公开(公告)号：US20200058367A1

公开(公告)日：2020-02-20

申请号：US16672601

申请日：2019-11-04

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Sarel FLEISHMAN ,  Adi GOLDENZWEIG ,  Dan S. TAWFIK

IPC: G16B15/00 ,  G16B15/20 ,  G16C20/60 ,  G16C20/10 ,  G16B35/00 ,  G16B30/00 ,  C12N9/10 ,  C12N9/16 ,  C12N9/18

Abstract: A method for designing and selecting a protein having a stabilized structure compared to a corresponding wild type protein, and proteins having at least six amino acid substitutions with respect to a corresponding wild type protein, designed for improved thermal stability, improved specific activity and/or improved expression levels, are provided herein.

公开(公告)号：US10553786B2

公开(公告)日：2020-02-04

申请号：US15507254

申请日：2015-08-27

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Oren Tal ,  David Rakhmilevich

IPC: H01L43/08 ,  G11B5/39 ,  G11C11/16 ,  H01F10/32 ,  H01L43/10 ,  G11C11/15 ,  H01F10/00

Abstract: This invention relates to structures comprising magnetic materials and conjugated molecules. The invention relates to magneto-resistive devices based on such structures. Structures and devices of the invention can be used as magnetic switches, magnetic sensors and in devices such in/as memory devices.

公开(公告)号：US10526416B2

公开(公告)日：2020-01-07

申请号：US15508112

申请日：2015-09-08

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yosef Yarden ,  Nadège Gaborit ,  Moshit Lindzen

IPC: C07K16/00 ,  A61K39/395 ,  C07K16/32 ,  A61K47/68 ,  C07K16/30 ,  G01N33/574 ,  A61K39/00 ,  C07K16/28

Abstract: An isolated polypeptide is provided. The isolated polypeptide comprising an antigen recognition domain specifically binding human HER-3 with a KD value of 10 nM or lower, wherein the polypeptide inhibits neuregulin (NRG) binding to the human HER3 and NRG-induced cancer cell migration and proliferation. Additionally clones NG83 and NG140 are provided which bind human HER-3 with a KD value of 10 nM or lower.

公开(公告)号：US10468119B2

公开(公告)日：2019-11-05

申请号：US15259311

申请日：2016-09-08

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Sarel Fleishman ,  Adi Goldenzweig ,  Dan S. Tawfik

IPC: G16B15/00 ,  C12N9/18 ,  C12N9/16 ,  C12N9/10 ,  G16B30/00 ,  G16B35/00 ,  G16C20/10 ,  G16C20/60 ,  G16B15/20

Abstract: A method for designing and selecting a protein having a stabilized structure compared to a corresponding wild type protein, and proteins having at least six amino acid substitutions with respect to a corresponding wild type protein, designed for improved thermal stability, improved specific activity and/or improved expression levels, are provided herein.

公开(公告)号：US20190267140A1

公开(公告)日：2019-08-29

申请号：US16412538

申请日：2019-05-15

Applicant: Yeda Research and Development Co. Ltd

Inventor： Eran SEGAL ,  Eran ELINAV

IPC: G16H50/20 ,  G06N20/00 ,  G16H50/70

Abstract: Method of predicting a response of a subject to food is disclosed. The method comprises: selecting a food to which a response of the subject is unknown; accessing a first database having data describing the subject but not a response of the subject to the selected food; accessing a second database having data pertaining to responses of other subjects to foods, the responses of the other subjects including responses of at least one other subject to the selected food or a food similar to said selected food; and analyzing the databases based on the selected food to estimate the response of the subject to the selected food.

公开(公告)号：US20190246638A1

公开(公告)日：2019-08-15

申请号：US15999587

申请日：2017-02-16

Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD, ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD

Inventor： Oren OSTERSETZER-BIRAN ,  Hagit ZER ,  Mark SAFRO ,  Liron KILIPCAN

IPC: A01N37/44 ,  A01N57/20

CPC classification number: A01N37/44 ,  A01N37/42 ,  A01N57/20

Abstract: Provided are methods of treating water and inhibiting growth of a photosynthetic bacterium, such as cyanobacterium as well as composition-of-matters and devices for treating water. Also provided are methods of using phenylalanine structural analogues as herbicides and/or combining same with a glyphosate.

公开(公告)号：US20190231874A1

公开(公告)日：2019-08-01

申请号：US16196537

申请日：2018-11-20

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Avigdor SCHERZ ,  Yoram SALOMON ,  Arie MARCOVICH ,  Alexander BRANDIS ,  Daniel WAGNER

IPC: A61K41/00 ,  A61K31/407 ,  A61K47/36 ,  A61N5/06 ,  A61K31/555 ,  A61K47/18 ,  A61K31/519 ,  A61K9/00

CPC classification number: A61K41/0071 ,  A61K9/0048 ,  A61K31/407 ,  A61K31/519 ,  A61K31/555 ,  A61K47/186 ,  A61K47/36 ,  A61N5/062 ,  A61N2005/0659

Abstract: An ophthalmic composition is provided, comprising chlorophyll or bacteriochlorophyll compounds for photodynamic treatment (PDT) of diseases, disorders and conditions associated with corneal or scleral anomalies, such as corneal thinning and scleral stretching.

公开(公告)号：US10331913B2

公开(公告)日：2019-06-25

申请号：US16070679

申请日：2017-01-19

Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Gil Segev ,  Ido Shahaf ,  Gilad Asharov ,  Moni Naor

IPC: G06F21/00 ,  G06F21/79 ,  G06F21/62 ,  G06F16/00 ,  G06F16/245 ,  G06F12/14 ,  G06F21/60 ,  H04L9/08

Abstract: A method for searchable symmetric encryption. The method includes: accessing a computerized database that comprises keyword lists, each of the keyword lists comprising memory addresses of electronic documents that all contain a respective keyword; binning the memory addresses by performing balanced allocation of the memory addresses into ordered bins, such that at least some of the ordered bins each contains memory addresses of electronic documents that contain different keywords; encrypting each of the memory addresses with an encryption key that is derived from the keyword of the respective memory address; and storing the ordered bins at consecutive locations in a non-transient computer-readable memory, wherein the consecutive locations preserve the order of the ordered bins.

公开(公告)号：US20190175658A1

公开(公告)日：2019-06-13

申请号：US16281490

申请日：2019-02-21

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michel Revel ,  Judith Chebath ,  Michal Izrael ,  Rosalia Kaufman

IPC: A61K35/30 ,  C12N5/079 ,  C12N5/0793

Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.

公开(公告)号：US20190167712A1

公开(公告)日：2019-06-06

申请号：US16273215

申请日：2019-02-12

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Alon CHEN ,  Eran HORNSTEIN ,  Orna ISSLER ,  Sharon HARAMATI ,  Naama VOLK

IPC: A61K31/7105 ,  A61K31/713 ,  A61K48/00 ,  C12Q1/6883 ,  C12N15/113

Abstract: microRNAs and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone-associated medical conditions are provided.