公开(公告)号：US07148964B2

公开(公告)日：2006-12-12

申请号：US11404162

申请日：2006-04-13

Applicant: Brian T. Cunningham ,  Peter Y. Li ,  Frank DiFilippi

Inventor： Brian T. Cunningham ,  Peter Y. Li ,  Frank DiFilippi

IPC: G01J3/28

CPC classification number: G01N21/253 ,  B01L3/5085 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N21/4788 ,  G01N21/7743 ,  G01N33/54373 ,  G01N2201/0635 ,  G01N2201/08 ,  G01N2201/0833 ,  G01N2201/0846 ,  G01N2201/1248 ,  G02B5/1809 ,  G02B5/1814 ,  G02B21/06

Abstract: Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.

公开(公告)号：US06851297B2

公开(公告)日：2005-02-08

申请号：US10324685

申请日：2002-12-19

Applicant: Brian T. Cunningham ,  John Williams

Inventor： Brian T. Cunningham ,  John Williams

IPC: G01N29/02 ,  G01N29/22 ,  H01L21/02

CPC classification number: G01N29/022 ,  G01N29/22 ,  G01N2291/02466 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0427 ,  G01N2291/106 ,  Y10T29/42 ,  Y10T29/49007

Abstract: A method for manufacturing a flexural plate wave sensor includes the steps of depositing an etch-stop layer over a substrate, depositing a membrane layer over the etch stop layer, depositing a piezoelectric layer over the membrane layer, forming a first transducer on the piezoelectric layer and forming a second transducer on the piezoelectric layer, spaced from the first transducer. The method further includes the steps of etching a cavity through the substrate, the cavity having substantially parallel interior walls, removing the portion of the etch stop layer between the cavity and the membrane layer to expose a portion of the membrane layer, and depositing an absorptive coating on the exposed portion of the membrane layer.

公开(公告)号：US09829435B2

公开(公告)日：2017-11-28

申请号：US13433619

申请日：2012-03-29

Applicant: Meng Lu ,  Chun Ge ,  Brian T. Cunningham ,  Stephen Schulz

Inventor： Meng Lu ,  Chun Ge ,  Brian T. Cunningham ,  Stephen Schulz

IPC: G01N21/64 ,  H01S3/1055 ,  H01S5/14

CPC classification number: G01N21/6428 ,  G01N21/6458 ,  G01N2021/6421 ,  H01S3/1055 ,  H01S5/141 ,  H01S5/142

Abstract: A label-free biosensor detection arrangement incorporating an external cavity laser (ECL) includes a tunable lasing element (e.g. an antireflection coated laser diode or semiconductor optical amplifier) and a narrow bandwidth resonant reflectance filter as the wavelength-selective element for the tunable lasing element. A sample is deposited on the surface of the resonant reflectance filter containing a biological material. The wavelength emitted by the external cavity laser is continuously tunable by binding interactions between the biological material and the resonant reflectance filter or adsorption of the biological material present in the sample on resonant reflectance filter. The narrow bandwidth resonance reflectance filter can take the form of photonic crystal (PC), a Bragg stack, or a Brag fiber reflection filter.

公开(公告)号：US08593630B2

公开(公告)日：2013-11-26

申请号：US12900172

申请日：2010-10-07

Applicant: Rohit Bhargava ,  Brian T. Cunningham

Inventor： Rohit Bhargava ,  Brian T. Cunningham

IPC: G01J3/40

CPC classification number: G01J3/12 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/0275 ,  G01J3/0286 ,  G01J3/0289 ,  G01N21/35

Abstract: Described herein are spectrometers comprising one or more wavelength-selective filters, such as guided mode resonance filters. Some of the spectrometers described herein are configured for obtaining absorbance spectra in a discrete fashion by measuring absorbances of a sample at multiple discrete wavelengths or wavelength bands. In another aspect, methods are also provided for obtaining spectra, images and chemical maps of samples in a discrete fashion.

Abstract translation: 这里描述的是包括一个或多个波长选择性滤波器的光谱仪，例如导模谐振滤波器。 这里描述的一些光谱仪被配置为通过测量在多个离散波长或波长带上的样品的吸光度以离散的方式获得吸收光谱。 在另一方面，还提供了用于以离散方式获得样品的光谱，图像和化学图谱的方法。

公开(公告)号：US08580578B2

公开(公告)日：2013-11-12

申请号：US13092296

申请日：2011-04-22

Applicant: Brian T. Cunningham ,  Jane Pepper ,  Bo Lin ,  Peter Li ,  Homer Pien ,  Jean Qiu

Inventor： Brian T. Cunningham ,  Jane Pepper ,  Bo Lin ,  Peter Li ,  Homer Pien ,  Jean Qiu

IPC: G01N33/551

CPC classification number: G01N21/253 ,  B01L3/5085 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N21/4788 ,  G01N21/7743 ,  G01N33/54373 ,  G02B5/1809 ,  G02B5/1852 ,  G02B6/02061 ,  Y10S435/808 ,  Y10S436/805 ,  Y10S436/807 ,  Y10S436/809 ,  Y10S436/811 ,  Y10S436/813

Abstract: Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters.

