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公开(公告)号：US06380369B1
公开(公告)日：2002-04-30
申请号：US08294312
申请日：1994-08-23
申请人： Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , William A. Haseltine , Craig A. Rosen , Steve Ruben , Ying-Fei Wei
发明人： Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , William A. Haseltine , Craig A. Rosen , Steve Ruben , Ying-Fei Wei
IPC分类号： C07H2102
CPC分类号： C07K14/47
摘要： The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins. The DNA repair proteins which may be produced by recombinant DNA techniques. One of the human DNA repair proteins, hMLH1, has been mapped to chromosome 3 while hMLH2 has been mapped to chromosome 2 and hMLH3 has been mapped to chromosome 7. The polynucleotide sequences of the DNA repair proteins may be used for diagnosis of a hereditary susceptibility to cancer.
摘要翻译： 本发明公开了三种人类DNA修复蛋白和编码这种蛋白质的DNA（RNA）。 可通过重组DNA技术产生的DNA修复蛋白。 人类DNA修复蛋白hMLH1已经被映射到染色体3，而hMLH2已被映射到染色体2，并且hMLH3已经被定位到染色体7上.DNA修复蛋白的多核苷酸序列可以用于诊断遗传易感性 到癌症。
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公开(公告)号：US07829293B2
公开(公告)日：2010-11-09
申请号：US11537681
申请日：2006-10-02
申请人： Ying-Fei Wei , Brent L. Kreider , Craig A. Rosen
发明人： Ying-Fei Wei , Brent L. Kreider , Craig A. Rosen
CPC分类号： C07K14/523
摘要： The present invention concerns a member of the human chemokine CC protein family. In particular, isolated nucleic acid molecules are provided encoding the chemokine β-15 protein. Chemokine β-15 polypeptides are also provided. The invention further concerns diagnostic methods for detecting thymus disorders and therapeutic methods for modulating bone marrow cell proliferation and differentiation.
摘要翻译： 本发明涉及人趋化因子CC蛋白家族的成员。 特别地，提供编码趋化因子和bgr-15蛋白的分离的核酸分子。 还提供了趋化因子和bgr-15多肽。 本发明还涉及用于检测胸腺疾病的诊断方法和用于调节骨髓细胞增殖和分化的治疗方法。
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公开(公告)号：US07135551B2
公开(公告)日：2006-11-14
申请号：US10263766
申请日：2002-10-04
申请人： Ying-Fei Wei , Brent L Kreider , Craig A Rosen
发明人： Ying-Fei Wei , Brent L Kreider , Craig A Rosen
IPC分类号： C07K14/475
CPC分类号： C07K14/523
摘要： The present invention concerns a member of the human chemokine CC protein family. In particular, isolated nucleic acid molecules are provided encoding the chemokine β-15 protein. Chemokine β-15 polypeptides are also provided. The invention further concerns diagnostic methods for detecting thymus disorders and therapeutic methods for modulating bone marrow cell proliferation and differentiation.
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公开(公告)号：US06503735B2
公开(公告)日：2003-01-07
申请号：US09272162
申请日：1999-03-19
申请人： Ying-Fei Wei , Brent L. Kreider , Craig A. Rosen
发明人： Ying-Fei Wei , Brent L. Kreider , Craig A. Rosen
IPC分类号： C12N121
CPC分类号： C07K14/523
摘要： The present invention concerns a member of the human chemokine CC protein family. In particular, isolated nucleic acid molecules are provided encoding the chemokine &bgr;-15 protein. Chemokine &bgr;-15 polypeptides are also provided. The invention further concerns diagnostic methods for detecting thymus disorders and therapeutic methods for modulating bone marrow cell proliferation and differentiation.
摘要翻译： 本发明涉及人趋化因子CC蛋白家族的成员。 特别地，提供编码趋化因子β-15蛋白的分离的核酸分子。 还提供趋化因子β-15多肽。 本发明还涉及用于检测胸腺疾病的诊断方法和用于调节骨髓细胞增殖和分化的治疗方法。
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公开(公告)号：US06929921B2
公开(公告)日：2005-08-16
申请号：US10413536
申请日：2003-04-15
IPC分类号： C12N15/09 , C07K14/705 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , G01N33/53 , C07K16/00 , C07K16/18 , C12P21/08
CPC分类号： C07K14/705 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to a novel member of the blue-light photoreceptor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human hCRY2 receptor. hCRY2 polypeptides are also provided as are vectors, host cells, antibodies, and recombinant methods for producing the same.
摘要翻译： 本发明涉及蓝光感光体受体家族的新成员。 特别地，提供编码人hCRY2受体的分离的核酸分子。 还提供hCRY2多肽，载体，宿主细胞，抗体和用于制备它们的重组方法。
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公开(公告)号：US6114503A
公开(公告)日：2000-09-05
申请号：US964268
申请日：1997-11-04
IPC分类号： C12N15/09 , C07K14/705 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C07K1/00 , C12N5/00 , C12N15/00 , C12P21/06
CPC分类号： C07K14/705 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to a novel member of the blue-light photoreceptor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human hCRY2 receptor. hCRY2 polypeptides are also provided as are vectors, host cells, antibodies, and recombinant methods for producing the same.
