公开(公告)号：US11986480B2

公开(公告)日：2024-05-21

申请号：US16482994

申请日：2018-02-02

申请人： TOHOKU UNIVERSITY

发明人： Hirokazu Arimoto ,  Kaori Itto ,  Daiki Takahashi ,  Nobuo Cho ,  Hiroshi Nara ,  Kenichiro Shimokawa ,  Taiichi Ohra ,  Shigekazu Sasaki ,  Naoki Ishii

IPC分类号： C07D495/04 ,  A61K31/513 ,  A61K31/522 ,  A61K31/551

CPC分类号： A61K31/522 ,  A61K31/513 ,  A61K31/551 ,  C07D495/04

摘要： Provided is a novel compound or salt thereof that induces degradation by autophagy of an intracellular molecule. In this compound, a ligand having activity to bind to an intracellular molecule and a structure having activity to induce autophagy of an intracellular molecule are linked via a linker without loss of the activity of the ligand and the structure.

公开(公告)号：US20240148776A1

公开(公告)日：2024-05-09

申请号：US18501539

申请日：2023-11-03

申请人： HK Pharma

发明人： Jeffrey Alan Klein ,  Paytra Alan Klein ,  Bram Alan Klein

IPC分类号： A61K31/714 ,  A61K9/00 ,  A61K9/08 ,  A61K31/137 ,  A61K31/167 ,  A61K31/4025 ,  A61K31/522 ,  A61K31/546 ,  A61K31/573 ,  A61P23/02 ,  A61P25/02 ,  A61P31/22

CPC分类号： A61K31/714 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/137 ,  A61K31/167 ,  A61K31/4025 ,  A61K31/522 ,  A61K31/546 ,  A61K31/573 ,  A61P23/02 ,  A61P25/02 ,  A61P31/22

摘要： A tumescent solution including: a vasoconstrictor; a B vitamin and a pharmaceutically acceptable carrier. In some examples, the tumescent solution further includes a drug or therapeutic agent dissolved in the tumescent solution. Some examples relate to a method of subcutaneous delivery of a drug or therapeutic agent to a subject including subcutaneously administering to said subject a tumescent solution as disclosed herein. In some examples, infiltration of the tumescent solution achieves both prolonged local drug or therapeutic agent concentration within a tumescent subcutaneous tissue as well as a prolonged slow constant systemic absorption of drugs from the tumescent tissue into a systemic circulation. In some examples, the tumescent solution reduces neuropathic pain or the risk of developing neuropathic pain, treats a localized condition or reduces persistent postsurgical pain (PPP) in a subject.

公开(公告)号：US20240125799A1

公开(公告)日：2024-04-18

申请号：US18235474

申请日：2023-08-18

申请人： Cyrano Therapeutics, Inc.

发明人： Robert I. HENKIN

IPC分类号： G01N33/68 ,  A61K9/00 ,  A61K31/197 ,  A61K31/352 ,  A61K31/44 ,  A61K31/4709 ,  A61K31/506 ,  A61K31/522 ,  A61K31/5377 ,  A61K31/5575 ,  A61K38/26 ,  A61K45/06

CPC分类号： G01N33/6893 ,  A61K9/0043 ,  A61K31/197 ,  A61K31/352 ,  A61K31/44 ,  A61K31/4709 ,  A61K31/506 ,  A61K31/522 ,  A61K31/5377 ,  A61K31/5575 ,  A61K38/26 ,  A61K45/06 ,  A61P27/00

摘要： Disclosed herein are methods for diagnosing a subject with loss and/or distortion of taste or smell, e.g., hyposmia, dysosmia, anosmia, phantosmia, hypogeusia, dysgeusia, phantogeusia, and/or ageusia. Also disclosed herein are methods and compositions for treating a subject for loss and/or distortion of taste or smell, e.g., hyposmia, dysosmia, anosmia, phantosmia, hypogeusia, dysgeusia, phantogeusia, and/or ageusia.

