公开(公告)号：US06831274B2

公开(公告)日：2004-12-14

申请号：US10091833

申请日：2002-03-05

申请人： Richard D. Smith ,  Keqi Tang ,  Yuehe Lin

发明人： Richard D. Smith ,  Keqi Tang ,  Yuehe Lin

IPC分类号： B01D5944

CPC分类号： H01J49/165 ,  H01J49/0018 ,  H01J49/107

摘要： A method and apparatus that utilizes two or more emitters simultaneously to form an electrospray of a sample that is then directed into a mass spectrometer, thereby increasing the total ion current introduced into an electrospray ionization mass spectrometer, given a liquid flow rate of a sample. The method and apparatus are most conveniently constructed as an array of spray emitters fabricated on a single chip, however, the present invention encompasses any apparatus wherein two or more emitters are simultaneously utilized to form an electrospray of a sample that is then directed into a mass spectrometer.

摘要翻译： 同时使用两个或更多个发射体形成样品的电喷雾的方法和装置，该样品的电喷雾随后被引导到质谱仪中，从而在给定样品的液体流速的情况下增加引入电喷雾离子化质谱仪中的总离子电流。 该方法和装置最方便地构造为在单个芯片上制造的喷射发射体的阵列，然而，本发明包括其中两个或更多个发射体同时用于形成样品的电喷雾的任何装置，然后将其引导到质量 光谱仪

公开(公告)号：US5840193A

公开(公告)日：1998-11-24

申请号：US686422

申请日：1996-07-26

申请人： Neil G. Smart ,  Chien M. Wai ,  Yuehe Lin ,  Yak Hwa Kwang

发明人： Neil G. Smart ,  Chien M. Wai ,  Yuehe Lin ,  Yak Hwa Kwang

IPC分类号： B09B3/00 ,  C22B3/16 ,  C22B3/20 ,  C22B3/26 ,  C22B3/38 ,  C22B7/00 ,  B01D11/00 ,  B01D11/02

CPC分类号： C22B3/0005 ,  C22B3/0043 ,  C22B7/006 ,  Y02P10/234 ,  Y10S210/909 ,  Y10S210/912

摘要： Methods for extracting metalloid and metal species from a solid or liquid material by exposing the material to a fluid solvent, particularly supercritical CO.sub.2, and a chelating agent are described. The chelating agent forms a chelate with the species, the chelate being soluble in the fluid to allow removal of the species from the material. In preferred embodiments the extraction solvent is supercritical CO.sub.2 and the chelating agent comprises an organophosphorous chelating agent, particularly sulfur-containing organophosphorous chelating agents, including mixtures of chelating agents. Examples of chelating agents include monothiophosphinic acid, di-thiophosphinic acid, phosphine sulfite, phosphorothioic acid, and mixtures thereof. The method provides an environmentally benign process for removing metal and metalloids from industrial waste solutions, particularly acidic solutions. Both the chelate and the supercritical fluid can be regenerated and the contaminant species recovered to provide an economic, efficient process.

摘要翻译： 描述了通过将材料暴露于流体溶剂，特别是超临界CO 2和螯合剂从固体或液体材料中提取准金属和金属物质的方法。 螯合剂与物质形成螯合物，螯合物可溶于流体以允许物质从材料中除去。 在优选的实施方案中，提取溶剂是超临界CO 2，螯合剂包括有机磷螯合剂，特别是含硫的有机磷螯合剂，包括螯合剂的混合物。 螯合剂的实例包括一硫代次膦酸，二硫代次膦酸，亚硫酸氢钠，硫代磷酸及其混合物。 该方法提供了一种从工业废物溶液，特别是酸性溶液中去除金属和准金属的环境友好方法。 螯合物和超临界流体都可以再生并且回收污染物质以提供经济，有效的方法。

公开(公告)号：US07122106B2

公开(公告)日：2006-10-17

申请号：US10154935

申请日：2002-05-23

申请人： Yuehe Lin ,  Liang Liang ,  Jun Liu

发明人： Yuehe Lin ,  Liang Liang ,  Jun Liu

IPC分类号： C25B1/00 ,  C25B3/00 ,  C25D15/00 ,  C25D5/48 ,  C25D11/00

CPC分类号： B82Y30/00 ,  C09D5/4476 ,  C25D9/00

摘要： A method for producing an array of oriented nanofibers that involves forming a solution that includes at least one electroactive species. An electrode substrate is brought into contact with the solution. A current density is applied to the electrode substrate that includes at least a first step of applying a first substantially constant current density for a first time period and a second step of applying a second substantially constant current density for a second time period. The first and second time periods are of sufficient duration to electrically deposit on the electrode substrate an array of oriented nanofibers produced from the electroactive species. Also disclosed are films that include arrays or networks of oriented nanofibers and a method for amperometrically detecting or measuring at least one analyte in a sample.

