-
公开(公告)号：US07914579B2
公开(公告)日：2011-03-29
申请号：US11351127
申请日：2006-02-09
申请人： Charles A. Vacanti , Yi Lin Cao , Robert S. Langer , Joseph P. Vacanti , Keith Paige , Joseph Upton
发明人： Charles A. Vacanti , Yi Lin Cao , Robert S. Langer , Joseph P. Vacanti , Keith Paige , Joseph Upton
CPC分类号： A61L27/3804 , A61F2/08 , A61L27/18 , A61L27/3604 , A61L27/3662 , A61L27/3817 , A61L27/3843 , A61L27/386 , A61L27/58 , A61L2430/10 , C08L67/04
摘要： Connective tissue, including neo-tendons and ligaments, has been constructed using biodegradable synthetic scaffolds seeded with tenocytes. The scaffolds are preferably formed from biodegradable fibers formed of a polymer such as polyglycolic acid-polylactic acid copolymers, and seeded with cells isolated from autologous tendon or ligament by means of enzymatic digestion or direct seeding into tissue culture dishes from explants. The cell polymer constructs are then surgically transplanted to replace missing segments of functioning tendon or ligament.
摘要翻译： 结缔组织，包括新肌腱和韧带，已经使用可生物降解的合成支架构建，种子与细胞接种。 支架优选由聚合物如聚乙醇酸 - 聚乳酸共聚物形成的可生物降解的纤维形成，并通过酶切消化或直接接种到外植体的组织培养皿中，从自体肌腱或韧带分离的细胞接种。 然后手术移植细胞聚合物构建体以代替功能性肌腱或韧带的缺失部分。
-
公开(公告)号：US07879019B2
公开(公告)日：2011-02-01
申请号：US11925466
申请日：2007-10-26
申请人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard, Jr.
发明人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard, Jr.
IPC分类号： A61M31/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： A method is provided for selectively opening a containment reservoir. The method includes providing a device which comprises a substrate in which at least one reservoir is located and covered by a reservoir cap; and directing laser light to the reservoir cap to cause the reservoir cap to disintegrate or become permeable. The device may be an implantable medical device. The reservoirs may contain a drug for controlled release or a biosensor.
摘要翻译： 提供了一种用于选择性地打开容纳储存器的方法。 该方法包括提供一种装置，其包括基板，其中至少一个储存器定位并被储存器盖覆盖; 并将激光引导到储存器盖以使储存器盖分解或变得可渗透。 该装置可以是可植入医疗装置。 储存器可以含有用于控制释放的药物或生物传感器。
-
23.再颁专利Composition and methods for enhancing receptor-mediated cellular internalization 有权用于增强受体介导的细胞内化的组合物和方法公开(公告)号：USRE41996E1
公开(公告)日：2010-12-14
申请号：US11821513
申请日：2007-06-21
CPC分类号： A61K9/0046 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/006 , A61K9/0073 , A61K9/06 , A61K31/56 , A61K31/573 , A61K31/715 , A61K47/38 , A61K48/00 , A61K48/0008 , A61K48/0083 , Y10S977/906
摘要： Compositions and methods for improving cellular internalization of one or more compounds are disclosed. The compositions include a compound to be delivered and a biocompatible viscous material, such as a hydrogel, lipogel, or highly viscous sol. The composition also include, or are administered in conjunction with, an enhancer in an amount effective to maximize expression of or binding to receptors and enhance RME of the compound into the cells. This leads to high transport rates of compounds to be delivered across cell membranes, facilitating more efficient delivery of drugs and diagnostic agents. Compositions are applied topically orally, nasally, vaginally, rectally, and ocularly. The enhancer is administered with the composition or separately, either systemically or preferably locally. The compound to be delivered can also be the enhancer.
摘要翻译： 公开了用于改善一种或多种化合物的细胞内化的组合物和方法。 组合物包括待递送的化合物和生物相容的粘性材料，例如水凝胶，脂凝胶或高粘度溶胶。 该组合物还包括或者与增效剂一起施用，其量可以有效地最大程度地使受体的表达或结合，并增强化合物进入细胞的RME。 这导致要跨细胞膜递送的化合物的高传输速率，有助于更有效地递送药物和诊断剂。 组合物经口，鼻，阴道，直肠和眼部局部应用。 增强剂与组合物一起施用或分开施用，全部或优选局部施用。 待递送的化合物也可以是增强剂。
-
公开(公告)号：US07833545B2
公开(公告)日：2010-11-16
申请号：US10835414
申请日：2004-04-29
CPC分类号： A61F6/08 , A61F6/142 , A61K9/0036 , A61K9/0056 , A61K31/565 , A61K31/57 , A61K38/09 , A61K45/06 , Y10S514/843 , A61K2300/00
摘要： The invention relates to an drug delivery device and a method for delivering multiple drugs over a prolonged period of time. The drug delivery device has two or more unitary segments comprising a drug-permeable polymeric substance, wherein at least one of the segments further comprises a pharmaceutically active agent. The invention also relates to a method for the treatment of a benign ovarian secretory disorder in a female mammal, a method of contraception, and a method of relieving the symptoms associated with menopausal, perimenopausal and post-menopausal periods in a woman.
