公开(公告)号：US20250111632A1

公开(公告)日：2025-04-03

申请号：US18840030

申请日：2023-02-21

Applicant: The Trustees of Dartmouth College

Inventor： Keith D. Paulsen ,  Xiaoyao FAN ,  William R. WARNER

IPC: G06T19/20 ,  A61B34/10 ,  A61B90/00 ,  G06T7/00 ,  G06T7/33

Abstract: An intraoperative stereovision system has a stereo imager configured to provide stereo images at first and second time (iSV0, iSV(n)) to an image processor configured with a computerized mechanical model of a spinal column, the computerized mechanical model configured to model vertebrae as rigid, displaceable, bodies. The image processor is configured to extract an iSV0 surface model from iSV0 and an iSV(n) surface model from the iSV(n); to register these surfaces, and identify differences therefrom. The image processor is configured to adjust the computerized mechanical model according to the identified differences thereby causing the adjusted computerized mechanical model to track the iSV(n) surface model at each of multiple timepoints.

公开(公告)号：US20240260909A1

公开(公告)日：2024-08-08

申请号：US18614944

申请日：2024-03-25

Applicant: The Trustees of Dartmouth College

Inventor： Kenneth Tichauer ,  Robert W. Holt ,  Frederic Leblond ,  Pablo Valdes ,  Brian W. Pogue ,  Keith D. Paulsen ,  David W. Roberts

IPC: A61B5/00 ,  A61K49/00

CPC classification number: A61B5/7278 ,  A61B5/0071 ,  A61K49/0058 ,  A61B5/0035 ,  A61B5/0062 ,  A61B2576/00

Abstract: A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.

公开(公告)号：US11751767B2

公开(公告)日：2023-09-12

申请号：US16673165

申请日：2019-11-04

Applicant: The Trustees of Dartmouth College

Inventor： Stephen Chad Kanick ,  Brian William Pogue ,  Keith D. Paulsen ,  Jonathan T. Elliott ,  David M. McClatchy, III ,  Venkataramanan Krishnaswamy

IPC: A61B5/00

CPC classification number: A61B5/0075 ,  A61B2576/00

Abstract: A method for determining sub-diffuse scattering parameters of a material includes illuminating the material with structured light and imaging remission by the material of the structured light. The method further includes determining, from captured remission images, sub-diffuse scattering parameters of the material. A structured-light imaging system for determining sub-diffuse scattering parameters of a material includes a structured-light illuminator, for illuminating the material with structured light of periodic spatial structure, and a camera for capturing images of the remission of the structured light by the material. The structured-light imaging system further includes an analysis module for processing the images to quantitatively determine the sub-diffuse scattering parameters. A software product includes machine-readable instructions for analyzing images of remission of structured light by a material to determine sub-diffuse scattering parameters of the material.

公开(公告)号：US20230075997A1

公开(公告)日：2023-03-09

申请号：US17961480

申请日：2022-10-06

Applicant: The Trustees of Dartmouth College

Inventor： Pablo Valdes ,  Frederic Leblond ,  Keith D. Paulsen ,  Brian Campbell Wilson ,  David W. Roberts ,  Michael Jermyn

IPC: A61B5/1455 ,  A61B5/1459 ,  A61B1/04 ,  A61B5/145 ,  A61B5/00 ,  A61B5/1495 ,  A61B1/06 ,  A61B5/055 ,  G01J3/28 ,  A61B1/05 ,  G01J3/12 ,  G01J3/02 ,  A61B1/00 ,  A61B1/07

Abstract: An imaging system, such as a surgical microscope, laparoscope, or endoscope or integrated with these devices, includes an illuminator providing patterned white light and/or fluorescent stimulus light. The system receives and images light hyperspectrally, in embodiments using a hyperspectral imaging array, and/or using narrowband tunable filters for passing filtered received light to an imager. Embodiments may construct a 3-D surface model from stereo images, and will estimate optical properties of the target using images taken in patterned light or using other approximations obtained from white light exposures. Hyperspectral images taken under stimulus light are displayed as fluorescent images, and corrected for optical properties of tissue to provide quantitative maps of fluorophore concentration. Spectral information from hyperspectral images is processed to provide depth of fluorophore below the tissue surface. Quantitative images of fluorescence at depth are also prepared. The images are displayed to a surgeon for use in surgery.