公开(公告)号：US6132491A

公开(公告)日：2000-10-17

申请号：US137563

申请日：1998-08-20

申请人： Chien M. Wai ,  Fred H. Hunt ,  Neil G. Smart ,  Yuehe Lin

发明人： Chien M. Wai ,  Fred H. Hunt ,  Neil G. Smart ,  Yuehe Lin

IPC分类号： C22B3/00 ,  B22F9/24 ,  B22F9/26 ,  B22F9/30 ,  C01B13/18 ,  C01G19/02 ,  C01G23/053 ,  C01G53/04 ,  C22B3/22 ,  C22B3/26 ,  C23C16/44 ,  C23C16/448 ,  C21B15/00 ,  C22B15/00

CPC分类号： B22F9/26 ,  B22F9/24 ,  B22F9/30 ,  B82Y30/00 ,  C01B13/18 ,  C01G19/02 ,  C01G23/0536 ,  C01G53/04 ,  C22B3/0021 ,  C22B3/22 ,  C23C16/4485 ,  B22F2999/00 ,  C01P2004/03 ,  C01P2004/10 ,  C01P2004/54 ,  C01P2004/62 ,  C01P2004/64 ,  C01P2006/10 ,  Y02P10/234 ,  Y02P20/544

摘要： A method for dissociating metal-ligand complexes in a supercritical fluid by treating the metal-ligand complex with heat and/or reducing or oxidizing agents is described. Once the metal-ligand complex is dissociated, the resulting metal and/or metal oxide form fine particles of substantially uniform size. In preferred embodiments, the solvent is supercritical carbon dioxide and the ligand is a .beta.-diketone such as hexafluoroacetylacetone or dibutyldiacetate. In other preferred embodiments, the metals in the metal-ligand complex are copper, silver, gold, tungsten, titanium, tantalum, tin, or mixtures thereof. In preferred embodiments, the reducing agent is hydrogen. The method provides an efficient process for dissociating metal-ligand complexes and produces easily-collected metal particles free from hydrocarbon solvent impurities. The ligand and the supercritical fluid can be regenerated to provide an economic, efficient process.

摘要翻译： 描述了通过用热和/或还原或氧化剂处理金属 - 配体络合物来解离超临界流体中的金属 - 配体络合物的方法。 一旦金属 - 配体络合物解离，所得到的金属和/或金属氧化物就形成基本上均匀尺寸的细颗粒。 在优选的实施方案中，溶剂是超临界二氧化碳，配体是β-二酮如六氟乙酰丙酮或二丁基二乙酸酯。 在其它优选实施方案中，金属 - 配体络合物中的金属是铜，银，金，钨，钛，钽，锡或它们的混合物。 在优选的实施方案中，还原剂是氢。 该方法提供了解离金属 - 配体络合物的有效方法，并产生容易收集的不含烃溶剂杂质的金属颗粒。 可以再生配体和超临界流体以提供经济，有效的方法。

公开(公告)号：US5792357A

公开(公告)日：1998-08-11

申请号：US692894

申请日：1996-07-26

申请人： Chien M. Wai ,  Neil G. Smart ,  Yuehe Lin

发明人： Chien M. Wai ,  Neil G. Smart ,  Yuehe Lin

IPC分类号： C22B3/16 ,  B01D11/02 ,  B01D11/04 ,  C22B3/02 ,  C22B3/26 ,  C22B59/00 ,  C22B60/02 ,  B01D11/00

CPC分类号： C22B59/00 ,  B01D11/0203 ,  B01D11/0407 ,  C22B3/0005 ,  C22B3/002 ,  C22B3/02 ,  C22B60/02 ,  Y02P10/234 ,  Y10S210/912

摘要： A method of extracting metal and metalloid species from a solid or liquid substrate using a supercritical fluid solvent containing one or more chelating agents followed by back-extracting the metal and metalloid species from the metal and metalloid chelates formed thereby. The back-extraction acidic solution is performed utilizing an acidic solution. Upon sufficient exposure of the metal and metalloid chelates to the acidic solution, the metal and metalloid species are released from the chelates into the acid solution, while the chelating agent remains in the supercritical fluid solvent. The chelating agent is thereby regenerated and the metal and metalloid species recovered.

