公开(公告)号：US20080018008A1

公开(公告)日：2008-01-24

申请号：US11781126

申请日：2007-07-20

申请人： David Edwards

发明人： David Edwards

IPC分类号： B29D11/00

CPC分类号： B29C45/34 ,  B29C45/2673 ,  B29D11/00125 ,  B29D11/005 ,  B29L2011/0041

摘要： Devices, systems, and methods for producing ophthalmic lens molds and molded ophthalmic lenses are described. The present devices, systems, and methods provide venting of gases produced during injection molding of ophthalmic lens molds. With the present devices, systems, and methods, improvements in mold quality, lens quality, mold quality consistency, and lens quality consistency can be achieved compared to existing injection molding devices, systems, and methods. An optic power insert bushing is described and includes a venting system that directs gas from a first end of the bushing toward a second end of the bushing. The gas is directed between an optic power insert and an inner sidewall surface of a bushing bore in which the optic power insert is located. The bushing or bushings, and optic power inserts, can be provided as components of an ophthalmic lens mold injection system. Methods of making and using the vented bushings are also described.

摘要翻译： 描述了用于生产眼镜片模具和模制眼镜片的装置，系统和方法。 本设备，系统和方法提供了在眼镜模具注射成型期间产生的气体的排气。 与现有的注塑设备，系统和方法相比，使用本设备，系统和方法可以实现模具质量，镜片质量，模具质量一致性和透镜质量一致性的改进。 描述了光功率插入套管，并且包括将气体从衬套的第一端朝向衬套的第二端引导的排气系统。 气体被引导在光功率插入件和光功率插入件所在的衬套孔的内侧壁表面之间。 衬套或衬套和光功率插入件可以被提供为眼镜模注射系统的组件。 还描述了制造和使用排气衬套的方法。

公开(公告)号：US20070035466A1

公开(公告)日：2007-02-15

申请号：US11584690

申请日：2006-10-20

申请人： James Coleman ,  David Edwards ,  Ian Forster ,  Pradeep Iyer ,  Mark Licon

发明人： James Coleman ,  David Edwards ,  Ian Forster ,  Pradeep Iyer ,  Mark Licon

IPC分类号： G08B13/14 ,  B32B37/00

CPC分类号： G06K19/0776 ,  G06K19/07718 ,  G06K19/07749 ,  G06K19/07752 ,  G06K19/07779 ,  G06K19/07783 ,  H05K3/00 ,  H05K3/205 ,  H05K3/245 ,  H05K3/386 ,  H05K2203/0117 ,  Y10T29/49016 ,  Y10T29/49018 ,  Y10T29/4902 ,  Y10T29/49117 ,  Y10T29/49155 ,  Y10T29/49224

摘要： A method of forming an electrically-conductive pattern includes selectively electroplating the top portions of a substrate that corresponds to the pattern, and separating the conductive pattern from the substrate. The electroplating may also include electrically connecting the conductive pattern to an electrical component. Conductive ink, such as ink including carbon particles, may be selectively placed on the conductive substrate to facilitate plating of the desired pattern and/or to facilitate separation of the pattern from the substrate. An example of a conductive pattern is an antenna for a radio-frequency identification (RFID) device such as a label or a tag. One example of an electrical component that may be electrically connected to the antenna, is an RFID strap or chip.

摘要翻译： 形成导电图案的方法包括选择性地电镀对应于图案的衬底的顶部部分，并且将导电图案与衬底分离。 电镀还可以包括将导电图案电连接到电气部件。 诸如包含碳颗粒的墨的导电油墨可以选择性地放置在导电基底上，以便于电镀所需图案和/或促进图案与基底的分离。 导电图案的示例是用于诸如标签或标签的射频识别（RFID）设备的天线。 可以电连接到天线的电气部件的一个例子是RFID带或芯片。

