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公开(公告)号：US20160153970A1
公开(公告)日：2016-06-02
申请号：US15017125
申请日：2016-02-05
IPC分类号： G01N33/50
摘要： A cell culture device can include: an internal chamber configured for an internal cell culture that has at least one port coupled to a perfusion modulating device capable of modulating perfusion in the internal chamber; at least one fluid channel bordering the internal chamber that is configured for a channel cell culture that has at least one port coupled to a perfusion modulating device capable of modulating perfusion in the fluid channel; and a wall separating the internal chamber and at least one fluid channel having gaps that fluidly couple the internal chamber with the at least one fluid channel, wherein the perfusion modulating device causes reduced fluid flow. The internal chamber can include a first cell type and the at least one fluid channel includes a second cell type. The first cell type has an ischemic zone in the middle, a non-ischemic zone adjacent with the at least one fluid channel, and a border zone between the ischemic zone and non-ischemic zone. In one aspect, the internal chamber and at least one fluid channel are modeled from physiological features. In one aspect, the internal chamber and at least one fluid channel are modeled from idealized features.
摘要翻译： 细胞培养装置可以包括：配置用于内部细胞培养物的内部室，其具有耦合到能够调节内部腔室灌注的灌注调节装置的至少一个端口; 至少一个与所述内室邻接的流体通道，其构造成用于通道细胞培养，所述通道细胞培养物具有至少一个端口，所述至少一个端口耦合到能够调节所述流体通道中的灌注的灌注调节装置; 以及分隔内室和至少一个流体通道的壁，所述至少一个流体通道具有使内室与至少一个流体通道流体连接的间隙，其中灌注调节装置引起减少的流体流动。 内部腔室可以包括第一细胞类型，并且所述至少一个流体通道包括第二细胞类型。 第一细胞类型在中间具有缺血区，与至少一个流体通道相邻的非缺血区，以及缺血区与非缺血区之间的边界区。 在一个方面，内部室和至少一个流体通道由生理特征建模。 在一个方面，内部室和至少一个流体通道由理想特征建模。
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公开(公告)号：US20140251813A1
公开(公告)日：2014-09-11
申请号：US14202105
申请日：2014-03-10
发明人： Yi Wang , Hongjun Song , Kapil Pant
IPC分类号： G01N27/447
CPC分类号： G01N27/44769 , B01L3/502753 , B01L3/502761 , B01L2200/0636 , B01L2200/0652 , B01L2300/0864 , B01L2400/0415 , B01L2400/0487 , B03C5/026 , B03C2201/26 , C07K1/24 , G01N15/0266 , G01N30/0005 , G01N2001/4038 , G01N2015/0288 , G01N2030/0065
摘要： An analyte selection device can include: a body defining a fluid channel having a channel inlet and channel outlet; a bipolar electrode (BPE) between the inlet and outlet; one of an anode or cathode electrically coupled with the BPE on a channel inlet side of the BPE and the other of the anode or cathode electrically coupled with the BPE on a channel outlet side of the BPE; and an electronic system operably coupled with the anode and cathode so as to polarize the BPE. The fluid channel can have any shape or dimension. The channel inlet and channel outlet can be longitudinal or lateral with respect to the longitudinal axis of the channel. The BPE can be any metallic member, such as a flat plate on a wall or mesh as a barrier BPE. The anode and cathode can be located at a position that polarizes the BPE.
摘要翻译： 分析物选择装置可以包括：主体，其限定具有通道入口和通道出口的流体通道; 入口和出口之间的双极电极（BPE）; 在BPE的通道入口侧上与BPE电耦合的阳极或阴极中的一个，阳极或阴极中的另一个在BPE的通道出口侧与BPE电耦合; 以及与阳极和阴极可操作地耦合以便使BPE偏振的电子系统。 流体通道可以具有任何形状或尺寸。 通道入口和通道出口可以相对于通道的纵向轴线纵向或横向。 BPE可以是任何金属构件，例如作为屏障BPE的壁或网上的平板。 阳极和阴极可以位于使BPE偏振的位置。
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公开(公告)号：US11600203B2
公开(公告)日：2023-03-07
申请号：US16696997
申请日：2019-11-26
摘要： A modular surrogate can include: a body having an external body surface with an anatomical shape, wherein the body includes an internal chamber with at least one port formed in the body extending inwardly; at least one anatomical module having an external module portion and a module stem coupled thereto, the module stem being received into a corresponding module port of the at least one port, the external module portion having an external module surface with an anatomical shape, the external body surface matches with the external module surface to provide a continuous anatomical shape; at least one sensor located in the at least one anatomical module; and at least one controller, wherein when the at least one anatomical module is coupled with the body, the at least one sensor is capable of being operably coupled with the at least one controller.
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公开(公告)号：US20220120237A1
公开(公告)日：2022-04-21
申请号：US17502517
申请日：2021-10-15
摘要： A variable 3D CD nozzle includes: a flexible body defining a flow path having an inlet extending through a narrowed throat to an expanded outlet, wherein the flexible body comprises a plurality of flexible members movably interconnected together; and at least one means for changing a shape of the flexible body to change a dimension or location of the throat plane relative to at least one of the inlet plane or outlet plane. A method of changing airflow in a nozzle includes operating at least one means for changing the shape of the flexible nozzle body to change the dimension or the location of the throat plane. A method of testing an object includes placing a test object in the test region of the test cell and passing a test gas from the outlet opening of the nozzle onto the test object.
