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公开(公告)号：US11572427B2
公开(公告)日：2023-02-07
申请号：US17165039
申请日：2021-02-02
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete Irene Modahl , Nini Hofsloekken Kjus , Astrid Evenroed Molteberg , Diem Thuy Thi Tran , Jo Aaserud , M. Talha Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F230/08 , C08F220/58 , C08F8/34 , C08F8/32 , C08F8/12 , C08F2/20 , C08F130/08 , C08F6/24 , C07F7/18 , C12Q1/686 , C08F2/26 , C08F222/38 , C12P19/34 , C12Q1/6874 , G01N27/414 , C08J9/20 , C08F220/60
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US11261480B2
公开(公告)日：2022-03-01
申请号：US16849833
申请日：2020-04-15
Applicant: LIFE TECHNOLOGIES AS
Inventor： Darren Ellis , Geir Fonnum , Nini Kjus
IPC: C12Q1/68 , C12N15/10 , C12Q1/6806
Abstract: A method for processing a nucleic acid, in which the nucleic acid is exposed to an aqueous medium which includes a polyol in sufficient proportion for at least a portion of the nucleic acid to enter or remain in an extra-solution phase. Thus, a polyol may be used to bind a nucleic acid which is in solution to a solid support or to wash a nucleic acid on a solid support whilst maintaining it on the support. The polyol may for example be a C2-C10 alkanediol.
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公开(公告)号：US10407676B2
公开(公告)日：2019-09-10
申请号：US14964060
申请日：2015-12-09
Applicant: LIFE TECHNOLOGIES CORPORATION , THERMO FISHER SCIENTIFIC GENEART GMBH , LIFE TECHNOLOGIES AS
Inventor： Thomas Poehmerer , Phillip Kuhn , Frank Notka , Andreas Zeidler , Korbinian Heil , Axel Trefzer , Geir Fonnum , Federico Katzen , Kristian Andersson
Abstract: The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
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公开(公告)号：US10202473B2
公开(公告)日：2019-02-12
申请号：US15005420
申请日：2016-01-25
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete Irene Modahl , Nini Hofsloekken Kjus , Astrid Evenroed Molteberg , Diem Thuy Thi Tran , Jo Aaserud , M. Talha Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F130/08 , C08F6/24 , C07F7/18 , C08F2/20 , C08F2/26 , C08F220/58 , C08F230/08 , C08F222/38 , C08F8/32 , C08F8/34 , C12Q1/686 , C12P19/34 , C12Q1/6874 , G01N27/414 , C08J9/20 , C08F8/12
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US20180163255A1
公开(公告)日：2018-06-14
申请号：US15891535
申请日：2018-02-08
Applicant: LIFE TECHNOLOGIES AS
Inventor： Darren ELLIS , Geir FONNUM , Nini KJUS
IPC: C12Q1/6806 , C12N15/10
CPC classification number: C12Q1/6806 , C12N15/1006 , C12N15/1013
Abstract: A method for processing a nucleic acid, in which the nucleic acid is exposed to an aqueous medium which includes a polyol in sufficient proportion for at least a portion of the nucleic acid to enter or remain in an extra-solution phase. Thus, a polyol may be used to bind a nucleic acid which is in solution to a solid support or to wash a nucleic acid on a solid support whilst maintaining it on the support. The polyol may for example be a C2-C10 alkanediol.
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Patent Agency Ranking
公开(公告)号：US09909165B2
公开(公告)日：2018-03-06
申请号：US15431678
申请日：2017-02-13
Applicant: LIFE TECHNOLOGIES AS
Inventor： Darren Ellis , Geir Fonnum , Nini Kjus
CPC classification number: C12Q1/6806 , C12N15/1006 , C12N15/1013
Abstract: A method for processing a nucleic acid, in which the nucleic acid is exposed to an aqueous medium which includes a polyol in sufficient proportion for at least a portion of the nucleic acid to enter or remain in an extra-solution phase. Thus, a polyol may be used to bind a nucleic acid which is in solution to a solid support or to wash a nucleic acid on a solid support while maintaining it on the support. The polyol may for example be a C2-C10 alkanediol.