-
公开(公告)号：US20100215708A1
公开(公告)日：2010-08-26
申请号：US12306794
申请日：2007-06-28
申请人： Andreas Zumbuehl , Danial S. Kohane , Lino Da Silva Ferreira , Robert S. Langer , Gerald R. Fink
发明人： Andreas Zumbuehl , Danial S. Kohane , Lino Da Silva Ferreira , Robert S. Langer , Gerald R. Fink
IPC分类号： A61F2/00 , A61K31/7088 , A61K31/713 , A61K31/7048 , A61K9/16 , A61K9/70 , A61P31/00 , A61M25/00 , A61M27/00 , A61M16/04
CPC分类号： A61L27/54 , A61L27/34 , A61L2300/404 , A61L2300/602
摘要： This invention is directed to substrates, materials and devices coated with a gel, foam, film, particle or composition comprising a polymei solvent and effector compounds attached thereto, processes of producing the same, and methods of use thereof, of in, inter-alia, biological applications, including preventing infection and the treatment of various diseases.
摘要翻译： 本发明涉及涂覆有凝胶，泡沫，膜，颗粒或组合物的基材，材料和装置，其包含多聚酯溶剂和附着于其上的效应化合物，其制备方法及其使用方法， ，生物应用，包括预防感染和各种疾病的治疗。
-
公开(公告)号：US07776024B2
公开(公告)日：2010-08-17
申请号：US11925507
申请日：2007-10-26
申请人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard, Jr.
发明人： John T. Santini, Jr. , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard, Jr.
IPC分类号： A61M31/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： Methods are provided for medical treatment or diagnosis of a patient. The method includes implanting into the patient a device which comprises (i) a substrate in which at least one reservoir is located and covered by a first reservoir cap, (ii) a drug or sensor located in the reservoir, and (iii) control circuitry and a power source for disintegrating or permeabilizing the reservoir cap, and (iv) an external interface to receive incident light energy; and directing focused light to the external interface of the implanted device to actuate disintegration or permeabilization of the reservoir cap to release the drug or expose the sensor. The device may implanted onto or into the sclera or other tissue surface of the eye of the patient. The focused light may be laser light, which may be used to transmit power or data to the device.
摘要翻译： 提供了用于治疗或诊断患者的方法。 该方法包括向患者植入一种装置，该装置包括：（i）至少一个储存器定位并被第一储存器盖覆盖的基底，（ii）位于储存器中的药物或传感器，以及（iii）控制电路 以及用于使储存器盖分解或渗透的电源，以及（iv）外部接口以接收入射光能; 并将聚焦的光引导到植入装置的外部界面以致驱动贮存器盖的分解或透化以释放药物或暴露传感器。 该装置可植入患者眼睛的巩膜或其他组织表面上或其中。 聚焦光可以是激光，其可以用于将功率或数据传输到设备。
-
公开(公告)号：US20100196492A1
公开(公告)日：2010-08-05
申请号：US12530330
申请日：2008-03-07
申请人： Jordan J. Green , Daniel G. Anderson , Robert S. Langer , Eugene Chiu , Elizaveta S. Leshchiner
发明人： Jordan J. Green , Daniel G. Anderson , Robert S. Langer , Eugene Chiu , Elizaveta S. Leshchiner
CPC分类号： C12N15/87 , A61K9/5146 , C12N2810/405
摘要： A system for electrostatically coating particles is provided. The system is particularly well suited for coating charged drug delivery particles (e.g., nanoparticles, microparticles) with a coating of opposite charge. The coating may include a targeting moiety such as a small molecule ligand, peptide, protein, aptamer, etc. The coated particles are biodegradable and/or biocompatible, have a near neutral zeta (ξ) potential, and are stable in serum. The invention also provides pharmaceutical compositions and kits including the inventive coated particles. Methods of preparing and using the inventive particles are also included.
