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65 条记录 (耗时 0.078 秒)

    Colon specific gene and protein
    31.
    发明授权
    Colon specific gene and protein 失效

    公开(公告)号：US5861494A

    公开(公告)日：1999-01-19

    申请号：US468413

    申请日：1995-06-06

    申请人： Daniel R. Soppet ,  Yi Li ,  Patrick J. Dillon

    发明人： Daniel R. Soppet ,  Yi Li ,  Patrick J. Dillon

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/68

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： Human colon specific gene polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides or polypeptides as a diagnostic marker for colon cancer and as an agent to determine if colon cancer has metastasized. Also disclosed are antibodies specific to the colon specific gene polypeptides which may be used to target cancer cells and be used as part of a colon cancer vaccine. Methods of screening for agonists and antagonists for the polypeptide and therapeutic uses of the antagonists are also disclosed.

    Human neuronal attachment factor-1 antibodies
    32.
    发明授权
    Human neuronal attachment factor-1 antibodies 失效
    人类神经元附着因子-1抗体

    公开(公告)号：US07485459B2

    公开(公告)日：2009-02-03

    申请号：US10788346

    申请日：2004-03-01

    申请人： Gregg A. Hastings ,  Patrick J. Dillon

    发明人： Gregg A. Hastings ,  Patrick J. Dillon

    IPC分类号： C12N5/22 ,  A61K39/395 ,  C07K16/28

    CPC分类号： C07K14/47 ,  A61K38/00 ,  Y02A50/411

    摘要： A human F-spondin-like protein and DNA (RNA) encoding such protein and a procedure for producing such protein by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating spinal cord injuries and damage to peripheral nerves by promoting neural-cell adhesion and neurite extension, inhibiting tumor metastases and tumor angiogenesis, and stimulating wound repair. Antagonists are also disclosed which may be utilized to prevent malaria. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

    摘要翻译： 公开了一种编码这种蛋白质的人类F-脊椎样蛋白样蛋白和DNA（RNA）以及通过重组技术产生这种蛋白质的方法。 还公开了通过促进神经细胞粘附和神经突延伸，抑制肿瘤转移和肿瘤血管发生以及刺激伤口修复来利用这种多肽来治疗脊髓损伤和损伤周围神经的方法。 还公开了可用于预防疟疾的拮抗剂。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

    Nucleotide sequence of Escherichia coli pathogenicity islands
    35.
    发明授权
    Nucleotide sequence of Escherichia coli pathogenicity islands 失效
    大肠杆菌致病岛的核苷酸序列

    公开(公告)号：US06787643B2

    公开(公告)日：2004-09-07

    申请号：US09956004

    申请日：2001-09-20

    申请人： Patrick J. Dillon ,  Gil H. Choi ,  Rodney A. Welch

    发明人： Patrick J. Dillon ,  Gil H. Choi ,  Rodney A. Welch

    IPC分类号： C07H2104

    CPC分类号： C07K14/245

    摘要： The present invention relates to novel genes located in two chromosomal regions within uropathogenic E. coli that are associated with virulence. These chromosomal regions are known as pathogenicity islands (PAIs). In particular, the present application discloses 142 sequenced fragments (contigs) of DNA from two pools of cosmids covering pathogenicity islands PAI IV and PAI V located on the chromosome of the uropathogenic Escherichia coli J96. Further disclosed are 351 predicted protein-coding open reading frames within the sequenced fragments.

    摘要翻译： 本发明涉及位于致病性大肠杆菌中与毒力相关的两个染色体区域中的新基因。 这些染色体区域被称为致病岛（PAIs）。 特别地，本申请公开了来自覆盖致病性大肠杆菌J96的染色体上的致病性岛PAI IV和PAI V的两个粘粒池的DNA的142个测序片段（重叠群）。 进一步披露了序列片段内的351个预测的蛋白质编码的开放阅读框。

    Nucleotide sequence of Escherichia coli pathogenicity islands
    38.
    发明授权
    Nucleotide sequence of Escherichia coli pathogenicity islands 失效
    大肠杆菌致病岛的核苷酸序列

    公开(公告)号：US06316609B1

    公开(公告)日：2001-11-13

    申请号：US08976259

    申请日：1997-11-21

    申请人： Patrick J. Dillon ,  Gil H. Choi ,  Rodney A. Welch

    发明人： Patrick J. Dillon ,  Gil H. Choi ,  Rodney A. Welch

    IPC分类号： C07H2104

    CPC分类号： C07K14/245

    摘要： The present invention relates to novel genes located in two chromosomal regions within uropathogenic E. coli that are associated with virulence. These chromosomal regions are known as pathogenicity islands (PAIs). In particular, the present application discloses 142 sequenced fragments (contigs) of DNA from two pools of cosmids covering pathogenicity islands PAI IV and PAI V located on the chromosome of the uropathogenic Escherichia coli J96. Further disclosed are 351 predicted protein-coding open reading frames within the sequenced fragments.

    摘要翻译： 本发明涉及位于致病性大肠杆菌中与毒力相关的两个染色体区域中的新基因。 这些染色体区域被称为致病岛（PAIs）。 特别地，本申请公开了来自覆盖致病性大肠杆菌J96的染色体上的致病性岛PAI IV和PAI V的两个粘粒池的DNA的142个测序片段（重叠群）。 进一步披露了序列片段内的351个预测的蛋白质编码的开放阅读框。

    Human XAG-1 polynucleotides and polypeptides
    39.
    发明授权
    Human XAG-1 polynucleotides and polypeptides 失效
    人类XAG-1多核苷酸和多肽

    公开(公告)号：US06171816B2

    公开(公告)日：2001-01-09

    申请号：US08916576

    申请日：1997-08-22

    申请人： Guo-Liang Yu ,  Patrick J. Dillon ,  Reinhard Ebner ,  Gregory A. Endress

    发明人： Guo-Liang Yu ,  Patrick J. Dillon ,  Reinhard Ebner ,  Gregory A. Endress

    IPC分类号： C12N1500

    CPC分类号： C07K14/475 ,  A61K38/00 ,  C07K2317/92

    摘要： The present invention relates to huXAG-1, huXAG-2 and huXAG-3 proteins which are novel human growth factors. In particular, isolated nucleic acid molecules are provided encoding the huXAG-1, huXAG-2 and huXAG-3 proteins. huXAG-1, huXAG-2 and huXAG-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of huXAG-1, huXAG-2 or huXAG-3 activity. Also provided are diagnostic and therapeutic uses of huXAG-1. huXAG-2 and huXAG-3.

    摘要翻译： 本发明涉及作为新型人生长因子的huXAG-1，huXAG-2和huXAG-3蛋白。 特别地，提供编码huXAG-1，huXAG-2和huXAG-3蛋白的分离的核酸分子。 还提供huXAG-1，huXAG-2和huXAG-3多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定huXAG-1，huXAG-2或huXAG-3活性的激动剂和拮抗剂的筛选方法。 还提供了huXAG-1的诊断和治疗用途。 huXAG-2和huXAG-3。