公开(公告)号：US20060189581A1

公开(公告)日：2006-08-24

申请号：US11405798

申请日：2006-04-18

申请人： David Edwards ,  Patricia Somers ,  Mitchell Glass

发明人： David Edwards ,  Patricia Somers ,  Mitchell Glass

IPC分类号： A61K31/66 ,  A61K31/185 ,  A61K31/277 ,  A61K31/18

CPC分类号： C07C323/25 ,  A61K31/18 ,  A61K31/185 ,  A61K31/222 ,  A61K31/66 ,  C07C323/20 ,  C07C323/21 ,  C07C323/56 ,  C07C323/60 ,  C07C323/66 ,  C07C323/67 ,  C07H15/203

摘要： The use of compounds of the formula and pharmaceutically acceptable salts thereof, alone or in combination for the treatment of transplant rejection, wherein the substituents are further defined in the application.

公开(公告)号：US20060128742A1

公开(公告)日：2006-06-15

申请号：US11345132

申请日：2006-02-01

申请人： David Edwards ,  Michael Berens ,  Christian Beaudry

发明人： David Edwards ,  Michael Berens ,  Christian Beaudry

IPC分类号： A61K31/4745

CPC分类号： G01N33/5011 ,  A61K31/00 ,  A61K31/192 ,  A61K31/215 ,  A61K31/381 ,  A61K31/4745 ,  A61K31/549 ,  A61K38/193 ,  A61K39/00 ,  A61K45/06 ,  G01N2500/10 ,  A61K2300/00

摘要： Methods for treating an individual having cancer are provided. The method may include administering a cell migration inhibitor and a chemotherapeutic agent to the individual to inhibit migration of cancer cell. Inhibiting cell migration may increase cell division. In this manner, the cell migration inhibitor and the chemotherapeutic agent in combination may have increased efficacy compared to the chemotherapeutic agent alone due to the increased cell division. The cell migration inhibitor may include any of the inhibitors described herein. For example, the cell migration inhibitor may be an organic molecule having a molecular weight of less than about 700, a monoclonal antibody, or a natural product.

摘要翻译： 提供了治疗患有癌症的个体的方法。 该方法可以包括向个体施用细胞迁移抑制剂和化学治疗剂以抑制癌细胞的迁移。 抑制细胞迁移可能增加细胞分裂。 以这种方式，由于细胞分裂增加，细胞迁移抑制剂和化学治疗剂的组合可能与单独的化学治疗剂相比具有增加的功效。 细胞迁移抑制剂可以包括本文所述的任何抑制剂。 例如，细胞迁移抑制剂可以是分子量小于约700的有机分子，单克隆抗体或天然产物。

公开(公告)号：US20060017301A1

公开(公告)日：2006-01-26

申请号：US10894488

申请日：2004-07-20

申请人： David Edwards

发明人： David Edwards

IPC分类号： B62D43/10

CPC分类号： B62D43/10

摘要： A retention system for a vehicular spare tire includes a chamber having a bottom portion. A tray is configured for movement in a first direction relative to the bottom portion between an extended position and a stored position. At least one removable interconnecting member is configured to selectively interface with both the tray and the chamber for substantially preventing movement of the tray relative in the first direction. At least one guide member is configured to selectively interface with a back portion of the tray for substantially preventing movement of the back portion of the tray in a second direction relative to the bottom portion while the tray is in the stored position. The second direction is generally perpendicular to the first direction.

摘要翻译： 车辆备用轮胎的保持系统包括具有底部的腔室。 托盘构造成用于在延伸位置和存储位置之间相对于底部部分在第一方向上移动。 至少一个可移除互连构件被配置为选择性地与托盘和腔室相接合，用于基本上防止托盘相对于第一方向的移动。 至少一个引导构件构造成与托盘的后部选择性地接合，用于当托盘处于存储位置时基本上防止托盘的后部在相对于底部的第二方向上移动。 第二方向通常垂直于第一方向。

公开(公告)号：USD513215S1

公开(公告)日：2005-12-27

申请号：US29217025

申请日：2004-11-12

申请人： Jarad W. Hall ,  Donald Lariviere ,  Thomas H. Kim ,  David Edwards

设计人： Jarad W. Hall ,  Donald Lariviere ,  Thomas H. Kim ,  David Edwards

公开(公告)号：US20050282355A1

公开(公告)日：2005-12-22

申请号：US10872235

申请日：2004-06-18

申请人： David Edwards ,  Jason Munn ,  Kouroche Kian ,  Reza Mehrabi ,  Ian Forster ,  Thomas Weakley

