-
21.发明授权Device for two-dimensional gas-phase separation and characterization of ion mixtures 有权用于二维气相分离和表征离子混合物的装置公开(公告)号：US07148474B2
公开(公告)日：2006-12-12
申请号：US11103984
申请日：2005-04-11
CPC分类号： G01N27/624 , H01J49/004
摘要： The present invention relates to a device for separation and characterization of gas-phase ions. The device incorporates an ion source, a field asymmetric waveform ion mobility spectrometry (FAIMS) analyzer, an ion mobility spectrometry (IMS) drift tube, and an ion detector. In one aspect of the invention, FAIMS operating voltages are electrically floated on top of the IMS drift voltage. In the other aspect, the FAIMS/IMS interface is implemented employing an electrodynamic ion funnel, including in particular an hourglass ion funnel. The present invention improves the efficiency (peak capacity) and sensitivity of gas-phase separations; the online FAIMS/IMS coupling creates a fundamentally novel two-dimensional gas-phase separation technology with high peak capacity, specificity, and exceptional throughput.
摘要翻译： 本发明涉及气相离子的分离和表征装置。 该装置包括离子源，场非对称波形离子迁移谱（FAIMS）分析仪，离子迁移谱（IMS）漂移管和离子检测器。 在本发明的一个方面，FAIMS工作电压在IMS漂移电压的顶部被浮动。 另一方面，使用电动离子漏斗实现FAIMS / IMS接口，特别包括沙漏离子漏斗。 本发明提高气相分离的效率（峰值容量）和灵敏度; 在线FAIMS / IMS耦合产生了具有高峰值容量，特异性和卓越吞吐量的基本上新颖的二维气相分离技术。
-
公开(公告)号：US08772711B1
公开(公告)日：2014-07-08
申请号：US14011529
申请日：2013-08-27
CPC分类号： H01J49/063 , H01J49/0063
摘要： A method of dissociating ions in a multipole ion guide is disclosed. A stream of charged ions is supplied to the ion guide. A main RF field is applied to the ion guide to confine the ions through the ion guide. An excitation RF field is applied to one pair of rods of the ion guide. The ions undergo dissociation when the applied excitation RF field is resonant with a secular frequency of the ions. The multipole ion guide is, but not limited to, a quadrupole, a hexapole, and an octopole.
摘要翻译： 公开了一种在多极离子导向器中离解离子的方法。 将带电离子流供给到离子导向器。 将主RF场施加到离子导向器以将离子限制在离子导向器上。 激发RF场施加到离子导向器的一对杆上。 当所施加的激发RF场与离子的长期频率谐振时，离子发生解离。 多极离子导向器是但不限于四极，六极和八极。
-
23.发明授权Sheathless interface for coupling capillary electrophoresis with mass spectrometry 有权用于将毛细管电泳与质谱联用的无缝界面公开(公告)号：US08754370B1
公开(公告)日：2014-06-17
申请号：US13788854
申请日：2013-03-07
申请人： Chenchen Wang , Keqi Tang , Richard D. Smith
发明人： Chenchen Wang , Keqi Tang , Richard D. Smith
CPC分类号： H01J49/167 , G01N27/44713 , G01N30/7266
摘要： A sheathless interface for coupling capillary electrophoresis (CE) with mass spectrometry is disclosed. The sheathless interface includes a separation capillary for performing CE separation and an emitter capillary for electrospray ionization. A portion of the emitter capillary is porous or, alternatively, is coated to form an electrically conductive surface. A section of the emitter capillary is disposed within the separation capillary, forming a joint. A metal tube, containing a conductive liquid, encloses the joint.
