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公开(公告)号：US06919960B2
公开(公告)日：2005-07-19
申请号：US10727832
申请日：2003-12-04
Applicant: Frans Ejner Rvan Hansen , Martin Glensbjerg , Borkur Arnvidarson , Jesper Myron Jeppesen
IPC: G01N33/483 , C12M1/34 , C12Q1/00 , C12Q1/06 , G01N20060101 , G01N15/00 , G01N15/02 , G01N15/06 , G01N15/14 , G01N21/00 , G01N21/49 , G01N21/59 , G01N21/64 , G01N21/65 , G01N24/00 , G01N24/08 , G01N27/12 , G01N33/04 , G01N33/48 , G01N33/487 , G06M11/00
CPC classification number: G01N15/1459 , B01L3/5027 , G01N15/1463 , G01N21/31 , G01N21/59 , G01N21/6428 , G01N21/6458 , G01N21/76 , G01N33/04 , G01N2015/025 , G01N2015/1452 , G01N2015/1486 , G01N2021/5957 , G01N2021/6491
Abstract: The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representations of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The size of the volume of the liquid sample is sufficiently large to permit the assessment of the quantity and quality parameters to fulfill a predetermined requirement to the statistical quality of the assessment based on substantially one exposure.
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公开(公告)号：US20240150820A1
公开(公告)日：2024-05-09
申请号：US18549611
申请日：2022-03-11
Applicant: CHEMOMETEC A/S
Inventor： Rune TROELSGAARD PEDERSEN , Søren KJÆRULFF , Alfred HANSWILLEMENKE
IPC: C12Q1/6844 , C12Q1/6834
CPC classification number: C12Q1/6846 , C12Q1/6834
Abstract: Detection and analysis of biological particles can provide useful information with respect to a wide range of applications. Those include but are not limited to analysis of disease markers in diagnostic samples, quantification of bacteria and/or viral particles in environmental samples, and detection of specific proteins in cell culture samples. The methods presented herein provide simple, rapid and reliable means of detecting and analyzing biological particles in a hydrogel, and are especially suitable for quantification of for example nucleic acids, viral particles, bacteria, yeast, animal cells, and proteins. The invention also relates to a kit of parts and to a system for detection and analysis of biological particles in a hydrogel.
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公开(公告)号：US10697884B2
公开(公告)日：2020-06-30
申请号：US15532216
申请日：2015-12-03
Applicant: ChemoMetec
Inventor： Martin Glensbjerg , Johan Holm , Søren Kjaerulff , Frans Ejner Ravn Hansen
Abstract: The present invention relates to methods and systems for image cytometry analysis, in particular using light sources to be cooled. Thereby is provided optimal light conditions for image cytometry.
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24.发明授权Method for the assessment of particles and a system and device for use in the method 有权评估粒子的方法以及用于该方法的系统和装置公开(公告)号：US08906697B2
公开(公告)日：2014-12-09
申请号：US11296662
申请日：2005-06-23
Applicant: Martin Glensbjerg
Inventor： Martin Glensbjerg
CPC classification number: G01N15/147 , B01L3/502715 , B01L2300/021 , G01N15/1434 , G01N15/1475 , Y10T436/117497 , Y10T436/25375
Abstract: A method and a device for the assessment of at least one parameter of particles in a liquid analyte material are disclosed. The method comprises providing a device having a sample compartment with an exposing domain, an inlet through which a volume of a liquid sample representing the analyte material can been introduced, and a flow system comprising at least a channel allowing at least a portion of the volume of the liquid sample to flow within the device. The volume of the liquid sample passes into the exposing domain of the sample compartment, which can quantitatively detect spatial image data and process the detected image electromagnetic signals from the sample in the exposing domain of the device. A spatial image representation of the exposing domain, and processing the detected image presentation obtaining the assessment of the at least one parameter is generated in the device.