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公开(公告)号：US20170204398A1
公开(公告)日：2017-07-20
申请号：US15431678
申请日：2017-02-13
Applicant: LIFE TECHNOLOGIES AS
Inventor： Darren ELLIS , Geir FONNUM , Nini KJUS
CPC classification number: C12Q1/6806 , C12N15/1006 , C12N15/1013
Abstract: A method for processing a nucleic acid, in which the nucleic acid is exposed to an aqueous medium which includes a polyol in sufficient proportion for at least a portion of the nucleic acid to enter or remain in an extra-solution phase. Thus, a polyol may be used to bind a nucleic acid which is in solution to a solid support or to wash a nucleic acid on a solid support whilst maintaining it on the support. The polyol may for example be a C2-C10 alkanediol.
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公开(公告)号：US09487603B2
公开(公告)日：2016-11-08
申请号：US14970241
申请日：2015-12-15
Applicant: LIFE TECHNOLOGIES CORPORATION , LIFE TECHNOLOGIES AS
Inventor： Geir Fonnum , Grete Irene Modahl , Nini Hofslokken Kjus , Astrid Evenroed Molteberg , Diem Tran , Jo Aaserud , M. Talha Gokmen , Steven M. Menchen , Carl Fuller , Luisa Andruzzi , Wolfgang Hinz
IPC: C08F130/08 , C08F6/24 , C08J9/20 , C07F7/18 , C08F2/20 , C08F2/26 , C08F220/58 , C08F230/08 , C08F222/38 , C08F8/32 , C08F8/34 , C12Q1/68 , C12P19/34 , G01N27/414
CPC classification number: C08F130/08 , C07F7/1804 , C07F7/188 , C08F2/20 , C08F2/26 , C08F6/24 , C08F8/12 , C08F8/32 , C08F8/34 , C08F220/58 , C08F222/385 , C08F230/08 , C08F2800/20 , C08J9/20 , C08J2343/04 , C12P19/34 , C12Q1/686 , C12Q1/6874 , G01N27/4145 , Y10T428/2982 , C08F257/02 , C08F2222/1013 , C08F212/36 , C08F220/60 , C12Q2563/149 , C12Q2563/159 , C12Q2565/543
Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
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公开(公告)号：US20160075800A1
公开(公告)日：2016-03-17
申请号：US14867394
申请日：2015-09-28
Applicant: Arvid BERGE , Viola Ugelstad , LIFE TECHNOLOGIES AS
Inventor： Arne JØRGEDAL , Elin Marie AKSNES , Geir FONNUM , Astrid MOLTEBERG , Rolf NORDAL , Henning PETTERSEN , Tollef TÅARNEBY , Solveig STAALE , Ellen WENG , Finn HANSEN , Silje NORDBØ , Oddvar AUNE , Arvid BERGE , John BJØRGUM , Turid ELLINGSEN , John UGELSTAD
CPC classification number: C08J9/16 , C08F2/22 , C08F257/02 , C08F265/04 , C08F265/10 , C08F291/00 , C08J9/22 , C08J9/224 , C08J2203/14 , C08J2325/06 , C08J2347/00
Abstract: A process for the preparation of monodisperse polymer particles which are formed by contacting monomers with aqueous dispersions comprising monodisperse swellable seed polymers/oligomers, and initiating polymerization in the presence of a steric stabilizer. The resulting swollen seed particles are characterized by the particle mode diameter.
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公开(公告)号：US20160024470A1
公开(公告)日：2016-01-28
申请号：US14806403
申请日：2015-07-22
Applicant: LIFE TECHNOLOGIES AS
Inventor： Tanja AARVAK , Anne-Marie RASMUSSEN , Gunnar KVALHEIM , Walter Gabriell Borelli PIEDRAS , Anne BRUNSVIG
IPC: C12N5/0783 , A61K35/17
CPC classification number: C12N5/0637 , A61K31/12 , A61K35/17 , A61K2035/122 , C12N5/0636 , C12N2501/04 , C12N2501/2302 , C12N2501/2304 , C12N2501/998 , C12N2501/999
Abstract: Methods are disclosed for the generation of immunosuppressive regulatory T cells. The methods can include contacting a population of CD4+CD25− T cells with a T cell receptor (TCR)/CD3 activator, a TCR co-stimulator activator, and rapamycin. Kits for the generation of immunosuppressive regulatory T cells, methods of use, and cell populations are also disclosed.
Abstract translation: 公开了用于产生免疫抑制性调节性T细胞的方法。 所述方法可以包括使CD4 + CD25-T细胞群与T细胞受体（TCR）/ CD3激活剂，TCR共刺激因子激活剂和雷帕霉素接触。 还公开了用于产生免疫抑制性调节性T细胞，使用方法和细胞群的试剂盒。
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