公开(公告)号：US20130210045A1

公开(公告)日：2013-08-15

申请号：US13805449

申请日：2011-08-22

申请人： Yosky Kataoka ,  Guanghua Jin ,  Yasuyoshi Watanabe ,  Seiki Tajima ,  Tomoyoshi Soga ,  Hirohiko Kuratsune ,  Emi Yamano

发明人： Yosky Kataoka ,  Guanghua Jin ,  Yasuyoshi Watanabe ,  Seiki Tajima ,  Tomoyoshi Soga ,  Hirohiko Kuratsune ,  Emi Yamano

IPC分类号： C12Q1/54 ,  C12Q1/34 ,  C12Q1/527 ,  C12Q1/32 ,  C12Q1/48 ,  C12Q1/52

CPC分类号： C12Q1/54 ,  C12Q1/32 ,  C12Q1/34 ,  C12Q1/485 ,  C12Q1/52 ,  C12Q1/527 ,  G01N33/50 ,  G01N2570/00 ,  G01N2800/306

摘要： Ratios of measured values of glucose, citrate, and cis-aconitate in a biological sample obtained from a subject to measured values of glucose, citrate, and cis-aconitate in a biological sample obtained from a healthy subject are calculated, and the glucose ratio, the citrate ratio, and the cis-aconitate ratio are used to evaluate and/or assess fatigue. Similarly, an isocitrate ratio, a succinate ratio, a malate ratio, and a lactate ratio are calculated, and these ratios are used together with the three ratios to evaluate and/or assess fatigue. This makes it possible to objectively and easily diagnose and evaluate fatigue.

摘要翻译： 计算从受试者获得的生物样品中的葡萄糖，柠檬酸盐和顺式乌头酸的测量值与从健康受试者获得的生物样品中的葡萄糖，柠檬酸盐和顺式乌头酸的测量值的比例， 柠檬酸盐比例和顺式乌头酸比率用于评估和/或评估疲劳。 类似地，计算异柠檬酸酯比例，琥珀酸酯比例，苹果酸酯比例和乳酸盐比例，并且将这些比率与三种比率一起使用以评估和/或评估疲劳。 这使得客观，轻松地诊断和评估疲劳成为可能。

公开(公告)号：US20120128588A1

公开(公告)日：2012-05-24

申请号：US13387753

申请日：2010-07-29

申请人： Misato Takashima ,  Miho Shukuri ,  Miki Goto ,  Hisashi Doi ,  Hirotaka Onoe ,  Masaaki Suzuki ,  Yasuyoshi Watanabe

发明人： Misato Takashima ,  Miho Shukuri ,  Miki Goto ,  Hisashi Doi ,  Hirotaka Onoe ,  Masaaki Suzuki ,  Yasuyoshi Watanabe

IPC分类号： A61K51/04 ,  C07C69/612 ,  C07C57/30 ,  C07C69/616

CPC分类号： A61K31/192 ,  A61K49/0433 ,  A61K51/04 ,  A61K51/0402 ,  C07B59/001 ,  C07B2200/05 ,  C07B2200/07 ,  C07C57/30 ,  C07C57/58 ,  C07C59/64 ,  C07C59/68 ,  C07C59/84 ,  C07C59/86 ,  C07C69/612 ,  C07C69/65 ,  C07C69/734 ,  C07C69/736 ,  C07C69/738 ,  C07C2601/08

摘要： Disclosed are: labeled NSAIDs compounds which can be produced within a short time, can be used suitably for a PET method, and enable the imaging of cyclooxygenase-2; and a process for producing the labeled NSAIDs compounds. Specifically disclosed are isotope-labeled 2-arylpropionic acid compounds, each of which is a compound represented by general formula (1) (wherein Ar represents an aryl group which may have a substituent; R1 represents anyone selected from 11CH3, CH218F and CF218F; and R2 represents a hydrogen atom, or an alkyl group which may have a branch, wherein a compound wherein Ar is a benzene ring, R1 is 11CH3, and R2 is a hydrogen atom is excluded), or a pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof.