摘要翻译： 提供了用于静电涂覆颗粒的系统。 该系统特别适合用具有相反电荷的涂层涂覆带电药物递送颗粒（例如，纳米颗粒，微粒）。 涂层可以包括靶向部分，例如小分子配体，肽，蛋白质，适体等。包被的颗粒是可生物降解的和/或生物相容的，具有接近中性的ζ（＆xgr）电位，并且在血清中是稳定的。 本发明还提供药物组合物和试剂盒，包括本发明的涂覆颗粒。 还包括制备和使用本发明颗粒的方法。
-
28.再颁专利Purification, composition and specificity of Heparinase I, II, and III from Flavobacterium heparinum 有权来自肝炎黄杆菌的肝素酶I，II和III的纯化，组成和特异性公开(公告)号：USRE41461E1
公开(公告)日：2010-07-27
申请号：US12199157
申请日：2008-08-27
申请人： Daniel L. Lohse , Robert J. Linhardt , Ramnath Sasisekharan , Charles L. Cooney , Robert S. Langer
发明人： Daniel L. Lohse , Robert J. Linhardt , Ramnath Sasisekharan , Charles L. Cooney , Robert S. Langer
CPC分类号： C12N9/88 , Y10S435/822 , Y10S435/85
摘要： A single, reproducible scheme to simultaneously purify all three of the heparin lyases from F. heparinum to apparent homogeneity is disclosed herein. The kinetic properties of the heparin lyases have been determined as well as the conditions to optimize their activity and stability. Mono-clonal antibodies to the three heparinases are also described and are useful for detection, isolation and characterization of the heparinases.
摘要翻译： 本文公开了将来自肝素肝素的所有三种肝素裂解酶同时纯化到表观均一性的单一可再现方案。 已经确定了肝素裂解酶的动力学性质以及优化其活性和稳定性的条件。 还描述了对三种肝素酶的单克隆抗体，并且其可用于肝素酶的检测，分离和表征。
-
29.发明授权Controlled release nanoparticle having bound oligonucleotide for targeted delivery 有权具有用于靶向递送的结合寡核苷酸的受控释放纳米颗粒公开(公告)号：US07727969B2
公开(公告)日：2010-06-01
申请号：US10456978
申请日：2003-06-06
IPC分类号： A61K31/7088 , A61K9/14 , C12Q1/68 , C12N11/08 , C12N11/04 , G01N33/545 , G01N33/549 , A61K38/00 , C07K17/04 , C07K17/08
CPC分类号： C12N15/87 , A61K9/1647 , A61K47/59 , A61K47/593 , A61K47/60 , A61K48/0041 , A61K48/0083 , Y10S530/817
摘要： The present invention relates to a conjugate that includes a nucleic acid ligand bound to a controlled release polymer system, a pharmaceutical composition that contains the conjugate, and methods of treatment using the conjugate. The controlled release polymer system includes an agent such as a therapeutic, diagnostic, prognostic, or prophylactic agent. The nucleic acid ligand that is bound to the controlled release polymer system, binds selectively to a target, such as a cell surface antigen, and thereby delivers the controlled release polymer system to the target.
摘要翻译： 本发明涉及包含与受控释放聚合物体系结合的核酸配体的缀合物，含有缀合物的药物组合物和使用该缀合物的治疗方法。 控释聚合物体系包括诸如治疗，诊断，预后或预防剂的试剂。 与受控释放聚合物体系结合的核酸配体选择性地结合到靶，例如细胞表面抗原，从而将受控释放的聚合物体系递送到靶。
-
公开(公告)号：US20100112026A1
公开(公告)日：2010-05-06
申请号：US12596405
申请日：2008-04-18
CPC分类号： A61L27/3808 , A61L27/34 , A61L27/507 , A61L27/54 , A61L27/58 , A61L31/005 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/25 , A61L2300/252 , A61L2400/06
摘要： In various aspects, the present invention provides surfaces and materials for cell rolling applications, methods of making such surfaces and materials, and devices having such surfaces and materials. In some embodiments, the present invention provides surfaces with at least partial coatings of an ordered layer of cell adhesion molecules, or fragments, analogs, or modifications thereof, covalently bound to the surface of the substrate through an immobilization moiety. In some embodiments, the layer of a cell adhesion molecules further comprises a cell modifying ligand that can be targeted, e.g., to one or more specific cell types.
摘要翻译： 在各个方面，本发明提供了用于电池轧制应用的表面和材料，制造这种表面和材料的方法，以及具有这种表面和材料的装置。 在一些实施方案中，本发明提供具有细胞粘附分子或其片段，类似物或修饰的有序层的至少部分涂层的表面，其通过固定部分共价结合到所述底物的表面。 在一些实施方案中，细胞粘附分子的层还包含可靶向例如一种或多种特定细胞类型的细胞修饰配体。
-
-
-
-
-
-
-
-
-
搜索结果
351 条记录 (耗时 0.065 秒)
