公开(公告)号：US20210041550A1

公开(公告)日：2021-02-11

申请号：US16978326

申请日：2019-03-05

Applicant: UNIVERSITÄT STUTTGART

Inventor： Ingmar KALLFASS ,  Christopher GRÖTSCH ,  Benjamin SCHOCH

IPC: G01S13/34 ,  G01N22/00 ,  G01N29/12 ,  G01S15/34

Abstract: A method for determining at least one physical parameter of a system comprising at least two reflection objects is presented, comprising: producing a transmission signal comprising at least one modulated electromagnetic or acoustic wave; receiving a first reception signal that is based on the transmission signal reflected by a first reflection object; receiving a second reception signal that is based on the transmission signal reflected by a second reflection object; receiving a third or further reception signal(s) that is/are based on the transmission signal reflected by a first or second or further reflection object(s); ascertaining the at least one physical parameter of the system on the basis of the first reception signal and further reception signals; ascertaining unknown distances between reflection objects or material properties, composition or nature of the media between the reflection objects of the system on the basis of the first reception signal and further reception signals.

公开(公告)号：US20200172619A1

公开(公告)日：2020-06-04

申请号：US16615536

申请日：2018-06-01

Applicant: UNIVERSITÄT STUTTGART

Inventor： Fabian RICHTER ,  Oliver SEIFERT ,  Roland KONTERMANN

IPC: C07K16/28 ,  C07K16/30 ,  C07K16/32 ,  C07K16/40

Abstract: The present invention provides a protein complex comprising heterodimerizing regions HRI and HRII, each comprised of antiparallel β-strands and intervening regions wherein HRI and HRII are each interspersed fusion proteins of two human constant regions of an immunoglobulin or immunoglobulin-like proteins. The present invention also provides nucleic acid molecules comprising a sequence encoding said protein complexes and vectors comprising the nucleic acid. The present invention also provides the protein complex, the nucleic acid and the vector for use as a medicament. The present invention further provides a method of determining the amino acid sequence of HRI and/or of the amino acid sequence of HRII. The present invention also provides a method of producing amino acid chains of HRI and/or amino acid chains of HRII. The present invention further provides the protein complex for use in the N prophylaxis, treatment or diagnosis of a disorder or a disease.

公开(公告)号：US20190144815A1

公开(公告)日：2019-05-16

申请号：US16093479

申请日：2017-03-22

Applicant: Universität Stuttgart

Inventor： Annette MICHALOWSKI ,  Martin SIEMANN-HERZBERG ,  Ralf TAKORS

IPC: C12N1/20 ,  C12N15/70 ,  C12N9/16

Abstract: The present invention relates to recombinant Escherichia coli (E. coli) host cells comprising, in relation to wild-type cells, at least one mutation selected from the group consisting of deletion of the gene relA (ΔrelA); amino acid substitutions R290E and K292D in the protein guanosine-3′,5′-bis pyrophosphate 3′-pyrophosphohydrolase (bifunctional (p)ppGpp synthetase II; SpoT) (spo T[R290E;K292D]); and amino acid substitution G267C in the protein pyruvate dehydrogenase subunit E1 (AceE) (aceE[G267C]). Said recombinant host cells are characterized by increased sugar uptake rates that lead to increased productivity when using said cells for the production of biosynthetic products. The present invention further relates to respective methods for the biosynthetic production of a product of interest using said host cells.

公开(公告)号：US20180307795A1

公开(公告)日：2018-10-25

申请号：US15756156

申请日：2016-09-08

Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. ,  UNIVERSITÄT STUTTGART ,  MEDIZINISCHE UNIVERSITÄT WIEN ,  UNIVERSITÄT WIEN

Inventor： Kai SOHN ,  Silke GRUMAZ ,  Philip STEVENS ,  Arndt VON HAESELER

IPC: G06F19/24 ,  G06F19/28 ,  C12Q1/6869

CPC classification number: G06F19/24 ,  C12Q1/6869 ,  C12Q2535/122 ,  C12Q2600/158 ,  G06F19/28 ,  C12Q2537/165

Abstract: The present invention relates to a method and a device for a nucleic acid based diagnostic approach including the determination of a deviant condition of a sample, wherein the deviant condition is preferably a health condition and/or a pathogenic condition.

