公开(公告)号：US20090279646A1

公开(公告)日：2009-11-12

申请号：US12458678

申请日：2009-07-20

申请人： Kaoru Kobayashi ,  Shigeru Takegishi

发明人： Kaoru Kobayashi ,  Shigeru Takegishi

IPC分类号： H04L27/06

CPC分类号： H04L27/0014 ,  H04B1/70752

摘要： A wireless communication device is provided to carry out correlation peak detection processing properly and efficiently in intermittent receiving unit. If a correlation peak is not detected in a first period in which a correlation peak detecting unit detects the correlation peak at a default frequency and a first frequency in a detecting period of a coarse frequency deviation detecting unit in the first period, a control unit makes the correlation peak detecting unit carry out the peak detection at the first frequency in a second period. If the correlation peak is detected in the correlation peak detecting unit and a second frequency is detected in a detecting period of a fine frequency deviation detecting unit in the first period, the control unit makes the correlation peak detecting unit carry out the peak detection at the first and second frequencies in a third period.

摘要翻译： 提供一种无线通信装置，用于在间歇接收单元中适当且有效地执行相关峰值检测处理。 如果在第一期间中相关峰值检测部检测到粗略频率偏差检测部的检测期间的默认频率的相关峰值和第一频率的第一期间没有检测到相关峰值，则控制部 相关峰值检测单元在第二周期中以第一频率执行峰值检测。 如果在相关峰值检测单元中检测到相关峰值，并且在第一周期内在精细频率偏差检测单元的检测周期中检测到第二频率，则控制单元使相关峰值检测单元在 第一和第二频率在第三个时期。

公开(公告)号：US20090196331A1

公开(公告)日：2009-08-06

申请号：US12382158

申请日：2009-03-10

申请人： Kaoru Kobayashi ,  Shigeru Takegishi

发明人： Kaoru Kobayashi ,  Shigeru Takegishi

IPC分类号： H04B1/00

CPC分类号： H04L27/0014 ,  H04B1/70752 ,  H04L2027/0036 ,  H04L2027/0051 ,  H04L2027/0095

摘要： A signal processing unit and a wireless communication device are provided for making it possible to detect a frequency by means of a small scale operation circuit in a short time. The signal processing unit and the wireless communication device are comprised of a carrier data generating unit; a carrier demodulation unit; a matched filter unit that divides carrier demodulated data into a plurality of portions, carries out despread processing and accumulating operation processing as partial correlation processing, further carries out full addition processing for the partial correlation processing result, and outputs correlation detected data; a correlation peak detecting unit that detects a correlation peak from the correlation detected data and outputs correlation peak position information; a coarse frequency deviation detecting unit that outputs a frequency deviation amount with respect to the carrier demodulated data to the carrier data generating unit; and a fine frequency deviation detecting unit that outputs a fine frequency deviation amount from the correlation detected data and the correlation peak position information to the carrier data generating unit.

摘要翻译： 提供信号处理单元和无线通信装置，以便能够在短时间内利用小规模的操作电路来检测频率。 信号处理单元和无线通信设备包括载波数据生成单元; 载波解调单元; 将载波解调数据分割为多个部分的匹配滤波器单元，进行解扩处理并积累作为部分相关处理的运算处理，进一步执行部分相关处理结果的全相加处理，并输出相关检测数据; 相关峰值检测单元，根据相关检测数据检测相关峰值，并输出相关峰值位置信息; 粗频率偏差检测单元，向载波数据生成单元输出相对于载波解调数据的频率偏差量; 以及精细频率偏差检测单元，其将相关检测数据和相关峰值位置信息的精细频率偏差量输出到载波数据生成单元。

公开(公告)号：US07235667B2

公开(公告)日：2007-06-26

申请号：US10471673

申请日：2002-03-11

申请人： Atsushi Naganawa ,  Tetsuji Saito ,  Kaoru Kobayashi ,  Takayuki Maruyama ,  Yoshihiko Nakai ,  Shinsuke Hashimoto

发明人： Atsushi Naganawa ,  Tetsuji Saito ,  Kaoru Kobayashi ,  Takayuki Maruyama ,  Yoshihiko Nakai ,  Shinsuke Hashimoto