摘要翻译： 一种使用含有一种或多种螯合剂的超临界流体溶剂从固体或液体底物中提取金属和准金属物质的方法，随后从由此形成的金属和类金属螯合物中反萃取金属和准金属物质。 使用酸性溶液进行反萃取的酸性溶液。 当金属和准金属螯合物充分暴露于酸性溶液时，金属和准金属物质从螯合物中释放到酸性溶液中，而螯合剂保留在超临界流体溶剂中。 从而再生螯合剂，回收金属和准金属物质。

公开(公告)号：US5770085A

公开(公告)日：1998-06-23

申请号：US458759

申请日：1995-06-02

申请人： Chien M. Wai ,  Neil G. Smart ,  Yuehe Lin

发明人： Chien M. Wai ,  Neil G. Smart ,  Yuehe Lin

IPC分类号： B01D11/02 ,  B01D11/04 ,  B08B7/00 ,  B09C1/02 ,  G21F9/12 ,  B01D11/00

CPC分类号： G21F9/125 ,  B01D11/0203 ,  B01D11/0407 ,  B08B7/0021 ,  B09C1/02 ,  Y10S210/912

摘要： A method of extracting metalloid and metal species from a solid or liquid material by exposing the material to a fluid solvent, particularly supercritical carbon dioxide, containing a chelating agent is described. The chelating agent forms chelates that are soluble in the fluid to allow removal of the species from the material. In preferred embodiments, the extraction solvent is supercritical carbon dioxide and the chelating agent comprises a trialkyl phosphate, a triaryl phosphate, a trialkylphosphine oxide, a triarylphosphine oxide, or mixtures thereof. The method provides an environmentally benign process for removing contaminants from industrial waste. The method is particularly useful for extracting actinides from acidic solutions, and the process can be aided by the addition of nitrate salts. The chelate and supercritical fluid can be regenerated, and the contaminant species recovered, to provide an economic, efficient process.

摘要翻译： 描述了通过将材料暴露于含有螯合剂的流体溶剂，特别是超临界二氧化碳，从固体或液体材料中提取准金属和金属物质的方法。 螯合剂形成可溶于流体中的螯合物，以允许物质从材料中除去。 在优选的实施方案中，提取溶剂是超临界二氧化碳，螯合剂包括磷酸三烷基酯，磷酸三芳基酯，三烷基氧化膦，三芳基氧化膦或其混合物。 该方法为从工业废物中除去污染物提供了环境友好的过程。 该方法特别适用于从酸性溶液中萃取锕系元素，该方法可以通过加入硝酸盐来辅助。 可以再生螯合物和超临界流体，回收污染物质，以提供经济，有效的方法。

公开(公告)号：US20090288962A1

公开(公告)日：2009-11-26

申请号：US12427431

申请日：2009-04-21

申请人： Wassana Yantasee ,  Glen E. Fryxell ,  Raymond S. Addleman ,  Yuehe Lin ,  Charles Timchalk

发明人： Wassana Yantasee ,  Glen E. Fryxell ,  Raymond S. Addleman ,  Yuehe Lin ,  Charles Timchalk

IPC分类号： G01N27/30 ,  B05D5/12 ,  G01N27/26

CPC分类号： G01N27/42 ,  G01N33/1813 ,  G01N33/493 ,  G01N2610/00

摘要： A mercury-free, electrochemical sensor is described that includes a self-assembled monolayer on a mesoporous support (SAMMS) composite and a fluoropolymer component that is deposited on a measurement surface. The SAMMS component provides outstanding metal preconcentration. The fluoropolymer component acts as an antifouling binder. The sensor can detect various metals at a low detection level in the presence of fouling agents and without sample pretreatment. The sensor is also able to detect mixtures of metals simultaneously with excellent single and inter-electrode reproducibility. Service lifetimes are excellent.

摘要翻译： 描述了一种无汞电化学传感器，其包括介孔载体（SAMMS）复合材料上的自组装单层和沉积在测量表面上的含氟聚合物组分。 SAMMS组件提供卓越的金属预浓缩。 氟聚合物组分用作防污粘合剂。 传感器可以在存在污染物的情况下检测低检测水平的各种金属，并且无需样品预处理。 传感器还能够同时检测金属的混合物，具有优异的单电极和电极间再现性。 使用寿命很好。

公开(公告)号：US20080292545A1

公开(公告)日：2008-11-27

申请号：US12062745

申请日：2008-04-04

申请人： Yuehe Lin ,  Guodong Liu ,  Hong Wu ,  Jun Wang ,  Darrell R. Fisher

发明人： Yuehe Lin ,  Guodong Liu ,  Hong Wu ,  Jun Wang ,  Darrell R. Fisher

IPC分类号： A61K9/14 ,  A61K39/395 ,  A61K39/00 ,  A61K38/00 ,  A61K31/7088 ,  A61K51/08 ,  A61K49/04 ,  A61K49/14 ,  A61K49/00 ,  G01N33/53 ,  C12Q1/68

