. Also provided are methods and kits for diagnosing, determining predisposition and/or prognosis of various disorders using as diagnostic markers the novel polypeptides and polynucleotides of the present invention.
摘要翻译： 提供了新的多肽和编码它们的多核苷酸。 还提供了可用于使用本发明的多肽和多核苷酸治疗各种疾病如癌症，免疫相关，血液相关和皮肤相关疾病的方法和药物组合物。 还提供了用于诊断，确定各种疾病的倾向和/或预后的方法和试剂盒，其使用本发明的新型多肽和多核苷酸作为诊断标记。
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公开(公告)号：US07939634B2
公开(公告)日：2011-05-10
申请号：US11043770
申请日：2005-01-27
申请人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
发明人： Michal Ayalon-Soffer , Zurit Levine , Osnat Sella-Tavor , Alex Diber , Ronen Shemesh , Amir Toporik , Galit Rotman , Sergey Nemzer , Avi Rosenberg , Dvir Dahary , Assaf Wool , Gad S. Cojocaru , Pinchas Akiva , Sarah Pollock , Kinneret Savitsky , Jeanne Bernstein
CPC分类号： C07K14/47 , Y10S435/81
摘要： Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention. Also provided are methods and kits for diagnosing, determining predisposition and/or prognosis of various disorders using as diagnostic markers the novel polypeptides and polynucleotides of the present invention.
摘要翻译： 提供了新的多肽和编码它们的多核苷酸。 还提供了可用于使用本发明的多肽和多核苷酸治疗各种疾病如癌症，免疫相关，血液相关和皮肤相关疾病的方法和药物组合物。 还提供了用于诊断，确定各种疾病的倾向和/或预后的方法和试剂盒，使用本发明的新型多肽和多核苷酸作为诊断标记。
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公开(公告)号：US20050277156A1
公开(公告)日：2005-12-15
申请号：US11043590
申请日：2005-01-27
申请人： Gad Cojocaru , Alexander Diber , Amit Novik , Sarah Pollock , Zurit Levine , Yossi Cohen , Michal Ayalon-Soffer
发明人： Gad Cojocaru , Alexander Diber , Amit Novik , Sarah Pollock , Zurit Levine , Yossi Cohen , Michal Ayalon-Soffer
IPC分类号： A61K38/17 , C07K14/705 , G01N33/53 , G01N33/74
CPC分类号： G01N33/74 , G01N2800/321 , G01N2800/325
摘要： Novel BNP variants. The novel BNP variants according to the present invention may optionally be used for diagnosis of a BNP variant-detectable disease as described herein.
摘要翻译： 新型BNP变体。 根据本发明的新型BNP变体可任选地用于本文所述的BNP变体可检测疾病的诊断。
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27.发明授权Method of treating an ischemia-reperfusion injury-related disorder by administering GPCR ligands 有权通过施用GPCR配体治疗缺血再灌注损伤相关疾病的方法公开(公告)号：US08828940B2
公开(公告)日：2014-09-09
申请号：US12968050
申请日：2010-12-14
申请人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Galit Rotman , Michal Ayalon-Soffer
发明人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Galit Rotman , Michal Ayalon-Soffer
摘要： Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
摘要翻译： 公开了用于G蛋白偶联受体的肽配体，其可用于治疗与G蛋白偶联受体活化相关的疾病。
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公开(公告)号：US07884180B2
公开(公告)日：2011-02-08
申请号：US11901975
申请日：2007-09-18
申请人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Galit Rotman , Michal Ayalon-Soffer
发明人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Galit Rotman , Michal Ayalon-Soffer
IPC分类号： A61K38/00 , A61K31/04 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00
摘要： Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
摘要翻译： 公开了用于G蛋白偶联受体的肽配体，其可用于治疗与G蛋白偶联受体激活相关的病症。
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公开(公告)号：US20090054342A1
公开(公告)日：2009-02-26
申请号：US11901975
申请日：2007-09-18
申请人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Galit Rotman , Michal Ayalon-Soffer
发明人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Galit Rotman , Michal Ayalon-Soffer
摘要： Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
摘要翻译： 公开了用于G蛋白偶联受体的肽配体，其可用于治疗与G蛋白偶联受体激活相关的病症。
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公开(公告)号：US08349801B2
公开(公告)日：2013-01-08
申请号：US11901939
申请日：2007-09-18
申请人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Merav Beiman , Galit Rotman , Michal Ayalon-Soffer
发明人： Yossi Cohen , Ronen Shemesh , Amir Toporik , Zurit Levine , Assaf Wool , Dvir Dahary , Iris Hecht , Merav Beiman , Galit Rotman , Michal Ayalon-Soffer
摘要： Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating myocardial and ischemic disorders associated with G-protein coupled receptor activation.
摘要翻译： 公开了用于G蛋白偶联受体的肽配体，其可用于治疗与G蛋白偶联受体激活相关的心肌和缺血性疾病。
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