摘要翻译： 公开了一种用于耦合毛细管电泳（CE）和质谱的无鞘界面。 无鞘界面包括用于进行CE分离的分离毛细管和用于电喷雾离子化的发射体毛细管。 发射管毛细管的一部分是多孔的，或者替代地，被涂覆以形成导电表面。 发射管毛细管的一部分设置在分离毛细管内，形成接头。 包含导电液体的金属管封闭接头。
-
公开(公告)号：US07491930B2
公开(公告)日：2009-02-17
申请号：US11617889
申请日：2006-12-29
CPC分类号： H01J49/004 , G01N27/624
摘要： Disclosed are a device and method for improved interfacing of differential mobility spectrometry (DMS) or field asymmetric waveform ion mobility spectrometry (FAIMS) analyzers of substantially planar geometry to subsequent or preceding instrument stages. Interfacing is achieved using curved DMS elements, where a thick ion beam emitted by planar DMS analyzers or injected into them for ion filtering is compressed to the gap median by DMS ion focusing effect in a spatially inhomogeneous electric field. Resulting thinner beams are more effectively transmitted through necessarily constrained conductance limit apertures to subsequent instrument stages operated at a pressure lower than DMS, and/or more effectively injected into planar DMS analyzers. The technology is synergetic with slit apertures, slit aperture/ion funnels, and high-pressure ion funnel interfaces known in the art which allow for increasing cross-sectional area of MS inlets. The invention may be used in integrated analytical platforms, including, e.g., DMS/MS, LC/DMS/MS, and DMS/IMS/MS that could replace and/or enhance current LC/MS methods, e.g., for proteomics research.
摘要翻译： 公开了一种用于改进基本平面几何形状的差分迁移率谱（DMS）或场非对称波形离子迁移谱（FAIMS）分析仪与随后或之前仪器级的接口的装置和方法。 使用弯曲的DMS元件实现接合，其中通过平面DMS分析仪发射或注入其中以进行离子过滤的厚离子束通过在空间不均匀电场中的DMS离子聚焦效应被压缩到间隙中间值。 所产生的较薄的梁更有效地通过必须约束的电导极限孔传输到在低于DMS的压力下操作的后续仪器级，和/或更有效地注入到平面DMS分析仪中。 该技术与本领域已知的狭缝孔，狭缝孔/离子漏斗和高压离子漏斗接口协同，允许增加MS入口的横截面面积。 本发明可以用于综合分析平台，包括例如DMS / MS，LC / DMS / MS和DMS / IMS / MS，其可以替代和/或增强当前的LC / MS方法，例如蛋白质组学研究。
-
公开(公告)号：US08907273B1
公开(公告)日：2014-12-09
申请号：US14292437
申请日：2014-05-30
申请人： Tsung-Chi Chen , Keqi Tang , Yehia M. Ibrahim , Richard D. Smith , Gordon A. Anderson , Erin M. Baker
发明人： Tsung-Chi Chen , Keqi Tang , Yehia M. Ibrahim , Richard D. Smith , Gordon A. Anderson , Erin M. Baker
IPC分类号： H01J49/06
CPC分类号： H01J49/062 , G01N27/622 , H01J49/06
摘要： An ion manipulation method and device is disclosed. The device includes a pair of substantially parallel surfaces. An array of inner electrodes is contained within, and extends substantially along the length of, each parallel surface. The device includes a first outer array of electrodes and a second outer array of electrodes. Each outer array of electrodes is positioned on either side of the inner electrodes, and is contained within and extends substantially along the length of each parallel surface. A DC voltage is applied to the first and second outer array of electrodes. A RF voltage, with a superimposed electric field, is applied to the inner electrodes by applying the DC voltages to each electrode. Ions either move between the parallel surfaces within an ion confinement area or along paths in the direction of the electric field, or can be trapped in the ion confinement area. A predetermined number of pairs of surfaces are disposed in one or more chambers, forming a multiple-layer ion mobility cyclotron device.
摘要翻译： 公开了一种离子操作方法和装置。 该装置包括一对基本平行的表面。 内部电极的阵列包含在每个平行表面内并且基本上沿着每个平行表面的长度延伸。 该装置包括电极的第一外部阵列和第二外部电极阵列。 每个外部电极阵列位于内部电极的任一侧上，并且基本上沿着每个平行表面的长度容纳并延伸。 DC电压施加到第一和第二外部电极阵列。 通过向每个电极施加直流电压，将具有叠加电场的RF电压施加到内部电极。 离子在离子限制区域内的平行表面之间或沿着电场方向的路径移动，或者可以被捕获在离子限制区域中。 预定数量的一对表面设置在一个或多个室中，形成多层离子迁移回旋加速器装置。
-
26.发明授权Platform for field asymmetric waveform ion mobility spectrometry with ion propulsion modes employing gas flow and electric field 有权具有采用气流和电场的离子推进模式的场非对称波形离子迁移谱的平台公开(公告)号：US08263930B2
公开(公告)日：2012-09-11
申请号：US12690818
申请日：2010-01-20
IPC分类号： H01J49/40
CPC分类号： G01N27/624
摘要： A differential ion mobility spectrometry or field asymmetric waveform ion mobility spectrometry (FAIMS) platform is disclosed that utilizes both gas flow and electric field, consecutively or simultaneously, to move ions through the analytical gap. The consecutive combination of flow and field enables rapid and flexible switching of the FAIMS stage “on” (for ion separation) and “off” (for high non-selective transmission) with no hardware modifications. This capability is needed for effective use of multidimensional instrument systems that couple FAIMS to mass spectrometry and/or conventional ion mobility spectrometry. The joint application of flow and field allows controlling the discrimination against high-mobility ions, maximizing it to remove the chemical noise or minimizing it to make the analyses of complex samples more predictable and uniform.