发明人： David Edwards ,  Jason Munn ,  Kouroche Kian ,  Reza Mehrabi ,  Ian Forster ,  Thomas Weakley

IPC分类号： H01L21/30 ,  H01L21/44 ,  H01L21/46 ,  H01L21/48 ,  H01L21/50 ,  H01L21/60 ,  H01L21/603

CPC分类号： H01L24/75 ,  H01L24/81 ,  H01L2224/16 ,  H01L2224/75315 ,  H01L2224/81801 ,  H01L2924/01019 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01047 ,  H01L2924/01075 ,  H01L2924/01078 ,  H01L2924/01082 ,  H01L2924/014 ,  H01L2924/07802 ,  H01L2924/10253 ,  H01L2924/14 ,  H01L2924/19041 ,  H01L2924/19042 ,  H01L2924/19043 ,  H01L2924/30105 ,  H01L2924/3011 ,  H01L2924/00

摘要： A method of thermocompressive bonding of one or more electrical devices using individual heating elements and a resilient member to force the individual heating elements into compressive engagement with the electrical devices is provided. The individual heating elements may be Curie-point heating elements or conventional resistive heating elements. A method of thermocompressive bonding of one or more electrical devices using a transparent flexible platen and thermal radiation is also provided. In one embodiment, the thermal radiation is near infra-red thermal radiation and the transparent flexible platen is composed of silicone rubber. The bonding material may be an adhesive or a thermoplastic bonding material. A method of capacitively coupling a semiconductor chip to an electrical component with a pressure sensitive adhesive is also provided. The method includes compressing the chip by forcing a flexible platen of a bonding device into compressive engagement with the semiconductor chip.

摘要翻译： 提供了一种使用各个加热元件和一个弹性部件热压接合一个或多个电气装置以迫使各个加热元件与电气装置压缩接合的方法。 各个加热元件可以是居里点加热元件或常规电阻加热元件。 还提供了使用透明柔性压板和热辐射的一个或多个电气装置的热压接合方法。 在一个实施例中，热辐射接近红外热辐射，透明柔性压板由硅橡胶组成。 接合材料可以是粘合剂或热塑性粘合材料。 还提供了利用压敏粘合剂将半导体芯片电容耦合到电气部件的方法。 该方法包括通过迫使粘结装置的柔性压板与半导体芯片压缩接合来压缩芯片。

公开(公告)号：US20050232872A1

公开(公告)日：2005-10-20

申请号：US11154067

申请日：2005-06-14

申请人： Daniel Deaver ,  David Edwards

发明人： Daniel Deaver ,  David Edwards

IPC分类号： A61K47/28 ,  A61K9/00 ,  A61K9/06 ,  A61K9/14 ,  A61K31/56 ,  A61K31/573 ,  A61K31/715 ,  A61K38/17 ,  A61K38/22 ,  A61K45/08 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61K48/00 ,  A61L9/04

CPC分类号： A61K9/0046 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/006 ,  A61K9/0073 ,  A61K9/06 ,  A61K31/56 ,  A61K31/573 ,  A61K31/715 ,  A61K47/38 ,  A61K48/00 ,  A61K48/0008 ,  A61K48/0083 ,  Y10S977/906

摘要： Compositions and methods for improving cellular internalization of one or more compounds are disclosed. The compositions include a compound to be delivered and a biocompatible viscous material, such as a hydrogel, lipogel, or highly viscous sol. The composition also include, or are administered in conjunction with, an enhancer in an amount effective to maximize expression of or binding to receptors and enhance RME of the compound into the cells. This leads to high transport rates of compounds to be delivered across cell membranes, facilitating more efficient delivery of drugs and diagnostic agents. Compositions are applied topically orally, nasally, vaginally, rectally, and ocularly. The enhancer is administered with the composition or separately, either systemically or preferably locally. The compound to be delivered can also be the enhancer.