摘要翻译： 公开的是：可以在短时间内生产的标记的NSAIDs化合物可以适用于PET方法，并且能够进行环氧合酶-2的成像; 以及生产标记的NSAIDs化合物的方法。 具体公开的是同位素标记的2-芳基丙酸化合物，其各自为通式（1）表示的化合物（其中Ar表示可具有取代基的芳基; R1表示选自11CH3，CH218F和CF218F的任何一种; R2表示氢原子或可具有支链的烷基，其中Ar为苯环，R1为11CH3，R2为氢原子的化合物除外），或其药学上可接受的盐，水合物，溶剂合物或 前药。

公开(公告)号：US07910328B2

公开(公告)日：2011-03-22

申请号：US11984901

申请日：2007-11-26

申请人： Takao Shimizu ,  Koji Kishimoto ,  Yasuyoshi Watanabe

发明人： Takao Shimizu ,  Koji Kishimoto ,  Yasuyoshi Watanabe

IPC分类号： C12P21/06 ,  C12N15/00 ,  C12N5/00 ,  C07H21/02 ,  C07H21/04 ,  C07K14/00

CPC分类号： C12N9/20

摘要： Novel calcium-independent phospholipases A2; genes encoding the same; an antibody against them; an inherent promoter or a regulator gene which comprises a base sequence occurring in intron and inducing site-specific expression in response to an external stimulus; a method of expressing a target protein in response to an external stimulus; and an organism having this gene transferred thereinto. Novel calcium-independent phospholipases A2 having an amino acid sequence represented by SEQ ID NO: 1, 3 or 5 or an amino acid sequence derived from such an amino acid sequence by the substitution, deletion or addition of one or more amino acids; a gene having a base sequence occurring in an intron and being capable of initiating RNA transcription due to an external stimulus such as a stimulus with kainic acid or an electrical stimulus; a method of regulating expression by using the gene; and an organism having the gene transferred thereinto.

摘要翻译： 新型钙依赖性磷脂酶A2; 编码基因的基因; 抗体; 固有的启动子或调节基因，其包含在内含子中出现的碱基序列并响应于外部刺激诱导位点特异性表达; 响应于外部刺激而表达靶蛋白的方法; 和转移有该基因的生物体。 具有由SEQ ID NO：1,3或5表示的氨基酸序列的新型钙依赖性磷脂酶A2或通过取代，缺失或添加一个或多个氨基酸衍生自该氨基酸序列的氨基酸序列; 具有在内含子中存在的碱基序列并且能够由于诸如用红藻氨酸或电刺激的刺激的外部刺激引发RNA转录的基因; 通过使用该基因调节表达的方法; 以及将基因转移到其中的生物体。

公开(公告)号：US20090094954A1

公开(公告)日：2009-04-16

申请号：US12084986

申请日：2006-12-28

申请人： Tsuruo Nakayama ,  Youhei Jikjhara ,  Yasuyoshi Watanabe ,  Nobukazu Motojima

发明人： Tsuruo Nakayama ,  Youhei Jikjhara ,  Yasuyoshi Watanabe ,  Nobukazu Motojima

IPC分类号： B32B5/16 ,  B01D39/16

CPC分类号： C08J7/045 ,  C08K3/22 ,  C08K9/06 ,  C09D5/1618 ,  C09D7/62 ,  D06M13/5135 ,  D06M15/277 ,  D06M23/08 ,  D06M2400/01 ,  Y10T428/254 ,  Y10T428/259 ,  Y10T428/31663 ,  Y10T442/218 ,  Y10T442/2287

摘要： [Object] To provide a dustproof, antifouling, and highly durable composite material.[Solving Means] An inorganic fine particle layer containing inorganic fine particles and a binder component is formed on a surface of a substrate by chemical bonding. The inorganic fine particles are coated with silane monomer each having an unsaturated bond. The content of the binder component is in the range of 0.1% by mass to 40% by mass to the content of the inorganic fine particles.

