公开(公告)号：US20060198897A1

公开(公告)日：2006-09-07

申请号：US11213288

申请日：2005-08-26

Applicant: Stephen Pacetti ,  Eugene Michal ,  Syed Hossainy ,  Ni Ding ,  Wouter Roorda

Inventor： Stephen Pacetti ,  Eugene Michal ,  Syed Hossainy ,  Ni Ding ,  Wouter Roorda

IPC: A61K9/50 ,  A61K9/16

CPC classification number: A61K31/727 ,  A61K31/728 ,  A61K31/737 ,  A61L31/10 ,  C08L89/00

Abstract: Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed.

公开(公告)号：US20060093842A1

公开(公告)日：2006-05-04

申请号：US10976551

申请日：2004-10-29

Applicant: Jessica DesNoyer ,  Stephen Pacetti ,  Syed Hossainy ,  Lothar Kleiner ,  Yiwen Tang ,  Gina Zhang

Inventor： Jessica DesNoyer ,  Stephen Pacetti ,  Syed Hossainy ,  Lothar Kleiner ,  Yiwen Tang ,  Gina Zhang

IPC: C08G63/02 ,  C08G69/08 ,  B32B27/34 ,  B32B27/36

CPC classification number: C09D177/12 ,  A61L31/06 ,  A61L31/10 ,  Y10S623/90 ,  Y10T428/31725 ,  Y10T428/31786 ,  C08L77/12

Abstract: Provided herein is a PEA polymer blend and coatings or implantable devices formed therefrom. The PEA polymer blend is formed of a PEA polymer and a material capable of hydrogen bonding with the PEA. The PEA polymer blend can form a coating on an implantable device, one example of which is a stent. The coating can optionally include a biobeneficial material and/or optionally with a bioactive agent. The implantable device can be used to treat or prevent a disorder such as one of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.

Abstract translation: 本文提供了由其形成的PEA聚合物共混物和涂层或可植入装置。 PEA聚合物共混物由PEA聚合物和能够与PEA氢键合的材料形成。 PEA聚合物共混物可以在可植入装置上形成涂层，其一个实例是支架。 涂层可任选地包括生物有益材料和/或任选地含有生物活性剂。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔之一，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍 导管阻塞，输尿管阻塞，肿瘤阻塞及其组合。

公开(公告)号：US20060018944A1

公开(公告)日：2006-01-26

申请号：US11213290

申请日：2005-08-26

Applicant: Stephen Pacetti ,  Eugene Michal ,  Syed Hossainy ,  Ni Ding ,  Wouter Roorda

Inventor： Stephen Pacetti ,  Eugene Michal ,  Syed Hossainy ,  Ni Ding ,  Wouter Roorda

IPC: A61K31/727 ,  A61F13/00

CPC classification number: A61K31/727 ,  A61K31/728 ,  A61K31/737 ,  A61L31/10 ,  C08L89/00

Abstract: Coatings for medical devices which include polycationic peptides such as L-arginine and methods for fabricating the coatings are disclosed.

公开(公告)号：US20060002968A1

公开(公告)日：2006-01-05

申请号：US10882506

申请日：2004-06-30

Applicant: Gordon Stewart ,  Gina Zhang ,  Nancy Kristen ,  Paul Consigny ,  Stephen Dugan ,  Gene Park ,  Christopher Feezor ,  Wouter Roorda ,  Syed Hossainy

Inventor： Gordon Stewart ,  Gina Zhang ,  Nancy Kristen ,  Paul Consigny ,  Stephen Dugan ,  Gene Park ,  Christopher Feezor ,  Wouter Roorda ,  Syed Hossainy

IPC: A61K31/4745 ,  A61F2/00

CPC classification number: A61K31/4745 ,  A61F2250/0067 ,  A61K31/436 ,  A61K31/573 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/45 ,  A61K2300/00

Abstract: Drug-delivery systems such as drug-delivery stents having an anti-proliferative agent such as everolimus and an anti-flammatory agent such as clobetasol are provided. Also disclosed are methods of treating a vascular impairment such as restenosis or vulnerable plaque.

