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    Anticancer compositions and methods for making and using them
    34.
    发明授权
    Anticancer compositions and methods for making and using them 有权

    公开(公告)号：US12016877B2

    公开(公告)日：2024-06-25

    申请号：US17895007

    申请日：2022-08-24

    申请人： The Regents of the University of California

    发明人： Catriona Jamieson ,  Raymond Diep ,  Jane Isquith ,  Qingfei Jiang ,  Jessica Pham

    IPC分类号： A61K31/7105 ,  C12N15/113 ,  C12Q1/68

    CPC分类号： A61K31/7105 ,  C12N15/113 ,  C12N2310/113

    摘要： In alternative embodiments, provided are compositions, including products of manufacture and kits, and methods, for treating or ameliorating a cancer by inhibiting expression or activity of Mouse Double Minute 2 homolog (MDM2), an APOBEC3G (A3G) protein, message (mRNA) or gene, and/or an ADAR1p150 protein, message (mRNA) or gene, e.g., by increasing the presence of in a cell or adding to a cell a molecule inhibitory to MDM2, APOBEC3G and/or ADAR1p150 expression, such as an miRNA that binds to MDM2, APOBEC3G and/or ADAR1p150 transcripts, or any molecule that can inhibit or destabilize the transcripts, resulting in decreased MDM2, APOBEC3G and/or ADAR1p150 expression, to treat a cancer such as leukemia, e.g., by inhibiting the propagation of a cancer cell, a leukemia cell, a leukemia stem cell (LSC) or a pre-leukemia cell stem cell (pre-LSC).

    Optical system
    36.
    发明授权
    Optical system 有权

    公开(公告)号：US12007543B2

    公开(公告)日：2024-06-11

    申请号：US18006219

    申请日：2021-07-21

    申请人： HOCHSCHULE EMDEN/LEER

    发明人： James Napier ,  Walter Neu

    IPC分类号： G02B21/00 ,  G01J1/04 ,  G02B27/14 ,  G02B21/33 ,  G02B26/08

    CPC分类号： G02B21/0032 ,  G01J1/0411 ,  G01J1/0425 ,  G02B21/008 ,  G02B27/146 ,  G02B21/0056 ,  G02B21/0076 ,  G02B21/33 ,  G02B26/08

    摘要： This relates to an optical system for detecting radiation from a measuring area, comprising at least one radiation source for generating radiation along an excitation beam path which guides radiation from the radiation source to the measuring area, and comprising a detection beam path which guides radiation from the measuring area to at least a first and a second detector,



    wherein along the detection beam path, exactly one tube lens having a first end and an opposite second end, a first beam splitter, a first detector in the reflection direction of the first beam splitter, and a second detector in the transmission direction of the first beam splitter are arranged in succession,
    wherein the first detector has a first detection surface and the second detector has a second detection surface which is spaced from the first detection surface,
    and the first and second detection surfaces are arranged along the detection beam path at the same distance from the second end of the tube lens.

    Threaded connection for pipe
    37.
    发明授权
    Threaded connection for pipe 有权

    公开(公告)号：US12007045B2

    公开(公告)日：2024-06-11

    申请号：US17754227

    申请日：2020-12-22

    申请人： NIPPON STEEL CORPORATION ,  VALLOUREC OIL AND GAS FRANCE

    发明人： Satoshi Maruta ,  Yousuke Oku

    IPC分类号： F16L15/00

    CPC分类号： F16L15/007

    摘要： In a threaded connection for pipe with a two-step thread construction, including intermediate shoulders, during stabbing, the internal-pressure sealing surface of the pin near its tip is prevented from contacting the intermediate shoulder of the box and thus receiving damage. LP, LB, hP and hB shown in FIG. 2 satisfy Expressions (1) and (2), provided below. θseal is the angle of slope of the straight line connecting the two ends, as determined along the axial direction, of the internal-pressure sealing surface of the pin. Expression (3), provided below, is also satisfied.

    LP

    Method for detecting unauthorized copying of content and service server using same
    40.
    发明授权
    Method for detecting unauthorized copying of content and service server using same 有权

    公开(公告)号：US12003597B2

    公开(公告)日：2024-06-04

    申请号：US17451877

    申请日：2021-10-22

    申请人： NAVER WEBTOON LTD.

    发明人： Inwoo Ro ,  Choong Hyun Seo

    IPC分类号： H04L67/50 ,  G06F21/10

    CPC分类号： H04L67/535 ,  G06F21/1078

    摘要： A method for detecting an unauthorized copy of a content according to an embodiment of the present invention includes providing content including a plurality of images to a terminal device; collecting scroll inputs applied by a user to the terminal device when viewing the content, and generating scroll log information from the scroll inputs; and constructing a database by collecting the scroll log information according to each user account registered in the service server or identification information of the terminal device.