Process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives
    31.
    发明授权
    Process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives 有权
    光学活性的2- [6-(羟甲基)-1,3-二恶烷-4-基]乙酸衍生物的制备方法

    公开(公告)号:US06903225B2

    公开(公告)日:2005-06-07

    申请号:US10242453

    申请日:2002-09-13

    Abstract: This invention provides a process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives, which are of value as intermediates of drugs, from inexpensive starting materials without using any special equipment such as that required for super-low temperature reactions.A process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives which comprises reacting an acetic acid derivative at a temperature of not less than −30° C. with an enolate prepared by permitting either a base or a metal having a valency of 0 to act on the derivative to produce a hydroxyoxohexanoic acid derivative, reducing this compound with the aid of a strain of microorganism to provide a halomethyldioxanylacetic acid derivative, treating this compound with an acetalizing agent in the presence of an acid catalyst to provide a halomethyl-dioxanylacetic acid derivative, reacted with an acyloxylating agent to provide a acyloxymethyldioxanylacetic acid derivative, and subjecting this compound to solvolysis in the presence of a base.

    Abstract translation: 本发明提供了从廉价起始原料生产具有价值作为药物中间体的光学活性的2- [6-(羟甲基)-1,3-二恶烷-4-基]乙酸衍生物的方法,而不使用任何特殊设备 例如超低温反应所需的。 一种制备光学活性的2- [6-(羟基甲基)-1,3-二恶烷-4-基]乙酸衍生物的方法,其包括使不饱和-30℃的乙酸衍生物与烯醇化物 通过使碱金属或0价金属作用于衍生物以制备羟基己酸衍生物而制备,借助于微生物菌株还原该化合物以提供卤代甲基二恶烷基乙酸衍生物,用缩醛化处理该化合物 在酸催化剂存在下,提供卤代甲基 - 二恶烷基乙酸衍生物,与酰氧基化剂反应,得到酰氧基甲基二恶烷基乙酸衍生物,并在碱的存在下使其溶解。

    (S)-&agr;-phenethylamine: pyruvate transaminase
    33.
    发明授权
    (S)-&agr;-phenethylamine: pyruvate transaminase 失效
    (S)-α-苯乙胺:丙酮酸转氨酶

    公开(公告)号:US06346402B1

    公开(公告)日:2002-02-12

    申请号:US09582764

    申请日:2000-06-30

    CPC classification number: C12N9/1096 C12P41/006

    Abstract: Relating to an enzyme capable of efficiently converting a ketone compound to an optically active amino compound by transamination, and a process for preparing an optically active amino compound using the enzyme. An (S)-&agr;-phenethylamine:pyruvate transaminase, which acts on (S)-&agr;-phenethylamine and a ketone compound, thereby catalyzing transamination for forming acetophenone and an amino compound corresponding to the ketone compound; a process for preparing an optically active amino compound using the transaminase; and a method for culturing a microorganism for producing the above transaminase, comprising adding to a medium one or more compounds selected from the group consisting of propylamine, 1-butylamine, 2-butylamine, 2-pentylamine, isopropylamine and isobutylamine as an inducer for the enzyme when a microorganism for producing (S)-&agr;-phenethylamine:pyruvate transaminase is cultured.

    Abstract translation: 关于能够通过转氨酶有效地将酮化合物转化为光学活性氨基化合物的酶,以及使用该酶制备光学活性氨基化合物的方法。 (S)-α-苯乙胺:丙酮酸转氨酶,其作用于(S)-α-苯乙胺和酮化合物,从而催化转氨酶形成苯乙酮和对应于酮化合物的氨基化合物; 使用转氨酶制备光学活性氨基化合物的方法; 以及培养用于制备上述转氨酶的微生物的方法,包括向培养基中加入一种或多种选自丙胺,1-丁胺,2-丁胺,2-戊胺,异丙胺和异丁胺的化合物作为诱导剂 用于生产(S)-α-苯乙胺:丙酮酸转氨酶的微生物培养时的酶。

    PTC-element, protective device and electric circuit board
    34.
    发明授权
    PTC-element, protective device and electric circuit board 有权
    PTC元件,保护器件和电路板

    公开(公告)号:US6114672A

    公开(公告)日:2000-09-05

    申请号:US167140

    申请日:1998-10-06

    CPC classification number: H01C7/027 H01H2085/466

    Abstract: A PTC-element to be used as a protective device against overcurrent or overvoltage, of which the volume resistivity does not substantially differ before and after a high temperature processing, such as reflowing of solder, and can be preserved even after having been subjected to repeated tripping, which contains a non-conductive crystalline polymer and a particulate conductor material dispersed in the non-conducting crystalline polymer, wherein the particulate conductor material includes electro-conductive particles having irregular surface contours.