摘要翻译： [对象]提供防尘，防污，高耐用的复合材料。 [解决方案]通过化学键合在基板的表面上形成含有无机微粒和粘合剂成分的无机微粒层。 无机细颗粒涂覆有各自具有不饱和键的硅烷单体。 粘合剂成分的含量相对于无机微粒的含量为0.1质量％〜40质量％。

公开(公告)号：US4778794A

公开(公告)日：1988-10-18

申请号：US870495

申请日：1986-06-04

申请人： Hiroshi Naruse ,  Masashi Takesada ,  Osamu Hayaishi ,  Yasuyoshi Watanabe

发明人： Hiroshi Naruse ,  Masashi Takesada ,  Osamu Hayaishi ,  Yasuyoshi Watanabe

IPC分类号： C07D475/04 ,  A61K31/40 ,  A61K31/505 ,  A61K31/519 ,  A61P25/00 ,  A61P25/18 ,  A61P43/00 ,  A61K31/50 ,  A61K31/495

CPC分类号： A61K31/505

摘要： A pharmaceutical composition for the treatment of infantile autism which contains tetrahydrobiopterin or a derivative thereof as a major effective ingredient and 5-hydroxytryptophan and/or L-DOPA as an optional auxiliary effective ingredient is provided.

摘要翻译： 提供了一种用于治疗婴幼儿自闭症的药物组合物，其包含四氢生物蝶呤或其衍生物作为主要有效成分和5-羟色氨酸和/或L-DOPA作为任选的辅助有效成分。

公开(公告)号：US08778298B2

公开(公告)日：2014-07-15

申请号：US13387753

申请日：2010-07-29

申请人： Misato Takashima ,  Miho Shukuri ,  Miki Goto ,  Hisashi Doi ,  Hirotaka Onoe ,  Masaaki Suzuki ,  Yasuyoshi Watanabe

发明人： Misato Takashima ,  Miho Shukuri ,  Miki Goto ,  Hisashi Doi ,  Hirotaka Onoe ,  Masaaki Suzuki ,  Yasuyoshi Watanabe

IPC分类号： A61K51/00 ,  A61M36/14 ,  A61K31/192 ,  A61K49/04 ,  A61K51/04

CPC分类号： A61K31/192 ,  A61K49/0433 ,  A61K51/04 ,  A61K51/0402 ,  C07B59/001 ,  C07B2200/05 ,  C07B2200/07 ,  C07C57/30 ,  C07C57/58 ,  C07C59/64 ,  C07C59/68 ,  C07C59/84 ,  C07C59/86 ,  C07C69/612 ,  C07C69/65 ,  C07C69/734 ,  C07C69/736 ,  C07C69/738 ,  C07C2601/08

摘要： Disclosed are: labeled NSAIDs compounds which can be produced within a short time, can be used suitably for a PET method, and enable the imaging of cyclooxygenase-2; and a process for producing the labeled NSAIDs compounds. Specifically disclosed are isotope-labeled 2-arylpropionic acid compounds, each of which is a compound represented by general formula (1) (wherein Ar represents an aryl group which may have a substituent; R1 represents anyone selected from 11CH3, CH218F and CF218F; and R2 represents a hydrogen atom, or an alkyl group which may have a branch, wherein a compound wherein Ar is a benzene ring, R1 is 11CH3, and R2 is a hydrogen atom is excluded), or a pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof.

摘要翻译： 公开的是：可以在短时间内生产的标记的NSAIDs化合物可以适用于PET方法，并且能够进行环氧合酶-2的成像; 以及生产标记的NSAIDs化合物的方法。 具体公开的是同位素标记的2-芳基丙酸化合物，其各自为通式（1）表示的化合物（其中Ar表示可具有取代基的芳基; R1表示选自11CH3，CH218F和CF218F的任何一种; R2表示氢原子或可具有支链的烷基，其中Ar为苯环，R1为11CH3，R2为氢原子的化合物除外），或其药学上可接受的盐，水合物，溶剂合物或 前药。

