公开(公告)号：US20020110922A1

公开(公告)日：2002-08-15

申请号：US10121425

申请日：2002-04-11

发明人： Robert Justice Shartle ,  Herbert Chow ,  Christa Hartmann

IPC分类号： G01N031/22

CPC分类号： B01L3/5027 ,  B01L3/502723 ,  B01L3/502738 ,  B01L2200/0621 ,  B01L2200/12 ,  B01L2300/0681 ,  B01L2300/0822 ,  B01L2300/0825 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0481 ,  B01L2400/0688 ,  G01N21/8483 ,  G01N33/4905 ,  G01N33/525 ,  G01N33/5304 ,  G01N33/54386 ,  G01N33/558 ,  G01N2333/7454 ,  G01N2333/96447 ,  Y10T436/112499 ,  Y10T436/25375

摘要： A fluidic medical diagnostic device permits measurement of analyte concentration or a property of a biological fluid, particularly the coagulation time of blood. The device has at one end a sample port for introducing a sample and at the other end a bladder for drawing the sample to a measurement area. A channel carries the sample from the sample port to the measurement area, and a stop junction, between the measurement area and bladder, halts the sample flow. The desired measurement can be made by placing the device into a meter which measures a physical property of the samplenulltypically, optical transmittancenullafter it has interacted with a reagent in the measurement area.

摘要翻译： 流体医学诊断装置允许测量分析物浓度或生物流体的性质，特别是血液的凝固时间。 该装置的一端具有用于引入样品的样品端口，另一端具有用于将样品抽吸到测量区域的气囊。 通道将样品从样品端口运送到测量区域，测量区域和气囊之间的停止点停止样品流动。 可以通过将装置放置在测量样品的物理性质（通常为光学透射率）的仪表中，在与测量区域中的试剂相互作用之后进行所需的测量。

公开(公告)号：US20020110498A1

公开(公告)日：2002-08-15

申请号：US09729241

申请日：2000-12-05

发明人： Jeffrey Dundale ,  Jana Pika

IPC分类号： G01N031/22

CPC分类号： A61L9/03 ,  A61L9/01 ,  A61L9/048 ,  A61L9/12 ,  G01N31/229

摘要： The invention concerns a composition aimed to indicate by color change when consumer articles, particularly volatile dispensers, containing or associated with said composition have become inefficient in use. The composition is constituted by a volatile liquid phase, a non-volatile polar phase and a useful amount of a dye originally dissolved essentially in the volatile liquid phase, said dye being able to adopt a different color according to the nature of the phase in which it is dissolved or deposited. Optionally, the composition can also contain an effective amount of an acidic compound. The invention also concerns the use of said composition in a consumer article, in particular a device aimed to diffuse a volatile or partially volatile liquid, more specifically an air freshener.

摘要翻译： 本发明涉及旨在通过颜色变化来指示当使用含有或与所述组合物相关联的消费品，特别是挥发性分配器变得无效时的组合物。 该组合物由挥发性液相，非挥发性极性相和基本上溶解在挥发性液相中的有用量的染料构成，所述染料能够根据相的性质采用不同的颜色，其中 它被溶解或沉积。 任选地，组合物还可以含有有效量的酸性化合物。 本发明还涉及所述组合物在消费品中的用途，特别是旨在扩散挥发性或部分挥发性液体，更具体地说是空气清新剂的装置。

