公开(公告)号：US10248764B2

公开(公告)日：2019-04-02

申请号：US15721277

申请日：2017-09-29

Applicant: STC.UNM

Inventor： Roy William Keyes ,  Christian Romano ,  Shuang Luan ,  Dorian C. Arnold

IPC: G06F19/00 ,  G16H50/50 ,  G06F9/50

Abstract: A method of calculating radiation fluence and energy deposition distributions on a networked virtual computational cluster is presented. With this method, complex Monte Carlo simulations that require expansive equipment, personnel, and financial resources can be done efficiently and inexpensively by hospitals and clinics requiring radiation therapy dose calculations.

公开(公告)号：US20190091150A1

公开(公告)日：2019-03-28

申请号：US16025557

申请日：2018-07-02

Applicant: STC.UNM ,  Sandia Corporation

Inventor： C. Jeffrey Brinker ,  Eric C. Carnes ,  Carlee Erin Ashley ,  Cheryl L. Willman

IPC: A61K9/127 ,  A61K31/704 ,  A61K33/24 ,  A61K47/69 ,  C07K14/47 ,  A61K45/06 ,  A61K47/62 ,  C12N15/88 ,  A61K39/05 ,  C12N15/113 ,  A61K31/711 ,  A61K48/00 ,  A61K38/00

Abstract: The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery.

公开(公告)号：US20190089355A1

公开(公告)日：2019-03-21

申请号：US16185921

申请日：2018-11-09

Applicant: STC.UNM

Inventor： James Plusquellic ,  James Aarestad

IPC: H03K19/003 ,  H03K23/00 ,  H03K3/84 ,  H04L9/08 ,  H03K19/21 ,  H04L9/06

Abstract: A Hardware-Embedded Delay PUF (HELP) leverages entropy by monitoring path stability and measuring path delays from core logic macros. HELP incorporates techniques to deal with bias. A unique feature of HELP is that it may compare data measured from different test structures. HELP may be implemented in existing FPGA platforms. HELP may leverage both path stability and within-die variations as sources of entropy.

公开(公告)号：US20190051783A1

公开(公告)日：2019-02-14

申请号：US16160272

申请日：2018-10-15

Applicant: STC.UNM

Inventor： Majeed M. Hayat ,  Payman Zarkesh-Ha

IPC: H01L31/107 ,  H03F3/08 ,  H01L25/16

CPC classification number: H01L31/107 ,  H01L25/167 ,  H03F1/0261 ,  H03F1/083 ,  H03F3/08 ,  H03F3/087 ,  H03F3/45475 ,  H03F2203/45112

Abstract: Systems and methods implementing a resonance circuit, including an avalanche photodiode, in which a resonance frequency of the resonance circuit is matched with the frequency of a dynamic biasing signal of the avalanche photodiode, can be used in a variety of applications. In various embodiments, a method for blocking and/or compensating current injection associated with the parasitic capacitance of APDs operated under dynamic biasing may be substantially realized by the matching of the resonance frequency of a resonance circuit including the avalanche photodiode with the frequency of an applied dynamic biasing signal. Additional systems and methods are described that can be used in a variety of applications.

公开(公告)号：US20190000830A1

公开(公告)日：2019-01-03

申请号：US16067721

申请日：2017-01-09

Applicant: STC.UNM

Inventor： Pamela Hall ,  Eric R. Prossnitz ,  Helen J. Hathaway

IPC: A61K31/473 ,  A61K45/06 ,  A61P31/04

CPC classification number: A61K31/473 ,  A61K31/4741 ,  A61K35/644 ,  A61K38/14 ,  A61K45/06 ,  A61P31/04 ,  C07K14/70567 ,  A61K2300/00

Abstract: The present invention is directed to the use of compounds which are modulators of the G protein-Coupled Estrogen Receptor (GPER) for the inhibition—and/or treatment of Bacterial infections, especially including metMctHin-resistant Staphylococcus aureus (MRSA) infections. Pharmaceutical compositions and methods of treatment of bacterial pathogens, including MRSA are also described.

