公开(公告)号：US20170211925A1

公开(公告)日：2017-07-27

申请号：US15329725

申请日：2015-07-29

Applicant: KOWA COMPANY, LTD.

Inventor： Naoki KOBAYASHI ,  Toshiaki NAKAGAWA

IPC: G01B9/02 ,  G01B11/02 ,  A61B3/15 ,  A61B3/10 ,  A61B3/13

CPC classification number: G01B9/02091 ,  A61B3/0058 ,  A61B3/102 ,  A61B3/13 ,  A61B3/15 ,  G01B9/02027 ,  G01B9/0203 ,  G01B9/02068 ,  G01B9/02077 ,  G01B11/02 ,  G01N21/17

Abstract: The tomographic image capturing device of the present invention comprises a display means (18) configured to: split light from a light source (11) into measurement light and reference light and cause the measurement light and the reference light to be incident to an object (E) and a reference object (49), respectively; capture tomographic images of the object (E) on the basis of interference light generated by superposition of the measurement light reflected from the object (E) and the reference light reflected from the reference object (49); and display tomographic pictures of the object generated on the basis of the captured tomographic images. The tomographic image capturing device has a first image capturing mode and a second image capturing mode. The first image capturing mode is a mode in which the measurement light is two-dimensionally scanned by raster scan to be incident to the object (E) and the tomographic images of the object (E) are captured. The second image capturing mode is a mode in which the measurement light is two-dimensionally scanned by raster scan to be incident to the object (E) and the tomographic images of the object (E) are captured. The raster scan in the second image capturing mode is thinned from the raster scan in the first image capturing mode. The display means (18) is configured to be switchable between a first display mode and a second display mode. The first display mode is a mode in which a plurality of tomographic pictures including a region of interest of the object (E) is selected from among the tomographic pictures generated on the basis of the tomographic images captured in the second image capturing mode and only the selected plurality of tomographic pictures is displayed. The second display mode is a mode in which all of the tomographic pictures generated on the basis of the tomographic images captured in the second image capturing mode are in turn displayed. The capturing of the tomographic images in the first image capturing mode is performed after separately performing a first adjustment operation and a second adjustment operation for adjustment of an image capturing condition necessary for capturing the tomographic images in the first image capturing mode. The first adjustment operation is based on the tomographic pictures displayed in the first display mode. The second adjustment operation is based on the tomographic pictures displayed in the second display mode.

公开(公告)号：US09616069B2

公开(公告)日：2017-04-11

申请号：US15060927

申请日：2016-03-04

Applicant: KOWA COMPANY, LTD.

Inventor： Isamu Sawai

IPC: A61K31/551 ,  A61K9/08 ,  A61K47/02 ,  A61K45/06 ,  A61K31/18 ,  A61K31/433 ,  A61K31/382 ,  A61K31/542 ,  A61K9/00

CPC classification number: A61K31/551 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/18 ,  A61K31/382 ,  A61K31/433 ,  A61K31/542 ,  A61K45/06 ,  A61K47/02 ,  A61K2300/00

Abstract: Provided is a technology for suppressing discoloration of a halo-isoquinoline derivative-containing aqueous composition during high-temperature storage. Provided is an aqueous composition containing a compound of formula (1): wherein X is a halogen atom, a salt of the compound, or a solvate of the compound or the salt; and a carbonic anhydrase inhibitor.

公开(公告)号：US20170079847A1

公开(公告)日：2017-03-23

申请号：US15123601

申请日：2015-03-03

Applicant: KOWA COMPANY, LTD.

Inventor： Akiharu TSUCHIYA ,  Hitoshi OJIMA ,  Hidenori KASENO

IPC: A61F13/06 ,  A61F5/01

Abstract: An ankle joint bandage includes a main body part of woven fabric in band shape, an anchor part of woven fabric joined to one end of the main body part and having a loop face of a touch fastener, and an engaging part joined to the other end of the main body part and having a hook face of a touch fastener. The main body part has a winding part which winds around an ankle of a wearer, a first supporting part which extends from an instep to the ankle, and a second supporting part which extends from the ankle to the instep of the wearer to cross the first supporting part at an upper portion of the instep of the wearer, the anchor part fastens around part corresponding to a metatarsal bone of the wearer, and the engaging part detachably sticks to the loop face of the anchor part.

公开(公告)号：US20170049314A1

公开(公告)日：2017-02-23

申请号：US15307887

申请日：2015-05-01

Applicant: KOWA COMPANY, LTD.

