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公开(公告)号：US09533088B2
公开(公告)日：2017-01-03
申请号：US13928622
申请日：2013-06-27
CPC分类号： A61M1/367 , A61M1/3626 , A61M1/3653 , A61M1/3656 , A61M39/223 , A61M2205/15 , Y10T137/86831
摘要： A flow reversing device for performing blood treatment can include a flow reversing actuator. The flow reversing actuator can receive and engage a disposable tubing set with multiple branches that form forward and reverse blood flow paths respectively when blood the flow reversing actuator is selectively changed between forward and reverse configurations. The shape of the tubing can be such that during forward operation, dead regions of non-flowing blood are defined. The flow reversing actuator can have a controller configured to operate generally in forward mode. At first times, the controller can cause the flow reversing actuator to clear the dead regions. At second times, the controller can cause the flow reversing actuator to test for leaks by reversing the flow of blood for a period of time sufficient to cause air to be drawn into the tubing set and conveyed to an air sensor.
摘要翻译： 用于进行血液处理的流量反转装置可以包括流动反转致动器。 流量反转致动器可以分别接收和接合具有多个分支的一次性管道组，其中分支形成正向和反向血流路径，当血液逆向致动器在正向和反向构造之间选择性地改变时。 管的形状可以使得在正向操作期间，限定非流动血液的死区。 流动反向致动器可以具有被配置为大体上以正向模式操作的控制器。 在第一时间，控制器可以使流动反向致动器清除死区。 在第二次时，控制器可以使流量反向致动器通过反转血液流动足以使空气被吸入管道组并传送到空气传感器的时间来测试泄漏。
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32.发明申请公开(公告)号：US20160022897A1
公开(公告)日：2016-01-28
申请号：US14773724
申请日：2014-03-13
发明人： William K. WEIGEL , Joseph E. TURK , Jan STANGE , Dennis M. TREU
CPC分类号： A61M1/3663 , A61M1/1603 , A61M1/1633 , A61M1/1645 , A61M1/1676 , A61M1/1694 , A61M1/3403 , A61M1/3417 , A61M1/3679
摘要： Methods, systems, and devices are disclosed, embodiments of which provide single pass dialysis to remove water and uremic toxins is performed simultaneously with the albumin dialysis therapy by passing the albumin solution through a dialysis filter which dialyses it before the solution is returned to the cycler. In embodiments, the single pass dialysis stage is upstream of the albumin filtering stage.
摘要翻译： 公开了方法，系统和装置，其实施方案提供单次透析以除去水和尿毒症毒素，其与白蛋白透析治疗同时进行，通过使白蛋白溶液通过透析过滤器，在透析过滤器将溶液返回到循环仪 。 在实施方案中，单次透析阶段在白蛋白过滤阶段的上游。
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公开(公告)号：US20150374895A1
公开(公告)日：2015-12-31
申请号：US14762831
申请日：2014-01-24
CPC分类号： A61M1/1656 , A61M1/1664 , A61M1/1666 , A61M1/1672 , C02F1/001 , C02F1/283 , C02F1/32 , C02F1/42 , C02F1/441 , C02F2001/427 , C02F2101/12 , C02F2103/026 , C02F2209/003 , C02F2209/02 , C02F2209/05 , C02F2209/29 , C02F2209/445
摘要： A water purification component, which may be integrated in a medicament production plant and/or a blood treatment system, removes chloramine and other chlorine compounds and deionizes water. The deionization is selected to be effective for providing product water whose resistivity is sufficiently high to allow chloramine to be detected in the product water if the chloramine removal filtration fails. This allows a chloramine removal filter to be changed based on a predicted exhaustion schedule with the safety of automatic chloramine breakthrough provided.
摘要翻译： 可以集成在药物生产设备和/或血液处理系统中的水净化组分可除去氯胺和其他氯化合物并使水去离子。 选择去离子电极对于提供电阻率足够高的产品水是有效的，以便如果氯胺除去过滤失败，则可以在产品水中检测到氯胺。 这允许基于预测的耗尽时间表改变氯胺去除过滤器，并提供自动氯胺突破的安全性。
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公开(公告)号：US20150359973A1
公开(公告)日：2015-12-17
申请号：US14763808
申请日：2014-01-31
发明人： MATTHEW ONKEN , STEVEN BELLETTI
CPC分类号： A61M5/3202 , A61M5/32 , A61M25/0631 , A61M25/0637
摘要： Methods and devices for use and handling of intravenous and/or subcutaneous needles, and, more particularly, to safety devices for shielding needles or other sharp articles or devices that present a safety hazard are disclosed. In an embodiment, a needle protective sheath can include a top wall, a bottom wall, and a pair of side walls joining the top and bottom walls. A finger shield extends from the top wall at a front opening of the sheath and is attached to the top wall by a hinge portion. The finger shield can be rotated about the hinge portion to block the front opening so as to secure a needle within the sheath.
