公开(公告)号：US5643553A

公开(公告)日：1997-07-01

申请号：US534198

申请日：1995-09-26

申请人： Michel Schneider ,  Daniel Bichon ,  Philippe Bussat ,  Jerome Puginier ,  Eva Hybl-Sutherland

发明人： Michel Schneider ,  Daniel Bichon ,  Philippe Bussat ,  Jerome Puginier ,  Eva Hybl-Sutherland

IPC分类号： A61B8/00 ,  A61B5/055 ,  A61K9/10 ,  A61K9/127 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/22 ,  A61K47/24 ,  A61K47/26 ,  A61K47/28 ,  A61K47/34 ,  A61K47/36 ,  A61K49/00 ,  A61K49/22 ,  A61B8/13

CPC分类号： A61K49/223 ,  A61K49/227 ,  Y10S514/975

摘要： Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.

摘要翻译： 在超声波回波成像中用作成像造影剂的水相中的气体或空气填充的微泡悬浮液。 它们含有层状表面活性剂和任选的亲水稳定剂。 层状表面活性剂可以是脂质体的形式。 通过在与水相混合之前或之后将层状表面活性剂暴露于空气或气体中获得悬浮液。

公开(公告)号：US5578292A

公开(公告)日：1996-11-26

申请号：US380588

申请日：1995-01-30

申请人： Michel Schneider ,  Feng Yan ,  Pascal Grenier, deceased ,  Jerome Puginier ,  Marie-Bernadette Barrau

发明人： Michel Schneider ,  Feng Yan ,  Pascal Grenier, deceased ,  Jerome Puginier ,  Marie-Bernadette Barrau

IPC分类号： A61B8/00 ,  A61K49/22 ,  A61K49/00

CPC分类号： A61K49/227 ,  A61K49/223 ,  Y10S977/788 ,  Y10S977/929

摘要： One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.

公开(公告)号：US5567414A

公开(公告)日：1996-10-22

申请号：US457581

申请日：1995-06-01

申请人： Michel Schneider ,  Daniel Bichon ,  Philippe Bussat ,  Jerome Puginier ,  Eva Hybl-Sutherland

发明人： Michel Schneider ,  Daniel Bichon ,  Philippe Bussat ,  Jerome Puginier ,  Eva Hybl-Sutherland

IPC分类号： A61B8/00 ,  A61B5/055 ,  A61K9/10 ,  A61K9/127 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/22 ,  A61K47/24 ,  A61K47/26 ,  A61K47/28 ,  A61K47/34 ,  A61K47/36 ,  A61K49/00 ,  A61K49/22

CPC分类号： A61K49/223 ,  A61K49/227 ,  Y10S514/975

摘要： Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophillc stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.

摘要翻译： 在超声波回波成像中用作成像造影剂的水相中的气体或空气填充的微泡悬浮液。 它们含有层状表面活性剂和任选的亲水稳定剂。 层状表面活性剂可以是脂质体的形式。 通过在与水相混合之前或之后将层状表面活性剂暴露于空气或气体中获得悬浮液。

公开(公告)号：US5445810A

公开(公告)日：1995-08-29

申请号：US128206

申请日：1993-09-29

申请人： Michel Schneider ,  Herve Tournier ,  Bernard Lamy

发明人： Michel Schneider ,  Herve Tournier ,  Bernard Lamy

IPC分类号： A61K9/127 ,  A61K9/50 ,  A61K49/04

CPC分类号： A61K49/0466

摘要： Injectable aqueous composition intended for opacifying certain organs with a view to examination by X-rays. This composition is based on liposomes containing, encapsulated thereein, an aqueous solution of an iodinated opacifying agent. The ratio between the weight of iodine encapsulated by the liposomes and the weight of the lipids from which their membrane is formed is not lower than 1.5 mg/mg.

摘要翻译： 可注射的含水组合物用于使某些器官不透明，以便通过X射线检查。 该组合物基于含有包封的含有所述碘化不透明剂的水溶液的脂质体。 由脂质体包封的碘的重量与其膜形成的脂质的重量之比不低于1.5mg / mg。

公开(公告)号：US5280149A

公开(公告)日：1994-01-18

申请号：US921690

申请日：1992-07-30

申请人： Michel Schneider ,  Gerard Masson ,  Eric Bescher

发明人： Michel Schneider ,  Gerard Masson ,  Eric Bescher

IPC分类号： A62D3/178 ,  A62D3/33 ,  A62D101/08 ,  A62D101/24 ,  A62D101/43 ,  B01J19/12 ,  B09B3/00 ,  C02F11/00 ,  C02F11/10 ,  C04B18/04 ,  C04B35/26 ,  C04B35/64 ,  C22B9/22 ,  H05B6/64