IPC分类号： C07D277/04 ,  A61K31/425

CPC分类号： C07D213/70 ,  C07D277/36 ,  C07D307/64 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

摘要： An N-phenylarylsulfonylamide compound of formula (I) (R1 is COOH etc.; R2 is hydrogen, methyl, etc.; R3 and R4 are a combination of methyl and methyl, etc.; R5 is isopropyl etc.; Ar is thiazolyl, pyridyl, 5-methyl-2-furyl each optionally substituted with methyl; n is zero or 1), a synthetic intermediate for the compound and a process for its preparation. The compound of formula (I) binds to a prostaglandin E2 receptor, especially an EP1 subtype receptor, and antagonizes it. It is less affected by protein binding, so it has a satisfactory in vivo activity. Therefore, it is considered to be useful as an analgesic, an antipyretic agent, an agent for the treatment of pollakiuria (frequent urination) and/or lower urinary tract disease syndrome or an antineoplastic agent.

摘要翻译： 式（I）的N-苯基芳基磺酰胺化合物（R 1）是COOH等; R 2是氢，甲基等; R 3 O >和R 4是甲基和甲基等的组合; R 5是异丙基等; Ar是噻唑基，吡啶基，5-甲基-2-呋喃基 任选被甲基取代; n为0或1），化合物的合成中间体及其制备方法。 式（I）化合物与前列腺素E 2受体结合，特别是EP 1亚型受体，并拮抗它。 蛋白质结合的影响较小，因此具有令人满意的体内活性。 因此，认为可用作止痛剂，解热剂，治疗尿频（尿频）和/或下尿路疾病综合征或抗肿瘤药物的药剂。

公开(公告)号：US20060030713A1

公开(公告)日：2006-02-09

申请号：US11239406

申请日：2005-09-30

申请人： Atsushi Naganawa ,  Tetsuji Saito ,  Kaoru Kobayashi ,  Takayuki Maruyama ,  Yoshihiko Nakai ,  Shinsuke Hashimoto

发明人： Atsushi Naganawa ,  Tetsuji Saito ,  Kaoru Kobayashi ,  Takayuki Maruyama ,  Yoshihiko Nakai ,  Shinsuke Hashimoto

IPC分类号： A61K31/44 ,  C07C309/28 ,  C07D277/36 ,  C07D285/18

CPC分类号： C07D213/70 ,  C07D277/36 ,  C07D307/64 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

摘要： An N-phenylarylsulfonylamide compound of formula (I) (R1 is COOH etc.; R2 is hydrogen, methyl, etc.; R3 and R4 are a combination of methyl and methyl, etc.; R5 is isopropyl etc.; Ar is thiazolyl, pyridyl, 5-methyl-2-furyl each optionally substituted with methyl; n is zero or 1), a synthetic intermediate for the compound and a process for its preparation. The compound of formula (I) binds to a prostaglandin E2 receptor, especially an EP1 subtype receptor, and antagonizes it. It is less affected by protein binding, so it has a satisfactory in vivo activity. Therefore, it is considered to be useful as an analgesic, an antipyretic agent, an agent for the treatment of pollakiuria (frequent urination) and/or lower urinary tract disease syndrome or an antineoplastic agent.

摘要翻译： 式（I）的N-苯基芳基磺酰胺化合物（R 1）是COOH等; R 2是氢，甲基等; R 3 O >和R 4是甲基和甲基等的组合; R 5是异丙基等; Ar是噻唑基，吡啶基，5-甲基-2-呋喃基 任选被甲基取代; n为0或1），化合物的合成中间体及其制备方法。 式（I）化合物与前列腺素E 2受体结合，特别是EP 1亚型受体，并拮抗它。 蛋白质结合的影响较小，因此具有令人满意的体内活性。 因此，认为可用作止痛剂，解热剂，治疗尿频（尿频）和/或下尿路疾病综合征或抗肿瘤药物的药剂。

公开(公告)号：US20050124577A1

公开(公告)日：2005-06-09

申请号：US10506536

申请日：2003-03-04

申请人： Kousuke Tani ,  Kaoru Kobayashi ,  Toru Maruyama ,  Tohru Kambe ,  Mikio Ogawa ,  Tsutomu Shiroya