摘要翻译： 公开了用于使用和处理静脉内和/或皮下针的方法和装置，更具体地，涉及用于屏蔽针或其它具有安全隐患的尖锐物品或装置的安全装置。 在一个实施例中，针保护套可以包括顶壁，底壁和连接顶壁和底壁的一对侧壁。 手指护罩在护套的前开口处从顶壁延伸并且通过铰链部分附接到顶壁。 手指护罩可以围绕铰链部分旋转以阻挡前开口，以便将针固定在护套内。
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公开(公告)号：US20150267821A1
公开(公告)日：2015-09-24
申请号：US14348509
申请日：2013-05-24
CPC分类号： F16K7/06 , A61M39/284 , B29C37/0003 , Y10T24/44906
摘要： Releasable tubing pinch clamps of a generally U-shaped configuration are described. The embodiments include ones that prevent cross-clamping of the tube by various interlocking features on riser portions of the clamp. Methods and molds for making the pinch clamps are also described. The pinch clamp consists generally of a strip that curves so that its ends can be brought together by manually squeezing the strip at its ends which oppose each other as a result of the strip curve. The strip ends contain locking edges or surfaces that cause the strip ends to interferingly engage with each other and lock together. The strip also contains opposing pinching projections that pinch a tube.
摘要翻译： 描述了大致U形构造的可释放的管夹紧夹具。 这些实施例包括通过夹具的立管部分上的各种互锁特征来防止管的交叉夹紧的实施例。 还描述了用于制造夹紧夹具的方法和模具。 夹紧夹具通常由条带组成，其弯曲，使得其端部可以通过在条带曲线的作用下手动挤压条带在彼此相对的端部而被带到一起。 条带端部包含锁定边缘或表面，其使得条带端部彼此干涉地接合并锁定在一起。 条带还包含夹紧管的相对的夹持突起。
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36.发明申请公开(公告)号：US20150005699A1
公开(公告)日：2015-01-01
申请号：US14348533
申请日：2012-09-23
IPC分类号： A61M1/28
摘要： An automated peritoneal dialysis system provides various features including prescription-driven dialysis fluid preparation, an integrated disposable fluid circuit, and sensor capabilities that allow accurate filing and draining control with high safety margins. Features include a peritoneal fluid circuit with a pressure sensor at either end and methods and devices for using the pressure signals. Other features and embodiments are disclosed.
摘要翻译： 自动腹膜透析系统提供各种功能，包括处方驱动的透析液制备，集成的一次性流体回路和传感器功能，可以在高安全裕度下进行精确的排放和排水控制。 特征包括一个腹膜液回路，两端都有一个压力传感器，以及使用压力信号的方法和装置。 公开了其它特征和实施例。
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37.发明授权Method and apparatus for machine error detection by combining multiple sensor inputs 有权通过组合多个传感器输入进行机器错误检测的方法和装置公开(公告)号：US08641615B2
公开(公告)日：2014-02-04
申请号：US13921115
申请日：2013-06-18
IPC分类号： A61B5/00 , A61M1/10 , A61M1/14 , A61M1/36 , A61M1/16 , G06F19/00 , G08B21/02 , G06K9/62 , G06Q50/22
CPC分类号： A61M1/10 , A61M1/1006 , A61M1/1086 , A61M1/14 , A61M1/1611 , A61M1/1692 , A61M1/34 , A61M1/3403 , A61M1/3607 , A61M1/3609 , A61M1/3621 , A61M1/3626 , A61M1/3639 , A61M1/3653 , A61M1/3655 , A61M1/3656 , A61M1/3659 , A61M2205/15 , A61M2205/18 , A61M2205/33 , A61M2205/3303 , A61M2205/3331 , A61M2205/3344 , A61M2205/3368 , A61M2205/3375 , A61M2205/502 , A61M2230/06 , A61M2230/205 , G01M3/26 , G06F19/00 , G06K9/62 , G06K9/6228 , G06K9/6278 , G06Q50/22 , G08B21/02 , G08B21/0211 , G16H40/63 , G16H50/20
摘要： One of the most significant safety concerns in the automation of extracorporeal blood treatments such as dialysis is the risk of blood leakage. Extracorporeal blood treatment systems draw blood at such a high rate that a loss of integrity in the blood circuit can be serious. There are a number of mechanisms for detecting and preventing leaks, but none is perfect. This tends to limit the use of such equipment in unsupervised settings, such as the home will be limited. Some leak detection schemes can be made sensitive enough to detect the barest of leaks, but when this is done, they result in too many false positives. The invention combines information from multiple inputs to enhance sensitivity in leak detection and reduce the problem of false positives.