公开(公告)号：US20050244363A1

公开(公告)日：2005-11-03

申请号：US10835912

申请日：2004-04-30

Applicant: Syed Hossainy ,  Eugene Michal ,  Thierry Glauser ,  Connie Kwok ,  Stephen Pacetti

Inventor： Syed Hossainy ,  Eugene Michal ,  Thierry Glauser ,  Connie Kwok ,  Stephen Pacetti

IPC: A61K31/727 ,  A61K31/728 ,  A61K31/785 ,  A61L27/00 ,  A61L31/10 ,  C08G63/48

CPC classification number: A61L31/10 ,  A61K31/727 ,  A61K31/728 ,  A61K31/785 ,  A61L31/16 ,  A61K2300/00 ,  C08L5/08 ,  C08L5/10

Abstract: Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.

Abstract translation: 提供了用于涂覆可植入装置的透明质酸（HA）缀合物或交联的HA组合物。 可植入装置可用于治疗动脉粥样硬化，血栓形成，再狭窄，高胆固醇，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍，胆管 梗阻，输尿管阻塞，肿瘤阻塞及其组合。

公开(公告)号：US20050238686A1

公开(公告)日：2005-10-27

申请号：US11089763

申请日：2005-03-25

Applicant: Syed Hossainy ,  Steven Wu ,  Manish Gada ,  Anthony Andreacchi

Inventor： Syed Hossainy ,  Steven Wu ,  Manish Gada ,  Anthony Andreacchi

IPC: A61F2/00 ,  A61F2/82 ,  A61L2/00 ,  A61L31/10 ,  A61L31/16 ,  B05D3/00

CPC classification number: A61F2/82 ,  A61F2250/0068 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/606

Abstract: Coatings for implantable devices or endoluminal prosthesis, such as stents, are provided, including a method of forming the coatings. The coatings can be used for the delivery of an active ingredient or a combination of active ingredients.

公开(公告)号：US20050196422A1

公开(公告)日：2005-09-08

申请号：US11064530

申请日：2005-02-22

Applicant: Syed Hossainy ,  Yiwen Tang ,  Andrew Tung ,  Stephen Pacetti

Inventor： Syed Hossainy ,  Yiwen Tang ,  Andrew Tung ,  Stephen Pacetti

IPC: A61F2/00 ,  A61F2/06 ,  A61L27/00 ,  A61L27/26 ,  A61L27/50 ,  A61L31/10 ,  B05D3/00 ,  B32B27/36

CPC classification number: A61F2/82 ,  A61F2250/0056 ,  A61F2250/0067 ,  A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  Y10T428/24942

Abstract: Methods for fabricating coatings for implantable medical devices are disclosed. The coatings include hydrophilic and hydrophobic components. The methods provide for treatment of the coatings to cause enrichment a region close to, at or on the outer surface of the coating with the hydrophilic component.

Abstract translation: 公开了用于制造可植入医疗装置的涂层的方法。 涂层包括亲水和疏水组分。 该方法提供了处理涂层以使亲水组分在涂层的外表面附近或附近的区域富集。

公开(公告)号：US20050169957A1

公开(公告)日：2005-08-04

申请号：US10815421

申请日：2004-03-31

Applicant: Syed Hossainy

Inventor： Syed Hossainy

IPC: A61K31/445 ,  A61L31/10 ,  A61L31/12 ,  A61L31/16 ,  A61F2/00

CPC classification number: A61L31/16 ,  A61K31/445 ,  A61K31/74 ,  A61L31/10 ,  C08L33/06

Abstract: A composition is disclosed comprising a structural component comprising linear acrylic homopolymers or linear acrylic copolymers and a biobeneficial component comprising copolymers having an acrylate moiety and a biobeneficial moiety.