公开(公告)号：US20240115529A1

公开(公告)日：2024-04-11

申请号：US18523772

申请日：2023-11-29

申请人： Alan B. CASH

发明人： Alan B. CASH

IPC分类号： A61K31/194 ,  A61K31/167 ,  A61K31/192 ,  A61K31/4402 ,  A61K31/522

CPC分类号： A61K31/194 ,  A61K31/167 ,  A61K31/192 ,  A61K31/4402 ,  A61K31/522

摘要： The invention relates to methods for treating symptoms of PMS and PMDD including muscle ache, bloating, cramping, acne, tender breasts, bloating, fatigue, difficulty concentrating, diminished impulse control, irritability, anxiety, tension, anger, depression, insomnia and/or rapid fluctuations in mood (mood swings). The method comprises administration of a pharmaceutical composition comprising oxaloacetate, oxaloacetate salts, oxaloacetic acid and/or anhydrous enol-oxaloacetate.

公开(公告)号：US11951144B2

公开(公告)日：2024-04-09

申请号：US17268316

申请日：2018-09-12

申请人： PM-INTERNATIONAL AG

发明人： Rolf Sorg ,  Tobias Kühne ,  Christian Lauinger ,  Wilhelm Messer

IPC分类号： A61K36/00 ,  A23L33/105 ,  A23L33/125 ,  A23L33/135 ,  A23L33/14 ,  A23L33/15 ,  A23L33/16 ,  A23L33/22 ,  A61K31/12 ,  A61K31/197 ,  A61K31/355 ,  A61K31/375 ,  A61K31/4188 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/51 ,  A61K31/519 ,  A61K31/522 ,  A61K31/525 ,  A61K31/593 ,  A61K31/714 ,  A61K33/06 ,  A61K33/30 ,  A61K33/34 ,  A61K35/20 ,  A61K36/064 ,  A61K36/67 ,  A61K36/9068 ,  A61K47/12 ,  A61K47/26 ,  A61K47/36 ,  A61K47/46 ,  A61K47/69

CPC分类号： A61K36/67 ,  A23L33/105 ,  A23L33/125 ,  A23L33/135 ,  A23L33/14 ,  A23L33/15 ,  A23L33/16 ,  A23L33/22 ,  A61K31/12 ,  A61K31/197 ,  A61K31/355 ,  A61K31/375 ,  A61K31/4188 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/51 ,  A61K31/519 ,  A61K31/522 ,  A61K31/525 ,  A61K31/593 ,  A61K31/714 ,  A61K33/06 ,  A61K33/30 ,  A61K33/34 ,  A61K35/20 ,  A61K36/064 ,  A61K36/9068 ,  A61K47/12 ,  A61K47/26 ,  A61K47/36 ,  A61K47/46 ,  A61K47/6951 ,  A23V2002/00 ,  A23V2400/113 ,  A23V2400/173

摘要： A composition, containing



a pepper component,
a curcumin-cyclodextrin mixture and
a mixture of fruits, vegetables and spices.

公开(公告)号：US11950616B2

公开(公告)日：2024-04-09

申请号：US17320657

申请日：2021-05-14

申请人： AXCESS GLOBAL SCIENCES, LLC

发明人： Gary Millet

IPC分类号： A61K36/258 ,  A23L2/52 ,  A23L33/105 ,  A61K31/12 ,  A61K31/335 ,  A61K31/52 ,  A61K31/522

CPC分类号： A23L33/105 ,  A23L2/52 ,  A61K31/522

摘要： An energy-promoting composition includes an exogenous ketone body component that provides a source of caloric energy, a vasodilator component, a stimulant component, such as caffeine, and optionally a nootropic component. In most if not all cases, the vasodilator, stimulant, and nootropic components do not themselves provide a source of caloric energy but may increase metabolism of available caloric energy. The separate components beneficially and synergistically interact with one another to enhance the overall energy-promoting effect of the composition more rapidly and to a greater degree than if one or more of the components are omitted. The energy-promoting composition is also formulated to minimize the crash effect common to stimulants such as energy drinks.

公开(公告)号：US20240083899A1

公开(公告)日：2024-03-14

申请号：US18217817

申请日：2023-07-03

申请人： ONO PHARMACEUTICAL CO., LTD.