公开(公告)号：US10164082B2

公开(公告)日：2018-12-25

申请号：US15466461

申请日：2017-03-22

Applicant: STC.UNM

Inventor： Steven R. J. Brueck ,  Seung-Chang Lee ,  Christian Wetzel ,  Mark Durniak

IPC: H01L29/778 ,  H01L21/02 ,  H01L21/306 ,  H01L29/66 ,  H01L29/205 ,  H01L29/08 ,  H01L21/78 ,  H01L29/04 ,  H01L29/423 ,  H01L29/06 ,  H01L33/00 ,  H01L33/32 ,  H01L29/40 ,  H01L33/24

Abstract: A transistor comprises a substrate comprising a Group III/V compound semiconductor material having a cubic crystalline phase structure positioned on a hexagonal crystalline phase layer having a first region and a second region, the cubic crystalline phase structure being positioned between the first region and the second region of the hexagonal crystalline phase layer. A source region and a drain region are both positioned in the Group III/V compound semiconductor material. A channel region is in the Group III/V compound semiconductor material. A gate is over the channel region. An optional backside contact can also be formed. A source contact and electrode are positioned to provide electrical contact to the source region. A drain contact and electrode are positioned to provide electrical contact to the drain region. Methods of forming transistors are also disclosed.

公开(公告)号：US10153725B2

公开(公告)日：2018-12-11

申请号：US15114374

申请日：2015-01-30

Applicant: STC.UNM

Inventor： Ganesh Balakrishnan ,  Christopher Hains ,  Andrew Aragon

IPC: H02J7/00 ,  H02S40/22 ,  G02B6/42 ,  H01L31/054 ,  H02S40/32 ,  H02S40/38 ,  H02J7/35 ,  F21V8/00

Abstract: A device includes a body and a rechargeable battery positioned within the body. A solar cell is coupled to the body and in communication with the battery. A connector is coupled to the body and configured to engage a corresponding connector of a fiber optic cable.

公开(公告)号：US20180349100A1

公开(公告)日：2018-12-06

申请号：US16051427

申请日：2018-07-31

Applicant: STC.UNM

Inventor： James Plusquellic

IPC: G06F7/58 ,  H04L9/08 ,  G09C1/00 ,  H04L9/00

CPC classification number: G06F7/588 ,  G06F2207/58 ,  G09C1/00 ,  H04L9/002 ,  H04L9/0866 ,  H04L2209/12 ,  H04L2209/26 ,  Y04S40/24

Abstract: This disclosure describes techniques for analyzing statistical quality of bitstrings produced by a physical unclonable function (PUF). The PUF leverages resistance variations in the power grid wires of an integrated circuit. Temperature and voltage stability of the bitstrings are analyzed. The disclosure also describes converting a voltage drop into a digital code, wherein the conversion is resilient to simple and differential side-channel attacks.

公开(公告)号：US20180299357A1

公开(公告)日：2018-10-18

申请号：US15950979

申请日：2018-04-11

Applicant: National Technology & Engineering Solutions of Sandia, LLC ,  STC.UNM

Inventor： Bryan J. Kaehr ,  C. Jeffrey Brinker ,  Jason L. Townson

IPC: G01N1/28 ,  C08K3/36 ,  C12N11/14

Abstract: The present invention is directed to the use of silicic acid to transform biological materials, including cellular architecture into inorganic materials to provide biocomposites (nanomaterials) with stabilized structure and function. In the present invention, there has been discovered a means to stabilize the structure and function of biological materials, including cells, biomolecules, peptides, proteins (especially including enzymes), lipids, lipid vesicles, polysaccharides, cytoskeletal filaments, tissue and organs with silicic acid such that these materials may be used as biocomposites. In many instances, these materials retain their original biological activity and may be used in harsh conditions which would otherwise destroy the integrity of the biological material. In certain instances, these biomaterials may be storage stable for long periods of time and reconstituted after storage to return the biological material back to its original form. In addition, by exposing an entire cell to form CSCs, the CSCs may function to provide a unique system to study enzymes or a cascade of enzymes which are otherwise unavailable.

公开(公告)号：US20180234447A1

公开(公告)日：2018-08-16

申请号：US15750236

申请日：2016-08-04

Applicant: STC.UNM

Inventor： Abdullah MUEEN ,  Nikan CHAVOSHI

IPC: H04L29/06 ,  G06F17/30

CPC classification number: H04L63/1425 ,  G06F16/2255 ,  G06F21/577 ,  G06F2221/034 ,  G06Q50/01 ,  H04L63/1408 ,  H04L2463/144

Abstract: Bots are detected real-time by correlating activity between users using a lag-sensitive hashing technique that captures warping-invariant correlation. Correlated users groups in social media may be found that represent bot behavior with thousands of bot accounts detected in a couple of hours.