Abstract translation: 公开了包含包含线性丙烯酸均聚物或线性丙烯酸共聚物的结构组分和包含具有丙烯酸酯部分和生物有益部分的共聚物的生物有益成分的组合物。

公开(公告)号：US20050033412A1

公开(公告)日：2005-02-10

申请号：US10912025

申请日：2004-08-04

Applicant: Steven Wu ,  Sameer Harish ,  Deborra Sanders-Millare ,  Judy Guruwaiya ,  Daryush Mirzaee ,  Syed Hossainy ,  Charlene Chen

Inventor： Steven Wu ,  Sameer Harish ,  Deborra Sanders-Millare ,  Judy Guruwaiya ,  Daryush Mirzaee ,  Syed Hossainy ,  Charlene Chen

IPC: A61F2/00 ,  A61F2/06 ,  A61F2/90

CPC classification number: A61F2/0077 ,  A61F2/848 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91533 ,  A61F2230/0013 ,  A61F2250/0067 ,  A61F2250/0068 ,  Y10S623/901

Abstract: An implantable medical device, such as a stent or graft, having asperities on a designated region of its outer surface is disclosed. The asperities can serve to improve retention of one or more layers of a coating on the device and to increase the amount of coating that can be carried by the device. The asperities can be formed by using a stream of pressurized grit to roughen the surface. The asperities can also be formed by removing material from the outer surface, for example, by chemical etching with or without a patterned mask. Alternatively, the asperities can be formed by adding material to the outer surface, for example, by welding powder particles to the outer surface or sputtering.

Abstract translation: 公开了一种在其外表面的指定区域上具有凹凸的可植入医疗装置，例如支架或移植物。 粗糙度可用于改善设备上一层或多层涂层的保留性并增加该装置可承载的涂层量。 可以通过使用加压砂粒流粗糙表面来形成凹凸。 也可以通过从外表面去除材料来形成凹凸，例如通过具有或不具有图案化掩模的化学蚀刻来形成。 或者，可以通过向外表面添加材料，例如通过将粉末颗粒焊接到外表面或溅射来形成凹凸。

公开(公告)号：US09572795B2

公开(公告)日：2017-02-21

申请号：US13572507

申请日：2012-08-10

Applicant: Syed Hossainy ,  Dariush Davalian ,  Mikael Trollsas ,  John Stankus ,  Jinping Wan

Inventor： Syed Hossainy ,  Dariush Davalian ,  Mikael Trollsas ,  John Stankus ,  Yuet Mei Khong ,  Jinping Wan

IPC: A61M37/00 ,  A61K31/409 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61L29/16 ,  A61K41/00 ,  A61M25/00 ,  A61M25/10

CPC classification number: A61K31/409 ,  A61K9/0009 ,  A61K9/0019 ,  A61K9/1272 ,  A61K9/5146 ,  A61K41/0071 ,  A61L29/16 ,  A61L2300/224 ,  A61L2300/626 ,  A61M25/0045 ,  A61M25/10 ,  A61M2025/105 ,  A61M2025/1086

Abstract: This invention relates to photodynamic therapy (PDT) of vulnerable plaque using two pluralities of nanoparticles, one plurality comprising a PDT agent that is sensitive to blue-green light wherein the nanoparticles are capable of penetrating only into the fibrous cap of the vulnerable plaque and one plurality comprising a PDT agent that is sensitive to red light wherein the nanoparticles are capable of penetrating into the core of the vulnerable plaque.

Abstract translation: 本发明涉及使用两种纳米颗粒的易损斑块的光动力疗法（PDT），其一个包括对蓝绿色光敏感的PDT剂，其中纳米颗粒仅能穿透易损斑块的纤维帽和一个 多个包含对红光敏感的PDT剂，其中纳米颗粒能够渗入易损斑块的核心。