Abstract translation: 公开了一种用于评估液体分析物质中的至少一个颗粒参数的方法和装置。 该方法包括提供具有带有曝光区域的样本室的装置，可以引入表示分析物材料的液体样本的体积的入口，以及至少包括允许体积的至少一部分的通道的流体系统 的液体样品在装置内流动。 液体样品的体积进入样品室的曝光区域，其可以定量检测空间图像数据并处理来自装置的曝光区域中的样品的检测到的图像电磁信号。 在该设备中产生曝光域的空间图像表示，以及处理检测到的图像呈现获得该至少一个参数的评估。
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公开(公告)号：US08432550B2
公开(公告)日：2013-04-30
申请号：US13433010
申请日：2012-03-28
Applicant: Frans Ejner Ravn Hansen , Martin Glensbjerg , Börkur Arnvidarson , Jesper Myron Jeppesen
CPC classification number: G01N15/1459 , B01L3/5027 , G01N15/1463 , G01N21/31 , G01N21/59 , G01N21/6428 , G01N21/6458 , G01N21/76 , G01N33/04 , G01N2015/025 , G01N2015/1452 , G01N2015/1486 , G01N2021/5957 , G01N2021/6491
Abstract: A method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representations of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals.
Abstract translation: 一种用于评估液体分析物质中生物颗粒的数量和质量参数的方法。 该方法包括将一定体积的液体样品施加到曝光区域，从该区域中的来自样品的曝光区域电磁信号可以从该区域传播到外部，并将其暴露于诸如CCD元件的主动检测元件阵列上，空间 在从暴露期间通过检测元件阵列检测到的强度的处理条件下，可以通过各个有源检测元件检测作为强度的表示作为强度的表示， 生物颗粒被识别为不同于来自背景信号的电磁信号的表示。
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Patent Agency Ranking
公开(公告)号：US20120223260A1
公开(公告)日：2012-09-06
申请号：US13433010
申请日：2012-03-28
Applicant: Frans Ejner Rvan HANSEN , Martin Glensbjerg , Borkur Arnvidarson , Jesper Myron Jeppesen
CPC classification number: G01N15/1459 , B01L3/5027 , G01N15/1463 , G01N21/31 , G01N21/59 , G01N21/6428 , G01N21/6458 , G01N21/76 , G01N33/04 , G01N2015/025 , G01N2015/1452 , G01N2015/1486 , G01N2021/5957 , G01N2021/6491
Abstract: A method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representations of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals.
Abstract translation: 一种用于评估液体分析物质中生物颗粒的数量和质量参数的方法。 该方法包括将一定体积的液体样品施加到曝光区域，从该区域中的来自样品的曝光区域电磁信号可以从该区域传播到外部，并将其暴露于诸如CCD元件的主动检测元件阵列上，空间 在从暴露期间通过检测元件阵列检测到的强度的处理条件下，可以通过各个有源检测元件检测作为强度的表示作为强度的表示， 生物颗粒被识别为不同于来自背景信号的电磁信号的表示。
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27.发明申请DETERMINATION OF CHEMICAL OR PYSICAL PROPERTIES OF SAMPLE OR COMPONENT OF A SAMPLE 有权确定样品或样品的成分或化学成分的化学或物理性质公开(公告)号：US20090024360A1
公开(公告)日：2009-01-22
申请号：US12094006
申请日：2006-11-16
Applicant: Borkur Arnvidarson
Inventor： Borkur Arnvidarson
CPC classification number: G01J3/45
Abstract: The present invention offers an alternative strategy for the correlation of interference information to chemical and/or physical properties of a sample. This strategy can be implemented in a method and a system, which offer substantial technical and commercial advantages over state of the art techniques based on interference spectroscopy. The method comprises the steps of: a. obtaining an interferogram and/or at least one interferogram element corresponding to a modulation of electromagnetic signal emitted from, transmitted onto or through, or having interacted with at least a part of the sample, b. performing i. at least one transformation of the interferogram and/or a segment of the interferogram and/or an interferogram element with at least one function, ii. optionally repeating i) for another segment of the interferogram and/or interferogram element, wherein the transformation does not comprise a Fourier Transformation if i) is conducted only once, thereby obtaining at least one score, c. correlating said at least one score to the at least one chemical or physical property.