公开(公告)号：US10066997B2

公开(公告)日：2018-09-04

申请号：US15120373

申请日：2015-02-17

Applicant: Universität Stuttgart

Inventor： Klaus Körner ,  Wolfgang Osten ,  Tobias Boettcher ,  Wolfram Lyda ,  Marc Gronle

IPC: G01N21/25 ,  G01J3/28 ,  G01J3/10 ,  G01J3/433 ,  G01B11/25 ,  G01J3/02 ,  G01B11/14 ,  G01B11/24 ,  G01J3/26

Abstract: The invention relates to methods and to devices for generating multispectral illuminating light having an addressable spectrum, for adaptive multispectral imaging and for capturing structural and/or topographical information of an object or of the distance to an object. The illuminating device comprises a multispectral light source and a modulator for temporal modulation of the individual spectral components of the multispectral light source having modulation frequencies. The multispectral light source comprises at least one light source having a continuous, quasi-continuous, or frequency comb spectrum and wavelength-dispersive means, or an assembly or array of monochromatic or quasi-monochromatic light sources having emission wavelengths or emission wavelength bands which are different from one another in each case. The modulator comprises at least one electrically controllable three-dimensional light modulator, or a plurality of electronic control modules assigned to the individual monochromatic or quasi-monochromatic light sources.

公开(公告)号：US20180094059A1

公开(公告)日：2018-04-05

申请号：US15558372

申请日：2016-03-18

Applicant: UNIVERSITÄT STUTTGART ,  BIONTECH AG

Inventor： Ugur SAHIN ,  Roland KONTERMANN ,  Klaus PFIZENMAIER ,  Martin SIEGEMUND ,  Meike HUTT ,  Oliver SEIFERT

IPC: C07K16/28 ,  C07K16/32 ,  C07K14/705

CPC classification number: C07K16/2863 ,  C07K14/70575 ,  C07K16/32 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/91

Abstract: The present invention relates to a polypeptide comprising a component A with at least three tumor necrosis factor (TNF) homology domains of TNF-ligand family members (THD) in which C-terminal and N-terminal reference points are defined by consensus sequences and which are connected through short stretches of additional C-terminal and/or N-terminal amino acids of the THD or variants thereof, and a component B comprising a dimerization domain. Further, the present invention relates to a polypeptide comprising at least three THDs in which C-terminal and N-terminal reference points are defined by consensus sequences and which are connected through short stretches of additional C-terminal and/or N-terminal amino acids of the THD or variants thereof. Further, the invention relates to a nucleic acid comprising said polypeptides, a vector comprising said nucleic acid and a pharmaceutical composition comprising said polypeptides, or said nucleic acids or said vector. Further, the present invention relates to said polypeptides, said nucleic acid or said vector for the use as a medicament or for the use in the diagnosis, prophylaxis or treatment of hyperproliferative disorders and inflammatory disorders.

公开(公告)号：US20170310073A1

公开(公告)日：2017-10-26

申请号：US15494102

申请日：2017-04-21

Applicant: Universität Stuttgart

Inventor： Stefan Piehler ,  Benjamin Dannecker ,  Jan-Philipp Negel ,  André Loescher

IPC: H01S3/23 ,  H01S3/06 ,  H01S3/00

CPC classification number: H01S3/2325 ,  H01S3/005 ,  H01S3/0071 ,  H01S3/0604 ,  H01S3/094084

Abstract: The present invention relates to an optical module configured to be optically coupleable to a laser amplifier module, the optical module comprising an inner optical element having a plurality of M inner reflective elements arranged around a center of the inner optical element; and a plurality of N outer reflective elements arranged around the inner optical element, the plurality of N outer reflective elements being configured to face the inner optical element, wherein the plurality of M inner reflective elements and the plurality of N outer reflective elements are configured to provide an optical path for a laser beam.

公开(公告)号：US20170182597A1

公开(公告)日：2017-06-29

申请号：US15389244

申请日：2016-12-22

Applicant: Universität Stuttgart

Inventor： MARWAN ABDOU-AHMED ,  RUDOLF WEBER ,  VOLKHER ONUSEIT

IPC: B23K26/388 ,  G02B27/42 ,  B23K26/067

CPC classification number: B23K26/388 ,  B23K26/0643 ,  B23K26/0648 ,  B23K26/0676 ,  B23K26/082 ,  B23K26/382 ,  B23K26/389 ,  G02B5/1814 ,  G02B5/1861 ,  G02B5/1871 ,  G02B27/4233

Abstract: The invention relates to a drilling device comprising a light source configured to provide a light beam and a diffractive beam propagation device having a substantially planar surface, wherein the light source is configured such that the light beam is incident on the planar surface of the diffractive beam propagation device, and wherein the diffractive beam propagation device is configured to propagate the light beam as one or more propagated beams such that the one or more propagated beams, at least when being integrated over time, surround an area with a substantially circular shape. A use of the drilling device for drilling a hole in a work piece and a method suitable for drilling a hole in a work piece are also provided.