摘要翻译： 公开了差分离子迁移谱或场非对称波形离子迁移谱（FAIMS）平台，其利用气流和电场连续或同时地将离子移动通过分析间隙。 流程和现场的连续组合使得无需硬件修改即可快速灵活地切换FAIMS阶段（离子分离）和“关闭”（用于高非选择性传输）。 需要这种能力来有效利用将FAIMS耦合到质谱和/或常规离子迁移谱的多维仪器系统。 流量和场的联合应用允许控制对高迁移率离子的鉴别，使其最大化以消除化学噪声或使其最小化，使得复杂样品的分析更可预测和均匀。
-
27.发明授权Method and apparatus for ion mobility spectrometry with alignment of dipole direction (IMS-ADD) 有权用于偶极方向对准的离子迁移光谱法的方法和装置（IMS-ADD）公开(公告)号：US07170053B2
公开(公告)日：2007-01-30
申请号：US11097855
申请日：2005-03-31
IPC分类号： H01J49/40
CPC分类号： G01N27/624 , H01J49/004 , H01J49/40
摘要： Techniques and instrumentation are described for analyses of substances, including complex samples/mixtures that require separation prior to characterization of individual components. A method is disclosed for separation of ion mixtures and identification of ions, including protein and other macromolecular ions and their different structural isomers. Analyte ions are not free to rotate during the separation, but are substantially oriented with respect to the drift direction. Alignment is achieved by applying, at a particular angle to the drift field, a much stronger alternating electric field that “locks” the ion dipoles with moments exceeding a certain value. That value depends on the buffer gas composition, pressure, and temperature, but may be as low as ˜3 Debye under certain conditions. The presently disclosed method measures the direction-specific cross-sections that provide the structural information complementing that obtained from known methods, and, when coupled to those methods, increases the total peak capacity and specificity of gas-phase separations. Simultaneous 2-D separations by direction-specific cross sections along and orthogonally to the ion dipole direction are also possible.
摘要翻译： 描述了用于分析物质的技术和仪器，包括在表征单个组分之前需要分离的复杂样品/混合物。 公开了用于分离离子混合物和鉴定离子的方法，包括蛋白质和其它大分子离子及其不同的结构异构体。 分离离子在分离期间不能自由旋转，而是基本上相对于漂移方向取向。 通过以特定的角度对漂移场施加更强的交变电场来实现对准，所述交变电场通过超过一定值的力矩“锁定”离子偶极子。 该值取决于缓冲气体组成，压力和温度，但在某些条件下可能低至〜3德拜。 目前公开的方法测量提供与已知方法获得的结构信息互补的方向特异性横截面，并且当与这些方法耦合时，增加气相分离的总峰容量和特异性。 沿垂直于离子偶极方向的方向特定横截面同时进行2-D分离也是可能的。
-
公开(公告)号：US06979816B2
公开(公告)日：2005-12-27
申请号：US10400356
申请日：2003-03-25
CPC分类号： H01J49/066 , H01J49/107 , H01J49/165
摘要： A method for introducing ions generated in a region of relatively high pressure into a region of relatively low pressure by providing at least two electrospray ion sources, providing at least two capillary inlets configured to direct ions generated by the electrospray sources into and through each of the capillary inlets, providing at least two sets of primary elements having apertures, each set of elements having a receiving end and an emitting end, the primary sets of elements configured to receive a ions from the capillary inlets at the receiving ends, and providing a secondary set of elements having apertures having a receiving end and an emitting end, the secondary set of elements configured to receive said ions from the emitting end of the primary sets of elements and emit said ions from said emitting end of the secondary set of elements. The method may further include the step of providing at least one jet disturber positioned within at least one of the sets of primary elements, providing a voltage, such as a dc voltage, in the jet disturber, thereby adjusting the transmission of ions through at least one of the sets of primary elements.