CPC分类号： A62D3/33 ,  A62D3/178 ,  B01J19/126 ,  C04B18/0463 ,  C04B35/26 ,  C04B35/64 ,  C22B9/225 ,  H05B6/64 ,  A62D2101/08 ,  A62D2101/24 ,  A62D2101/43 ,  A62D2203/04 ,  Y02W30/91

摘要： The subject of the present invention is a process for treating highly environmentally polluting residues such as for example residues derived from dry or wet filtration. The process consists in mixing the residues with a product containing iron oxide, in placing the mixture in a crucible, in protecting the crucible with insulating fibers, in putting the crucible in a microwave oven and in exposing the mixture to microwaves for a time of between 2 and 15 minutes at a temperature of between 1000.degree. and 1300.degree. C. in order to produce a dry fusion of the mixture and to obtain a solid material. The present invention is applicable to the reclaiming of sludge from the iron and steel industry.

摘要翻译： 用于处理对环境高度污染的残留物的方法，例如来自干燥或湿滤液的残余物。 该方法包括将残余物与含有氧化铁的产物混合，将混合物置于坩埚（5）中，用绝缘纤维（6）保护坩埚（5），将坩埚（5）放置在微波炉（1）中， 并在1000至1300℃的温度下将混合物暴露于微波2至15分钟之间，以产生混合物的干熔融并获得固体材料。 本发明适用于钢铁生产污泥的升级改造。

公开(公告)号：US4224179A

公开(公告)日：1980-09-23

申请号：US931242

申请日：1978-08-04

申请人： Michel Schneider

发明人： Michel Schneider

IPC分类号： B01J13/12 ,  A61K9/10 ,  A61K9/127 ,  A61K9/50 ,  B01J13/02

CPC分类号： A61K9/1277 ,  Y10S516/929

摘要： A process for the preparation of a solution or suspension of liposomes in an aqueous medium comprising the steps of dispersing a first aqueous liquid in an essentially water-insoluble solvent in the presence of a compound of the formula XY wherein X is a hydrophilic lipophobic group and Y is a lipophilic hydrophobic group to form a dispersion of liposome precursors in the solvent, the precursors consisting of small vesicles of the first aqueous liquid surrounded by a monomolecular film of compound XY, emulsifying the liposome precursors in a second aqueous medium in the presence of a compound of the formula ZW wherein Z is a hydrophilic group and W is a hydrophobic group to thereby form a solution or suspension of liposomes in the second aqueous medium, said liposomes consisting of the first aqueous liquid surrounded by a bimolecular film of the structure XY-WZ and removing the water-insoluble solvent prior to after said emulsification.

摘要翻译： 一种用于制备脂质体在水性介质中的溶液或悬浮液的方法，包括以下步骤：在式XY化合物的存在下，将基本上不溶于水的溶剂中分散第一含水液体，其中X为亲水疏乳基团， Y是亲脂性疏水基团，以在溶剂中形成脂质体前体的分散体，前体由第一含水液体由化合物XY的单分子膜包围的第一含水液体组成，在第二种含水介质中，在第二种含水介质的存在下乳化脂质体前体 式ZW的化合物，其中Z是亲水基团，W是疏水基团，从而在第二水性介质中形成脂质体的溶液或悬浮液，所述脂质体由由结构XY的双分子膜包围的第一含水液体组成 -WZ，并在所述乳化之前除去水不溶性溶剂。

公开(公告)号：US09072492B2

公开(公告)日：2015-07-07

申请号：US12811089

申请日：2008-12-23

申请人： Marcel Arditi ,  Tristan Messager ,  Michel Schneider ,  Peter Frinking

发明人： Marcel Arditi ,  Tristan Messager ,  Michel Schneider ,  Peter Frinking

IPC分类号： A61B8/14 ,  A61B8/08 ,  G06F19/12

CPC分类号： A61B8/481 ,  A61B8/14 ,  A61B8/5223 ,  G06F19/12

摘要： An embodiment analyzes a body part of a patient, which patient is perfused with a contrast agent that is capable of circulating within the patient and of being substantially immobilized on a biological target. An embodiment of a corresponding system provides an echo signal that is indicative of a response over time to an interrogation signal of the body part, fits the echo signal with a time model function that models an evolution over time of the contrast agent in the body part, the time model function including a combination of a circulation function that models the circulation of the contrast agent and a decay function that models a decay of the echo signal from the immobilized contrast agent, and estimates at least one kinetics indicator of the contrast agent from the time model function.