    Abstract translation: 用作抵抗过电流或过电压的保护装置的PTC元件,其在高温处理之前和之后的体积电阻率基本上不同,例如焊料的回流,并且即使在经受重复之后也可以保存 其包含分散在非导电结晶聚合物中的非导电结晶聚合物和颗粒状导体材料,其中所述颗粒状导体材料包括具有不规则表面轮廓的导电颗粒。

    Process for the production of D-.alpha.-amino acids by hydrolysis of the
corresponding N-carbamyl derivative
    35.
    发明授权
    Process for the production of D-.alpha.-amino acids by hydrolysis of the corresponding N-carbamyl derivative 失效
    通过水解相应的N-氨基甲酰基衍生物生产D-氨基酸的方法

    公开(公告)号:US5902736A

    公开(公告)日:1999-05-11

    申请号:US244657

    申请日:1994-06-06

    CPC classification number: C12P13/04 C12P41/009 Y10S435/874 Y10S435/911

    Abstract: In a process for the production of a D-.alpha.-amino acid, in which an N-carbamyl-D-.alpha.-amino acid corresponding to the general formula: ##STR1## wherein R represents phenyl, hydroxy-substituted phenyl, substituted or unsubstituted alkyl, or thienyl, is converted by a microbial enzyme in an aqueous medium to a D-.alpha.-amino acid corresponding to the general formula: ##STR2## wherein R is the same as defined above, decarbamylase produced by a microorganism of the genus Comamonas, Blastobacter, Alcaligenes, Sporosarcina, Rhizobium, Bradyrhizobium or Arthrobacter is used as the enzyme converting the N-carbamyl-D-.alpha.-amino acid to the D-.alpha.-amino acid.The conversion of the N-carbamyl-D-.alpha.-amino acids to the D-.alpha.-amino acids is carried out in a neutral to alkaline pH range.

    Abstract translation: PCT No.PCT / JP93 / 01408 Sec。 371日期:1994年6月6日 102(e)日期1994年6月6日PCT提交1993年10月1日PCT公布。 公开号WO94 / 08030 日期1994年4月14日在制备D-氨基酸的方法中,其中N-氨基甲酰基-D-α-氨基酸对应于通式:其中R表示苯基,羟基取代的苯基,取代的 或未取代的烷基或噻吩基通过微生物酶在水性介质中转化成对应于以下通式的D-α-氨基酸:其中R与上述定义相同,由Comamonas属的微生物产生的脱氨基甲酰酶, 使用喷杆菌属,产碱杆菌属,孢子体菌属,根瘤菌属,Bradyrhizobium或节杆菌作为将N-氨基甲酰基-D-α-氨基酸转化为D-氨基酸的酶。 N-氨基甲酰基-D-α-氨基酸向D-α-氨基酸的转化在中性至碱性pH范围内进行。

    Metal roof board connecting structure
    36.
    发明授权
    Metal roof board connecting structure 失效
    金属屋顶板连接结构

    公开(公告)号:US5715639A

    公开(公告)日:1998-02-10

    申请号:US523944

    申请日:1995-09-06

    Applicant: Yukio Yamada

    Inventor: Yukio Yamada

    CPC classification number: E04D3/363 E04D3/364 E04D3/366

    Abstract: A metal roof board connecting structure for connecting metal roof boards includes a raised-up flat lock seam portion formed by bending flatly and seamly raised-up regions of two metal roof boards which are arranged adjacently to each other, and a cap member capped on the raised-up flat lock seam portion. A part of the raised-up region of one of the two metal roof boards forms a first cap engaging projection and a bent portion of the raised-up flat lock seam portion forms a second cap engaging projection so as to be arranged in symmetrical with the first projection. The cap member has a two elastic side walls a center portion of each of which has an engaging recess and a lower end portion of each of which is extended downwardly and outwardly to extend away from each other. When the cap member is capped on the raised-up flat lock seam portion, the engaging recesses of the two side walls of the cap member are engaged with the first and second cap engaging projections of the one raised-up region and the raised-up flat lock seam portion of the two metal roof boards, and that engagement is semipermanently secured by the elastic force of the two side walls of the cap member.

    Abstract translation: 用于连接金属屋顶板的金属屋顶板连接结构包括通过相互相邻布置的两个金属屋顶板的平坦地和接缝的上升区域弯曲而形成的上升平的锁定缝部分,以及盖 抬起的平锁缝部分。 两个金属屋顶板中的一个的升高区域的一部分形成第一盖接合突起,并且升高的平锁锁缝部分的弯曲部分形成第二帽接合突起,以便与 第一投影。 盖构件具有两个弹性侧壁,每个中心部分具有接合凹部,并且每个的下端部向下和向外延伸以彼此远离延伸。 当帽构件被盖在上升的平锁锁缝部分上时,帽构件的两个侧壁的接合凹槽与一个抬起区域的第一和第二帽接合突起接合,并且凸起 两个金属屋顶板的平锁锁缝部分,并且通过盖构件的两个侧壁的弹力半接头被固定。

    Thermocompression bonding equipment
    37.
    发明授权
    Thermocompression bonding equipment 失效
    热压粘合设备

    公开(公告)号:US5698068A

    公开(公告)日:1997-12-16

    申请号:US429695

    申请日:1995-04-27

    Abstract: This invention provides a thermocompression bonding equipment which, when the material to be bonded is to be changed, allows easy replacement and preparation of a compression bonding head, reduction of working time required for replacement and preparation of a compression bonding head, and simplified adjustment of the compression bonding head. The thermocompression bonding equipment is provided with a head unit 20 comprising a base 10, thermocompression bonding head 56 and sliding mechanism 50 for sliding the thermocompression bonding head 56 provided on the base 10, pressing means 30, which are structured independently from the head unit, for pressing the sliding mechanism 50 to slide the thermocompression bonding head 56, thereby thermocompression bonding the material of ACF, LCD, and TAB, and a base frame 40 provided with positioning means 40, 41 for positioning the base 10.

