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公开(公告)号：US20090270353A1
公开(公告)日：2009-10-29
申请号：US12496902
申请日：2009-07-02
申请人： Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
发明人： Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
IPC分类号： A61K31/427 , A61K31/425 , A61K31/4439 , A61K31/501 , A61K31/506 , A61K31/675
CPC分类号： C07D275/02 , A61K31/425 , A61K31/4439 , A61K31/506 , C07D417/04 , C07D417/10 , C07F9/6539 , C07F9/65586
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
摘要翻译： 本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂化物，包合物和前药，其中R a，R b和R 2在本文中定义。 这些化合物抑制微管蛋白聚合和/或靶向脉管系统，并且可用于治疗增殖性疾病如癌症。
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公开(公告)号：US20070249661A1
公开(公告)日：2007-10-25
申请号：US11233224
申请日：2005-09-21
申请人： Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhi Xia
发明人： Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhi Xia
IPC分类号： A61K31/44 , A61K31/40 , A61K31/415 , A61P19/02 , A61P5/00 , C07D235/28 , C07D471/02 , C07D455/02 , C07D235/00 , A61P3/10 , A61P17/00 , A61K31/437
CPC分类号： A61K31/437 , A61K31/403 , A61K31/4184 , A61K31/4439 , A61K31/444 , A61K31/537 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/24 , C07D235/28 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/12 , C07D471/04 , Y02A50/422
摘要： The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions and immune disorders.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物，包合物或前药，其中X，Y，A，Z，L和n如本文所定义。 这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症和免疫疾病。
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公开(公告)号：US20070179159A1
公开(公告)日：2007-08-02
申请号：US11601590
申请日：2006-11-17
申请人： Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
发明人： Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
IPC分类号： A61K31/506 , A61K31/4439 , A61K31/425 , C07F9/06 , C07F9/6512 , C07D417/02
CPC分类号： C07D275/02 , A61K31/425 , A61K31/4439 , A61K31/506 , C07D417/04 , C07D417/10 , C07F9/6539 , C07F9/65586
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
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24.发明申请公开(公告)号：US20050148633A1
公开(公告)日：2005-07-07
申请号：US10897682
申请日：2004-07-22
申请人： Yu Xie , Mats Holmqvist , Jerome Mahiou , Mitsunori Ono , Lijun Sun , Shoujun Chen , Shijie Zhang , Jun Jiang , Dinesh Chimmanamada , Andrea Fleig , Chih-Yi Yu
发明人： Yu Xie , Mats Holmqvist , Jerome Mahiou , Mitsunori Ono , Lijun Sun , Shoujun Chen , Shijie Zhang , Jun Jiang , Dinesh Chimmanamada , Andrea Fleig , Chih-Yi Yu
IPC分类号： A61K31/35 , A61K31/381 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4196 , A61K31/42 , A61K31/4439 , A61K31/444 , A61K31/535 , A61K31/724 , A61P20060101 , A61P27/00 , C07D20060101
CPC分类号： C07C233/66 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/535 , C07C237/42 , C07D213/81 , C07D231/14 , C07D239/28 , C07D263/34 , C07D277/56 , C07D285/06 , C07D333/38 , Y02A50/422
摘要： The invention relates to a method for modulating Ca2+-release-activated Ca2+ channels (CRAC) in a cell by administering to the cell a compound of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein.
摘要翻译： 本发明涉及一种通过向细胞施用式（I（I））化合物来调节细胞中的Ca 2+ - 释放激活的Ca 2+ 2 +通道（CRAC）的方法 ）或其药学上可接受的盐，溶剂化物，包合物或前药，其中X，Y，A，Z，L和n如本文所定义。
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公开(公告)号：US08680100B2
公开(公告)日：2014-03-25
申请号：US13132106
申请日：2009-12-01
申请人： Jun Jiang , Teresa Kowalczyk-Przewloka , Stefan M. Schweizer , Zhi-Qiang Xia , Shoujun Chen , Christopher Borella , Lijun Sun
发明人： Jun Jiang , Teresa Kowalczyk-Przewloka , Stefan M. Schweizer , Zhi-Qiang Xia , Shoujun Chen , Christopher Borella , Lijun Sun
IPC分类号： A61K31/5375 , A61K31/4965 , A61K31/445 , A61K31/4409 , A61K31/426 , A61K31/421 , A61K31/402 , A61K31/381 , A61K31/357 , A61K31/341 , A61K31/27 , A61K31/16 , C07D295/215 , C07D241/28 , C07D211/98 , C07D213/78 , C07D277/56 , C07D263/34 , C07D207/12 , C07D333/68 , C07D317/46 , C07D307/68 , C07C333/12 , C07C327/18 , A61P35/00
CPC分类号： C07D295/195 , C07C327/56 , C07C333/12 , C07C335/40 , C07C337/02 , C07C337/06 , C07C2601/02 , C07C2601/04 , C07D211/72 , C07D213/86 , C07D213/87 , C07D241/24 , C07D277/56 , C07D295/155 , C07D307/68 , C07D317/68 , C07D333/38 , C07D333/68
摘要： The present invention is directed to compounds represented by structural formula (I), or a pharmaceutically acceptable salt or a transition metal chelate, coordinate or complex thereof or a transition metal chelate, coordinate or complex of a deprotonated form of the compound. Pharmaceutical composition and method of use for these compounds are also included.