摘要翻译： 一个实施方案分析患者的身体部分，该患者被灌注了能够在患者体内循环并且基本上固定在生物靶上的造影剂。 对应系统的一个实施例提供一个回波信号，其指示随着时间的推移对身体部位的询问信号的响应，将回波信号与时间模型函数拟合，该时间模型函数对身体部位中造影剂的时间演化进行建模 时间模型功能包括对造影剂的循环进行建模的循环功能和对来自固定的造影剂的回波信号的衰减进行建模的衰减函数的组合，并估计造影剂的至少一个动力学指标 时间模型功能。

公开(公告)号：US20110245663A1

公开(公告)日：2011-10-06

申请号：US13010044

申请日：2011-01-20

申请人： Michel Schneider ,  Christophe Golay ,  Laurent Jakob ,  Jean Brochot ,  Feng Yan ,  Christian Mathieu

发明人： Michel Schneider ,  Christophe Golay ,  Laurent Jakob ,  Jean Brochot ,  Feng Yan ,  Christian Mathieu

IPC分类号： A61B6/00

CPC分类号： A61M5/1456 ,  A61B2017/22008 ,  A61B2090/3925 ,  A61B2090/3933 ,  A61M5/007 ,  A61M2205/6072 ,  B01F9/0016 ,  B01F11/0002 ,  B01F2003/0035

摘要： A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.

摘要翻译： 一种功率辅助方法和注射器装置，用于向患者可控地递送分散药物或诊断活性剂，其均匀性在整个递送期间保留。 所公开的诊断活性剂是用于超声诊断成像的气体微泡悬浮液和其中脂质体囊泡装载碘化化合物的脂质体制剂。

公开(公告)号：US07749485B2

公开(公告)日：2010-07-06

申请号：US11596447

申请日：2005-05-31

申请人： Herve Tournier ,  Roland Hyacinthe ,  Michel Schneider

发明人： Herve Tournier ,  Roland Hyacinthe ,  Michel Schneider

IPC分类号： A61K51/00 ,  A61M36/14 ,  B32B5/16 ,  B01F3/00

CPC分类号： A61K9/1075 ,  A61K9/1271 ,  A61K48/0091 ,  A61K49/1812 ,  C12N15/88 ,  Y10S977/907 ,  Y10T428/2982

摘要： Composition for diagnostic or therapeutic use which comprises an assembly comprising an active agent. The assembly comprises a liposome and a plurality of micellar components associated thereto, said micellar components being associated to the outer surface of the envelope of said liposome through a substantially electrostatic interaction, When an active compound is incorporated into the micelles, a substantial amount of said active compound can be linked to a singe liposome. Furthermore, the presence of the outer micellar layer allows to increase the residence time of said liposome in the blood stream.

摘要翻译： 用于诊断或治疗用途的组合物，其包含包含活性剂的组合物。 组合物包含脂质体和与其相关联的多个胶束组分，所述胶束组分通过基本上静电的相互作用与所述脂质体的外壳的外表面结合。当将活性化合物并入胶束中时，大量的所述 活性化合物可以连接到单个脂质体。 此外，外胶束层的存在允许增加所述脂质体在血流中的停留时间。

公开(公告)号：US20080008657A1

公开(公告)日：2008-01-10

申请号：US11660188

申请日：2005-08-17

申请人： Philippe Bussat ,  Peter Frinking ,  Christian Guillot ,  Michel Schneider

发明人： Philippe Bussat ,  Peter Frinking ,  Christian Guillot ,  Michel Schneider

IPC分类号： A61K49/22

CPC分类号： A61K49/223

摘要： The present invention relates to a new composition comprising gas-filled microvesicles for contrast imaging which are particularly suitable for providing an effective echo response to at least two selected ultrasound waves having different frequencies. Said composition preferably comprises at least two different preparations of gas-filled microvesicles, which preferably have respective different mean sizes. In particular, said preparations preferably have respective Dv values differing from each other by at least 0.5 μm, more preferably at least 1.0 μm. Alternatively, said composition has a volume size distribution showing a value of Bowley skewness of 0.16 or higher. According to a preferred embodiment, at least 95% of the total volume of gas contained in said microvesicles, calculated on the population of microvesicles up to a diameter of 10 μm, is contained in microvesicles having a diameter of 8 micron or less. The composition of the invention can be effectively employed at rather different ultrasound transmission frequencies differing by about 8 MHz.

摘要翻译： 本发明涉及一种新的组合物，其包括用于对比成像的气体填充微泡，其特别适合于向至少两个具有不同频率的选定超声波提供有效的回波响应。 所述组合物优选包含至少两种气体填充微泡的不同制剂，其优选具有不同的平均尺寸。 特别地，所述制剂优选具有彼此不同的至少0.5μm，更优选至少1.0μm的相应的D V值。 或者，所述组合物具有显示Bowley偏度值为0.16或更高的体积大小分布。 根据一个优选实施方案，所述微泡中包含的气体的总体积的至少95％是以直径为10微米的微泡总数计算的，包含在直径为8微米或更小的微泡中。 本发明的组合物可以以不同于约8MHz的相当不同的超声波传播频率有效地使用。