公开(公告)号：US08680260B2

公开(公告)日：2014-03-25

申请号：US13320421

申请日：2010-05-14

申请人： Yasuyoshi Watanabe ,  Masaaki Suzuki ,  Hisashi Doi ,  Takeshi Kuboyama ,  Satoshi Obika ,  Takeshi Imanishi

发明人： Yasuyoshi Watanabe ,  Masaaki Suzuki ,  Hisashi Doi ,  Takeshi Kuboyama ,  Satoshi Obika ,  Takeshi Imanishi

IPC分类号： C07H21/00

CPC分类号： A61K51/0453 ,  A61K51/0491 ,  C07B59/005 ,  C07B2200/05 ,  C07C247/16 ,  C07D249/06

摘要： The present invention provides an 18F-labeled azide compound usable in the Huisgen reaction which enables 18F-labeling although only a small quantity of alkyne compound is available as a counterpart substrate, more specifically the 18F-labeled azide compound enabling the PET to be applied to peptides or oligonucleotides and enabling the 18F-labeling of any sites of oligonucleotide other than the 5′ end or 3′ end thereof, a reagent for 18F-labeling, and a method for 18F-labeling of an alkyne compound using the same.

摘要翻译： 本发明提供了可用于Huisgen反应的18F标记的叠氮化合物，其能够进行18F标记，尽管只有少量的炔化合物可用作对应的基质，更具体地说，18F-标记的叠氮化合物使PET能够应用于 肽或寡核苷酸，并且能够进行除了5'末端或3'末端以外的寡核苷酸的任何位点的18F标记，用于18F标记的试剂，以及使用其的18E-标记的炔化合物的方法。

公开(公告)号：US20130137322A1

公开(公告)日：2013-05-30

申请号：US13816010

申请日：2011-08-19

申请人： Yasuyoshi Watanabe

发明人： Yasuyoshi Watanabe

IPC分类号： H01B7/42

CPC分类号： H01B7/428 ,  C08K3/22 ,  C08K2003/2227 ,  C09J7/29 ,  C09J2201/602 ,  C09J2203/326 ,  C09J2205/106 ,  C09J2400/263 ,  D06N3/0002 ,  D06N3/0006 ,  D06N3/0063 ,  D06N2209/062 ,  D06N2213/045 ,  H01L23/3733 ,  H01L23/3737 ,  H01L2924/0002 ,  H05K7/20481 ,  Y10T442/164 ,  Y10T442/176 ,  H01L2924/00

摘要： A thermally conductive sheet includes a mesh sheet and a thermally conductive composition containing a resin composition and a thermally conductive filler and coating both sides of the mesh sheet so as to form a thermally conductive layer. The thermally conductive sheet is prevented from trapping air bubbles so as to exhibit high thermal conductivity, and is so strong that does not easily tear. The mesh sheet has mesh holes defined by thread intersecting with each other. The intersection of the threads is provided with an bubble inclusion inhibition part for preventing air bubbles from being trapped in the interface between the thermally conductive composition and the mesh sheet. The bubble inclusion inhibition part may be a fused portion, a pressure-bonded portion or the like.

摘要翻译： 导热片包括网片和含有树脂组合物和导热填料的导热组合物，并且将网片的两面涂覆以形成导热层。 防止导热片捕获气泡，从而表现出高的导热性，并且非常坚固，不易撕裂。 网片具有由彼此相交的螺纹限定的网孔。 螺纹的交点设置有气泡夹杂物抑制部分，用于防止气泡被捕获在导热组合物和网片之间的界面中。 气泡包合抑制部分可以是熔融部分，压接部分等。

公开(公告)号：US08298513B2

公开(公告)日：2012-10-30

申请号：US12525599

申请日：2008-02-05

申请人： Koichi Fukase ,  Katsunori Tanaka ,  Yasuyoshi Watanabe ,  Tsuyoshi Tahara ,  Koki Hasegawa

发明人： Koichi Fukase ,  Katsunori Tanaka ,  Yasuyoshi Watanabe ,  Tsuyoshi Tahara ,  Koki Hasegawa

