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    CONTAINER FOR SEPARATING MICROCARRIERS FROM CELL CULTURE FLUIDS
    32.
    发明申请
    CONTAINER FOR SEPARATING MICROCARRIERS FROM CELL CULTURE FLUIDS 有权

    公开(公告)号：US20210238536A1

    公开(公告)日：2021-08-05

    申请号：US16330413

    申请日：2017-10-23

    Applicant: EMD Millipore Corporation

    Inventor： Martin Morrissey

    IPC: C12M1/00 ,  C12M1/12 ,  C12M1/26

    Abstract: Containers for separating microcarriers from a cell culture fluid that offer a greater efficiency of filtration of cell culture fluids containing microcarriers relative to systems described in the art. The container may include a first compartment that may include a sterile collapsible bag, an inlet port providing a fluid path into the first compartment and an outlet port providing a fluid path exiting the first compartment; and a second compartment fluidly connected with the inlet port of the first compartment and including a plurality of independent or discrete microcarrier receiving regions defined by boundary walls which are partially or fully porous and having a porosity sufficient to retain the microcarriers inside the second compartment, while allowing the cell culture fluid to pass through the second compartment into the outlet port of the first compartment, where the cell culture fluid can be collected.

    Mixed gas integrity testing of porous materials without permeate side access
    33.
    发明授权
    Mixed gas integrity testing of porous materials without permeate side access 有权

    公开(公告)号：US10955328B2

    公开(公告)日：2021-03-23

    申请号：US16349855

    申请日：2017-11-20

    Applicant: EMD Millipore Corporation

    Inventor： Salvatore Giglia

    IPC: G01N15/08 ,  G01N33/00 ,  B01D65/10 ,  G01N15/06

    Abstract: A method of integrity testing porous materials that is non-destructive to the material being tested. The inlet gas stream includes at least two gases, wherein one of the gases has a different permeability in liquid than the other, such as oxygen and nitrogen in water. The relative permeability of the gases is measured in the retentate stream, thereby avoiding accessing the permeate stream and potentially introducing contaminants to the material being tested. The integrity test is capable of detecting the presence of oversized pores or defects that can compromise the retention capability of the porous material.

    Single Use Container Including a Collapsible Baffle Having Channels
    34.
    发明申请
    Single Use Container Including a Collapsible Baffle Having Channels 有权

    公开(公告)号：US20210054327A1

    公开(公告)日：2021-02-25

    申请号：US16964646

    申请日：2019-03-13

    Applicant: EMD Millipore Corporation

    Inventor： Jeffrey Pearsons ,  Amy Wood ,  David Kraus

    IPC: C12M1/00 ,  C12M3/00 ,  C12M1/06 ,  C12M1/34

    Abstract: A collapsible container for a fluid that includes a flexible material, defining an internal working volume; at least one collapsible baffle adhered within the working volume of said collapsible container, the at least one baffle having one or more channels for delivering one or more fluids into the working volume via at least one hole in said one or more channels, one or more channels in said container for exiting or venting fluids from the working volume, and an impeller assembly disposed at least partially within said working volume of said container.

    Abrasion resistant film for biocontainers
    36.
    发明授权
    Abrasion resistant film for biocontainers 有权

    公开(公告)号：US10272639B2

    公开(公告)日：2019-04-30

    申请号：US15544644

    申请日：2016-03-22

    Applicant: EMD Millipore Corporation

    Inventor： David DeCoste ,  Joseph Cianciolo ,  Michael Furbush ,  John Saragosa

    IPC: B32B5/02 ,  B32B27/08 ,  B32B27/12 ,  B32B27/32 ,  B32B27/34 ,  B32B27/40 ,  B01L3/00 ,  B65D65/40 ,  B65D75/58 ,  G01M3/32

    Abstract: A biocontainer film enhanced with an abrasion resistant or “cut-proof” substrate. Such substrates can be combined with current biocontainer materials, via various techniques of embedding, coextrusion or laminating, to maintain the cleanliness and low extractables already validated for biotech manufacturing. The substrate of choice may be constructed from materials known to be more resistant to abrasion and sharp razor type cuts or from materials oriented in such a way to prevent puncture to occur. The new substrate must also be flexible to allow for typical folding as demonstrated by current packaging practices. The new substrate may be constructed from materials other than polymers such as metal, glass or carbon or in combination with polymers. A non-constrained pressure test is also disclosed.

    Micro-incubation systems for microfluidic cell culture and methods
    39.
    发明授权
    Micro-incubation systems for microfluidic cell culture and methods 有权

    公开(公告)号：US10190085B2

    公开(公告)日：2019-01-29

    申请号：US15163818

    申请日：2016-05-25

    Applicant: EMD Millipore Corporation

    Inventor： Philip J. Lee ,  Terry Gaige ,  Wei Hsuan (Jessie) Ho

    IPC: C12M3/06 ,  C12M1/00 ,  C12Q1/02 ,  C12M1/34 ,  B01L3/00 ,  B01L7/00 ,  C12M1/107 ,  C12M1/02 ,  C12M1/36 ,  G01N33/50 ,  G01N33/574

    Abstract: A micro-incubator manifold for improved microfluidic configurations and systems and methods of manufacture and operation for a manifold and automated microfluidic systems are disclosed. Various embodiments relate to assays, systems, and/or devices for culturing cells or other biologic material in controlled environments and are applicable to related fields generally using microfluidic systems. Particular embodiments involve configurations that can be used with various standard automated handling systems, with active or passive loading and perfusion of medium and to provide high-throughput multi-assay automated systems for culturing, viewing, and analyzing cell growth, invasion, movement, chemotaxis or other properties. More specifically, specific embodiments relate to heat control systems for microfluidic culture plates and other automated systems for culture plates.

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