CPC分类号： A61K31/7088 ,  A61K9/5169 ,  A61K47/6929 ,  A61K48/00 ,  A61K51/1244 ,  B82Y5/00 ,  G01N33/5438 ,  G01N33/585

摘要： Apoferritin nanoparticles with functionalized surfaces have been prepared that include preselected agents within the cavity of the apoferritin molecule and preselected functionalized surface characteristics on the outer surface of the nanoparticle. Such materials provide for utilization and selective modification in a variety of applications including therapeutic and diagnostic uses. Examples of several of these applications are described herein. In addition a method for the creation of these materials by alternatively assembling, functionalizing, or functionalizing, disassembling and reassemblying the materials provides for creative customization of various types of materials applicable for varying types of applications which are also described herein.

摘要翻译： 已经制备了具有官能化表面的中铁素体纳米颗粒，其包括脱铁铁蛋白分子的腔内的预选药剂和纳米颗粒外表面上的预选的官能化表面特征。 这些材料提供了在各种应用中的利用和选择性修饰，包括治疗和诊断用途。 这里描述了几个这些应用的示例。 此外，通过交替地组装，功能化或功能化，拆卸和重新组装材料来创建这些材料的方法提供了适用于本文中描述的不同类型的应用的各种类型的材料的创造性定制。

公开(公告)号：US20060021879A1

公开(公告)日：2006-02-02

申请号：US11233632

申请日：2005-09-22

申请人： Yuehe Lin ,  Liang Liang ,  Jun Liu

发明人： Yuehe Lin ,  Liang Liang ,  Jun Liu

IPC分类号： C25D11/00 ,  C25D15/00

CPC分类号： B82Y30/00 ,  C09D5/4476 ,  C25D9/00

摘要： A method for producing an array of oriented nanofibers that involves forming a solution that includes at least one electroactive species. An electrode substrate is brought into contact with the solution. A current density is applied to the electrode substrate that includes at least a first step of applying a first substantially constant current density for a first time period and a second step of applying a second substantially constant current density for a second time period. The first and second time periods are of sufficient duration to electrically deposit on the electrode substrate an array of oriented nanofibers produced from the electroactive species. Also disclosed are films that include arrays or networks of oriented nanofibers and a method for amperometrically detecting or measuring at least one analyte in a sample.

公开(公告)号：US06699384B1

公开(公告)日：2004-03-02

申请号：US09667034

申请日：2000-09-20

申请人： Yuehe Lin ,  Wendy D. Bennett ,  Charles Timchalk ,  Karla D. Thrall

发明人： Yuehe Lin ,  Wendy D. Bennett ,  Charles Timchalk ,  Karla D. Thrall

IPC分类号： G01N27327

CPC分类号： B01F13/0064 ,  B01D61/28 ,  B01D63/08 ,  B01D63/081 ,  B01F5/0475 ,  B01F5/048 ,  B01F5/0604 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0094 ,  B01F2215/0431 ,  B01J19/0093 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/10 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2400/0439

摘要： Microanalytical systems based on a microfluidics/electrochemical detection scheme are described. Individual modules, such as microfabricated piezoelectrically actuated pumps and a microelectrochemical cell were integrated onto portable platforms. This allowed rapid change-out and repair of individual components by incorporating “plug and play” concepts now standard in PC's. Different integration schemes were used for construction of the microanalytical systems based on microfluidics/electrochemical detection. In one scheme, all individual modules were integrated in the surface of the standard microfluidic platform based on a plug-and-play design. Microelectrochemical flow cell which integrated three electrodes based on a wall-jet design was fabricated on polymer substrate. The microelectrochemical flow cell was then plugged directly into the microfluidic platform. Another integration scheme was based on a multilayer lamination method utilizing stacking modules with different functionality to achieve a compact microanalytical device. Application of the microanalytical system for detection of lead in, for example, river water and saliva samples using stripping voltammetry is described.

摘要翻译： 描述了基于微流体/电化学检测方案的微量分析系统。 单个模块，如微加压压电泵和微电化学电池集成到便携式平台上。 这允许通过在PC中组合“即插即用”概念来快速更换和修复各个组件。 基于微流体/电化学检测的微分析系统的构建使用了不同的集成方案。 在一个方案中，基于即插即用设计将所有单个模块集成在标准微流体平台的表面中。 在聚合物基板上制造基于壁喷射设计集成三个电极的微电化学流动池。 然后将微电化学流动池直接插入微流体平台。 另一种集成方案基于利用具有不同功能的堆叠模块的多层层压方法来实现紧凑的微量分析装置。 描述了使用溶出伏安法在例如河水和唾液样品中检测铅的微量分析系统的应用。