IPC分类号： A61K49/00

CPC分类号： C07K1/13 ,  A61K49/0039 ,  A61K49/0041 ,  A61K49/0047 ,  A61K49/0056 ,  A61K49/0058 ,  A61K51/081 ,  A61K51/083 ,  A61K51/085 ,  A61K51/088 ,  A61K51/10 ,  A61K51/1093 ,  C07C229/44 ,  C07C237/04 ,  C07D271/12 ,  C07D311/16 ,  C07D311/90 ,  C07D413/12 ,  C07D495/04 ,  C07F5/02 ,  C07F7/1804

摘要： A label with which labeling is easy when labeling a molecule, i.e., a label that has a high reaction rate upon labeling and that produces a high reaction yield, as well as a precursor for the production of the label are provided. This is achieved by a hexatriene-β-carbonyl compound represented by Formula (I), a hexatriene-β-carbonyl compound represented by Formula (II), a hexatriene-β-carbonyl compound represented by Formula (III) and a hexatriene-β-carbonyl compound represented by Formula (IV). (wherein R1, R2, R3, R4, R5, X1, X2 and Z are as defined in the specification)

摘要翻译： 提供了标记分子时标签易于标记的标签，即标记时具有高反应速率并产生高反应产率的标记，以及用于生产标签的前体。 由式（I）表示的己三烯 - 羰基化合物，由式（II）表示的己三烯 - 羰基化合物，由式（III）表示的己三烯 - 羰基化合物和式 由式（Ⅳ）表示的己三烯 - 羰基化合物。 （其中R1，R2，R3，R4，R5，X1，X2和Z如说明书中所定义）

公开(公告)号：US20110288424A1

公开(公告)日：2011-11-24

申请号：US13142604

申请日：2010-10-26

申请人： Etsuko Kanai ,  Masami Funakura ,  Yasuyoshi Watanabe ,  Masaaki Tanaka ,  Yoshihito Shigihara ,  Kei Mizuno

发明人： Etsuko Kanai ,  Masami Funakura ,  Yasuyoshi Watanabe ,  Masaaki Tanaka ,  Yoshihito Shigihara ,  Kei Mizuno

IPC分类号： A61B5/02

CPC分类号： A61B5/16 ,  A61B5/024 ,  A61B5/0261 ,  A61B5/0476 ,  A61B5/048 ,  A61B5/14551 ,  A61B5/18 ,  A61B5/4035

摘要： A human fatigue assessment device capable of performing highly accurate fatigue assessment is provided. The human fatigue assessment device (100) includes: a physiological signal measuring unit (101) which measures a pulse wave signal of a user; a feature value extracting unit (102) which extracts first feature values each of which is obtained from a systolic posterior component of the pulse wave signal measured by the physiological signal measuring unit (101); a storage unit (103) in which the first feature values extracted to by the feature value extracting unit (102) are stored; and a fatigue determining unit (104) which determines whether or not the user is fatigued, using the first feature values extracted by the feature value extracting unit (102), in which the fatigue determining unit (104) compares a first feature value among the first feature values extracted by the feature value extracting unit (102) and at least one of the first feature values stored in the storage unit (103), to determine whether or not the user is fatigued.

摘要翻译： 提供能够进行高精度疲劳评估的人体疲劳评估装置。 人体疲劳评价装置（100）包括：测量用户的脉搏波信号的生理信号测量单元（101）; 特征值提取单元（102），其提取从生理信号测量单元（101）测量的脉搏波信号的收缩后分量获得的第一特征值; 存储由特征值提取单元（102）提取的第一特征值的存储单元（103）; 以及疲劳确定单元（104），其使用由所述特征值提取单元（102）提取的所述第一特征值来确定所述用户是否疲劳，其中所述疲劳确定单元（104）比较所述第一特征值 由特征值提取单元（102）提取的第一特征值和存储在存储单元（103）中的第一特征值中的至少一个，以确定用户是否疲劳。