公开(公告)号：US20020102739A1

公开(公告)日：2002-08-01

申请号：US09728153

申请日：2000-12-02

发明人： Hiroshi Nomura ,  Arthur R. Kydd ,  August R. Hanson ,  Robert J. Petersen

IPC分类号： G01N031/22

CPC分类号： G01N1/30 ,  G01N33/558

摘要： A wicking material is disclosed that exhibits a horizontal wicking velocity of at least about 1.0 millimeter per second when contacted with a physiological fluid such as blood, lymph or cellular interstitial fluid. This high wicking rate is achieved by means of treatment of a fibrous wicking material candidate with a low temperature gas plasma, particularly a glow discharge gas plasma formed in a gaseous blend made up predominantly of a mixture of oxygen with a saturated alkane chosen from the group consisting of methane, ethane and propane. Diagnostic test strips made with the surface-modified wicking material, and containing an immobilized reagent means for analysis of an analyte in a physiological fluid, show improved performance in terms of increased accuracy, finer precision of analyses, reduced time of analysis, a smaller fluid sample size requirement, and improved compliance with manufacturing standards resulting in lower manufacturing costs. blood sugar determinations.

摘要翻译： 公开了一种芯吸材料，当与诸如血液，淋巴或细胞间质液的生理液体接触时，其呈现至少约1.0毫米每秒的水平芯吸速度。 通过用低温气体等离子体处理纤维芯吸材料，特别是以主要由氧与饱和烷烃的混合物组成的气体共混物形成的辉光放电气体等离子体来实现这种高芯吸速率 由甲烷，乙烷和丙烷组成。 使用表面改性芯吸材料制成并含有用于分析生理液体中的分析物的固定化试剂的诊断试纸在提高精度，分析精度更高，分析时间更短，分析更少的流体方面表现出改进的性能 样品尺寸要求，并改进了制造标准的符合性，从而降低制造成本。 血糖测定。

公开(公告)号：US20020085958A1

公开(公告)日：2002-07-04

申请号：US09903062

申请日：2001-07-11

发明人： Thomas A. Nemcek ,  John Brian Barclay II ,  Jovo Dragicevic ,  Paul Leonard Eck ,  David Henry Gement ,  Seymour Greenfield ,  Michelle Petra Haddon ,  Michael James Nolan ,  Steven Louis Strang ,  Stephen Melamed ,  Vincent Shine ,  Peter Langmar ,  Laura A. Ferrario ,  Luc Heiligenstein

IPC分类号： G01N031/22 ,  B01L003/14

CPC分类号： B01L3/502715 ,  B01L3/5023 ,  B01L3/5029 ,  B01L2200/027 ,  B01L2300/0663 ,  B01L2400/0644

摘要： The present invention relates to a container having internal projections capable of exerting compressive, frictional, or other forces on a sample-collecting device and sample before detecting an analyte in the sample. The invention can be used whenever detecting an analyte in a sample is improved or made possible by first changing the physical or chemical properties of the sample or analyte in a pretreatment step.

摘要翻译： 本发明涉及具有能够在检测样品中的分析物之前在样品收集装置和样品上施加压缩，摩擦或其它力的内部突起的容器。 只要通过在预处理步骤中首先改变样品或分析物的物理或化学性质来检测样品中的分析物被改善或可能，则可以使用本发明。

公开(公告)号：US20020051733A1

公开(公告)日：2002-05-02

申请号：US09741633

申请日：2000-12-19

发明人： Patricia A. Antonoplos ,  Henry K. Hui ,  Alireza Ebrahim ,  Leslie A. Feldman ,  Nitu Kohli

IPC分类号： G01N031/22 ,  C12M001/34

CPC分类号： A61L2/28 ,  C12Q1/22 ,  G01N31/226

摘要： An apparatus for determining exposure to an oxidative sterilant is described. The apparatus includes a chemical indicator for indicating exposure to the oxidative sterilant and a biological indicator for determining the effectiveness of the exposure to the oxidative sterilant. The chemical indicator has a metallic surface with a non-pH sensitive permanent indicator on the surface for indicating exposure to the oxidative sterilant. The chemical indicator may be on a self-contained biological indicator. The biological indicator and chemical indicator may be inside a test pack, where the test pack restricts sterilant flow to the indicators.