Abstract translation: 提供了用于检测生物分子相互作用的方法和组合物。 不需要使用标签，并且可以以高通量的方式执行方法。 本发明还提供用作窄带滤波器的光学装置。

公开(公告)号：US08344333B2

公开(公告)日：2013-01-01

申请号：US13135246

申请日：2011-06-28

Applicant: Meng Lu ,  Stephen C. Shulz ,  Brian T. Cunningham ,  Anusha Pokhriyal

Inventor： Meng Lu ,  Stephen C. Shulz ,  Brian T. Cunningham ,  Anusha Pokhriyal

IPC: G01N21/64

CPC classification number: G01N21/648 ,  G01N21/6428 ,  G01N21/7743

Abstract: A photonic crystal substrate exhibiting resonant enhancement of multiple fluorophores has been demonstrated. The device, which can be fabricated uniformly from plastic materials over a ˜3×5 in2 surface area by nanoreplica molding, features a 1-D periodic grating structure which utilizes two distinct resonant modes to enhance electric field stimulation of a first dye excited by a first laser (e.g., λ=632.8 nm laser exciting cyanine-5) and a second dye excited by a second laser (e.g., λ=532 nm laser exciting cyanine-3). The first and second lasers could be replaced by a single variable wavelength (tunable) laser. Resonant coupling of the laser excitation to the photonic crystal surface is obtained for each wavelength at a distinct incident angle θ. The photonic crystal is capable of amplifying the output of any fluorescent dye with an excitation wavelength in a given wavelength range (e.g., the range 532 nm

Abstract translation: 已经证明了表现出多个荧光团的共振增强的光子晶体衬底。 可以通过纳米尺寸成型在〜3×5 in2表面积上由塑料材料均匀地制造的器件具有1-D周期性光栅结构，其利用两种不同的谐振模式来增强第一染料激发的电场刺激 第一激光（例如，λ= 632.8nm激光花青-5）和由第二激光器激发的第二染料（例如，λ= 532nm激光花青-3）。 第一和第二激光器可以由单个可变波长（可调谐）激光器代替。 获得激光激发与光子晶体表面的共振耦合，每个波长处于不同的入射角。 通过选择适当的入射角，光子晶体能够通过给定波长范围（例如，532nm <λ<660nm）的激发波长放大任何荧光染料的输出。 该装置可用于在单个成像区域内利用多种荧光染料的生物测定法，例如基因表达微阵列。

公开(公告)号：US20120309080A1

公开(公告)日：2012-12-06

申请号：US13438950

申请日：2012-04-04

Applicant: Brian T. Cunningham ,  Charles J. Choi ,  Alysia R. Watkins

Inventor： Brian T. Cunningham ,  Charles J. Choi ,  Alysia R. Watkins

IPC: G01N21/65 ,  B05D3/12 ,  C12M1/34 ,  B82Y15/00

CPC classification number: G02B1/005 ,  G01N21/658

Abstract: Tubing such as clear plastic disposable tubing or glass tubing includes a photonic sensor formed in or placed within the tubing. The photonic sensors can take the form of photonic crystal sensors, distributed feedback laser sensors, and surface enhanced Raman spectroscopy (SERS) sensors, including photonic crystal enhanced SERS sensors. Detection arrangements for the sensors are described. The invention has many applications including tubing used in hospital care (e.g., urinary catheters, intravenous fluid delivery tubing, tubing used in dialysis, e.g. heparin lines or blood tubing sets), food manufacturing, pharmaceutical manufacturing, water quality monitoring, and environmental monitoring.

Abstract translation: 诸如透明塑料一次性管道或玻璃管的管道包括形成在管道中或放置在管道内的光子传感器。 光子传感器可以采用光子晶体传感器，分布式反馈激光传感器和表面增强拉曼光谱（SERS）传感器的形式，包括光子晶体增强型SERS传感器。 描述传感器的检测装置。 本发明具有许多应用，包括在医院护理中使用的管道（例如，导尿管，静脉输液管道，透析中使用的管，例如肝素管线或血管套件），食品制造，药物制造，水质监测和环境监测。

公开(公告)号：US20120276549A1

公开(公告)日：2012-11-01

申请号：US13438969

申请日：2012-04-04

Applicant: Brian T. Cunningham ,  Charles J. Choi ,  Alysia R. Watkins

Inventor： Brian T. Cunningham ,  Charles J. Choi ,  Alysia R. Watkins

IPC: G01N21/65 ,  A61M39/00 ,  A61M5/00 ,  B32B37/14 ,  B32B37/02 ,  B23P11/00 ,  B23P17/04 ,  C12M1/34 ,  B29D11/00 ,  B82Y15/00

CPC classification number: A61M39/08 ,  B29D11/0074 ,  B82Y15/00 ,  B82Y20/00 ,  G01J3/02 ,  G01J3/44 ,  G01N21/65 ,  G01N21/658 ,  Y10T29/49826 ,  Y10T29/49947

Abstract: Tubing such as clear plastic disposable tubing or glass tubing includes a photonic sensor formed in or placed within the tubing. The photonic sensors can take the form of photonic crystal sensors, distributed feedback laser sensors, and surface enhanced Raman spectroscopy (SERS) sensors, including photonic crystal enhanced SERS sensors. Detection arrangements for the sensors are described. The invention has many applications including tubing used in hospital care (e.g., urinary catheters, intravenous fluid delivery tubing, tubing used in dialysis, e.g. heparin lines or blood tubing sets), food manufacturing, pharmaceutical manufacturing, water quality monitoring, and environmental monitoring.