Inventor： Toshiaki NAKAGAWA

IPC: A61B3/00 ,  G06T7/00 ,  A61B3/12

CPC classification number: A61B3/0025 ,  A61B3/10 ,  A61B3/102 ,  A61B3/12 ,  G06T7/0012 ,  G06T7/11 ,  G06T2207/10101 ,  G06T2207/30041

Abstract: Image processing device (50) of the present invention comprises: an enhancement processing means (51) that enhances a speckle pattern in an ocular fundus tomographic image; a region-of-interest setting means (52) that sets a desired region in the ocular fundus tomographic image with the enhanced speckle pattern as a region-of-interest; a feature value extracting means (53) that extracts a feature value of the speckle pattern in the region-of-interest; and a disease determining means (54) that makes disease determination for an ocular fundus on the basis of the feature value. Image processing method of the present invention comprises: a step (S3) of enhancing a speckle pattern in an ocular fundus tomographic image; a step (S4) of setting a desired region in the ocular fundus tomographic image with the enhanced speckle pattern as a region-of-interest; a step (S5) of extracting a feature value of the speckle pattern in the region-of-interest; and a step (S6) of making disease determination for an ocular fundus on the basis of the feature value.

Abstract translation: 本发明的图像处理装置（50）包括：增强眼底层断层图像中的斑纹图案的增强处理装置（51） 感兴趣区域设置装置（52），其将具有增强的散斑图案的眼底切片图像中的期望区域设置为感兴趣区域; 特征值提取装置，其提取所述感兴趣区域中的斑纹图案的特征值; 以及基于特征值对眼底进行疾病判定的疾病判定单元（54）。 本发明的图像处理方法包括：增强眼底层断层图像中的斑纹图案的步骤（S3）; 将具有增强的散斑图案的眼底层断层图像中的期望区域设置为感兴趣区域的步骤（S4） 提取所述感兴趣区域中的斑纹图案的特征量的步骤（S5）; 以及基于特征值对眼底进行疾病判定的步骤（S6）。

公开(公告)号：US20170045756A1

公开(公告)日：2017-02-16

申请号：US15125097

申请日：2015-01-28

Applicant: KOWA COMPANY, LTD.

Inventor： Haruo Ishikawa

IPC: G02C7/02 ,  A61F2/16

CPC classification number: G02C7/028 ,  A61F2/16 ,  A61F2/1637 ,  A61F2/1645 ,  G02B3/06 ,  G02C7/02 ,  G02C7/022 ,  G02C7/024 ,  G02C7/04 ,  G02C2202/22

Abstract: It is provided with an ophthalmic lens having a cross-sectional shape in an arbitrary meridian direction on a lens surface of the ophthalmic lens. The cross-sectional shape is expressed by the following formula (1), Z = cr 2 1 + [ 1 - c 2  r 2  ( k + 1 ) ] 1  /  2 + A  ( θ )  r 2 + B  ( θ )  r 4 (1) wherein c is a paraxial curvature of the ophthalmic lens, r is a distance from a lens center of the ophthalmic lens, k is a conic constant of a surface which is in rotation symmetry with respect to an optical axis of the lens in the ophthalmic lens, c, r and k are used in common in the meridian direction on the lens surface, and A(θ) and B(θ) are parameters expressed by functions depending on an angle in the meridian direction.

Abstract translation: 在眼镜片的镜片表面设置有在任意子午线方向上具有横截面形状的眼科镜片。 横截面形状由以下Z = cr 2 1 + 1'c 2 r 2 k + 1½+ A¸r 2 + B¸r 4（1）表示，其中c是眼镜片的近轴曲率 r是距离眼镜片的透镜中心的距离，k是相对于眼镜片中的透镜的光轴旋转对称的表面的圆锥常数，c，r和k被共同使用 在透镜表面的子午线方向上，A（¸）和B（¸）是根据子午线方向上的角度的函数表示的参数。

公开(公告)号：US09501846B2

公开(公告)日：2016-11-22

申请号：US14761973

申请日：2014-01-20

Applicant: KOWA COMPANY, LTD.

Inventor： Toshiaki Nakagawa

IPC: G06T11/00 ,  A61B3/12 ,  H04N1/409 ,  H04N5/21 ,  G06T5/00 ,  G06T5/50 ,  H04N5/357

CPC classification number: G06T11/008 ,  A61B3/12 ,  G06T5/002 ,  G06T5/50 ,  G06T2207/10004 ,  G06T2207/10101 ,  G06T2207/20216 ,  G06T2207/30041 ,  H04N1/409 ,  H04N5/21 ,  H04N5/357

Abstract: An average image producing means 52 produces an average image from all or some of a plurality of images captured at the same location. A noise extracting means 53 extracts a noise pixel on the basis of the result of a comparison between the pixel values of the pixels in the captured images and the pixel values of the pixels at the same position in the average image. An interpolating means 54 interpolates the pixel value of the noise pixel included in the captured images using the pixel values of other pixels to produce a noise-eliminated image.