发明人： Kousuke Tani ,  Kaoru Kobayashi ,  Toru Maruyama ,  Tohru Kambe ,  Mikio Ogawa ,  Tsutomu Shiroya

IPC分类号： C07D207/27 ,  A61P1/00 ,  A61P1/16 ,  A61P7/00 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/06 ,  A61P11/08 ,  A61P13/12 ,  A61P15/06 ,  A61P15/10 ,  A61P19/02 ,  A61P19/08 ,  A61P19/10 ,  A61P25/00 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07D207/26 ,  C07D263/24 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D413/06 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  A61K31/724 ,  A61K31/557 ,  C07D413/02 ,  C07D417/02

CPC分类号： C07D413/06 ,  C07D207/26 ,  C07D263/24 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12

摘要： An 8-azaprostaglandin represented by formula (I) (wherein all symbols have the same meanings as described in the specification), a pharmaceutically acceptable salt thereof or a cyclodextrin clathrate thereof. Since the compound represented by formula (I) binds to EP2 subtype among PGE receptor strongly, it is useful for preventive and/or treatment for immune diseases, allergic diseases, neuronal cell death, dysmenorrhea, premature birth, abortion, baldness, retinal neuropathy such as glaucoma, erectile dysfunction, arthritis, pulmonary injury, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, hepatic injury, acute hepatitis, liver cirrhosis, shock, nephritis, renal failure, circulatory diseases, systemic inflammatory response syndrome, sepsis, hemophagocytosis syndrome, macrophage activation syndrome, still disease, Kawasaki Disease, burn, systemic granuloma, ulcerative colitis, Crohn disease, hypercytokinemia at dialysis, multiple organ failure, or bone diseases etc.

摘要翻译： 由式（I）（其中所有符号具有与说明书中所述相同的含义）表示的8-氮杂前列腺素，其药学上可接受的盐或其环糊精包合物。 由于式（I）表示的化合物强烈地与PGE受体中的EP2亚型结合，因此可用于免疫疾病，过敏性疾病，神经元细胞死亡，痛经，早产，流产，秃发，视网膜神经病变等的预防和/或治疗 青光眼，勃起功能障碍，关节炎，肺损伤，肺纤维化，肺气肿，支气管炎，慢性阻塞性肺病，肝损伤，急性肝炎，肝硬化，休克，肾炎，肾衰竭，循环系统疾病，全身性炎症反应综合征，败血症， 血细胞增多综合征，巨噬细胞活化综合征，静止病，川崎病，烧伤，全身肉芽肿，溃疡性结肠炎，克罗恩病，透析中的高细胞因子血症，多器官功能衰竭或骨骼疾病等。

公开(公告)号：US06618917B2

公开(公告)日：2003-09-16

申请号：US09939745

申请日：2001-08-28

申请人： Hitoshi Sugiura ,  Yoshinobu Yasuda ,  Masami Funamoto ,  Kaoru Kobayashi

发明人： Hitoshi Sugiura ,  Yoshinobu Yasuda ,  Masami Funamoto ,  Kaoru Kobayashi

IPC分类号： B23Q3900

CPC分类号： B23Q39/024 ,  B23B3/162 ,  B23F9/08 ,  B23P23/02 ,  B23Q2039/008 ,  Y10T29/5114 ,  Y10T82/10 ,  Y10T82/25 ,  Y10T82/2508 ,  Y10T82/2524 ,  Y10T409/10159 ,  Y10T409/101749

摘要： A headstock 10 having a chuck 12 and a tailstock 20 having a shaft 21 are mounted on a bed 1 and can move with respect to each other in the direction of the Z-axis, A carriage 50 is slidably mounted on the bad 1 and can move in the Z-axis direction with respect to the rotational axis of a spindle 11. A turning device (lathe tool) 30 is provided to perform a turning operation on a workpiece and a gear cutting device 40 is provided to perform a gear cutting on the workpiece. The turning device 30 and the gear cutting device are preferably slidably mounted on the carriage 50 in a side-by-side relationship. The turning device 30 and the gear cutting device 40 may have respective traverse slide bases 31 and 41. The traverse slide bases 31 and 41 are mounted on the carriage 50 and can move independently in the direction of the X-axis perpendicular to the axis of the spindle 11, i.e. in a traverse sliding direction.