Abstract translation: 诸如透明塑料一次性管道或玻璃管的管道包括形成在管道中或放置在管道内的光子传感器。 光子传感器可以采用光子晶体传感器，分布式反馈激光传感器和表面增强拉曼光谱（SERS）传感器的形式，包括光子晶体增强型SERS传感器。 描述传感器的检测装置。 本发明具有许多应用，包括在医院护理中使用的管道（例如，导尿管，静脉输液管道，透析中使用的管，例如肝素管线或血管套件），食品制造，药物制造，水质监测和环境监测。

公开(公告)号：US20120258549A1

公开(公告)日：2012-10-11

申请号：US13433619

申请日：2012-03-29

Applicant: Meng Lu ,  Chun Ge ,  Brian T. Cunningham ,  Stephen Schulz

Inventor： Meng Lu ,  Chun Ge ,  Brian T. Cunningham ,  Stephen Schulz

IPC: G01N21/75 ,  G01N21/64

CPC classification number: G01N21/6428 ,  G01N21/6458 ,  G01N2021/6421 ,  H01S3/1055 ,  H01S5/141 ,  H01S5/142

Abstract: A label-free biosensor detection arrangement incorporating an external cavity laser (ECL) includes a tunable lasing element (e.g. an antireflection coated laser diode or semiconductor optical amplifier) and a narrow bandwidth resonant reflectance filter as the wavelength-selective element for the tunable lasing element. A sample is deposited on the surface of the resonant reflectance filter containing a biological material. The wavelength emitted by the external cavity laser is continuously tunable by binding interactions between the biological material and the resonant reflectance filter or adsorption of the biological material present in the sample on resonant reflectance filter. The narrow bandwidth resonance reflectance filter can take the form of photonic crystal (PC), a Bragg stack, or a Brag fiber reflection filter.

Abstract translation: 包含外腔激光器（ECL）的无标签生物传感器检测装置包括可调谐激光元件（例如抗反射涂层激光二极管或半导体光放大器）和窄带谐振反射滤光器，作为可调谐激光元件的波长选择元件 。 将样品沉积在含有生物材料的共振反射滤光片的表面上。 外腔激光器发出的波长可以通过生物材料和谐振反射滤光片之间的结合相互作用或者在样品中存在于共振反射滤光片上的生物材料的吸附来连续调节。 窄带谐振反射滤波器可以采用光子晶体（PC），布拉格堆叠或布拉格光纤反射滤光片的形式。

公开(公告)号：US20120007000A1

公开(公告)日：2012-01-12

申请号：US13135246

申请日：2011-06-28

Applicant: Meng Lu ,  Stephen C. Schulz ,  Brian T. Cunningham ,  Anusha Pokhriyal

Inventor： Meng Lu ,  Stephen C. Schulz ,  Brian T. Cunningham ,  Anusha Pokhriyal

IPC: G01N21/64

CPC classification number: G01N21/648 ,  G01N21/6428 ,  G01N21/7743

Abstract: A photonic crystal substrate exhibiting resonant enhancement of multiple fluorophores has been demonstrated. The device, which can be fabricated uniformly from plastic materials over a ˜3×5 in2 surface area by nanoreplica molding, features a 1-D periodic grating structure which utilizes two distinct resonant modes to enhance electric field stimulation of a first dye excited by a first laser (e.g., λ=632.8 nm laser exciting cyanine-5) and a second dye excited by a second laser (e.g., λ=532 nm laser exciting cyanine-3). The first and second lasers could be replaced by a single variable wavelength (tunable) laser. Resonant coupling of the laser excitation to the photonic crystal surface is obtained for each wavelength at a distinct incident angle θ. The photonic crystal is capable of amplifying the output of any fluorescent dye with an excitation wavelength in a given wavelength range (e.g., the range 532 nm

Abstract translation: 已经证明了表现出多个荧光团的共振增强的光子晶体衬底。 可以通过纳米尺寸成型在〜3×5 in2表面积上由塑料材料均匀地制造的器件具有1-D周期性光栅结构，其利用两种不同的谐振模式来增强第一染料激发的电场刺激 第一激光（例如，λ= 632.8nm激光花青-5）和由第二激光器激发的第二染料（例如，λ= 532nm激光花青-3）。 第一和第二激光器可以由单个可变波长（可调谐）激光器代替。 获得激光激发与光子晶体表面的共振耦合，每个波长处于不同的入射角。 通过选择适当的入射角，光子晶体能够通过给定波长范围（例如，532nm <λ<660nm）的激发波长放大任何荧光染料的输出。 该装置可用于在单个成像区域内利用多种荧光染料的生物测定法，例如基因表达微阵列。