    Abstract translation: 本发明提供一种热压接设备,当要被接合的材料被改变时,允许容易地更换和制备压接头,减少更换所需的工作时间并制备压接头,并且简化了 压接头。 热压接设备设置有头单元20,头单元20包括基座10,热压接头56和用于滑动设置在基座10上的热压接头56的滑动机构50,独立于头单元构造的按压装置30, 用于按压滑动机构50以滑动热压接头56,从而热压接ACF,LCD和TAB的材料,以及设置有用于定位基座10的定位装置40,41的基架40。

    Thermocompression bonding apparatus, thermocompression bonding method
and process of manufacturing liquid crystal display device
    38.
    发明授权
    Thermocompression bonding apparatus, thermocompression bonding method and process of manufacturing liquid crystal display device 失效
    热压接合装置,热压接法及制造液晶显示装置的工序

    公开(公告)号:US5439161A

    公开(公告)日:1995-08-08

    申请号:US301389

    申请日:1994-09-07

    Abstract: A thermocompression bonding apparatus wherein object parts can be connected with a high degree of accuracy by thermocompression bonding and the entire apparatus is not deformed readily by a high pressure and a member of a large size can be connected at a fine pitch with a high degree of accuracy. The thermocompression bonding apparatus is constructed so as to bond a first member to a second member by thermocompression bonding and comprises a base member, a holding device for holding the second member thereon, a heat generation element for applying heat to the first member, and a pressurization member for pressing the heat generation element against the first member and the second member. The holding device, the heat generation element and the pressurization member are disposed mechanically separately from the base member. Also a thermocompression bonding method and a process of manufacturing a liquid crystal display device which are performed using the thermocompression bonding apparatus are disclosed.

    Abstract translation: 一种热压接装置,其中通过热压接可以高精度地连接对象部分,并且整个装置不会由于高压而容易地变形,并且可以以高度的细度将大尺寸的部件连接在一起 准确性。 热压接装置被构造成通过热压接将第一构件结合到第二构件,并且包括基座构件,用于将第二构件保持在其上的保持装置,用于向第一构件施加热量的发热元件,以及 加压构件,用于将发热元件按压在第一构件和第二构件上。 保持装置,发热元件和加压构件与基座构件分开设置。 还公开了使用热压接装置进行的热压接方法和制造液晶显示装置的方法。

    Container for precision parts
    40.
    发明授权
    Container for precision parts 失效
    集装箱用于精密零件

    公开(公告)号:US5125509A

    公开(公告)日:1992-06-30

    申请号:US722399

    申请日:1991-06-20

    CPC classification number: H01L21/67356

    Abstract: A container of substantially rectangular cross section is formed of synthetic resin and comprises a container body and a lid member to be detachably mounted to the container body. The container body is provided with longitudinal and lateral side walls and a bottom wall and is capable of being molded as a single piece and thereafter foldable into a container. A locking device for locking the container body and the lid member is located on an outer surface of a side wall of the container body and on a corresponding inner surface of a side wall of the lid. The locking member comprises projections extending outwardly from outer surfaces of the lateral side walls of the container body and corresponding recesses extending inwardly from inner surfaces of the lateral side walls of the lid member. A pair of the longitudinal side walls of the lid member are provided with projected portions formed on upper edges thereof and with recessed portions formed on lower edges thereof, wherein each recessed portion formed so as to have an inner shape corresponding to an outer shape of each projected portion. Projecting pieces are formed on the inner surfaces of the lateral side walls of the container body for abutting against and supportably fixing the contents, which have an outer perimeter surface area smaller than a surface area of the bottom wall of the container body.

    Abstract translation: 大致矩形截面的容器由合成树脂形成,并且包括容器主体和可拆卸地安装到容器主体上的盖构件。 容器主体设置有纵向和侧向侧壁和底壁,并且能够被模制成单件,然后可折叠成容器。 用于锁定容器主体和盖构件的锁定装置位于容器主体的侧壁的外表面上并且位于盖的侧壁的相应内表面上。 锁定构件包括从容器主体的侧壁的外表面向外延伸的凸起和从盖构件的侧壁的内表面向内延伸的对应的凹部。 盖构件的一对纵向侧壁设置有形成在其上边缘上的突出部分和形成在其下边缘上的凹部,其中每个凹部形成为具有与每个的外部形状对应的内部形状 投影部分。 在容器主体的侧壁的内表面上形成有突出部件,用于抵靠并可支撑地固定外周表面面积小于容器主体底壁表面积的内容物。

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