摘要翻译： 描述了一种用于确定暴露于氧化灭菌剂的装置。 该装置包括用于指示暴露于氧化灭菌剂的化学指示剂和用于确定暴露于氧化灭菌剂的有效性的生物指示剂。 化学指示剂具有表面上具有非pH敏感性永久性指示剂的金属表面，用于指示暴露于氧化灭菌剂。 化学指示剂可以是独立的生物指示剂。 生物指示剂和化学指示剂可能在测试包内，其中测试包限制灭菌剂流向指示剂。

公开(公告)号：US20020042145A1

公开(公告)日：2002-04-11

申请号：US09737601

申请日：2000-12-18

发明人： Bengt Erik Forsberg

IPC分类号： G01N031/22

CPC分类号： B01L3/502 ,  A61B10/007 ,  A61B2010/0009 ,  B01L2200/0605 ,  B01L2300/0663 ,  B01L2300/069 ,  B01L2400/0633 ,  G01N33/54366

摘要： An assay device for determining the presence of specific analytes in a liquid sample comprises a container for collecting the sample liquid and a removable cap for sealing the container. The cap includes one or more test strips, such as chromatography strips, supported thereon for visually displaying the results of the assay. A chamber in the cap, collects, through an inlet, a volume of liquid from the container when it is inverted by depressing and subsequently releasing a piston located in the chamber. The liquid collected in the chamber is transferred to the chromatography strips by a wicking system. The piston frictionally engages a seal pad made of resilient material. The seal pad closes the inlet and forms a hermetic seal between the liquid contained within the container and the outside thereby preventing such liquid from becoming contaminated and any leakage of the contained liquid.

摘要翻译： 用于确定液体样品中特定分析物的存在的测定装置包括用于收集样品液体的容器和用于密封容器的可移除盖。 盖子包括一个或多个测试条，例如支撑在其上的色谱条，用于可视地显示测定结果。 当盖子通过按压并随后释放位于腔室中的活塞反转时，盖中的腔室通过入口收集来自容器的一定体积的液体。 收集在室中的液体通过芯吸系统转移到色谱条上。 活塞摩擦地接合由弹性材料制成的密封垫。 密封垫封闭入口并在容纳在容器内的液体与外部之间形成气密密封，从而防止这种液体被污染并且容纳液体的泄漏。

公开(公告)号：US20020025580A1

公开(公告)日：2002-02-28

申请号：US09068333

申请日：1998-10-29

发明人： PANKAJ MAGANLAL VADGAMA ,  SUBRAYAL MEDAPATI REDDY ,  MARIKA S.K. KYROLAINEN

IPC分类号： G01N031/22

CPC分类号： C12Q1/002

摘要： Membranes incorporating surfactants of a synthetic polymer rendered permeable by the surfactant. The membranes are blood compatible and may be used in biosensors and also for dialysis. The preferred polymer is PVC.

摘要翻译： 包含由表面活性剂渗透的合成聚合物的表面活性剂的膜。 膜与血液相容，可用于生物传感器，也可用于透析。 优选的聚合物是PVC。

公开(公告)号：US20020009388A1

公开(公告)日：2002-01-24

申请号：US09782428

申请日：2001-02-13

发明人： Franco Lombardo ,  Marina Y. Shalaeva ,  Karl A. Tupper

IPC分类号： G01N031/22

CPC分类号： G01N30/8682 ,  B01D15/325 ,  G01N30/8672 ,  G01N30/88 ,  G01N30/89 ,  G01N2030/342 ,  G01N2030/8813 ,  G01N2030/884 ,  Y10T436/200833 ,  G01N2030/324

摘要： This invention provides a RP-HPLC method, for the determination of logPoct values, which combines ease of operation and high accuracy, and which has been shown to work for a set of 36 molecules largely comprised of drugs. The general features of the method are: i) compound sparing (null1 mL of a 30-50 nullg/mL solution needed), ii) rapid determinations (20 minutes on average), iii) low sensitivity to impurities, iv) wide lipophilicity range (6 logPoct units), v) good accuracy, vi) excellent reproducibility. A linear free energy relationship (LFER) analysis, based on solvation parameters, shows that the method encodes the same information obtained from a shake-flask logPoct determination. The value generated via this method is referred to as ElogPoct .