Abstract translation: 本发明提供了用于将干扰信息与样品的化学和/或物理性质相关的替代策略。 该策略可以在与基于干涉光谱技术的现有技术相比提供实质的技术和商业优势的方法和系统中实现。 该方法包括以下步骤：a。 b）获得干涉图和/或至少一个干涉图元素，所述干涉图元素对应于从至少部分样品b发射的或经过或已经与样品的至少一部分相互作用的电磁信号的调制。 表演我 干涉图和/或具有至少一个功能的干涉图和/或干涉图元素的段的至少一次变换，ii。 可选地重复i）干涉图和/或干涉图元素的另一段，其中如果i）仅进行一次，则转换不包括傅立叶变换，从而获得至少一个分数c。 将所述至少一个得分与所述至少一种化学或物理性质相关联。
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公开(公告)号：US20080248966A1
公开(公告)日：2008-10-09
申请号：US12062328
申请日：2008-04-03
Applicant: Frans Ejner Rvan Hansen , Martin Glensbjerg , Borkur Arnvidarson , Jesper Myron Jeppesen
CPC classification number: G01N15/1459 , B01L3/5027 , G01N15/1463 , G01N21/31 , G01N21/59 , G01N21/6428 , G01N21/6458 , G01N21/76 , G01N33/04 , G01N2015/025 , G01N2015/1452 , G01N2015/1486 , G01N2021/5957 , G01N2021/6491
Abstract: The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representations of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The size of the volume of the liquid sample is sufficiently large to permit the assessment of the quantity and quality parameters to fulfill a predetermined requirement to the statistical quality of the assessment based on substantially one exposure.
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公开(公告)号：US20080248964A1
公开(公告)日：2008-10-09
申请号：US12062267
申请日：2008-04-03
Applicant: Frans Ejner Rvan Hansen , Martin Glensbjerg , Borkur Arnvidarson , Jesper Myron Jeppesen
CPC classification number: G01N15/1459 , B01L3/5027 , G01N15/1463 , G01N21/31 , G01N21/59 , G01N21/6428 , G01N21/6458 , G01N21/76 , G01N33/04 , G01N2015/025 , G01N2015/1452 , G01N2015/1486 , G01N2021/5957 , G01N2021/6491
Abstract: The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representations of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The size of the volume of the liquid sample is sufficiently large to permit the assessment of the quantity and quality parameters to fulfill a predetermined requirement to the statistical quality of the assessment based on substantially one exposure.
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30.发明申请公开(公告)号：US20080186493A1
公开(公告)日：2008-08-07
申请号：US12062318
申请日：2008-04-03
Applicant: Frans Ejner Rvan Hansen , Martin Glensbjerg , Borkur Arnvidarson , Jesper Myron Jeppesen
IPC: G01N21/00
CPC classification number: G01N15/1459 , B01L3/5027 , G01N15/1463 , G01N21/31 , G01N21/59 , G01N21/6428 , G01N21/6458 , G01N21/76 , G01N33/04 , G01N2015/025 , G01N2015/1452 , G01N2015/1486 , G01N2021/5957 , G01N2021/6491
Abstract: The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representations of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The size of the volume of the liquid sample is sufficiently large to permit the assessment of the quantity and quality parameters to fulfill a predetermined requirement to the statistical quality of the assessment based on substantially one exposure.
Abstract translation: 本发明涉及一种用于评估液体分析物质中生物颗粒的数量和质量参数的方法。 该方法包括将一定体积的液体样品施加到曝光区域，从该区域中的来自样品的曝光区域电磁信号可以从该区域传播到外部，并将其暴露于诸如CCD元件的主动检测元件阵列上，空间 在从暴露期间通过检测元件阵列检测到的强度的处理条件下，可以通过各个有源检测元件检测作为强度的表示作为强度的表示， 生物颗粒被识别为不同于来自背景信号的电磁信号的表示。 液体样品的体积大小足够大以允许评估数量和质量参数以满足基于基本上一次暴露的评估的统计质量的预定要求。
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