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公开(公告)号：US11180452B2
公开(公告)日：2021-11-23
申请号：US16904364
申请日：2020-06-17
发明人： Anuj Singhal , Robert H. Cichewicz , Lin Du , JianLan You , Hanumantha Rao Paritala , Abigail Grace Edwards
IPC分类号： C07D209/30 , A61K47/60 , A01N43/38 , C07D417/12 , A01N55/00 , C07D401/12 , A01N43/40 , C07D471/04 , C07F7/18 , A01N43/90 , A61K47/54 , A01N25/08
摘要： A method of selectively inhibiting pathogenic microbes includes: providing a compound that is functional as a selective antimicrobial having a structure of Formula 1, or derivative thereof, salt thereof, or stereoisomer thereof, or having any chirality at any chiral center, or tautomer, polymorph, solvate, or combination thereof; and contacting a pathogenic microbe with the compound such that the pathogenic microbe is selectively inhibited; wherein: ring A is a cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or polycycle combination thereof; X is S, SO, or SO2; Y is a linker or bond; Z is CH, CR2, or N; Z1 is C or N to form an imidazopyridine; each Z2, Z3, or Z4 is independently CH, CR2, or N; each Z5 or Z6 is C or CH; each R1, R2, R3 and/or R4 is independently a substituent; m is 0, 1, 2, 3, or 4; and n is zero or a positive integer.
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公开(公告)号：US11127966B2
公开(公告)日：2021-09-21
申请号：US16266950
申请日：2019-02-04
IPC分类号： H01M4/90 , C12N11/14 , H01M8/16 , C12N9/02 , H01M4/66 , H01M8/1007 , H01M4/96 , H01M4/92 , H01M4/62 , B82Y30/00
摘要： A cathode can include: an electrode substrate; a porphyrin precursor attached to the substrate; and an enzyme coupled to the electrode substrate to be associated with the porphyrin precursor, the enzyme reduces oxygen. The cathode can include a conductive material associated with the porphyrin precursor and/or the enzyme. The cathode can include 1-pyrenebutanoic acid, succinimidyl ester (PBSE) associated with the porphyrin precursor and/or the enzyme and/or the conductive material. The cathode can include 2,5-dimethyl-1-phenyl-1H-pyrrole-3-carbaldehyde (DMY-Carb) associated with the 1-pyrenebutanoic acid, succinimidyl ester (PBSE) and/or the porphyrin precursor and/or the enzyme and/or the conductive material. The porphyrin precursor is attached to the substrate through covalent coupling. In some aspects, substrate is linked to the porphyrin precursor, the porphyrin precursor is linked to the conductive material, the conductive material is linked to the PBSE, the PBSE is linked to the DMY-carb, and the DMY-carb is linked to the enzyme.
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公开(公告)号：US20210230212A1
公开(公告)日：2021-07-29
申请号：US17151858
申请日：2021-01-19
发明人： Anuj Singhal
IPC分类号： C07J31/00 , C07C59/72 , C07D409/04 , A61K45/06 , A61P35/04
摘要： In an aspect, the disclosure pertains to inhibitors of ANGPTL4; synthesis methods for making disclosed compounds; pharmaceutical compositions comprising disclosed compounds; methods of treating disorders of uncontrolled cellular proliferation, e.g., a cancer; and methods of treating a disease associated with an ANGPTL4 dysfunction using disclosed compounds and pharmaceutical compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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公开(公告)号：US10983020B2
公开(公告)日：2021-04-20
申请号：US16356997
申请日：2019-03-18
申请人： CFD Research Corporation , The Government of The United States, as represented by The Secretary of The Army
发明人： Zhijian Chen , Andrzej Przekwas , Vincent Harrand , Raj K. Gupta
摘要： A system for reconstruction of an explosion blast loading on a subject can include at least two pressure sensors and a computing system configured to: receive sensor data from the at least two pressure sensors, the sensor data being generated in response to an explosion blast wave; compute an explosion location and explosive charge mass of an explosive that caused the explosion blast wave based on the sensor data; and compute explosion blast loading on a subject from the explosion location and explosive charge mass. The pressure sensors can be configured as wearable pressure sensors or on equipment. The computing of the explosion location and explosive charge mass includes processing the sensor data through an inverse problem solver (IPS); and/or the computing of the explosion blast loading on the subject includes simulating the explosion blast wave with a forward problem solver (FPS).
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39.发明申请公开(公告)号：US20200300720A1
公开(公告)日：2020-09-24
申请号：US16356997
申请日：2019-03-18
申请人： CFD Research Corporation , The Government of The United States, as represented by the Secretary of the Army
发明人： Zhijian Chen , Andrzej Przekwas , Vincent Harrand , Raj K. Gupta
摘要： A system for reconstruction of an explosion blast loading on a subject can include at least two pressure sensors and a computing system configured to: receive sensor data from the at least two pressure sensors, the sensor data being generated in response to an explosion blast wave; compute an explosion location and explosive charge mass of an explosive that caused the explosion blast wave based on the sensor data; and compute explosion blast loading on a subject from the explosion location and explosive charge mass. The pressure sensors can be configured as wearable pressure sensors or on equipment. The computing of the explosion location and explosive charge mass includes processing the sensor data through an inverse problem solver (IPS); and/or the computing of the explosion blast loading on the subject includes simulating the explosion blast wave with a forward problem solver (FPS).
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公开(公告)号：US10570360B2
公开(公告)日：2020-02-25
申请号：US15898032
申请日：2018-02-15
摘要： A method of testing an analyte can include using a cell culture device that includes: at least three distinct chambers between the top wall and bottom wall. The chambers can include: an internal chamber defined by at least one porous internal wall; one or more boundary layer chambers having at least an inner boundary layer chamber defined by the at least one porous internal wall and at least one porous inner boundary layer wall, the at least one porous internal wall having a plurality of pores fluidically coupling the central internal chamber to the one or more boundary layer chamber; and an outer chamber.
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