公开(公告)号：US11964422B2

公开(公告)日：2024-04-23

申请号：US17245140

申请日：2021-04-30

Applicant: University of Florida Research Foundation, Inc.

Inventor： Joshua Muse ,  Meghan Hughes ,  Carl David Crane ,  Thomas Ettor Angelini ,  Kyle D. Schulze ,  Tapomoy Bhattacharjee ,  Wallace Gregory Sawyer ,  Curtis Taylor

IPC: B29C64/106 ,  B29C48/05 ,  B29C48/50 ,  B29C48/92 ,  B29C64/118 ,  B29C67/00 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00

CPC classification number: B29C64/106 ,  B29C48/501 ,  B29C64/118 ,  B29C67/00 ,  B33Y10/00 ,  B33Y30/00 ,  B29C48/05 ,  B29C48/92 ,  B29C2948/92904 ,  B33Y70/00

Abstract: Described herein are various embodiments of a valve that may be opened and closed using a thixotropic or “stress yield” material, or other material that temporarily changes phase upon application of energy to the material. More particularly, some embodiments may include a valve that is opened and closed using a granular gel that is a temporary phase change material.

公开(公告)号：US11963936B2

公开(公告)日：2024-04-23

申请号：US17456956

申请日：2021-11-30

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Anuj Chauhan ,  Robert A. Damitz

IPC: A61K31/05 ,  A61K9/00 ,  A61K9/107 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44

CPC classification number: A61K31/05 ,  A61K9/0019 ,  A61K9/107 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44

Abstract: Disclosed herein is a composition comprising a biologically active agent; a base oil; an additional oil that is soluble in the base oil with a partition coefficient for the biologically active molecule that is at least twice that of the base oil; where the base oil and the additional oil are present in the composition in an amount effective to reduce the amount of the biologically active agent in an aqueous phase to less than 80 wt % of the amount with just the base oil present in an otherwise identical composition at the same total oil loading; a non-ionic surfactant; and water.

公开(公告)号：US11941515B2

公开(公告)日：2024-03-26

申请号：US17342096

申请日：2021-06-08

Applicant: University of Florida Research Foundation, Inc.

Inventor： Juan Claudio Nino ,  Jack Kendall

IPC: G06N3/063 ,  G06N3/044 ,  G06N3/049 ,  G06N3/065 ,  G06N3/08

CPC classification number: G06N3/065 ,  G06N3/044 ,  G06N3/049 ,  G06N3/08 ,  G06N3/044 ,  G06N3/044

Abstract: Disclosed are various embodiments of memristive devices comprising a number of nodes. Memristive fibers are used to form conductive and memristive paths in the devices. Each memristive fiber may couple one or more nodes to one or more other nodes. In one case, a memristive device includes a first node, a second node, and a memristive fiber. The memristive fiber includes a conductive core and a memristive shell surrounding at least a portion of the conductive core along at least a portion of the memristive fiber. The memristive fiber couples the first node to the second node through a portion of the memristive shell and at least a portion of the conductive core.

公开(公告)号：US20240041575A1

公开(公告)日：2024-02-08

申请号：US18489926

申请日：2023-10-19

Applicant: University of Florida Research Foundation, Inc.

Inventor： Josephine F. Esquivel-Upshaw ,  Fan Ren ,  Patrick Carey ,  Arthur E. Clark, JR. ,  Christopher D. Batich

IPC: A61C13/083 ,  A61C8/00

CPC classification number: A61C13/0835 ,  A61C8/0013 ,  A61C2201/00

Abstract: Disclosed herein is a method for forming an anti-microbial layer on an apparatus. Also disclosed is a method for improving the anti-bacterial properties of a titanium device coated with titanium-nitride (TiN). Also disclosed is a medical apparatus comprising an anti-microbial layer prepared by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US20240030362A1

公开(公告)日：2024-01-25

申请号：US18203436

申请日：2023-05-30

Applicant: University of Florida Research Foundation, Inc.

Inventor： Peng JIANG ,  Zhuxiao GU ,  Ruwen TAN

IPC: H01L31/0216 ,  H01L31/18 ,  G02B1/118

CPC classification number: H01L31/02168 ,  H01L31/186 ,  G02B1/118

Abstract: Embodiments of the present disclosure provide for methods of making substrates having an (AR) antireflective layer, substrates having an antireflective layer, devices including a substrate having an antireflective layer, and the like. The AR layer can have a total specular reflection of less than 10% at a wavelength of about 400-800 nm, and a height of about 500-1000 nm.

公开(公告)号：US11866353B2

公开(公告)日：2024-01-09

申请号：US17241340

申请日：2021-04-27

Applicant: University of Florida Research Foundation, Inc.