公开(公告)号：US20050115935A1

公开(公告)日：2005-06-02

申请号：US10502530

申请日：2003-01-24

申请人： David Edwards ,  Brian Bryden

发明人： David Edwards ,  Brian Bryden

IPC分类号： B26F1/31 ,  B23K26/40 ,  B26F3/16 ,  B65B61/06 ,  B65D65/46 ,  C11D17/04 ,  B23K26/14

CPC分类号： B65B61/06 ,  B23K2103/42 ,  B23K2103/50 ,  C11D17/042

摘要： A process for cutting or perforating a water-soluble or water-dispersible film or stack of films in the form of a web comprising a plurality of compartments by which each compartment is cut or perforated by applying a laser beam to the film or stack of films. The process for producing a water-soluble or water-dispersible container containing a composition comprises: a producing a base web water-soluble or water-dispersible film containing a plurality of pockets; b. filling each pocket with a composition; c. sealing the pockets with a top web water-soluble or water-dispersible film to produce closed containers; and d. separating at least one container from the plurality of containers by cutting or perforating the combined web with a laser beam.

摘要翻译： 一种用于切割或穿孔纤维网形式的水溶性或水分散性薄膜或一叠薄膜的方法，该薄膜或薄片包括多个隔室，每个隔间通过将激光束施加到薄膜或薄膜层而被切割或穿孔 。 制备含有组合物的水溶性或水分散性容器的方法包括：产生含有多个袋的基网水溶性或水分散性膜; b。 用一个组合填充每个口袋; C。 用顶部网状水溶性或水分散性膜密封袋，以产生密闭容器; 和d。 通过用激光束切割或穿孔组合的网来将至少一个容器与多个容器分离。

公开(公告)号：US20050056667A1

公开(公告)日：2005-03-17

申请号：US10663889

申请日：2003-09-16

申请人： Kerry McClure ,  Brian Shanfeld ,  David Edwards

发明人： Kerry McClure ,  Brian Shanfeld ,  David Edwards

IPC分类号： B62D43/10 ,  B62D43/00

CPC分类号： B62D43/10

摘要： The present invention relates to a support structure for a spare tire on a vehicle. A shell is attached to the vehicle and includes first and second end portions and a bottom portion extending at least partially between the first and second end portions. The shell at least partially defines a spare tire storage chamber and includes an opening providing access to the storage chamber, wherein the opening is adjacent to the first end portion. A support member is adapted to support a spare tire. The support member is slidably positioned above the bottom portion and is movable back and forth along a movement path from a first position in which the support member is substantially disposed within the shell and a second position in which the support member is at least partially disposed outside the shell. The support member includes a lower interface surface for directly contacting an upper interface surface of the bottom portion of the shell in sliding engagement as the support member is moved along the movement path. In certain embodiments, a retention member can be fixedly attached to the shell. In further embodiments, the support member and the shell have a cooperative locking configuration. A support structure adapted to support a spare tire for a vehicle is also disclosed.

摘要翻译： 本发明涉及一种用于车辆上备用轮胎的支撑结构。 壳体附接到车辆并且包括第一和第二端部以及至少部分地在第一和第二端部之间延伸的底部部分。 壳体至少部分地限定备用轮胎储存室，并且包括提供进入储存室的开口，其中开口邻近第一端部。 支撑构件适于支撑备用轮胎。 所述支撑构件可滑动地定位在所述底部的上方，并且可沿着运动路径从所述支撑构件基本上设置在所述壳体内的第一位置和所述支撑构件至少部分地设置在外部的第二位置来回移动; 贝壳。 支撑构件包括下接口表面，用于当支撑构件沿着移动路径移动时，滑动接合直接接触壳体底部的上部界面表面。 在某些实施例中，保持构件可以固定地附接到外壳。 在另外的实施例中，支撑构件和壳体具有协作锁定配置。 还公开了一种适于支撑用于车辆的备用轮胎的支撑结构。