摘要翻译： 体外血液治疗如透析自动化中最重要的安全问题之一是出现血液渗漏的风险。 体外血液处理系统以如此高的速度吸取血液，使得血液回路的完整性丧失可能严重。 有一些检测和防止泄漏的机制，但没有一个是完美的。 这样会限制在无监督设置中使用这种设备，例如家庭将受到限制。 一些泄漏检测方案可以做得足够灵敏，可以检测最多的泄漏，但是当这样做时，它们会产生太多的假阳性。 本发明组合来自多个输入的信息，以提高泄漏检测的灵敏度，并减少误报的问题。
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公开(公告)号：US20130283891A1
公开(公告)日：2013-10-31
申请号：US13928622
申请日：2013-06-27
IPC分类号： A61M1/36
CPC分类号： A61M1/367 , A61M1/3626 , A61M1/3653 , A61M1/3656 , A61M39/223 , A61M2205/15 , Y10T137/86831
摘要： A flow reversing device for performing blood treatment can include a flow reversing actuator. The flow reversing actuator can receive and engage a disposable tubing set with multiple branches that form forward and reverse blood flow paths respectively when blood the flow reversing actuator is selectively changed between forward and reverse configurations. The shape of the tubing can be such that during forward operation, dead regions of non-flowing blood are defined. The flow reversing actuator can have a controller configured to operate generally in forward mode. At first times, the controller can cause the flow reversing actuator to clear the dead regions. At second times, the controller can cause the flow reversing actuator to test for leaks by reversing the flow of blood for a period of time sufficient to cause air to be drawn into the tubing set and conveyed to an air sensor.
摘要翻译： 用于进行血液处理的流量反转装置可以包括流动反转致动器。 流量反转致动器可以分别接收和接合具有多个分支的一次性管道组，其中分支形成正向和反向血流路径，当血液逆向致动器在正向和反向构造之间选择性地改变时。 管的形状可以使得在正向操作期间，限定非流动血液的死区。 流动反向致动器可以具有被配置为大体上以正向模式操作的控制器。 在第一时间，控制器可以使流动反向致动器清除死区。 在第二次时，控制器可以使流动反向致动器通过反转血液流动足以使空气被吸入管道组并传送到空气传感器的时间来测试泄漏。
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公开(公告)号：US20020147481A1
公开(公告)日：2002-10-10
申请号：US09829670
申请日：2001-04-09
IPC分类号： A61F007/00
CPC分类号： A61F7/0085 , A61F2007/0054 , A61M5/44
摘要： An external fluid warming device is described that includes a fluid warming chamber and an air separation chamber. The fluid warming chamber has a fluid inlet that communicates with a fluid pathway. The air separation chamber that communicates with the fluid pathway has a fluid outlet and a gas outlet. A heating source, such as heat plates, are disposed adjacent the fluid pathway for transferring heat to the fluid. In use, the air separation chamber is positioned above the fluid warming chamber and the heating source. The fluid inlet is connected to a source of fluid and the fluid outlet is connected to an output device, such as an ultrafiltration machine. Gas generated during warming of the fluid collects at a top of the air separation chamber and is vented through the gas outlet, whereas fluid passes through a bottom of the air separation chamber and through the fluid outlet.
摘要翻译： 描述了包括流体加热室和空气分离室的外部流体加温装置。 流体加热室具有与流体通路连通的流体入口。 与流体通道连通的空气分离室具有流体出口和气体出口。 加热源，例如加热板，邻近流体通道设置，用于将热量传递到流体。 在使用中，空气分离室位于流体加热室和加热源的上方。 流体入口连接到流体源，并且流体出口连接到诸如超滤机器的输出装置。 在加热流体期间产生的气体聚集在空气分离室的顶部并通过气体出口排出，而流体通过空气分离室的底部并通过流体出口。
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公开(公告)号：US20230112605A1
公开(公告)日：2023-04-13
申请号：US18078299
申请日：2022-12-09
发明人： James M. BRUGGER , Dennis M. TREU , Jeffrey H. BURBANK , Scott W. NEWELL , William J. SCHNELL , Kenneth E. BUCKLER
摘要： A method for measuring pressure includes securing a flow channel to a chassis of a measurement device, the flow channel having a flexible wall with a first mechanical engagement feature presented from an external surface thereof. The method also includes engaging the mechanical engagement feature with a complementary engagement member connected to a force transducer, the securing being effective to immobilize the flow channel relative to the force transducer, and detecting at least one of the position and orientation of the of the flow channel relative to transducer and comparing to at least one of a predefined position and orientation. Further, the method includes generating a signal responsive to the detecting, flowing a fluid through the flow channel, and transmitting forces caused by displacement of the flexible wall through the complementary engagement member to the force transducer. Further, electrical signals are generated responsively to a state of the force transducer.
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