公开(公告)号：US10064965B2

公开(公告)日：2018-09-04

申请号：US15691286

申请日：2017-08-30

Applicant: EMD Millipore Corporation

Inventor： Mikhail Kozlov ,  Wilson Moya ,  Gabriel Tkacik

IPC: B01D39/16 ,  A61L2/00 ,  B01D67/00 ,  B01D69/00 ,  C02F1/44

Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.

公开(公告)号：US09993785B2

公开(公告)日：2018-06-12

申请号：US15791869

申请日：2017-10-24

Applicant: EMD Millipore Corporation

Inventor： Martin Morrissey ,  Brian Pereira

IPC: B01F15/00 ,  C12M1/00 ,  B01F7/00 ,  C12M1/06 ,  B01F13/08

CPC classification number: B01F15/0085 ,  B01F7/00241 ,  B01F13/0827 ,  B01F15/00487 ,  B01F2215/0034 ,  B01F2215/0073 ,  C12M23/14 ,  C12M27/02

Abstract: A disposable container, such as a deformable bag, for a fluid, having one or more inlets and one or more outlets and an impeller assembly within the container to cause mixing, dispersing, homogenizing and/or circulation of one or more ingredients contained or added to the container. The region within the container that can contain liquid is funnel shaped, which allows very low fluid level mixing, dispensing while mixing, and a reduction or elimination of vortex formation.

公开(公告)号：US20180079560A1

公开(公告)日：2018-03-22

申请号：US15825635

申请日：2017-11-29

Applicant: EMD Millipore Corporation

Inventor： Chris Scott ,  Kurt Greenizen ,  Paul Sydlowski ,  Jay Doyle

IPC: B65D41/04 ,  B65D1/02 ,  B01L3/00 ,  B65B7/28 ,  B65D41/06

CPC classification number: B65D41/0471 ,  B01L3/502 ,  B01L3/508 ,  B01L2300/042 ,  B01L2300/046 ,  B01L2300/0681 ,  B01L2300/0832 ,  B65B7/2828 ,  B65D1/0246 ,  B65D41/0414 ,  B65D41/0442 ,  B65D41/0485 ,  B65D41/06 ,  B65D2203/12 ,  B65D2251/01

Abstract: A container and a container engaging member. The container engaging member may include a sample holder or reservoir, a filtration element and collar. In the assembled condition, the sample holder or reservoir is upstream of the filtration element, the container is downstream of the filtration element, and the sample holder or reservoir is attached to the container. The container engagement member is engageable and disengageable from the bottle or container in a quick attach, quick release manner, such as with only a 90 degree, ¼ turn. A tactile and/or audible indication that the engagement is complete is provided.

公开(公告)号：US09920841B2

公开(公告)日：2018-03-20

申请号：US14646438

申请日：2013-12-16

Applicant: EMD Millipore Corporation

Inventor： John Saragosa ,  John Cieciuch ,  James E. Kelly ,  Luc Messier ,  Nicholas Vigorito

IPC: G01N1/20 ,  F16K3/04 ,  G01N1/10 ,  G01N1/22

CPC classification number: F16K3/04 ,  G01N1/10 ,  G01N1/22 ,  G01N1/2226 ,  G01N2001/1037

Abstract: A fluid transfer system (100) includes a transfer device (104) and an interface device (102). The transfer device (104) includes a fluid transfer member (164) and a transfer coupling member (125) to align the fluid transfer member (164) with the interface device (102). The interface device (102) includes a reservoir port (108), a fluid transfer member receptacle (144), an interface coupling member (124), and a reservoir valve (110). The interface coupling member (124) is configured to close the fluid transfer member receptacle (144) and to couple to the transfer coupling member (125) and open the fluid transfer member receptacle (144) to receive the fluid transfer member (164). The reservoir valve (110), e.g., a sliding seal, is configured to close the reservoir port (108) from the fluid transfer member receptacle (144) and to open the reservoir port (108) to the fluid transfer member (164) when the fluid transfer member (164) is positioned in the fluid transfer member receptacle (144). The fluid transfer member (164) can include a plunger assembly configured to open and close the reservoir port (108).

公开(公告)号：US09920112B2

公开(公告)日：2018-03-20

申请号：US14061080

申请日：2013-10-23

Applicant: EMD Millipore Corporation

Inventor： Shari Spector

IPC: C07K16/12 ,  C07K1/22 ,  C07K14/31 ,  B01J20/286 ,  B01J20/32

CPC classification number: C07K16/1271 ,  B01J20/286 ,  B01J20/3274 ,  C07K1/22 ,  C07K14/31

Abstract: The present invention relates to modified immunoglobulin-binding proteins, e.g., Staphylococcus protein A, having improved binding specificity for immunoglobulins and methods of making and using the same.