公开(公告)号：US20170050994A1

公开(公告)日：2017-02-23

申请号：US15306521

申请日：2015-04-24

Applicant: UNIVERSITÄT STUTTGART

Inventor： Michael R. Buchmeiser ,  Suman Sen ,  Roman Schowner

IPC: C07F11/00 ,  C07C6/04 ,  C07C67/333 ,  B01J31/22 ,  C08G61/08 ,  C08G61/12

CPC classification number: C07F11/00 ,  B01J31/1805 ,  B01J31/2273 ,  B01J31/2278 ,  B01J2231/543 ,  B01J2531/64 ,  B01J2531/66 ,  C07C6/04 ,  C07C67/333 ,  C07C253/30 ,  C07C319/20 ,  C07C2531/22 ,  C07C2601/10 ,  C07C2601/16 ,  C08G61/08 ,  C08G61/12 ,  C08G2261/418 ,  C08G2261/419 ,  C07C13/20 ,  C07C11/02 ,  C07C255/46 ,  C07C321/28 ,  C07C69/74

Abstract: The invention relates to an N-heterocyclic carbene complex of general formulas I to IV (I) (II) (III) (IV), according to which A1 stands for NR2 or PR2, A2 stands for CR2 R2′, NR2, PR2, 0 or S, A3 stands for N or P, and C stands for a carbene carbon atom, ring B is an unsubstituted or a mono or poly-substituted 5 to 7-membered ring, substituents R2 and R2′ stand, inter alia, for a linear or branched C1-Cw-alkyl group and, if N and N each stand for NR2 or PR2, are the same or different, M in formulas I, II, III or IV stands for Cr, Mo or W, X 1 or X2 in formulas I to IV are the same or different and represent, inter alia, C1-C1s carboxylates and C1-C1s-alkoxides, Y is inter alia oxygen or sulphur, Z is inter alia a linear or branched C1-Cw-alkylenoxy group, and R 1 and R1′ in formulas I to IV are, inter alia, an aliphatic or aromatic group. These compounds are particularly suitable for use as catalysts for olefin metathesis reactions and have the advantage, compared to known Schrock carbene complexes, of displaying clearly increased tolerance to functional groups such as, in particular, aldehydes, secondary amines, nitriles, carboxylic acids and alcohols.

Abstract translation: 本发明涉及通式I至IV（I）（II）（III）（IV）的N-杂环卡宾络合物，其中A1代表NR2或PR2，A2代表CR2 R2'，NR2，PR2， 0或S，A3代表N或P，C代表碳原子，环B是未取代的或单取代的或多取代的5至7元环，取代基R 2和R 2'尤其用于 直链或支链C 1 -C 6烷基，如果N和N各自代表NR 2或PR 2，则相同或不同，式I，II，III或IV中的M代表Cr，Mo或W，X 1或 式I至IV中的X 2相同或不同，特别表示C 1 -C 6羧酸酯和C 1 -C 6醇盐，Y尤其是氧或硫，Z尤其是直链或支链C 1 -C 6 - 亚烷基氧基 ，式I至IV中的R 1和R 1'特别是脂族或芳族基团。 这些化合物特别适合用作烯烃复分解反应的催化剂，并且与已知的Schrock卡宾络合物相比具有明显增加的对官能团的耐受性，特别是醛，仲胺，腈，羧酸和醇的显着增加的优点 。

公开(公告)号：US20160322632A1

公开(公告)日：2016-11-03

申请号：US15107583

申请日：2013-12-23

Applicant: UNIVERSITÄT STUTTGART

Inventor： Horst Strunk ,  Fei Qu

IPC: H01M4/38 ,  H01M4/134 ,  H01M4/04 ,  H01M10/0525 ,  H01M4/1395

CPC classification number: H01M4/386 ,  H01L21/02532 ,  H01L21/0259 ,  H01L21/02656 ,  H01M4/0404 ,  H01M4/0471 ,  H01M4/134 ,  H01M4/1395 ,  H01M10/052 ,  H01M10/0525 ,  H01M2004/021

Abstract: A method for producing a porous nanocrystalline semiconductor layer (100) is provided, including: a) providing a substrate (10) having a substrate surface; b) coating a semiconductor layer (12) on the substrate surface; c) coating a metal containing layer (14) on the semiconductor layer; d) heat treating the semiconductor layer and the metal containing layer at a temperature and for a time period such that the semiconductor and the metal partially interdiffuse and the semiconductor is at least partially crystallized; and e) least partially removing the metal. Further, a porous nanocrystalline semiconductor layer, a use thereof, an anode, and a secondary lithium-ion battery are provided.

Abstract translation: 提供了一种制造多孔纳米晶半导体层（100）的方法，包括：a）提供具有基板表面的基板（10）; b）在衬底表面上涂覆半导体层（12）; c）在所述半导体层上涂覆含金属层（14）; d）在半导体和金属部分相互扩散并且半导体至少部分结晶的温度和时间周期内热处理半导体层和含金属层; 和e）至少部分地除去金属。 此外，提供了多孔纳米晶半导体层，其用途，阳极和二次锂离子电池。