发明人： Shingo YAMAMOTO ,  Toshio YOSHIZAWA

IPC分类号： C07D473/34 ,  A61K31/522 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00

CPC分类号： C07D473/34 ,  A61K31/522 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00

摘要： Compounds represented by general formula (I) (all of the symbols in the formula conform to the definitions in the Description) are compounds that, in addition to having a Btk-selective inhibitory activity, exhibit an excellent metabolic stability and can avoid hepatotoxicity or the like, and as a consequence can provide safe therapeutic agents for diseases in which B cells or mast cells participate.

公开(公告)号：US20240075036A1

公开(公告)日：2024-03-07

申请号：US18280370

申请日：2022-03-18

申请人： CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT GEORG-SPEYER-HAUS

发明人： Florian GRETEN ,  Mark SCHMITT ,  Jalaj GUPTA

IPC分类号： A61K31/513 ,  A61K31/17 ,  A61K31/198 ,  A61K31/416 ,  A61K31/436 ,  A61K31/4418 ,  A61K31/522 ,  A61K31/551 ,  A61K31/65 ,  A61K31/675 ,  A61K31/7076 ,  A61K31/7084 ,  A61K38/17 ,  A61K38/20 ,  A61K38/45 ,  A61K45/06 ,  A61P35/00

CPC分类号： A61K31/513 ,  A61K31/17 ,  A61K31/198 ,  A61K31/416 ,  A61K31/436 ,  A61K31/4418 ,  A61K31/522 ,  A61K31/551 ,  A61K31/65 ,  A61K31/675 ,  A61K31/7076 ,  A61K31/7084 ,  A61K38/1793 ,  A61K38/2006 ,  A61K38/45 ,  A61K45/06 ,  A61P35/00

摘要： The present invention relates to the use of inhibitors of the P2X4 receptor or inhibitors of the P2X4 receptor signaling pathway in combination with an effective amount of a “cell death inducing chemotherapeutic drug” or “cell death inducing therapy” in the prevention and/or treatment of a solid tumor or metastases thereof in a subject, in particular in colorectal cancer (CRC).

公开(公告)号：US11903924B2

公开(公告)日：2024-02-20

申请号：US17593632

申请日：2020-01-20

申请人： XI'AN XINTONG PHARMACEUTICAL RESEARCH CO., LTD.

发明人： Weibo Guo ,  Dengke Zhang ,  Weili Jin ,  Mingzhe Ji ,  Yanxia Zhang

IPC分类号： A61K31/4025 ,  A61P31/20 ,  A61K31/341 ,  A61K31/381 ,  A61K31/404 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4192 ,  A61K31/42 ,  A61K31/421 ,  A61K31/423 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/513 ,  A61K31/522 ,  A61K31/536 ,  A61K31/675 ,  A61K31/7056 ,  C07D263/34 ,  C07D277/56 ,  C07D307/68 ,  C07D333/38 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14

CPC分类号： A61K31/4025 ,  A61K31/341 ,  A61K31/381 ,  A61K31/404 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4192 ,  A61K31/42 ,  A61K31/421 ,  A61K31/423 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4709 ,  A61K31/498 ,  A61K31/513 ,  A61K31/522 ,  A61K31/536 ,  A61K31/675 ,  A61K31/7056 ,  A61P31/20 ,  C07D263/34 ,  C07D277/56 ,  C07D307/68 ,  C07D333/38 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14

摘要： The present invention provides anti-HBV compounds, pharmaceutically acceptable compounds or stereoisomers thereof, and preparation methods and uses for treating, eradicating or inhibiting HBV infection or for alleviating liver injury caused by HBV infection, and so on.

公开(公告)号：US20240041890A1

公开(公告)日：2024-02-08

申请号：US18255027

申请日：2021-11-25

申请人： WELLA GERMANY GMBH

发明人： Christian Springob ,  Massimo Morini

IPC分类号： A61K31/522 ,  A61K31/045 ,  A61K47/12 ,  A61K45/06 ,  A61K47/10 ,  A61K31/455 ,  A61P17/14

CPC分类号： A61K31/522 ,  A61K31/045 ,  A61K47/12 ,  A61K45/06 ,  A61K47/10 ,  A61K31/455 ,  A61P17/14

摘要： A composition for promoting hair growth, and/or reducing or preventing hair loss, respectively, comprises sandal pentanol, caffeine, one or more saturated and unsaturated C10-C18 fatty acids, and a solvent.