Inventor： Jonathan Judy

IPC: C02F1/48 ,  B82Y25/00 ,  B82Y30/00 ,  C02F103/00 ,  C02F101/20 ,  C02F101/10 ,  B82Y40/00

CPC classification number: C02F1/481 ,  B82Y25/00 ,  B82Y30/00 ,  B82Y40/00 ,  C02F2101/105 ,  C02F2101/203 ,  C02F2103/001 ,  C02F2303/18

Abstract: The present disclosure provides for methods and systems for separating ultrafine particulate pollutants from aqueous suspensions. The present disclosure provide for methods and systems that can reduce the amount of ultrafine particulate pollutants from aqueous solutions, for example storm water runoff, which are not readily or easily removed using current state of the art techniques. In general, methods of the present disclosure provide for removing a portion of target ultrafine particulate pollutants using magnetic nanoparticles, which form aggregates with the ultrafine particulate pollutants. After a time period a magnetic field is applied and the aggregate can be separated from the aqueous suspension. Subsequently, the aggregates can be broken down and the magnetic nanoparticles recycled or reused while the ultrafine particulate contaminants are further processed, recycled, or disposed of.

公开(公告)号：US11857774B2

公开(公告)日：2024-01-02

申请号：US17453420

申请日：2021-11-03

Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Andrey Suprun ,  David Hutchinson

IPC: A61M5/36 ,  A61M5/168

CPC classification number: A61M5/36 ,  A61M5/16813 ,  A61M5/16881

Abstract: Provided herein is a method and apparatus for venting of intravenous tubing to remove air bubbles, and more particularly, to a venting valve that allows air bubbles to escape along a venting path while not permitting fluid passage through the venting path. An example air extraction device may include: a chamber; a fluid inlet to convey fluid from intravenous tubing into the chamber; a fluid outlet to convey fluid from the chamber to intravenous tubing for supplying to a patient; a top portion of the chamber; a branch tube extending from the top portion of the chamber, where the branch tube receives air from the fluid in the chamber; and a ball received within the chamber, where the ball is configured to rise with an influx of fluid to the chamber from the fluid inlet and to seal off the branch tube from the chamber in response to the fluid level rising to the top portion of the chamber.

公开(公告)号：US20230414748A1

公开(公告)日：2023-12-28

申请号：US18036793

申请日：2021-11-16

Applicant: University of Florida Research Foundation, Inc. ,  Emmune, Inc.

Inventor： Michael Farzan ,  Brian Quinlan ,  Yan Guo ,  Huihui Mu ,  Wenhui He ,  Hyeryun Choe ,  Lizhou Zhang ,  Charles Bailey ,  Michael Alpert

IPC: A61K39/215 ,  A61P37/04

CPC classification number: A61K39/215 ,  A61P37/04 ,  A61K2039/6031

Abstract: The present invention provides scaffolded antigens that have demonstrated improved biochemical and immunogenic properties. The invention also provides engineered SARS-CoV-2 immunogens that contain a modified receptor-binding domain (RBD) sequence. Also provided in the invention are vaccine compositions that contain the scaffolded antigens, including the engineered RBD polypeptides that are fused to the scaffold proteins described herein. The invention also provides methods of using such vaccine compositions in various therapeutic applications, e.g., for preventing or treating SARS-CoV-2 infections.

公开(公告)号：US20230381778A1

公开(公告)日：2023-11-30

申请号：US18245947

申请日：2021-09-24

Applicant: University of Florida Research Foundation, Inc.

Inventor： Benjamin Earl VALLEY ,  Jason E BUTLER ,  Anthony J. LADD

IPC: B01L3/00

CPC classification number: B01L3/50273 ,  B01L3/502715 ,  B01L2300/16 ,  B01L2400/0421

Abstract: Provided herein are microfluidic devices that can be configured to generate an electrophoretic flow that is in opposition to a fluid flow through a microcapillary of a microfluidic device provided herein for nucleic acid isolation. Also provided herein are systems comprising such. Also provided herein are methods that include adding an amount of a sample comprising nucleic acids to the inlet area of a microfluidic device as provided herein, generating a first fluid flow through a microcapillary of a microfluidic device provided herein; and applying a uniform electric field to the microfluidic device, where the uniform electric field generates an electrophoretic flow that is in opposition to the fluid flow. Methods as described herein can further comprise quantifying or otherwise characterizing isolated nucleic acids separated by devices, systems, and methods as described herein.

公开(公告)号：US11829475B2

公开(公告)日：2023-11-28

申请号：US17500016

申请日：2021-10-13

Applicant: University of Florida Research Foundation, Inc.

Inventor： Prabhat Kumar Mishra ,  Zhixin Pan ,  Jennifer M. Sheldon

IPC: G06F21/56 ,  G06N3/04 ,  G06F18/2433 ,  G06F21/57 ,  G06F21/00

CPC classification number: G06F21/567 ,  G06F18/2433 ,  G06F21/566 ,  G06F21/577 ,  G06N3/04

Abstract: The present disclosure describes systems and methods for hardware-assisted malware detection. One such system comprises a memory; and a hardware processor of a computing device operatively coupled to the memory. The hardware processor is configured to execute a software application suspected of being malware; monitor behavior of the software application at run-time; and acquire an input time sequence of data records based on a trace analysis of the software application, wherein the input time sequence comprises a plurality of features of the software application. The hardware processor is further configured to classify the software application as being a malicious software application based on the plurality of features of the software application; and output a ranking of a subset plurality of features by their respective contributions towards the classification of the software application as being malicious software.