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    Flexible cathodes
    31.
    发明授权
    Flexible cathodes 有权
    柔性阴极

    公开(公告)号：US07753968B2

    公开(公告)日：2010-07-13

    申请号：US12408869

    申请日：2009-03-23

    Applicant: Christopher Boczer ,  Frank M. Delnick ,  Rosauro Del Rosario ,  Minkoo Kang ,  Lucyna M. Pawlowska ,  Michael Pozin ,  Dharmendra Rana ,  Maya Stevanovic ,  John J. Weckesser

    Inventor： Christopher Boczer ,  Frank M. Delnick ,  Rosauro Del Rosario ,  Minkoo Kang ,  Lucyna M. Pawlowska ,  Michael Pozin ,  Dharmendra Rana ,  Maya Stevanovic ,  John J. Weckesser

    IPC: H01M4/139 ,  H01M4/62

    CPC classification number: H01M10/0569 ,  H01M4/0404 ,  H01M4/0411 ,  H01M4/131 ,  H01M4/1391 ,  H01M4/505 ,  H01M4/621 ,  H01M4/622 ,  H01M4/661 ,  H01M10/0525 ,  Y10T29/49108 ,  Y10T29/49115

    Abstract: This disclosure relates to methods of making a cathode for a lithium batter. The methods include: (a) treating a cathode current collector with flame or corona; (b) coating a slurry containing iron disulfide, a first solvent, and a binder onto the cathode current collector obtained from step (a) to form a coated cathode current collector, in which the slurry contains about 73-75% by weight solids and the binder contains a polymer selected from the group consisting of linear di- and tri-block copolymers, linear tri-block copolymers cross-linked with melamine resin, ethylene-propylene copolymers, ethylene-propylene-diene terpolymers, tri-block fluorinated thermoplastics, hydrogenated nitrile rubbers, fluoro-ethylene-vinyl ether copolymers, thermoplastic polyurethanes, thermoplastic olefins, and polyvinylidene fluoride homopolymers; and (c) drying the coated cathode current collector obtained from step (b) to provide a cathode, in which the cathode contains no more than 0.5% by volume of the first solvent and is capable of being bent to 180°. This disclosure also relates to methods of making a lithium battery.

    Abstract translation: 本公开涉及制备用于锂电池的阴极的方法。 方法包括：（a）用火焰或电晕处理阴极集电器; （b）将含有二硫化铁，第一溶剂和粘合剂的浆料涂布到从步骤（a）获得的阴极集流体上，以形成涂覆的阴极集电器，其中浆料含有约73-75重量％的固体， 粘合剂含有选自直链二嵌段和三嵌段共聚物，与三聚氰胺树脂交联的直链三嵌段共聚物，乙烯 - 丙烯共聚物，乙烯 - 丙烯 - 二烯三元共聚物，三嵌段氟化热塑性塑料， 氢化丁腈橡胶，氟乙烯 - 乙烯基醚共聚物，热塑性聚氨酯，热塑性烯烃和聚偏氟乙烯均聚物; 和（c）将由步骤（b）获得的涂覆的阴极集电体干燥以提供阴极，其中阴极含有不超过0.5体积％的第一溶剂并且能够弯曲至180°。 本公开还涉及制造锂电池的方法。

    METHOD FOR PROLONGING ACTIVITY OF AUTODEGRADABLE ENZYMES AND COMPOSITIONS THEREOF
    32.
    发明申请
    METHOD FOR PROLONGING ACTIVITY OF AUTODEGRADABLE ENZYMES AND COMPOSITIONS THEREOF 审中-公开
    用于增强可自由可扩链酶活性的方法及其组合物

    公开(公告)号：US20100104551A1

    公开(公告)日：2010-04-29

    申请号：US12603988

    申请日：2009-10-22

    Applicant: Dharmendra M. Jani ,  Kai Kwok ,  Gregory L. McIntire ,  Bruce A. Pfeffer ,  Afshin Shafiee ,  Ruiwen Shi ,  Srini Venkatesh ,  Hongna Wang ,  Yan Huang ,  Stephen R. Davio

    Inventor： Dharmendra M. Jani ,  Kai Kwok ,  Gregory L. McIntire ,  Bruce A. Pfeffer ,  Afshin Shafiee ,  Ruiwen Shi ,  Srini Venkatesh ,  Hongna Wang ,  Yan Huang ,  Stephen R. Davio