Abstract translation: 平均图像产生装置52从在同一位置拍摄的多个图像的全部或一些中产生平均图像。 噪声提取装置53基于拍摄图像中的像素的像素值与平均图像中的相同位置处的像素的像素值之间的比较结果来提取噪声像素。 内插装置54使用其他像素的像素值内插包含在拍摄图像中的噪声像素的像素值，以产生噪声去除图像。

公开(公告)号：US20160206598A1

公开(公告)日：2016-07-21

申请号：US14913064

申请日：2014-08-27

Applicant: KOWA COMPANY, LTD.

Inventor： Toshiaki Takizawa

IPC: A61K31/423 ,  A61K31/232 ,  A61K31/202

Abstract: This invention provides a combination-drug composition and a combination use of pharmaceuticals for preventing and/or treating dyslipidemia states, such as hyper-LDL cholesterolemia, in mammals, including humans. This invention pertains to a drug composition for preventing and/or treating dyslipidemia and the like, said drug composition comprising the following: (R)-2-[3-[[N-(benzoxazole-2-yl)-N-3-(4-methoxyphenoxy)propyl]aminomethyl]phenoxy]butyric acid, a salt thereof, or a solvate of either; and an omega-3 fatty acid or an ester derivative of an ω-3 fatty acid.

Abstract translation: 本发明提供组合药物组合物和用于预防和/或治疗包括人在内的哺乳动物中的高LDL胆固醇血症的血脂异常状态的药物的组合用途。 本发明涉及用于预防和/或治疗血脂异常等的药物组合物，所述药物组合物包含以下物质：（R）-2- [3 - [[N-（苯并恶唑-2-基）-N- （4-甲氧基苯氧基）丙基]氨基甲基]苯氧基]丁酸，其盐或其溶剂合物; 和ω-3脂肪酸的ω-3脂肪酸或酯衍生物。

公开(公告)号：USD753309S1

公开(公告)日：2016-04-05

申请号：US29483216

申请日：2014-02-26

Applicant: KOWA COMPANY, LTD.

Designer： Shouta Yabe ,  Yuuki Arai ,  Naoki Kambe

公开(公告)号：US20150342452A1

公开(公告)日：2015-12-03

申请号：US14414520

申请日：2013-07-11

Applicant: Kowa Company, Ltd.

Inventor： Takuya Hara

IPC: A61B3/024 ,  A61B3/00

CPC classification number: A61B3/024 ,  A61B3/0025 ,  A61B3/0083 ,  A61B3/0091

Abstract: A perimeter having means for setting a measurement coordinate system CS, a detector for blind spots, a means for measuring a visual field of the same subject eye based on set measurement coordinate systems at a first and second point of time and a memory for storing the position of the blind spot, a detector for detecting the position of the blind spot at the second point of time and computing amount of deviation with the position of the blind spot, and a control for conducting new measurement coordinate based on the deviation (α).

Abstract translation: 具有用于设置测量坐标系CS的装置的周边，用于盲点的检测器，用于在第一和第二时间点基于设定的测量坐标系测量同一被摄体的视野的装置，以及用于存储 盲点的位置，用于检测第二时间点的盲点的位置的检测器和盲点的位置的计算偏差量，以及基于偏差（α）进行新的测量坐标的控制， 。

公开(公告)号：US20150138552A1

公开(公告)日：2015-05-21

申请号：US14402948

申请日：2012-11-15

Applicant: KOWA COMPANY, LTD.

Inventor： Taisuke Hirono

IPC: G01N21/49 ,  G01N33/487

CPC classification number: G01N21/49 ,  G01N21/0332 ,  G01N21/51 ,  G01N21/82 ,  G01N33/487 ,  G01N2021/0357 ,  G01N2021/0367 ,  G01N2021/4707 ,  G01N2201/064

Abstract: With regard to the detection of a physiological active substance of biological origin and the measurement of its concentration in a sample, the invention provides a technique for moving gel particles that are produced in the sample without using a mechanical stirring member, and allows a highly accurate detection of the physiological active substance of biological origin and measurement of its concentration with a simple arrangement. By partial heating/cooling of a sample cell, thermal convection is generated within a mixture liquid in the sample cell, and as a result the gel particles that are produced in the mixture liquid are moved. In addition, based on the intensity of forward scattered light, the rate of change in the number of gel particles is measured.

Abstract translation: 关于生物来源的生物活性物质的检测及其在样品中的浓度的测定，本发明提供一种移动在样品中生产的凝胶颗粒而不使用机械搅拌构件的技术，并且允许高精度 检测生物来源的生理活性物质，并用简单的排列测定其浓度。 通过对样品池进行部分加热/冷却，在样品池内的混合液体中产生热对流，结果，在混合液中产生的凝胶粒子移动。 此外，基于前向散射光的强度，测定凝胶粒子数量的变化率。