摘要翻译： 具有卡盘12和具有轴21的尾架20的主轴箱10安装在床1上，并且可以在Z轴方向上相对于彼此移动，滑架50可滑动地安装在坏1上，并且可以 相对于主轴11的旋转轴线在Z轴方向上移动。设置有转动装置（车刀）3​​0，以对工件进行转动操作，并且设置齿轮切割装置40以进行齿轮切割 工件。 转动装置30和齿轮切割装置优选地并排地可滑动地安装在滑架50上。 转动装置30和齿轮切割装置40可以具有各自的横动滑动基座31和41.横动滑动基座31和41安装在滑架50上，并且可以沿与X轴垂直的轴线的X轴方向独立地移动 主轴11，即横移滑动方向。

公开(公告)号：US6096904A

公开(公告)日：2000-08-01

申请号：US121551

申请日：1998-07-23

申请人： Amos B. Smith, III ,  Yuping Qiu ,  Michael Kaufman ,  Hirokazu Arimoto ,  David R. Jones ,  Kaoru Kobayashi ,  Thomas J. Beauchamp

发明人： Amos B. Smith, III ,  Yuping Qiu ,  Michael Kaufman ,  Hirokazu Arimoto ,  David R. Jones ,  Kaoru Kobayashi ,  Thomas J. Beauchamp

IPC分类号： C07D263/22 ,  A61K31/047 ,  A61K31/12 ,  A61K31/27 ,  A61K31/336 ,  A61K31/351 ,  A61K31/366 ,  A61K31/422 ,  A61K31/427 ,  A61K31/5355 ,  A61K31/7028 ,  A61P35/00 ,  A61P37/06 ,  C07C29/38 ,  C07C33/02 ,  C07C33/42 ,  C07C239/06 ,  C07C271/12 ,  C07D303/16 ,  C07D309/10 ,  C07D309/30 ,  C07D309/32 ,  C07D319/06 ,  C07D413/06 ,  C07D413/12 ,  C07D417/06 ,  C07F7/18 ,  C07F9/54 ,  C07H23/00 ,  C07F9/02

CPC分类号： C07C239/06 ,  C07D263/22 ,  C07D309/30 ,  C07D319/06 ,  C07D407/06 ,  C07D413/06 ,  C07D413/12 ,  C07F7/1856 ,  C07F7/1892 ,  Y02P20/55

摘要： Synthetic methods for lactone-containing compounds such as the discodermolides are provided, as are compounds which mimic the chemical and/or biological activity thereof, and methods and intermediates useful in their preparation.

摘要翻译： 提供了含内酯化合物如脱氧胆甾醇的合成方法，以及模拟其化学和/或生物活性的化合物，以及可用于其制备的方法和中间体。

公开(公告)号：US5869626A

公开(公告)日：1999-02-09

申请号：US606941

申请日：1996-02-26

申请人： Kazunori Yamamoto ,  Hideyuki Funasaka ,  Takeshi Takahashi ,  Takeshi Akasaka ,  Tatsuhisa Kato ,  Shigeru Nagase ,  Kaoru Kobayashi

发明人： Kazunori Yamamoto ,  Hideyuki Funasaka ,  Takeshi Takahashi ,  Takeshi Akasaka ,  Tatsuhisa Kato ,  Shigeru Nagase ,  Kaoru Kobayashi

IPC分类号： C07F7/02 ,  C01B31/00 ,  C01F1/00 ,  C07F5/00 ,  C07F7/08 ,  C07F7/22 ,  C07F7/30 ,  C07F19/00

CPC分类号： C07F7/0807 ,  C07F7/082 ,  Y10S977/734

摘要： A novel metal-encapsulated fullerene compound wherein a side chain is introduced in a metal-encapsulated fullerene is provided.A metal-encapsulated fullerene compound represented by the following structural formula (1) is synthesized by causing a disilirane derivative or digermirane derivative having the following structural formula (2) to react with a metal-encapsulation fullerene so as to add functional groups to the fullerene. ##STR1## Herein, M is an encapsulated metal atom, m is an integer from 1 to 3, n is an even number from 28 to 200, and R is a t-butyl group or an aromatic group having alkyl groups in the 2,6-positions, such as mesityl, 2,6-diethylphenyl or 2,6-dimethylphenyl groups.