公开(公告)号：US10575792B2

公开(公告)日：2020-03-03

申请号：US16278703

申请日：2019-02-18

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Ryan J. Halter ,  Keith D. Paulsen ,  Alexander Hartov

IPC: G06K9/00 ,  A61B5/00 ,  A61B6/00 ,  A61B5/055 ,  G06T7/00 ,  A61B5/024 ,  A61B5/1455 ,  A61B5/0205 ,  A61B5/053 ,  G06F19/00 ,  A61B6/03 ,  A61B5/0245 ,  A61B5/026

Abstract: A method for cardiovascular-dynamics correlated imaging includes receiving a time series of images of at least a portion of a patient, receiving a time series of cardiovascular data for the patient, evaluating correlation between the time series of images and the time series of cardiovascular data, and determining a property of the at least a portion of a patient, based upon the correlation. A system for cardiovascular-dynamics correlated imaging includes a processing device having: a processor, a memory communicatively coupled therewith, and a correlation module including machine-readable instructions stored in the memory that, when executed by the processor, perform the function of correlating a time series of images of at least a portion of a patient with a time series of cardiovascular data of the patient to determine a property of the at least a portion of a patient.

公开(公告)号：US20190384069A1

公开(公告)日：2019-12-19

申请号：US16443519

申请日：2019-06-17

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Jonathan D. Olson ,  Keith D. Paulsen ,  David W. Roberts

IPC: G02B27/28 ,  G02B5/20 ,  H04N5/33 ,  H04N5/225

Abstract: A birefringent spectral demultiplexer for hyperspectral imaging includes N birefringent beamsplitting stages arranged along a light propagation path, to produce 2N mutually divergent output light beams. Each of the output light beams differs from every other one of the output light beams in polarization and/or spectral bandwidth. Each birefringent beamsplitting stage includes a retarder for modifying polarization of each light beam received by the birefringent beamsplitting stage, and a Wollaston prism for splitting each light beam into two orthogonally polarized and divergent light beams. The Wollaston prism has a beamsplitting interface arranged at an oblique angle to the light propagation path. The oblique angle of the beamsplitting interface of each Wollaston prism of the series, except for the first one, is smaller than the oblique angle of the beamsplitting interface of each preceding Wollaston prism. The demultiplexer may be configured to accept input light of any polarization.

公开(公告)号：US10463256B2

公开(公告)日：2019-11-05

申请号：US15013623

申请日：2016-02-02

Applicant: The Trustees of Dartmouth College

Inventor： Stephen Chad Kanick ,  Brian William Pogue ,  Keith D. Paulsen ,  Jonathan T. Elliott ,  David M. McClatchy, III ,  Venkataramanan Krishnaswamy

IPC: A61B5/00

Abstract: A method for determining sub-diffuse scattering parameters of a material includes illuminating the material with structured light and imaging remission by the material of the structured light. The method further includes determining, from captured remission images, sub-diffuse scattering parameters of the material. A structured-light imaging system for determining sub-diffuse scattering parameters of a material includes a structured-light illuminator, for illuminating the material with structured light of periodic spatial structure, and a camera for capturing images of the remission of the structured light by the material. The structured-light imaging system further includes an analysis module for processing the images to quantitatively determine the sub-diffuse scattering parameters. A software product includes machine-readable instructions for analyzing images of remission of structured light by a material to determine sub-diffuse scattering parameters of the material.

公开(公告)号：US09532029B2

公开(公告)日：2016-12-27

申请号：US13726050

申请日：2012-12-22

Applicant: The Trustees of Dartmouth College

Inventor： Matthew Pallone ,  Paul M. Meaney ,  Keith D. Paulsen

IPC: H04N13/02 ,  A61B5/00 ,  A61B5/05 ,  A61B5/107 ,  G06T15/06 ,  G06T17/00 ,  G06T1/00 ,  G06T5/00 ,  G06T7/00

CPC classification number: A61B5/0091 ,  A61B5/0507 ,  A61B5/1077 ,  A61B5/4312 ,  G06T1/0007 ,  G06T5/006 ,  G06T7/521 ,  G06T15/06 ,  G06T17/00 ,  G06T2210/41 ,  H04N13/221

Abstract: Systems and methods generate a 3D model of a surface of an object immersed in a transparent liquid within a stationary cylindrical transparent tank. First and second laser line projectors and a camera are rotated around a central axis of the cylindrical tank. The first and second laser line projectors each generate a laser line perpendicular to a plane or rotation and aligned with the center of rotation. The camera images the object. An image from the camera is captured at each of several angular positions of the camera relative to a reference position of the stationary cylindrical tank. The captured images are processed to determine, for each laser line within each image, a plurality of 3D positions where the laser line is incident upon a surface of the object. In embodiments, images are corrected with ray tracing or image warping and registration functions.