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公开(公告)号：US06620619B2
公开(公告)日：2003-09-16
申请号：US08210143
申请日：1994-03-16
申请人： William A. Haseltine , Steven Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Craig A. Rosen , Rebecca A. Fuldner , Ewen F. Kirkness
发明人： William A. Haseltine , Steven Ruben , Ying-Fei Wei , Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Craig A. Rosen , Rebecca A. Fuldner , Ewen F. Kirkness
IPC分类号： G01N3306
CPC分类号： C07K14/47
摘要： The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins. The DNA repair proteins may be produced by recombinant DNA techniques. One of the human DNA repair proteins, hmlh1, has been mapped on chromosome 3. The polynucleotide sequences of DNA repair proteins may be used for diagnosis of a hereditary susceptibility to cancer.
摘要翻译： 本发明公开了三种人类DNA修复蛋白和编码这种蛋白质的DNA（RNA）。 DNA修复蛋白可以通过重组DNA技术产生。 人类DNA修复蛋白之一hmlh1已被绘制在染色体3上.DNA修复蛋白的多核苷酸序列可用于诊断遗传性对癌症的易感性。
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公开(公告)号：US06482606B1
公开(公告)日：2002-11-19
申请号：US08187757
申请日：1994-01-27
申请人： Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , William A. Haseltine , Craig A. Rosen , Steve Ruben , Ying-Fei Wei
发明人： Mark D. Adams , Robert D. Fleischmann , Claire M. Fraser , Rebecca A. Fuldner , Ewen F. Kirkness , William A. Haseltine , Craig A. Rosen , Steve Ruben , Ying-Fei Wei
IPC分类号： C12P2102
CPC分类号： C07K14/47
摘要： The present invention discloses three human DNA repair proteins and DNA (RNA) encoding such proteins. The DNA repair proteins may be produced by recombinant DNA techniques. One of the human DNA repair proteins, hmlh1, has been mapped on chromosome 3. The polynucleotide sequences of DNA repair proteins may be used for diagnosis of a hereditary susceptibility to cancer.
摘要翻译： 本发明公开了三种人类DNA修复蛋白和编码这种蛋白质的DNA（RNA）。 DNA修复蛋白可以通过重组DNA技术产生。 人类DNA修复蛋白之一hmlh1已被绘制在染色体3上.DNA修复蛋白的多核苷酸序列可用于诊断遗传性对癌症的易感性。
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公开(公告)号：US5981231A
公开(公告)日：1999-11-09
申请号：US874460
申请日：1997-06-16
申请人： Ying-Fei Wei , Brent L. Kreider , Craig A. Rosen
发明人： Ying-Fei Wei , Brent L. Kreider , Craig A. Rosen
CPC分类号： C07K14/523
摘要： The present invention concerns a member of the human chemokine CC protein family. In particular isolated nucleic acid molecules are provided encoding the chemokine .beta.-15 protein. Chemokine .beta.-15 polypeptides are also provided. The invention further concerns diagnostic methods for detecting thymus disorders and therapeutic methods for modulating bone marrow cell proliferation and differentiation.
摘要翻译： 本发明涉及人趋化因子CC蛋白家族的成员。 特别提供编码趋化因子β-15蛋白的分离的核酸分子。 也提供趋化因子β-15多肽。 本发明还涉及用于检测胸腺疾病的诊断方法和用于调节骨髓细胞增殖和分化的治疗方法。
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公开(公告)号：US07511017B2
公开(公告)日：2009-03-31
申请号：US11182946
申请日：2005-07-18
申请人： Ying-Fei Wei , Jian Ni , Reiner L. Gentz , Steven M. Ruben
发明人： Ying-Fei Wei , Jian Ni , Reiner L. Gentz , Steven M. Ruben
IPC分类号： A61K38/16 , A61K38/00 , C07K14/435 , C07K14/00
CPC分类号： A61K31/522 , A61K31/66 , A61K39/395 , A61K45/06 , A61K48/00 , A61K2039/505 , C07K14/70578 , C07K16/2878 , C07K2319/00 , C07K2319/30 , C12N2799/026 , A61K2300/00
摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as “TNFR-5” or “TR5,” and now referred to hereinafter as “TRAIL receptor without intracellular domain” or “TRID.” TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.
摘要翻译： 本发明涉及编码作为TNF受体家族成员的多肽的新型人基因，现已发现其结合TRAIL。 更具体地，提供编码称为肿瘤坏死因子受体-5（有时称为“TNFR-5”或“TR5”）的人多肽的分离的核酸分子，以下在下文中称为“没有细胞内结构域的TRAIL受体”或 “TRID”。 还提供了TRID多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及用于鉴定TRAIL多肽活性的激动剂或拮抗剂的筛选方法。 还提供了利用这种组合物的诊断和治疗方法。
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