摘要翻译： 提供了一种新型金属包封的富勒烯化合物，其中侧链引入金属包封的富勒烯中。 通过使具有下列结构式（2）的二异硅烷衍生物或二氢呋喃衍生物与金属包覆的富勒烯反应以便向富勒烯添加官能团来合成由以下结构式（1）表示的金属包封的富勒烯化合物 。 （1）l原子，m为1〜3的整数，n为28〜200的偶数，R为叔丁基或在2,6-位具有烷基的芳香族基 ，如三甲基甲硅烷基，2,6-二乙基苯基或2,6-二甲基苯基。

公开(公告)号：US5771333A

公开(公告)日：1998-06-23

申请号：US705004

申请日：1996-08-29

申请人： Ryo Hirayama ,  Kaoru Kobayashi

发明人： Ryo Hirayama ,  Kaoru Kobayashi

IPC分类号： H04N5/783 ,  H04N5/923 ,  H04N5/937 ,  H04N9/793 ,  H04N9/81

CPC分类号： H04N9/7936 ,  H04N5/923 ,  H04N5/937 ,  H04N9/81 ,  H04N5/783

摘要： An input video signal is applied to a transmission line first through a time direction emphasizer for emphasizing the levels of time direction high frequency components of the video signal, relative to the levels of low frequency components thereof; secondary through a vertical direction emphasizer; and thirdly through a horizontal direction emphasizer. Further, the received video signal is outputted as an output video signal from the transmission line first through a horizontal direction deemphasizer for deemphasizing the levels of horizontal direction high frequency components of the video signal, relative to the levels of low frequency components thereof; secondary through a vertical direction deemphasizer; and thirdly through a time direction deemphasizer. The emphasis and deemphasis method enables the dynamic range of the transmission line to be utilized effectively, while preventing erroneous operation on the reception side.

摘要翻译： 输入视频信号首先通过时间方向增强器施加到传输线，用于相对于其低频分量的电平强调视频信号的时间方向高频分量的电平; 通过垂直方向强调器辅助; 第三次通过水平方向加强器。 此外，接收的视频信号作为来自传输线的输出视频信号首先通过水平方向去加噪器输出，用于相对于其低频分量的电平去强调视频信号的水平方向高频分量的电平; 次要通过垂直方向去加重; 第三，通过时间方向去强调。 强调和去加重方法能够有效地利用传输线的动态范围，同时防止接收侧的错误操作。

公开(公告)号：US5759819A

公开(公告)日：1998-06-02

申请号：US745184

申请日：1996-11-07

申请人： Kaoru Kobayashi ,  Kenji Tomomitsu ,  Shinobu Kuwae ,  Tomoshi Ohya ,  Toyoo Ohda

发明人： Kaoru Kobayashi ,  Kenji Tomomitsu ,  Shinobu Kuwae ,  Tomoshi Ohya ,  Toyoo Ohda

IPC分类号： C07K14/765 ,  C12N15/14 ,  C12N15/81 ,  C12P21/02 ,  C12N1/14 ,  C12P21/00

CPC分类号： C12N15/81 ,  C07K14/765 ,  Y10S435/911 ,  Y10S435/938 ,  Y10S435/942

摘要： A process for producing recombinant human serum albumin (HSA) which comprises culturing an HSA producing host prepared by gene manipulation techniques at a temperature of from 21.degree. to 29.degree. C. Culturing the HSA producing host under such a specified temperature condition makes it possible to increase productivity of HSA production, improve the growth yield of an HSA producing host, and reduce the degree of coloring in the HSA preparation.

摘要翻译： 一种重组人血清白蛋白（HSA）的制备方法，其包括在21〜29℃的温度下培养通过基因操作技术制备的HSA生成宿主体。在规定的温度条件下培养产生HSA的宿主， 提高HSA生产的生产力，提高HSA生产主体的生长产量，并降低HSA制剂中的着色程度。