摘要翻译： 本发明提供了一种RP-HPLC方法，用于测定logPoct值，其结合了操作的易操作性和高精度，并已被证明可用于主要由药物组成的一组36个分子。 该方法的一般特征是：i）复合备用（<= 1 mL需要30-50 mug / mL溶液），ii）快速测定（平均20分钟），iii）对杂质的敏感性低，iv）宽 亲油性范围（6logPoct单位），v）准确度好，vi）优异的重复性。 基于溶剂化参数的线性自由能关系（LFER）分析显示该方法编码从摇瓶logPoct测定获得的相同信息。 通过此方法生成的值称为ElogPoct。

公开(公告)号：US20020004019A1

公开(公告)日：2002-01-10

申请号：US09754523

申请日：2001-01-04

发明人： Steven S. Bachand ,  Geoffrey R. Anderson ,  Lawrence C. McPhee ,  Stephen K. Schultheis ,  Dennis D. Blevins

IPC分类号： G01N031/22 ,  G01N001/10 ,  C12M001/30

CPC分类号： B01L3/5023 ,  A61B10/0051 ,  B01L3/5027 ,  B01L3/5029 ,  B01L2200/026 ,  B01L2300/0663 ,  B01L2300/0825 ,  B01L2300/0864 ,  B08B1/003 ,  G01N33/558 ,  Y10T436/25

摘要： A saliva testing and confirmation device generally includes an expresser cup adapted to receive and compress a foam collection swab pressed into the cup. The swab includes a sponge or foam portion capable of absorbing a fluid specimen such as saliva, and a generally rigid handle for facilitating manipulation thereof. The device also includes a testing and confirmation platform integral with the expresser cup. A channel or groove in the cup is provided for directing a flow of expressed fluid from the expresser into both a test well and a confirmation well. A lateral flow reagent test strip, in fluid communication with the test well may be encased in the platform and partially revealed for analysis of test results. The confirmation well includes a fluid tight cap having a tamper evident seal.

公开(公告)号：US20010055817A1

公开(公告)日：2001-12-27

申请号：US09760213

申请日：2001-01-12

发明人： Magnus Malmqvist ,  Hakan Roos ,  Stefan Sjolander ,  Mattias Tidare ,  Hakan Sjodin ,  Ralph Stalberg

IPC分类号： G01N031/22

CPC分类号： G01N21/553 ,  B01J2219/00511 ,  B01J2219/00572 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00734 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2200/12 ,  B01L2300/0636 ,  B01L2300/0877 ,  B82Y30/00 ,  G01N21/05 ,  G01N21/648 ,  G01N2021/0346 ,  G01N2021/058 ,  Y10S366/01 ,  Y10S366/03 ,  Y10T436/11 ,  Y10T436/117497 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

摘要： Methods and devices are provided for controlling a fluid flow over a sensing surface within a flow cell The methods employ laminar flow techniques to position a fluid flow over one or more discrete sensing areas on the sensing surface of the flow cell. Such methods permit selective sensitization of the discrete sensing areas, and provide selective contact of the discrete sensing areas with a sample fluid flow. Immobilization of a ligand upon the discrete sensing area, followed by selective contact with an analyte contained within the sample fluid flow, allows analysis by a wide variety of techniques. Sensitized sensing surfaces, and sensor devices and systems are also provided.

摘要翻译： 提供了用于控制流动池内的感测表面上的流体流动的方法和装置。该方法采用层流技术将流体流动定位在流动池的感测表面上的一个或多个离散的感测区域上。 这样的方法允许离散感测区域的选择性敏化，并且提供离散感测区域与样品流体流的选择性接触。 将配体固定在离散的感测区域上，然后与包含在样品流体流中的分析物进行选择性接触，允许通过多种技术进行分析。 还提供敏感传感表面，传感器设备和系统。