Abstract translation: 系统和方法产生浸在固定圆柱形透明罐内的透明液体中的物体表面的3D模型。 第一和第二激光线投影机和照相机围绕圆筒形罐的中心轴旋转。 第一和第二激光线投影仪各自产生垂直于平面或旋转并与旋转中心对准的激光线。 相机拍摄对象。 摄像机的图像相对于固定圆筒形罐的参考位置被捕获在摄像机的几个角度位置的每一个处。 对捕获的图像进行处理，以确定每个图像内的每个激光线，其中激光线入射到物体的表面上的多个3D位置。 在实施例中，利用光线跟踪或图像翘曲和注册功能校正图像。

公开(公告)号：US09336592B2

公开(公告)日：2016-05-10

申请号：US14375311

申请日：2013-02-01

Applicant: The Trustees of Dartmouth College

Inventor： Xiaoyao Fan ,  David W. Roberts ,  Keith D. Paulsen ,  Songbai Ji ,  Alex Hartov

IPC: G06K9/00 ,  G06T7/00 ,  G06T17/00 ,  A61B6/00 ,  A61B5/00 ,  A61B5/107 ,  G06K9/60 ,  G06T19/20 ,  A61B5/055 ,  A61B19/00 ,  A61B8/08

CPC classification number: G06T7/0012 ,  A61B5/0013 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/055 ,  A61B5/1077 ,  A61B5/1079 ,  A61B5/7425 ,  A61B6/501 ,  A61B6/5247 ,  A61B8/0808 ,  A61B34/10 ,  A61B34/20 ,  A61B90/20 ,  A61B2034/105 ,  A61B2034/107 ,  A61B2034/2055 ,  A61B2090/367 ,  A61B2090/378 ,  G06K9/60 ,  G06T7/33 ,  G06T17/00 ,  G06T19/20 ,  G06T2200/08 ,  G06T2207/10021 ,  G06T2207/10028 ,  G06T2207/30004 ,  G06T2207/30096

Abstract: A system and method for determining intraoperative locations of a lesion in tissue from lesion locations determined in preoperative imaging includes determining three dimensional locations of surface features of the organ in the preoperative images. A preoperative surface map is extracted from stereo images annotated with surface features from preoperative images. An intraoperative surface map of the organ is extracted from stereo images, and surface features are identified in the stereo images corresponding to surface features annotated into the preoperative surface map. Three dimensional displacements of the surface features are determined and used to constrain a computer model of deformation of the organ. In embodiments, the model of deformation is adapted or constrained to model locations and dimensions of surgical cavities using an optical flow method and/or locations of surgical instruments in the organ. The model of deformation is used to determine intraoperative locations for the lesion.

Abstract translation: 用于确定术前成像中确定的病变位置的组织中的病变的术中位置的系统和方法包括确定术前图像中器官的表面特征的三维位置。 从术前图像表面特征注释的立体图像中提取术前表面图。 从立体图像提取器官的术中表面图，并且在对应于注释到术前表面图的表面特征的立体图像中识别表面特征。 确定表面特征的三维位移，并用于约束器官变形的计算机模型。 在实施例中，变形模型被适配或约束以使用手术器械的光学流动方法和/或外科器械的位置对外科腔的位置和尺寸进行建模。 变形模型用于确定病变的术中位置。

公开(公告)号：US20140276230A1

公开(公告)日：2014-09-18

申请号：US13831160

申请日：2013-03-14

Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Adam J. Pattison ,  Matthew DJ McGarry ,  Keith D. Paulsen ,  John B. Weaver

IPC: G06F19/00 ,  G01R33/563 ,  A61B5/11 ,  G01N3/32

CPC classification number: G06F19/3437 ,  A61B5/0051 ,  A61B5/055 ,  A61B5/1128 ,  A61B5/4064 ,  A61B5/6868 ,  G01N3/32 ,  G01N2203/0005 ,  G01N2203/0069 ,  G01N2203/0073 ,  G01N2203/0094 ,  G01N2203/0218 ,  G01R33/56358 ,  G06F19/00 ,  G06F19/3481 ,  G16H50/50

Abstract: A system for determining parameters of porous media or material, which in an embodiment is biological tissue, includes an actuator and a displacement monitor. The actuator is adapted to apply a displacement to tissue at a particular frequency selected from a range of frequencies, and the force monitor adapted to monitor a mechanical response of tissue. The system also has a processor coupled to drive the actuator and to read the mechanical response, the processor coupled to execute from memory a poroelastic model of mechanical properties of the material, and a convergence procedure for determining parameters for the poroelastic model such that the model predicts mechanical response of the tissue to within limits.

Abstract translation: 用于确定在一个实施方案中为生物组织的多孔介质或材料的参数的系统包括致动器和位移监测器。 致动器适于以选自频率范围的特定频率向组织施加位移，并且力监测器适于监测组织的机械响应。 该系统还具有耦合以驱动致动器并且读取机械响应的处理器，该处理器被耦合以从存储器执行材料的机械性能的多弹性模型，以及用于确定多孔弹性模型的参数的收敛过程，使得该模型 将组织的机械反应预测在限度内。