摘要翻译： 一种通过提供至少两个电喷雾离子源将相对较高压力区域产生的离子引入至少两个电喷雾离子源的方法，提供至少两个毛细管入口，其构造成将由电喷雾源产生的离子引入和穿过每个 毛细管入口，提供具有孔的至少两组主要元件，每组元件具有接收端和发射端，所述主要元件组被配置为在接收端处从毛细管入口接收离子，并且提供次级 具有孔的一组元件具有接收端和发射端，所述次级元件被配置为从所述主要元件组的发射端接收所述离子，并从所述次级元件组的所述发射端发射所述离子。 该方法还可以包括提供位于主要元件组中的至少一个中的至少一个喷射干燥器的步骤，在喷射干燥器中提供诸如直流电压的电压，从而通过至少调节离子的透过率 其中一个主要元素。
-
29.发明授权公开(公告)号：US06967325B2
公开(公告)日：2005-11-22
申请号：US10933661
申请日：2004-09-02
CPC分类号： H01J49/066 , G01N27/622 , H01J49/40
摘要： A method and apparatus enabling increased sensitivity in ion mobility spectrometry/mass spectrometry instruments which substantially reduces or eliminates the loss of ions in ion mobility spectrometer drift tubes utilizing a device for transmitting ions from an ion source which allows the transmission of ions without significant delay to an hourglass electrodynamic ion funnel at the entrance to the drift tube and/or an internal ion funnel at the exit of the drift tube. An hourglass electrodynamic funnel is formed of at least an entry element, a center element, and an exit element, wherein the aperture of the center element is smaller than the aperture of the entry element and the aperture of the exit elements. Ions generated in a relatively high pressure region by an ion source at the exterior of the hourglass electrodynamic funnel are transmitted to a relatively low pressure region at the entrance of the hourglass funnel through a conductance limiting orifice. Alternating and direct electrical potentials are applied to the elements of the hourglass electrodynamic funnel thereby drawing ions into and through the hourglass electrodynamic funnel thereby introducing relatively large quantities of ions into the drift tube while maintaining the gas pressure and composition at the interior of the drift tube as distinct from those at the entrance of the electrodynamic funnel and allowing a positive gas pressure to be maintained within the drift tube, if desired. An internal ion funnel is provided within the drift tube and is positioned at the exit of said drift tube. The advantage of the internal ion funnel is that ions that are dispersed away from the exit aperture within the drift tube, such as those that are typically lost in conventional drift tubes to any subsequent analysis or measurement, are instead directed through the exit of the drift tube, vastly increasing the amount of ions exiting the drift tube.
-
公开(公告)号：US06831274B2
公开(公告)日：2004-12-14
申请号：US10091833
申请日：2002-03-05
申请人： Richard D. Smith , Keqi Tang , Yuehe Lin
发明人： Richard D. Smith , Keqi Tang , Yuehe Lin
IPC分类号： B01D5944
CPC分类号： H01J49/165 , H01J49/0018 , H01J49/107
摘要： A method and apparatus that utilizes two or more emitters simultaneously to form an electrospray of a sample that is then directed into a mass spectrometer, thereby increasing the total ion current introduced into an electrospray ionization mass spectrometer, given a liquid flow rate of a sample. The method and apparatus are most conveniently constructed as an array of spray emitters fabricated on a single chip, however, the present invention encompasses any apparatus wherein two or more emitters are simultaneously utilized to form an electrospray of a sample that is then directed into a mass spectrometer.
摘要翻译： 同时使用两个或更多个发射体形成样品的电喷雾的方法和装置，该样品的电喷雾随后被引导到质谱仪中，从而在给定样品的液体流速的情况下增加引入电喷雾离子化质谱仪中的总离子电流。 该方法和装置最方便地构造为在单个芯片上制造的喷射发射体的阵列，然而，本发明包括其中两个或更多个发射体同时用于形成样品的电喷雾的任何装置，然后将其引导到质量 光谱仪
-
-
-
-
-
-
-
-
-
搜索结果
43 条记录 (耗时 0.029 秒)