    IPC: A61K38/48 ,  A61P27/02

    CPC classification number: C12N9/50 ,  A61K31/198 ,  C12N9/6435 ,  C12N9/96 ,  C12Y304/21007

    Abstract: A composition of a long-acting enzyme comprises the enzyme in a formulation comprising a buffer and an additive selected from the group consisting of tranexamic acid, ε-aminocaproic acid, and analogs of L-lysine other than tranexamic acid and ε-aminocaproic acid, combinations thereof, and mixtures thereof. The composition can further comprise another additive selected from the group consisting of L-lysine, L-arginine, L-ornithine (or its pharmaceutically acceptable salts; e.g., L-ornithine hydrochloride), γ-aminobutyric acid, 5-aminovaleric acid, 7-aminoheptanoic acid, glycylglycine, triglycine, N-α-acetyl-L-arginine, betaine, sarcosine, gelatin, HSA, streptokinase, tPA, uPA, non-ionic surfactants, glycerin, D-sorbitol, combinations thereof, and mixtures thereof. A method for prolonging the activity of an autodegradable enzyme comprises storing the enzyme after manufacture at a low pH, and reconstituting the acidified enzyme before use with a solution containing at least one of such additives. The method is useful to provide enzyme for wide use, which otherwise would lose activity upon long storage. In one embodiment the method is applicable to provide enzyme for inducing controlled posterior vitreous detachment.

    Abstract translation: 长效酶的组合物包含在包含缓冲液和添加剂的制剂中的酶，所述缓冲剂和添加剂选自氨甲环酸，氨基己酸和除了氨甲环酸以外的L-赖氨酸和β-氨基己酸 酸，其组合，及其混合物。 所述组合物可以进一步包含选自L-赖氨酸，L-精氨酸，L-鸟氨酸（或其药学上可接受的盐，例如L-鸟氨酸盐酸盐），γ-氨基丁酸，5-氨基戊酸，7 氨基庚酸，甘氨酰甘氨酸，三甘氨酸，N-α-乙酰基-L-精氨酸，甜菜碱，肌氨酸，明胶，HSA，链激酶，tPA，uPA​​，非离子表面活性剂，甘油，D-山梨糖醇，其组合及其混合物。 用于延长自动降解酶的活性的方法包括在低pH下制备后储存酶，并且在使用前将酸化酶与含有至少一种这样的添加剂的溶液重新组合。 该方法对于提供广泛使用的酶是有用的，否则将在长期储存时失去活性。 在一个实施方案中，该方法适用于提供用于诱导受控的后玻璃体脱离的酶。

    Optical hydrogel material with photosensitizer and method for modifying the refractive index
    34.
    发明申请
    Optical hydrogel material with photosensitizer and method for modifying the refractive index 有权
    具有光敏剂的光学水凝胶材料和用于改变折射率的方法

    公开(公告)号：US20090287306A1

    公开(公告)日：2009-11-19

    申请号：US12380892

    申请日：2009-03-04

    Applicant: Thomas Smith ,  Wayne H. Knox ,  Li Ding ,  Dharmendra Jani ,  Jeffrey G. Linhardt

    Inventor： Thomas Smith ,  Wayne H. Knox ,  Li Ding ,  Dharmendra Jani ,  Jeffrey G. Linhardt

    IPC: A61F2/16 ,  B29D11/00 ,  A61F2/14

    CPC classification number: A61F9/00804 ,  A61F2/1451 ,  A61F2/1627 ,  A61F2/1635 ,  A61L27/50 ,  A61L27/52 ,  A61L2430/16 ,  B29D11/00009 ,  G02C2202/14

    Abstract: A method for modifying the refractive index of an optical, hydrogel polymeric material. The method comprises irradiating predetermined regions of an optical, polymeric material with a laser to form refractive structures. To facilitate the formation of the refractive structures the optical, hydrogel polymeric material comprises a photosensitizer. The presence of the photosensitizer permits one to set a scan rate to a value that is at least fifty times greater than a scan rate without the photosensitizer in the material, yet provides similar refractive structures in terms of the observed change in refractive index. Alternatively, the photosensitizer in the polymeric material permits one to set an average laser power to a value that is at least two times less than an average laser power without the photosensitizer in the material, yet provide similar refractive structures.