摘要翻译： 本发明涉及由结构式（I）表示的化合物或其药学上可接受的盐或过渡金属螯合物，其配位体或络合物或过渡金属螯合物，化合物去质子化形式的配位体或络合物。 也包括这些化合物的药物组合物和使用方法。
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公开(公告)号：US08598366B2
公开(公告)日：2013-12-03
申请号：US13558886
申请日：2012-07-26
申请人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
发明人： Lijun Sun , Christopher Borella , Hao Li , Jun Jiang , Shoujun Chen , Keizo Koya , Takayo Inoue , Zhenjian Du , Kevin Foley , Yaming Wu , Mei Zhang , Weiwen Ying
IPC分类号： C07D261/02
CPC分类号： C07D413/14 , A61K31/42 , A61K31/426 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/675 , A61K45/06 , C07D261/08 , C07D413/04 , C07D413/10 , C07F9/653
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
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公开(公告)号：US20130203824A1
公开(公告)日：2013-08-08
申请号：US13785724
申请日：2013-03-05
申请人： Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
发明人： Lijun Sun , Jun Jiang , Christopher Borella , Shoujun Chen , Keizo Koya
IPC分类号： C07D275/02
CPC分类号： C07D275/02 , A61K31/425 , A61K31/4439 , A61K31/506 , C07D417/04 , C07D417/10 , C07F9/6539 , C07F9/65586
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are defined herein. These compounds inhibit tubulin polymerization and/or target vasculature and are useful for treating proliferative disorders, such as cancer.
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公开(公告)号：US20110098476A1
公开(公告)日：2011-04-28
申请号：US12934903
申请日：2009-03-31
申请人： Shoujun Chen , Jun Jiang , Lijun Sun , Keizo Koya
发明人： Shoujun Chen , Jun Jiang , Lijun Sun , Keizo Koya
IPC分类号： C07D213/44 , C07C327/48
CPC分类号： C07C327/56 , C07C2601/02 , C07D213/86 , C07D213/87
摘要： Disclosed herein are methods of preparing a bis(thio-hydrazide amides) compounds of the following structural formula: wherein R1, R2, R3, R4, R5, R6 and R13 are defined herein.
摘要翻译： 本文公开了制备以下结构式的双（硫代酰肼酰胺）化合物的方法：其中R1，R2，R3，R4，R5，R6和R13如本文所定义。
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公开(公告)号：US07709518B2
公开(公告)日：2010-05-04
申请号：US11233224
申请日：2005-09-21
申请人： Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhi Qiang Xia
发明人： Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhi Qiang Xia
IPC分类号： A61K31/415 , A01N43/52 , C07D235/00 , C07D235/18
CPC分类号： A61K31/437 , A61K31/403 , A61K31/4184 , A61K31/4439 , A61K31/444 , A61K31/537 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/24 , C07D235/28 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/12 , C07D471/04 , Y02A50/422
摘要： The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions and immune disorders.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物，包合物或前药，其中X，Y，A，Z，L和n如本文所定义。 这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症和免疫疾病。
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30.发明申请公开(公告)号：US20070254363A1
公开(公告)日：2007-11-01
申请号：US11698781
申请日：2007-01-25
申请人： Shoujun Chen , Lijun Sun , Jun Jiang , Yu Xie
发明人： Shoujun Chen , Lijun Sun , Jun Jiang , Yu Xie
IPC分类号： A61K31/165 , A61K31/21 , A61K31/36 , A61K31/40 , A61K31/41 , A61K31/421 , A61K31/425 , A61K31/44 , A61K31/445 , A61K31/497 , A61P29/00 , A61P37/00 , C07D263/30 , C07D403/00 , C07D413/00 , C12N5/00
CPC分类号： C07D263/32 , C07C211/52 , C07C229/52 , C07C233/59 , C07D207/16 , C07D211/62 , C07D213/64 , C07D213/75 , C07D277/28 , C07D317/58 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein A, Y, L, R1, W1 and W2 are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.
摘要翻译： 本发明涉及结构式（I）的化合物或其药学上可接受的盐，溶剂合物，包合物或前药，其中A，Y，L，R 1，W 1， SUB＆gt;和W 2＆lt; 2＆gt;在本文中定义。 这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症，过敏性疾病和免疫疾病。
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