公开(公告)号：US09850040B2

公开(公告)日：2017-12-26

申请号：US14641843

申请日：2015-03-09

Applicant: EMD Millipore Corporation

Inventor： Chris Scott ,  Kurt Greenizen ,  Paul Sydlowski ,  Jay Doyle

IPC: B65D41/04 ,  B65B7/28 ,  B65D41/06 ,  B01L3/00 ,  B65D1/02

CPC classification number: B65D41/0471 ,  B01L3/502 ,  B01L3/508 ,  B01L2300/042 ,  B01L2300/046 ,  B01L2300/0681 ,  B01L2300/0832 ,  B65B7/2828 ,  B65D1/0246 ,  B65D41/0414 ,  B65D41/0442 ,  B65D41/0485 ,  B65D41/06 ,  B65D2203/12 ,  B65D2251/01

Abstract: A container and a container engaging member. The container engaging member may include a sample holder or reservoir, a filtration element and collar. In the assembled condition, the sample holder or reservoir is upstream of the filtration element, the container is downstream of the filtration element, and the sample holder or reservoir is attached to the container. The container engagement member is engageable and disengageable from the bottle or container in a quick attach, quick release manner, such as with only a 90 degree, ¼ turn. A tactile and/or audible indication that the engagement is complete is provided.

公开(公告)号：US09827541B1

公开(公告)日：2017-11-28

申请号：US15658503

申请日：2017-07-25

Applicant: EMD Millipore Corporation

Inventor： Martin Morrissey ,  Brian Pereira

IPC: B01F15/00 ,  B01F13/08 ,  C12M1/06 ,  B01F7/00 ,  C12M1/00

CPC classification number: B01F15/0085 ,  B01F7/00241 ,  B01F13/0827 ,  B01F15/00487 ,  B01F2215/0034 ,  B01F2215/0073 ,  C12M23/14 ,  C12M27/02

Abstract: A disposable container, such as a deformable bag, for a fluid, having one or more inlets and one or more outlets and an impeller assembly within the container to cause mixing, dispersing, homogenizing and/or circulation of one or more ingredients contained or added to the container. The region within the container that can contain liquid is funnel shaped, which allows very low fluid level mixing, dispensing while mixing, and a reduction or elimination of vortex formation.

公开(公告)号：US20170267961A1

公开(公告)日：2017-09-21

申请号：US15459332

申请日：2017-03-15

Applicant: EMD Millipore Corporation

Inventor： Paul J. Hung ,  Philip J. Lee

IPC: C12M1/32 ,  C12M1/00 ,  C12M1/12 ,  C12M3/06

CPC classification number: C12M23/12 ,  C12M23/16 ,  C12M25/14 ,  C12M29/04 ,  C12M29/10 ,  C12M29/14

Abstract: Microfluidic devices, systems, and methods providing for an invasion assay using microfluidic culture systems.

公开(公告)号：US20170252703A1

公开(公告)日：2017-09-07

申请号：US15518300

申请日：2015-12-02

Applicant: EMD Millipore Corporation

Inventor： Jiwan Adhikari ,  John Erickson

IPC: B01D65/10 ,  G01M3/26 ,  G01N15/08

CPC classification number: B01D65/104 ,  B01D65/10 ,  G01M3/26 ,  G01N15/082 ,  G01N2015/084

Abstract: A testing apparatus employs an interface module removably attached to a filter testing device. The interface module includes a first flowpath communicating with an outlet of the testing device and a housing of the filter device, a first valve disposed in the first flowpath, a second flowpath communicating with the housing of the filter device and an exhaust, a second valve disposed in the second flowpath, and an enclosure enclosing the first flowpath, the first valve, the second flowpath, and the second valve. The interface module is cleanable and/or sterilizable, and replaceable. A filter integrity testing method uses an interface module to prevent contamination of the testing device and cross-contamination of different filter devices and avoid liquid ingress into the testing device.

公开(公告)号：US09694304B2

公开(公告)日：2017-07-04

申请号：US14440370

申请日：2013-11-26

Applicant: EMD Millipore Corporation

Inventor： Jeremy Perreault ,  Sean Foley ,  Kevin Rautio

IPC: B01D19/00 ,  A61L2/00 ,  B01D61/14 ,  B01D61/18 ,  B01D63/08

CPC classification number: B01D19/0031 ,  A61L2/0017 ,  B01D61/142 ,  B01D61/18 ,  B01D63/084 ,  B01D2313/16 ,  B01D2313/44 ,  B01D2315/08 ,  B01D2317/025 ,  B01D2317/06 ,  B01D2325/36 ,  B01D2325/38

Abstract: Redundant filtration system that includes at least one barrier filter as a process filter, the barrier filter having both hydrophilic and hydrophobic paths, allowing both fluid and gas permeability. The need for vents is eliminated, as is an intermediate drain filter. The device also can be dried in series. The filtration system includes a network of conduits and receptacles, the network receiving liquid raw and/or starting material at one end, conducting it through the process stream defined thereby, and producing the desired liquid product at another end. The network is provided with one or more in-puts for introducing liquid raw material into the fluid process stream, and one or more output ports for discharging fluid out of the fluid process stream. The network is preferably an essentially closed network, and also, preferably sterile and/or aseptic.