    Abstract translation: 一种用于改变光学水凝胶聚合物材料的折射率的方法。 该方法包括用激光照射光学聚合材料的预定区域以形成折射结构。 为了促进折射结构的形成，光学水凝胶聚合物材料包含光敏剂。 光敏剂的存在允许将扫描速率设置为比材料中没有光敏剂的扫描速率至少大五十倍的值，但是根据观察到的折射率变化提供相似的折射结构。 或者，聚合物材料中的光敏剂允许将平均激光功率设置为比平均激光功率小至少两倍的值，而不需要材料中的光敏剂，但是提供类似的折射结构。

    Method and system for adaptive back-off and advance for non-volatile storage (NVS) occupancy level management
    38.
    发明授权
    Method and system for adaptive back-off and advance for non-volatile storage (NVS) occupancy level management 失效
    用于非易失性存储（NVS）占用级别管理的自适应退避和提前的方法和系统

    公开(公告)号：US07496714B2

    公开(公告)日：2009-02-24

    申请号：US12026569

    申请日：2008-02-06

    Applicant: Binny S. Gill ,  Dharmendra S. Modha

    Inventor： Binny S. Gill ,  Dharmendra S. Modha

    IPC: G06F12/00

    CPC classification number: G06F12/0804 ,  G06F12/0866 ,  G06F2212/222

    Abstract: A technique for determining when to destage write data from a fast, NVS of a computer system from an upper level to a lower level of storage in the computer system comprises adaptively varying a destage rate of the NVS according to a current storage occupancy of the NVS; maintaining a high threshold level for the NVS; maintaining a low threshold level that is set to be a predetermined fixed amount below the high threshold; setting the destage rate of the NVS to zero when the NVS occupancy is below the low threshold; setting the destage rate of the NVS to be maximum when the NVS occupancy is above the high threshold; linearly increasing the destage rate of the NVS from zero to maximum as the NVS occupancy goes from the low to the high threshold; and adaptively varying the high threshold in response to a dynamic computer storage workload.

    Abstract translation: 一种用于确定何时从计算机系统的快速NVS将计算机系统的写入数据从计算机系统中的较高级别存储到较低级别的存储装置的技术包括根据NVS的当前存储占用自适应地改变NVS的流率 ; 维持NVS的高门槛值; 保持低阈值水平，其被设置为低于高阈值的预定固定量; 当NVS占用率低于低阈值时，将NVS的流出率设置为零; 当NVS占用率高于高阈值时，将NVS的流出率设置为最大值; 随着NVS占用率从低到高的阈值，将NVS的流失率从零线性上升到最大值; 以及响应于动态计算机存储工作负载自适应地改变高阈值。

    COMPOSITIONS FOR REDUCING, AMELIORATING, TREATING, OR PREVENTING CONDITION OF DRY EYE AND METHODS OF MAKING AND USING SAME
    40.
    发明申请
    COMPOSITIONS FOR REDUCING, AMELIORATING, TREATING, OR PREVENTING CONDITION OF DRY EYE AND METHODS OF MAKING AND USING SAME 审中-公开
    用于减少，调理，治疗或预防干眼症状的组合物及其制备和使用方法

    公开(公告)号：US20080280853A1

    公开(公告)日：2008-11-13

    申请号：US12114878

    申请日：2008-05-05

    Applicant: Erning Xia ,  Dharmendra M. Jani

    Inventor： Erning Xia ,  Dharmendra M. Jani

    IPC: A61K31/715 ,  A61P27/02

    CPC classification number: A61K9/0048 ,  A61K47/26 ,  A61K47/36

    Abstract: Compositions for relief, treatment, or prevention of a condition of dry eye comprise alginate, at least a polyol, and a pharmaceutically acceptable carrier, wherein the compositions have pH in the range from about 5 to about 7.5. In some embodiment, the compositions can further include a chelating agent, a buffering system or agent, an organic acid, or combinations thereof.

    Abstract translation: 用于缓解，治疗或预防干眼症状的组合物包括藻酸盐，至少多元醇和药学上可接受的载体，其中所述组合物的pH在约5至约7.5的范围内。 在一些实施方案中，组合物可进一步包括螯合剂，缓冲系统或试剂，有机酸或其组合。

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