Abstract:
A wearable device for use with a smart phone or tablet includes LEDs for measuring physiological parameters by modulating the LEDs and generating a near-infrared multi-wavelength optical beam. At least one LED emits at a first wavelength having a first penetration depth and at least another LED emits at a second wavelength having a second penetration depth into tissue. The device includes lenses that deliver the optical beam to the tissue, which reflects the first and second wavelengths. A receiver is configured to capture light while the LEDs are off and while at least one of the LEDs is on and to difference corresponding signals to improve a signal-to-noise ratio of the optical beam reflected from the tissue. The signal-to-noise ratio is further increased by increasing light intensity of at least one of the LEDs. The device generates an output signal representing a non-invasive measurement on blood within the tissue.
Abstract:
A measurement apparatus includes sensors adapted to be coupled to tissue containing blood and configured to generate signals associated with physiological parameters. The device is configured to communicate with a software application through a base device. The software application is configured to operate on a control system. The control system is capable of receiving physiological parameter signals. The control system includes a touch-screen, a proximity sensor, circuitry for obtaining movement information from a positioning sensor, a mechanical system having actuators, and a wireless transmitter to transmit data to a host. The software application is operable to generate the physiological information based on the signals from the sensors. The control system is further configured to receive voice input signals and manually entered input signals. The host is configured to generate status information from the data and includes a memory storage device and a communication device.
Abstract:
A measurement system includes a wearable measurement device for measuring one or more physiological parameters, including a light source comprising a plurality of light emitting diodes (LEDs) configured to generate an output optical beam with a near-infrared wavelength between 700 nanometers and 2500 nanometers. The light source is configured to increase signal-to-noise ratio by increasing a light intensity and pulse rate of the LEDs. The system includes a plurality of lenses configured to receive the output optical beam and to deliver an analysis output beam to a sample. The wearable measurement device includes a receiver configured to process the analysis output beam reflected or transmitted from the sample and to generate an output signal that may be transmitted to a remote device configured to process the received output status to generate processed data and to store the processed data.
Abstract:
A diagnostic system includes a sensor configured to generate signals associated with physiological parameters, a proximity sensor, a positioning sensor, and a software application configured to operate on a control system adapted to receive and process physiological information including a touch-screen, a mechanical system having actuators, and a wireless transmitter to transmit data over a wireless link to a host. The software application is operable to generate the physiological information using the signals from the sensor. The control system receives voice and manually entered input signals. The host generates status information from the date and includes a memory storage device for recording the status information and a communication device for communicating the status information over a communication link to one or more display output devices located remotely from the host.
Abstract:
A system and method for selectively processing target tissue material in a patient include a laser subsystem for generating an output laser beam and a catheter assembly including an optical fiber for guiding the output laser beam. The beam has a predetermined selected wavelength between 900 nm and 2600 nm. The catheter assembly is sized to extend through an opening in a first part of the patient to a tissue material processing site within the patient. A beam delivery and focusing subsystem includes a focal distance, which may be adjustable, that positions the beam into at least one focused spot on the target tissue material disposed within a second part of the patient for a duration sufficient to allow laser energy to be absorbed by the target tissue material and converted to heat to produce a desired physical change in the target tissue material without causing undesirable changes to adjacent non-target material.
Abstract:
A diagnostic system includes a plurality of semiconductor diodes, a multiplexer, and one or more waveguide structures to form an output beam. A lens system communicates some of the output beam onto a part of a user's body comprising blood to perform a measurement. A software application is capable of generating data based at least in part on the measurement, and it operates on a control system that may have a touch-screen, a proximity sensor, and a wireless transceiver to transmit wireless data over a wireless link. A host comprises a digital file, control logic at the host to process at least the portion of the wireless data to generate a status of the user, a memory storage device for recording the status, and an output for communicating at least a portion of the status or associated information over a communication link to one or more remote display output devices.
Abstract:
A system and method for using near-infrared or short-wave infrared (SWIR) light sources for early detection and monitoring of breast cancer, as well as other kinds of cancers may detect decreases in lipid content and increases in collagen content, possibly with a shift in the collagen peak wavelengths and changes in spectral features associated with hemoglobin and water content as well. Wavelength ranges between 1000-1400 nm and 1600-1800 nm may permit relatively high penetration depths because they fall within local minima of water absorption, scattering loss decreases with increasing wavelength, and they have characteristic signatures corresponding to overtone and combination bands from chemical bonds of interest, such as hydrocarbons. Broadband light sources and detectors permit spectroscopy in transmission, reflection, and/or diffuse optical tomography. High signal-to-noise ratio may be achieved using a fiber-based super-continuum light source. Risk of pain or skin damage may be mitigated using surface cooling and focused infrared light.
Abstract:
Focused infrared light at wavelengths selected to target tissue below the skin may be used in a non-invasive procedure for vasectomies, varicose veins, hemorrhoids, or fungal nail infections. Infrared light from various sources selected for a particular application may be focused so that the cone of light has lower intensity on the skin/outer tissue and higher intensity at a desired depth to cause thermal coagulation or occlusion of the target tissue beneath the skin. Surface cooling techniques, such as cryogenic sprays or contact cooling may be used to protect the skin. More generally, the focused infrared light with or without surface cooling may be used in applications for thermally coagulating or occluding relatively shallow vessels while protecting or minimizing damage to outer layers of the tissue or skin.
Abstract:
A system and method for using near-infrared or short-wave infrared (SWIR) light sources for identification of counterfeit drugs may perform spectroscopy using a super-continuum laser to provide detection in a non-contact and non-destructive manner at stand-off or remote distances with minimal sample preparation. Also, near-infrared or SWIR light may penetrate through plastic containers and packaging, permitting on-line inspection and rapid scanning. The near-infrared or SWIR spectroscopy may also be used to detect illicit drugs and their chemical composition. Moreover, the spectroscopic techniques may also be applied to quality assessment and control in pharmaceutical manufacturing, thus permitting the implementation of smart manufacturing with feedback control. Fiber super-continuum lasers may emit light in the near-infrared or SWIR between approximately 1.4-1.8 microns, 2-2.5 microns, 1.4-2.4 microns, 1-1.8 microns. In particular embodiments, the detection system may be a dispersive spectrometer, a Fourier transform infrared spectrometer, or a hyper-spectral imaging detector or camera.
Abstract:
An optical system comprises a wearable device for measuring one or more physiological parameters. The physiological parameters may change in response to stretching of the hand or movement of fingers or thumb of the user, or the parameters may be related to blood constituents or blood flow. The wearable device comprises a light source with a plurality of semiconductor diodes and a detection system that measures reflected light from tissue comprising skin. The semiconductor diodes may be light emitting diodes or laser diodes. The signal to noise ratio for the output signal may be improved by synchronizing the detection system to the light source, increasing light intensity of at least one of the plurality of semiconductor diodes from an initial light intensity, and using change detection that compares light on versus light off for the detection system output. The wearable device is also configured to identify an object.